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The map label for this gene is tesB [H]

Identifier: 218710143

GI number: 218710143

Start: 2317314

End: 2318174

Strand: Direct

Name: tesB [H]

Synonym: VS_2166

Alternate gene names: 218710143

Gene position: 2317314-2318174 (Clockwise)

Preceding gene: 218710141

Following gene: 218710146

Centisome position: 70.24

GC content: 48.2

Gene sequence:

>861_bases
ATGAGTCAACCTTTAAATGAATTACTCAATTTACTTCAGCTAGAGAAACTAGAGGAAGGCCTGTTCCGCGGGCAAAGTGA
GAACCTAGGTCTGCCACAGGTATACGGCGGTCAAGTATTAGGGCAAGCGCTTTCTGCTGCTCGTTATACGGTTCAAGACG
ACCGCAGTGTTCACTCGTTCCACAGTTACTTTCTATTTCCCGGCGACCCTGAAAAACCCATTATTTACGATGTTGAGAAC
CTAAGAGATGGACGCAGCTTTAGTACACGCCGCGTGAAAGCGATTCAAAATGGCCGCCCTATTTTCTATCTTACGGCTTC
TTATCATGGTGACGCACCCGGCTTTGAACACCAGAATGAAATGCCAAACATCCCAGGGCCAGAGAACTTTGCATCAGAAA
CTGAGTTAGCAAGCCACATTGCTGAATTTTTGCCTGAGAAACTGCGTAAGACTTTCTGTGGCGAAAAGCCAATTGAGATG
CGCCCGGTAACAATAGTGAACCCGCTTAACCCTAAGAAAGCCGACCCAAAACAATACCTTTGGGTGAGAGCAAATGGCGC
GATGCCAGACAACCAATTGATTCACCAATACCTGCTTGCTTACGCATCGGATTGGGGGTTCTTGGTGACGGCGCTTCACC
CTCACGAAGTTTCTATCATGACGCCGAACTTCCAAGTAGCGACGATTGACCACTCTATCTGGTTCCACCGCCCATTCAAG
ATGGATGAGTGGTTGCTTTATGCGATTGAAAGCCCAACGGCAGCGAACACTCGTGGCCTAGTGCGCGGCGAGATCTTTAA
TCAGAAAGGTGAGCTAGTAGCGACTGCCGTTCAAGAAGGTGTGATGCGTTTTACTAAATAG

Upstream 100 bases:

>100_bases
ATTCTGTCTCGAAACCCTATGATTTATTGACAGATATCTGACTAAGCTGAATGATTAACACCATAATCTGACACCTATTT
TACCAAGAGGCATGCTGGCG

Downstream 100 bases:

>100_bases
CGATCAAGTAATACCAATCGTAGTAAATAACTGGTCATCCTAGCTTGTTAAAAACCTCGATAACTTCGTTAGAATTTTTG
ATTGTAGAATAACTACTTAT

Product: acyl-Coa thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSQPLNELLNLLQLEKLEEGLFRGQSENLGLPQVYGGQVLGQALSAARYTVQDDRSVHSFHSYFLFPGDPEKPIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQNEMPNIPGPENFASETELASHIAEFLPEKLRKTFCGEKPIEM
RPVTIVNPLNPKKADPKQYLWVRANGAMPDNQLIHQYLLAYASDWGFLVTALHPHEVSIMTPNFQVATIDHSIWFHRPFK
MDEWLLYAIESPTAANTRGLVRGEIFNQKGELVATAVQEGVMRFTK

Sequences:

>Translated_286_residues
MSQPLNELLNLLQLEKLEEGLFRGQSENLGLPQVYGGQVLGQALSAARYTVQDDRSVHSFHSYFLFPGDPEKPIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQNEMPNIPGPENFASETELASHIAEFLPEKLRKTFCGEKPIEM
RPVTIVNPLNPKKADPKQYLWVRANGAMPDNQLIHQYLLAYASDWGFLVTALHPHEVSIMTPNFQVATIDHSIWFHRPFK
MDEWLLYAIESPTAANTRGLVRGEIFNQKGELVATAVQEGVMRFTK
>Mature_285_residues
SQPLNELLNLLQLEKLEEGLFRGQSENLGLPQVYGGQVLGQALSAARYTVQDDRSVHSFHSYFLFPGDPEKPIIYDVENL
RDGRSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQNEMPNIPGPENFASETELASHIAEFLPEKLRKTFCGEKPIEMR
PVTIVNPLNPKKADPKQYLWVRANGAMPDNQLIHQYLLAYASDWGFLVTALHPHEVSIMTPNFQVATIDHSIWFHRPFKM
DEWLLYAIESPTAANTRGLVRGEIFNQKGELVATAVQEGVMRFTK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=41.5492957746479, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=60.4240282685512, Blast_Score=353, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17558508, Length=309, Percent_Identity=36.2459546925566, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71988741, Length=298, Percent_Identity=33.5570469798658, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17531889, Length=268, Percent_Identity=34.3283582089552, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI115532456, Length=268, Percent_Identity=34.3283582089552, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=268, Percent_Identity=34.3283582089552, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=283, Percent_Identity=29.3286219081272, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982224, Length=300, Percent_Identity=27.3333333333333, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32452; Mature: 32321

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPLNELLNLLQLEKLEEGLFRGQSENLGLPQVYGGQVLGQALSAARYTVQDDRSVHSF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEECCCCHHHHH
HSYFLFPGDPEKPIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQNE
HEEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPNIPGPENFASETELASHIAEFLPEKLRKTFCGEKPIEMRPVTIVNPLNPKKADPKQYL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEE
WVRANGAMPDNQLIHQYLLAYASDWGFLVTALHPHEVSIMTPNFQVATIDHSIWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCEEEEEEECCEEEECCCC
MDEWLLYAIESPTAANTRGLVRGEIFNQKGELVATAVQEGVMRFTK
CCCEEEEEECCCCCCCCCCEEEHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQPLNELLNLLQLEKLEEGLFRGQSENLGLPQVYGGQVLGQALSAARYTVQDDRSVHSF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEECCCCHHHHH
HSYFLFPGDPEKPIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQNE
HEEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPNIPGPENFASETELASHIAEFLPEKLRKTFCGEKPIEMRPVTIVNPLNPKKADPKQYL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEE
WVRANGAMPDNQLIHQYLLAYASDWGFLVTALHPHEVSIMTPNFQVATIDHSIWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCEEEEEEECCEEEECCCC
MDEWLLYAIESPTAANTRGLVRGEIFNQKGELVATAVQEGVMRFTK
CCCEEEEEECCCCCCCCCCEEEHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]