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The map label for this gene is aceE [H]

Identifier: 218710503

GI number: 218710503

Start: 2733755

End: 2736418

Strand: Reverse

Name: aceE [H]

Synonym: VS_2542

Alternate gene names: 218710503

Gene position: 2736418-2733755 (Counterclockwise)

Preceding gene: 218710504

Following gene: 218710502

Centisome position: 82.94

GC content: 45.68

Gene sequence:

>2664_bases
ATGTCTGACATGAAGCATGACGTTGATGCTCTGGAAACTCAAGATTGGTTAGAAGCTCTTGAGTCAGTAGTACGTGAAGA
AGGTGTAGAACGTGCACAGTTTTTACTAGAACAAGTTCTAGATAAAGCGCGTTTAGATGGTGTTGATATGGCTACAGGCA
TCAACACGAACTACATCAACACAATTCCAGCAGCACAAGAGCCAGCTTACCCTGGTGACGTAACTCTTGAGCGTCGTATT
CGTTCGATTATTCGCTGGAACGCAATCATGATTGTATTGCGTGCTTCTAAGAAAGACCTAGACCTTGGTGGTCACATGGC
TTCTTACCAGTCAGCTGCTGCGTTCTACGAAGTATGTTTTAACCACTTCTTCCGTGCTCCAAACGAGACGGACGGTGGCG
ATCTAGTTTATTACCAAGGTCACATCTCTCCTGGTATCTACTCTCGTGCATTCGTTGAAGGTCGTCTAACTGAAGAACAG
CTAGATAACTTCCGTCAAGAAGTTGATGGTAAAGGTATCCCTTCATACCCGCACCCTAAACTAATGCCTGAATTCTGGCA
GTTCCCAACAGTATCTATGGGTCTAGGCCCTATCTCTGCTATCTACCAAGCGCGCTTCCTTAAGTACCTTGAAGGTCGTG
GCATGAAAGATACTTCAGGTCAGCGTGTATACGCGTTCCTAGGTGACGGTGAGATGGATGAGCCAGAATCACGTGGTGCT
ATCTCTTTCGCTGCGCGTGAGAAGCTAGACAACCTATGTTTCCTAATCAACTGTAACCTACAGCGTCTAGACGGCCCTGT
AATGGGTAACGGTAGCATCATCCAAGAACTTGAAGGCCTATTTAAAGGCGCAGGTTGGAACGTTGTTAAAGTTATCTGGG
GTAGCAACTGGGATTCTCTACTAGCTAAAGACACGACTGGTAAGCTTCTTCAACTAATGAATGAAACTATCGATGGTGAC
TACCAAACATTCAAATCTAAAGATGGCGCATACGTACGTGAGCACTTCTTTGGTAAGTACCCAGAAACAGCTGCACTAGT
TGCAGACATGACTGACGACCAAATCTTCGAACTGAAACGTGGTGGTCACGATTCTTCTAAACTGTTCGCTGCATTCAACA
ATGCAAAAGAGACAGGTGGCAAACCAACAGTAATCCTAGCTAAGACAGTTAAAGGTTACGGTATGGGTGAAGCTGCAGAA
GGTAAGAACATCGCTCACGGTGTTAAGAAGATGGACATGACTCACGTACAATACCTACGTGACCGTCTAGGCCTACAAGA
CATCCTTTCTGATGAGAAAGTATCTGAGCTTCCTTACCTAACACTGGAAGAAGGTTCAGCTGAGTACGAATACCTACATG
CTCGTCGTAAAGCACTACAAGGTTACACTCCTCAGCGTCTGCCAAAATTCACTCAAGAGTTCAAAGTTCCTGAGCTAGAC
GCATTCGCACCTCTACTGGGTGAACAGAAGCGTGATATCTCTACAACGATGGCTTATGTACGTACGCTTAACATCCTTCT
TAAAGATAAGAACATTGGTAAGAACATTGTTCCTATCATCTGTGATGAAGCTCGTACATTCGGTATGGAAGGTCTATTCC
GTCAGGTTGGTATCTACAACCCACACGGTCAAGACTACACGCCTGAAGATAAAGGCATCGTTTCTTACTACAAAGAAGCA
ACGTCTGGTCAAGTTCTTCAAGAAGGTATCAACGAACTAGGTTCTATGGCTTCATGGGTTGCAGCTGCAACTTCATACAG
CACAAACGATCTACCGATGATTCCGTTCTACATCTACTACTCAATGTTCGGTTTCCAACGTATTGGTGACATGGCTTGGT
TAGCAGGTGACCAACAAGCTCGTGGTTTCCTACTTGGTGCAACTGCAGGCCGTACAACGCTAAACGGCGAAGGTCTACAG
CACGAAGATGGCCACTCGCACATCATGGCGAACACTGTACCTAACTGTATCTCTTACGACCCAACGTTTGCTTACGAGCT
AGCGGTAATCATGCAAGACGGTATCCGTCGCATGTACGGTGAGAACCAAGAGAATGTTTACTACTACCTAACAGTAATGA
ACGAAAACTACGCAATGCCAGCAATGCCAGAAGGCGCTGAAGAAGGCATCCGTAAGGGTATTTACAAGCTTGAGTCTTAC
GCAGGTTCTAAGTCTAAGGTTCAATTAATGAGCTCTGGTACTATCATGAACGAAGCGCGTAAAGCCGCTAAGATCCTGAG
CGAAGAGTACGGCGTAGCATCTGATGTATTCTCTGTAACGTCGTTCAACGAATTGACTCGTGACGGCCAAGCGGTAGAGC
GTGACAACATGCTTCACCCAGAAGCTGAAGAGAAAGTACCGTACATCACAACTGTTCTTGGTAACGAACCTGCAATCGCA
GTTACGGATTACATGAAGAACTACGCTGAGCAAGTACGTGCATTCATGCCTTCTGAGTCTTACAAAGTACTTGGTACTGA
CGGTTTCGGTCGCTCAGACAGCCGTGAAAACCTACGTCGTCACTTCGAAGTAAATGCAGGCTACGTTGTTGTTGCAGCAC
TTACTGAACTGGCTAAACGTGGTGATGTTGAGAAATCAGTAGTTGCTGAAGCAATTGCTAAATTCGGCATCGACGCAGAC
AAAATTAACCCGCAATACGCATAA

Upstream 100 bases:

>100_bases
GCGAACGTTCTTTACGTCGAATCCAACAGGGTAAATAGTCGTAATACTTCGGCTTTTTACGTGTTTAGTAGAATCCAACT
AACAAAAAGGATAGATCGCC

Downstream 100 bases:

>100_bases
GACTGGCATTAAGGTAGGTAAATACAATGACAATCGAAATTAATGTACCAGACATCGGTGCTGACGAGGTTGAAGTAACT
GAGATTCTTGTAAACGTTGG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQFLLEQVLDKARLDGVDMATGINTNYINTIPAAQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGMKDTSGQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGEAAE
GKNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVSELPYLTLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELD
AFAPLLGEQKRDISTTMAYVRTLNILLKDKNIGKNIVPIICDEARTFGMEGLFRQVGIYNPHGQDYTPEDKGIVSYYKEA
TSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENVYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESY
AGSKSKVQLMSSGTIMNEARKAAKILSEEYGVASDVFSVTSFNELTRDGQAVERDNMLHPEAEEKVPYITTVLGNEPAIA
VTDYMKNYAEQVRAFMPSESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELAKRGDVEKSVVAEAIAKFGIDAD
KINPQYA

Sequences:

>Translated_887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQFLLEQVLDKARLDGVDMATGINTNYINTIPAAQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGMKDTSGQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGEAAE
GKNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVSELPYLTLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELD
AFAPLLGEQKRDISTTMAYVRTLNILLKDKNIGKNIVPIICDEARTFGMEGLFRQVGIYNPHGQDYTPEDKGIVSYYKEA
TSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENVYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESY
AGSKSKVQLMSSGTIMNEARKAAKILSEEYGVASDVFSVTSFNELTRDGQAVERDNMLHPEAEEKVPYITTVLGNEPAIA
VTDYMKNYAEQVRAFMPSESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELAKRGDVEKSVVAEAIAKFGIDAD
KINPQYA
>Mature_886_residues
SDMKHDVDALETQDWLEALESVVREEGVERAQFLLEQVLDKARLDGVDMATGINTNYINTIPAAQEPAYPGDVTLERRIR
SIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQL
DNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGMKDTSGQRVYAFLGDGEMDEPESRGAI
SFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGDY
QTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGEAAEG
KNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVSELPYLTLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELDA
FAPLLGEQKRDISTTMAYVRTLNILLKDKNIGKNIVPIICDEARTFGMEGLFRQVGIYNPHGQDYTPEDKGIVSYYKEAT
SGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQH
EDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENVYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESYA
GSKSKVQLMSSGTIMNEARKAAKILSEEYGVASDVFSVTSFNELTRDGQAVERDNMLHPEAEEKVPYITTVLGNEPAIAV
TDYMKNYAEQVRAFMPSESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELAKRGDVEKSVVAEAIAKFGIDADK
INPQYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=883, Percent_Identity=72.0271800679502, Blast_Score=1370, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=226, Percent_Identity=29.2035398230088, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99026; Mature: 98895

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMKHDVDALETQDWLEALESVVREEGVERAQFLLEQVLDKARLDGVDMATGINTNYIN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEE
TIPAAQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGMKDTSGQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHH
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKR
HHCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHH
GGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGEAAEGKNIAHGVKKMDMTHVQYLR
CCCCCHHHHHHHHCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKVSELPYLTLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELD
HHCCHHHHHCCCHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
AFAPLLGEQKRDISTTMAYVRTLNILLKDKNIGKNIVPIICDEARTFGMEGLFRQVGIYN
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCHHHHCHHHHHHHHCCCC
PHGQDYTPEDKGIVSYYKEATSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIMANTVPNCISYD
HHHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCC
PTFAYELAVIMQDGIRRMYGENQENVYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESY
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AGSKSKVQLMSSGTIMNEARKAAKILSEEYGVASDVFSVTSFNELTRDGQAVERDNMLHP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC
EAEEKVPYITTVLGNEPAIAVTDYMKNYAEQVRAFMPSESYKVLGTDGFGRSDSRENLRR
CHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALTELAKRGDVEKSVVAEAIAKFGIDADKINPQYA
HEECCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SDMKHDVDALETQDWLEALESVVREEGVERAQFLLEQVLDKARLDGVDMATGINTNYIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEE
TIPAAQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGMKDTSGQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHH
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKR
HHCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHH
GGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGEAAEGKNIAHGVKKMDMTHVQYLR
CCCCCHHHHHHHHCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKVSELPYLTLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELD
HHCCHHHHHCCCHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
AFAPLLGEQKRDISTTMAYVRTLNILLKDKNIGKNIVPIICDEARTFGMEGLFRQVGIYN
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCHHHHCHHHHHHHHCCCC
PHGQDYTPEDKGIVSYYKEATSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIMANTVPNCISYD
HHHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCC
PTFAYELAVIMQDGIRRMYGENQENVYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESY
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AGSKSKVQLMSSGTIMNEARKAAKILSEEYGVASDVFSVTSFNELTRDGQAVERDNMLHP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC
EAEEKVPYITTVLGNEPAIAVTDYMKNYAEQVRAFMPSESYKVLGTDGFGRSDSRENLRR
CHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALTELAKRGDVEKSVVAEAIAKFGIDADKINPQYA
HEECCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]