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The map label for this gene is pgm [H]

Identifier: 218710219

GI number: 218710219

Start: 2420071

End: 2421726

Strand: Reverse

Name: pgm [H]

Synonym: VS_2252

Alternate gene names: 218710219

Gene position: 2421726-2420071 (Counterclockwise)

Preceding gene: 218710220

Following gene: 218710217

Centisome position: 73.4

GC content: 46.74

Gene sequence:

>1656_bases
ATGTCGATAATGGCTATGCACCCTCGTGCCGGGCAGAAAGCTCTGCAGGAAGATCTTCATAATATCCCGGCTTTAGTTGC
AAACTATTTCTTACAGCAACCGGATGCTACTAACCCAGATCATAAAGTACTGTTCGGCACTTCAGGTCACCGCGGTACAG
CAGACAAATCAACATTTAATGAAAACCACATTCTAGCGATCGCACAAGCGGTTGCTGAGGTTCGTGCCGATCAAGGTACA
ACAGGCCCACTTTTCTTAGGCAAAGATACTCACGCTCTATCTGAGCCTGCTTTTTCTACGGTTATTGAAGTGCTAGTTGC
AAACGGCGTTGAAGTTATCGTTCAAGAAAACAATGGCTTTACTCCAACTCCAGGTATCTCGCACGCGATTCTTACGCACA
ATCTAGTGAATGATAAAAAAGCTGACGGCATTGTTATCACGCCTTCACATAACCCACCTCAAGACGGGGGCATTAAATAC
AACCCGACACACGGTGGCCCTGCTGAAGCTGAACTGACTCAAGCGATTGAAGATCGTGCGAATGTGATCATTGCTGAGCA
AATGCAAGGCGTTAAGCGCACTCCTATCGCACAGGCTAAACAGTCTGAGCTAGTGAAAGAAGTTGATTTAGTTGCTCCTT
ACGTTGCTGACTTGGTTAACGTGGTTGATATGGAAGCAATCCAGAAAGCAAACATCAAGATTGGTGTTGATCCACTGGGT
GGTAGCGGTATTGATTACTGGCGTCAAATTGGCAAAGCGTACAACCTAGACCTGACTCTGGTCAGTGAAGCTGTTGATCC
TTCGTTCCAATTTATGTCTCTAGACAAAGATGGTGTGGTTCGTATGGACTGTTCTTCTCCATACGCAATGGCAGGTTTAC
TAGCACTTAAAGACGACTATCAATTAGCGTTTGGCAACGACCCAGACTACGATCGCCACGGCATTGTTACGCCAAAAGGC
TTGATGAATCCCAACCACTTCCTAGCGGTGTGTATTGACTACTTATACCGCAACCGTGAAGGTTGGGGTAAAGACGTTGC
AGTGGGTAAAACACTGGTATCAAGTGCTCTGATTGACCGCGTTGTTGCTGACTTAGGTCGCGAGCTTTGCGAAGTGCCAG
TGGGATTCAAATGGTTCGTTGATGGCCTATATAACGGTCAGTTTGGTTTCGGTGGTGAAGAGAGTGCGGGTGCGTCTTTC
TTACGTAAAGACGGAACGCCTTGGTCAACAGATAAAGATGGCCTGATTCTTTGCCTACTTGCGGCCGAAATCACAGCAGT
AACGGGCAAGAACCCACAAGAATACTACGAAGAACTTGCCGCTAAACATGGCGAATCTAAGTACAACCGTATTCAAGCAG
TAGCTAACGGCGCACAAAAAGACGTGCTTAAGAAGCTATCTCCAGAGATGGTTTCAGCTGAGACGCTTGCTGGTGATGCA
ATTACTGCACGCTTAACGCACGCTCCAGGTAATGGTGCTGCGATTGGTGGCCTAAAAGTGACGACTGAAAACGGTTGGTT
TGCCGCTCGTCCATCAGGTACTGAAGACATCTATAAGATCTACTGTGAAAGCTTTAAAGGCGAAGAGCACCTAAAAGCAA
TCGAAGCAGAAGCTCAAGAGATTGTTAATCAAGTATTTGCAGCCGCTGGCCTATAA

Upstream 100 bases:

>100_bases
AAGTAACAGGTTCAATTTAACGAAATCTGATTTAAACCTCATAATATCCATGGCTAAGAAGATATTATGAGGTTTTTTTG
TTTTTAAATTTTATATAAGG

Downstream 100 bases:

>100_bases
TCGAATACAGATTAGTAGAGTTACAAGGTAAATAGTGAAAGGGTTGATGTGAAAGCATCAGCCCTTTTTTATAGTTTGTG
GATAAAGCGGCTAGGACTAA

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSIMAMHPRAGQKALQEDLHNIPALVANYFLQQPDATNPDHKVLFGTSGHRGTADKSTFNENHILAIAQAVAEVRADQGT
TGPLFLGKDTHALSEPAFSTVIEVLVANGVEVIVQENNGFTPTPGISHAILTHNLVNDKKADGIVITPSHNPPQDGGIKY
NPTHGGPAEAELTQAIEDRANVIIAEQMQGVKRTPIAQAKQSELVKEVDLVAPYVADLVNVVDMEAIQKANIKIGVDPLG
GSGIDYWRQIGKAYNLDLTLVSEAVDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDDYQLAFGNDPDYDRHGIVTPKG
LMNPNHFLAVCIDYLYRNREGWGKDVAVGKTLVSSALIDRVVADLGRELCEVPVGFKWFVDGLYNGQFGFGGEESAGASF
LRKDGTPWSTDKDGLILCLLAAEITAVTGKNPQEYYEELAAKHGESKYNRIQAVANGAQKDVLKKLSPEMVSAETLAGDA
ITARLTHAPGNGAAIGGLKVTTENGWFAARPSGTEDIYKIYCESFKGEEHLKAIEAEAQEIVNQVFAAAGL

Sequences:

>Translated_551_residues
MSIMAMHPRAGQKALQEDLHNIPALVANYFLQQPDATNPDHKVLFGTSGHRGTADKSTFNENHILAIAQAVAEVRADQGT
TGPLFLGKDTHALSEPAFSTVIEVLVANGVEVIVQENNGFTPTPGISHAILTHNLVNDKKADGIVITPSHNPPQDGGIKY
NPTHGGPAEAELTQAIEDRANVIIAEQMQGVKRTPIAQAKQSELVKEVDLVAPYVADLVNVVDMEAIQKANIKIGVDPLG
GSGIDYWRQIGKAYNLDLTLVSEAVDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDDYQLAFGNDPDYDRHGIVTPKG
LMNPNHFLAVCIDYLYRNREGWGKDVAVGKTLVSSALIDRVVADLGRELCEVPVGFKWFVDGLYNGQFGFGGEESAGASF
LRKDGTPWSTDKDGLILCLLAAEITAVTGKNPQEYYEELAAKHGESKYNRIQAVANGAQKDVLKKLSPEMVSAETLAGDA
ITARLTHAPGNGAAIGGLKVTTENGWFAARPSGTEDIYKIYCESFKGEEHLKAIEAEAQEIVNQVFAAAGL
>Mature_550_residues
SIMAMHPRAGQKALQEDLHNIPALVANYFLQQPDATNPDHKVLFGTSGHRGTADKSTFNENHILAIAQAVAEVRADQGTT
GPLFLGKDTHALSEPAFSTVIEVLVANGVEVIVQENNGFTPTPGISHAILTHNLVNDKKADGIVITPSHNPPQDGGIKYN
PTHGGPAEAELTQAIEDRANVIIAEQMQGVKRTPIAQAKQSELVKEVDLVAPYVADLVNVVDMEAIQKANIKIGVDPLGG
SGIDYWRQIGKAYNLDLTLVSEAVDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDDYQLAFGNDPDYDRHGIVTPKGL
MNPNHFLAVCIDYLYRNREGWGKDVAVGKTLVSSALIDRVVADLGRELCEVPVGFKWFVDGLYNGQFGFGGEESAGASFL
RKDGTPWSTDKDGLILCLLAAEITAVTGKNPQEYYEELAAKHGESKYNRIQAVANGAQKDVLKKLSPEMVSAETLAGDAI
TARLTHAPGNGAAIGGLKVTTENGWFAARPSGTEDIYKIYCESFKGEEHLKAIEAEAQEIVNQVFAAAGL

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI133922562, Length=453, Percent_Identity=25.8278145695364, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI290463102, Length=468, Percent_Identity=26.7094017094017, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI21361621, Length=458, Percent_Identity=25.9825327510917, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=70.1465201465201, Blast_Score=789, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323752, Length=557, Percent_Identity=25.8527827648115, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322722, Length=443, Percent_Identity=27.765237020316, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17864244, Length=444, Percent_Identity=27.2522522522523, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59277; Mature: 59145

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIMAMHPRAGQKALQEDLHNIPALVANYFLQQPDATNPDHKVLFGTSGHRGTADKSTFN
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCC
ENHILAIAQAVAEVRADQGTTGPLFLGKDTHALSEPAFSTVIEVLVANGVEVIVQENNGF
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCC
TPTPGISHAILTHNLVNDKKADGIVITPSHNPPQDGGIKYNPTHGGPAEAELTQAIEDRA
CCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
NVIIAEQMQGVKRTPIAQAKQSELVKEVDLVAPYVADLVNVVDMEAIQKANIKIGVDPLG
CEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
GSGIDYWRQIGKAYNLDLTLVSEAVDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDDY
CCCHHHHHHHCCCCCCEEEEEHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHEECCCC
QLAFGNDPDYDRHGIVTPKGLMNPNHFLAVCIDYLYRNREGWGKDVAVGKTLVSSALIDR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VVADLGRELCEVPVGFKWFVDGLYNGQFGFGGEESAGASFLRKDGTPWSTDKDGLILCLL
HHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEE
AAEITAVTGKNPQEYYEELAAKHGESKYNRIQAVANGAQKDVLKKLSPEMVSAETLAGDA
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCC
ITARLTHAPGNGAAIGGLKVTTENGWFAARPSGTEDIYKIYCESFKGEEHLKAIEAEAQE
EEEEEEECCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
IVNQVFAAAGL
HHHHHHHHCCC
>Mature Secondary Structure 
SIMAMHPRAGQKALQEDLHNIPALVANYFLQQPDATNPDHKVLFGTSGHRGTADKSTFN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCC
ENHILAIAQAVAEVRADQGTTGPLFLGKDTHALSEPAFSTVIEVLVANGVEVIVQENNGF
CCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCC
TPTPGISHAILTHNLVNDKKADGIVITPSHNPPQDGGIKYNPTHGGPAEAELTQAIEDRA
CCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
NVIIAEQMQGVKRTPIAQAKQSELVKEVDLVAPYVADLVNVVDMEAIQKANIKIGVDPLG
CEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
GSGIDYWRQIGKAYNLDLTLVSEAVDPSFQFMSLDKDGVVRMDCSSPYAMAGLLALKDDY
CCCHHHHHHHCCCCCCEEEEEHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHEECCCC
QLAFGNDPDYDRHGIVTPKGLMNPNHFLAVCIDYLYRNREGWGKDVAVGKTLVSSALIDR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VVADLGRELCEVPVGFKWFVDGLYNGQFGFGGEESAGASFLRKDGTPWSTDKDGLILCLL
HHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEE
AAEITAVTGKNPQEYYEELAAKHGESKYNRIQAVANGAQKDVLKKLSPEMVSAETLAGDA
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCC
ITARLTHAPGNGAAIGGLKVTTENGWFAARPSGTEDIYKIYCESFKGEEHLKAIEAEAQE
EEEEEEECCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
IVNQVFAAAGL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]