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The map label for this gene is cysM [C]

Identifier: 218710146

GI number: 218710146

Start: 2319855

End: 2320922

Strand: Direct

Name: cysM [C]

Synonym: VS_2169

Alternate gene names: 218710146

Gene position: 2319855-2320922 (Clockwise)

Preceding gene: 218710143

Following gene: 218710151

Centisome position: 70.31

GC content: 47.94

Gene sequence:

>1068_bases
ATGTGCACTGACCATCAATGGATTAACAACGCGATTCGTAAAATTGAAGCGGACTACCAACGCTCAGCGGATACGCACCT
TATCAAGCTCGATCTACCAAGTATCGAAGGCATTGATGTTTACCTTAAAGATGAAAGCACACACCCTACAGGCTCTTTAA
AGCACCGCTTAGCGCGTTCTCTGTTCTTATACGCTATCTGTAACGGTTGGGTTGGCCCAGAAACAACGATCATTGAATCT
TCATCAGGCAGTACTGCAGTATCTGAAGCGTACTTCGCTCGCCTACTTGGCCTGCCGTTTATTGCGGTAATGCCGAAATG
CACAGCGAAGAAGAAGATTGAGCAGATTGAATTCTACGGCGGCCAAGCGCATCTTGTTGACCGCTCAGATGAAATTTACG
ATGAGTCTCGTCGCTTAGCAGAAGAACTGAATGGTCACTACATGGACCAATTTACCTACGCTGAGCGCGCAACCGACTGG
CGTGGTAACAACAACATCGCGAACTCCATTTTCAATCAAATGCAGATGGAAGATCACCCAGTTCCAGCGTGGGTAGTCAT
GAGCCCAGGTACTGGCGGTACGTCTGCAACTATCGGCCGCTTCATTCGCTACCAACAGCATGAAACTAAGCTTTGTGTTG
TCGACCCTGAGAACTCAGTATTCCACGAATACTTCCAAACCGGCAATGCGAACGTGAAAGGCAACACATTCAGCAAAATT
GAAGGCATTGGTCGCCCACGAGCAGAGCCAAGCTTCATTCCTGGTGTGGTTGACGAAATGCGCAAAATTCCAGATGCAGC
AAGTATCGCAACGACACATTGGTTATCTGACATTCTTGGTCGCAAGGTTGGCGCATCAACCGGTACCAACATGTACGGTG
TGCTTCAGTTAGCCAGTGAAATGAAAGCACGTGGCGAAACAGGTTCTATTGTGACTTTGCTATGTGACAGCGGTGAGCGT
TACCTAGACACTTACTTCAATGACGAGTGGGTAAATCTGAATATTGGTGACCTACAACCGTACGCGGCGAAGTTAGAAGC
TTTCTCGCAAACGGGTGAGTTGGCTTAA

Upstream 100 bases:

>100_bases
CAAAACAAAGCAAATATGGCAAAGTTTTTCTCTCAAATTCTAGCTAAATTGGAAGCATACCAATTACAAAGAATTCCTAC
ACTCGATCAGGAGAACGCTT

Downstream 100 bases:

>100_bases
CCACAGAACAAACACCGACGCAAAAATAAAAAGAGCCCTGATGGGCTCTTTTTTGGTTTGTTCTATTCATCAATTTCTAG
CGAGAACAAATTATTCTGGC

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MCTDHQWINNAIRKIEADYQRSADTHLIKLDLPSIEGIDVYLKDESTHPTGSLKHRLARSLFLYAICNGWVGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTAKKKIEQIEFYGGQAHLVDRSDEIYDESRRLAEELNGHYMDQFTYAERATDW
RGNNNIANSIFNQMQMEDHPVPAWVVMSPGTGGTSATIGRFIRYQQHETKLCVVDPENSVFHEYFQTGNANVKGNTFSKI
EGIGRPRAEPSFIPGVVDEMRKIPDAASIATTHWLSDILGRKVGASTGTNMYGVLQLASEMKARGETGSIVTLLCDSGER
YLDTYFNDEWVNLNIGDLQPYAAKLEAFSQTGELA

Sequences:

>Translated_355_residues
MCTDHQWINNAIRKIEADYQRSADTHLIKLDLPSIEGIDVYLKDESTHPTGSLKHRLARSLFLYAICNGWVGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTAKKKIEQIEFYGGQAHLVDRSDEIYDESRRLAEELNGHYMDQFTYAERATDW
RGNNNIANSIFNQMQMEDHPVPAWVVMSPGTGGTSATIGRFIRYQQHETKLCVVDPENSVFHEYFQTGNANVKGNTFSKI
EGIGRPRAEPSFIPGVVDEMRKIPDAASIATTHWLSDILGRKVGASTGTNMYGVLQLASEMKARGETGSIVTLLCDSGER
YLDTYFNDEWVNLNIGDLQPYAAKLEAFSQTGELA
>Mature_355_residues
MCTDHQWINNAIRKIEADYQRSADTHLIKLDLPSIEGIDVYLKDESTHPTGSLKHRLARSLFLYAICNGWVGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTAKKKIEQIEFYGGQAHLVDRSDEIYDESRRLAEELNGHYMDQFTYAERATDW
RGNNNIANSIFNQMQMEDHPVPAWVVMSPGTGGTSATIGRFIRYQQHETKLCVVDPENSVFHEYFQTGNANVKGNTFSKI
EGIGRPRAEPSFIPGVVDEMRKIPDAASIATTHWLSDILGRKVGASTGTNMYGVLQLASEMKARGETGSIVTLLCDSGER
YLDTYFNDEWVNLNIGDLQPYAAKLEAFSQTGELA

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=293, Percent_Identity=26.962457337884, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI295821200, Length=293, Percent_Identity=26.962457337884, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4557415, Length=293, Percent_Identity=26.962457337884, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI2367138, Length=330, Percent_Identity=27.5757575757576, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=362, Percent_Identity=31.767955801105, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539800, Length=360, Percent_Identity=32.2222222222222, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17539640, Length=367, Percent_Identity=28.8828337874659, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17535051, Length=331, Percent_Identity=26.8882175226586, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=26.517571884984, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=27.0627062706271, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=339, Percent_Identity=27.4336283185841, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=23.7237237237237, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643623, Length=318, Percent_Identity=28.6163522012579, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129101, Length=318, Percent_Identity=28.6163522012579, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39577; Mature: 39577

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTDHQWINNAIRKIEADYQRSADTHLIKLDLPSIEGIDVYLKDESTHPTGSLKHRLARS
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYAICNGWVGPETTIIESSSGSTAVSEAYFARLLGLPFIAVMPKCTAKKKIEQIEFYG
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHEEC
GQAHLVDRSDEIYDESRRLAEELNGHYMDQFTYAERATDWRGNNNIANSIFNQMQMEDHP
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
VPAWVVMSPGTGGTSATIGRFIRYQQHETKLCVVDPENSVFHEYFQTGNANVKGNTFSKI
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHH
EGIGRPRAEPSFIPGVVDEMRKIPDAASIATTHWLSDILGRKVGASTGTNMYGVLQLASE
HCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MKARGETGSIVTLLCDSGERYLDTYFNDEWVNLNIGDLQPYAAKLEAFSQTGELA
HHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MCTDHQWINNAIRKIEADYQRSADTHLIKLDLPSIEGIDVYLKDESTHPTGSLKHRLARS
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
LFLYAICNGWVGPETTIIESSSGSTAVSEAYFARLLGLPFIAVMPKCTAKKKIEQIEFYG
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHEEC
GQAHLVDRSDEIYDESRRLAEELNGHYMDQFTYAERATDWRGNNNIANSIFNQMQMEDHP
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
VPAWVVMSPGTGGTSATIGRFIRYQQHETKLCVVDPENSVFHEYFQTGNANVKGNTFSKI
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHH
EGIGRPRAEPSFIPGVVDEMRKIPDAASIATTHWLSDILGRKVGASTGTNMYGVLQLASE
HCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MKARGETGSIVTLLCDSGERYLDTYFNDEWVNLNIGDLQPYAAKLEAFSQTGELA
HHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]