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The map label for this gene is pdhR [H]

Identifier: 218710504

GI number: 218710504

Start: 2736481

End: 2737287

Strand: Reverse

Name: pdhR [H]

Synonym: VS_2543

Alternate gene names: 218710504

Gene position: 2737287-2736481 (Counterclockwise)

Preceding gene: 218710506

Following gene: 218710503

Centisome position: 82.97

GC content: 44.61

Gene sequence:

>807_bases
TTGGTAATACCAATTGTCAGCGAAGAAAAAGAAGAACAACAAACTATGGCTTATCAAAGGATTCGTCAGCCAAAACTCTC
GGACGTTATCGAACAAGAGTTAGAAAGGTTGATAGTGGAAGGAACACTGGCTCCAGGGCAGCAGCTGCCGCCTGAGCGTG
AACTGGCGAAACAGTTCGATGTGTCTCGTCCTTCAATCCGAGAAGCGATACAACGTTTAGAAGCAAAACGCTTGCTTACT
CGCCGTCAAGGTGGAGGTACGTTTGTTAGCGAAAATATCTGGAAAAGCTTTTCAGATCCTTTGCTTAATTTGTTGTCCTC
CCATTCTGAAACCCAACTAGACTTGTTGGAATCGCGTCATGCGATGGAAGGGATTTCGGCTTACTTCGCGGCATTACGTG
GTACTGATGAAGACTTTGCTCGAATTCAAGCATGCCAAGAAAAAATTCGCGGTGCGCAAGATAAGGGTGATATTGAAGCC
GAGTCTGCAGCTGTGATGGCTTTTCTTATTGCTTTAACAGAGGCAGCGCACAATGTGGTGTTATTGCACATTGTTCGTAG
TTTGGCTCCGTTACTCGAACAAAACGTCTTAGAAAATTTAAAACTGTTGCATCGTCGTAAAGACGTTGTGGAGAAAGTGA
GTATACATCGAGCTAATATTGTAGATGCGATCGTTTCAGGACAGCCAGAACAGGCGCGTGAAATGTCACACTCTCATTTA
GCTTACATCGAAGAAACATTGATGGATTTGACCAAAGAAGAGTCGCGCCGCGAACGTTCTTTACGTCGAATCCAACAGGG
TAAATAG

Upstream 100 bases:

>100_bases
TTGTTAAATCATGGTTAATTCGTGCTGTGTTCTATGATTCAGGTCAATTTTAGTCTGGACAGTGGCGTTTTAATTATGTT
AATTTCTGCCCAACTTAAAA

Downstream 100 bases:

>100_bases
TCGTAATACTTCGGCTTTTTACGTGTTTAGTAGAATCCAACTAACAAAAAGGATAGATCGCCATGTCTGACATGAAGCAT
GACGTTGATGCTCTGGAAAC

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MVIPIVSEEKEEQQTMAYQRIRQPKLSDVIEQELERLIVEGTLAPGQQLPPERELAKQFDVSRPSIREAIQRLEAKRLLT
RRQGGGTFVSENIWKSFSDPLLNLLSSHSETQLDLLESRHAMEGISAYFAALRGTDEDFARIQACQEKIRGAQDKGDIEA
ESAAVMAFLIALTEAAHNVVLLHIVRSLAPLLEQNVLENLKLLHRRKDVVEKVSIHRANIVDAIVSGQPEQAREMSHSHL
AYIEETLMDLTKEESRRERSLRRIQQGK

Sequences:

>Translated_268_residues
MVIPIVSEEKEEQQTMAYQRIRQPKLSDVIEQELERLIVEGTLAPGQQLPPERELAKQFDVSRPSIREAIQRLEAKRLLT
RRQGGGTFVSENIWKSFSDPLLNLLSSHSETQLDLLESRHAMEGISAYFAALRGTDEDFARIQACQEKIRGAQDKGDIEA
ESAAVMAFLIALTEAAHNVVLLHIVRSLAPLLEQNVLENLKLLHRRKDVVEKVSIHRANIVDAIVSGQPEQAREMSHSHL
AYIEETLMDLTKEESRRERSLRRIQQGK
>Mature_268_residues
MVIPIVSEEKEEQQTMAYQRIRQPKLSDVIEQELERLIVEGTLAPGQQLPPERELAKQFDVSRPSIREAIQRLEAKRLLT
RRQGGGTFVSENIWKSFSDPLLNLLSSHSETQLDLLESRHAMEGISAYFAALRGTDEDFARIQACQEKIRGAQDKGDIEA
ESAAVMAFLIALTEAAHNVVLLHIVRSLAPLLEQNVLENLKLLHRRKDVVEKVSIHRANIVDAIVSGQPEQAREMSHSHL
AYIEETLMDLTKEESRRERSLRRIQQGK

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=65.8119658119658, Blast_Score=320, Evalue=5e-89,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=32.6446280991736, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789353, Length=235, Percent_Identity=31.063829787234, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790780, Length=228, Percent_Identity=30.2631578947368, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI48994955, Length=160, Percent_Identity=35.625, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082208, Length=224, Percent_Identity=28.125, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 30455; Mature: 30455

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIPIVSEEKEEQQTMAYQRIRQPKLSDVIEQELERLIVEGTLAPGQQLPPERELAKQFD
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
VSRPSIREAIQRLEAKRLLTRRQGGGTFVSENIWKSFSDPLLNLLSSHSETQLDLLESRH
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AMEGISAYFAALRGTDEDFARIQACQEKIRGAQDKGDIEAESAAVMAFLIALTEAAHNVV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLHIVRSLAPLLEQNVLENLKLLHRRKDVVEKVSIHRANIVDAIVSGQPEQAREMSHSHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AYIEETLMDLTKEESRRERSLRRIQQGK
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVIPIVSEEKEEQQTMAYQRIRQPKLSDVIEQELERLIVEGTLAPGQQLPPERELAKQFD
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
VSRPSIREAIQRLEAKRLLTRRQGGGTFVSENIWKSFSDPLLNLLSSHSETQLDLLESRH
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AMEGISAYFAALRGTDEDFARIQACQEKIRGAQDKGDIEAESAAVMAFLIALTEAAHNVV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLHIVRSLAPLLEQNVLENLKLLHRRKDVVEKVSIHRANIVDAIVSGQPEQAREMSHSHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AYIEETLMDLTKEESRRERSLRRIQQGK
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]