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The map label for this gene is ppiB [H]

Identifier: 218709996

GI number: 218709996

Start: 2162069

End: 2162563

Strand: Direct

Name: ppiB [H]

Synonym: VS_2015

Alternate gene names: 218709996

Gene position: 2162069-2162563 (Clockwise)

Preceding gene: 218709993

Following gene: 218709997

Centisome position: 65.53

GC content: 45.25

Gene sequence:

>495_bases
ATGATCATCCTTCACACAAATTTTGGTGACATCAAAGTTCAACTTAACGAAGAAAAAGCACCAGAAACAAGCGCAAACTT
CCTACAGTACTGCCGTGACGGTTTTTACGACAACACGCTATTCCACCGTGTTATCGATGGTTTCATGGTTCAAGGCGGCG
GCATGACTTCTGGCCTTAAAGAAAAAACAACTCGCGCGACTATCAAGAACGAAGCAAACAACGGCCTAGCGAACAAAGTG
GGTACGCTAGCAATGGCTCGTACTATGGAACCGCATTCAGCGAGCTCTCAGTTCTTCATCAACGTTAACGACAACTCTTT
CCTAAACTTCCGTAGCGAAAGCCTAGACGGTTGGGGCTACTGTGTATTCGCAGAAGTTGTTGAAGGCATGGACATCGTAA
ACAAGATCAAAGGTGTTAGCACTGGTTCTATGGGTATGCACCAAGACGTACCTCTAGAAGAAGTGATCATCACTGGTACT
ACAATCGAAGCTTAA

Upstream 100 bases:

>100_bases
CTCAAACATCCGAGTTAAGTTAATGATTTGGTGATTTGAAAGTCCGCCAACATGCGCTAGAATTCGAACTTCATATTAAA
AAGACAGTAAGGTAACAATC

Downstream 100 bases:

>100_bases
TCACTTGCTTTCGGTTAGTATTAATAATTGATGAGCCGATAAAATCAGGATATAGGGAGCGAATCGCTCCTTTTTTTAGA
TCTATGAAAACATATTTTAT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIILHTNFGDIKVQLNEEKAPETSANFLQYCRDGFYDNTLFHRVIDGFMVQGGGMTSGLKEKTTRATIKNEANNGLANKV
GTLAMARTMEPHSASSQFFINVNDNSFLNFRSESLDGWGYCVFAEVVEGMDIVNKIKGVSTGSMGMHQDVPLEEVIITGT
TIEA

Sequences:

>Translated_164_residues
MIILHTNFGDIKVQLNEEKAPETSANFLQYCRDGFYDNTLFHRVIDGFMVQGGGMTSGLKEKTTRATIKNEANNGLANKV
GTLAMARTMEPHSASSQFFINVNDNSFLNFRSESLDGWGYCVFAEVVEGMDIVNKIKGVSTGSMGMHQDVPLEEVIITGT
TIEA
>Mature_164_residues
MIILHTNFGDIKVQLNEEKAPETSANFLQYCRDGFYDNTLFHRVIDGFMVQGGGMTSGLKEKTTRATIKNEANNGLANKV
GTLAMARTMEPHSASSQFFINVNDNSFLNFRSESLDGWGYCVFAEVVEGMDIVNKIKGVSTGSMGMHQDVPLEEVIITGT
TIEA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=30.7228915662651, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.3170731707317, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.3170731707317, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=31.4814814814815, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI64276486, Length=112, Percent_Identity=41.0714285714286, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI24308049, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=31.4465408805031, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=67.9012345679012, Blast_Score=242, Evalue=1e-65,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=48.4472049689441, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=141, Percent_Identity=32.6241134751773, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=30.625, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=34.2657342657343, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=144, Percent_Identity=38.1944444444444, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=156, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=31.3253012048193, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355677, Length=170, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18037; Mature: 18037

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILHTNFGDIKVQLNEEKAPETSANFLQYCRDGFYDNTLFHRVIDGFMVQGGGMTSGLK
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCH
EKTTRATIKNEANNGLANKVGTLAMARTMEPHSASSQFFINVNDNSFLNFRSESLDGWGY
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCE
CVFAEVVEGMDIVNKIKGVSTGSMGMHQDVPLEEVIITGTTIEA
EHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECEEECC
>Mature Secondary Structure
MIILHTNFGDIKVQLNEEKAPETSANFLQYCRDGFYDNTLFHRVIDGFMVQGGGMTSGLK
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCH
EKTTRATIKNEANNGLANKVGTLAMARTMEPHSASSQFFINVNDNSFLNFRSESLDGWGY
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCE
CVFAEVVEGMDIVNKIKGVSTGSMGMHQDVPLEEVIITGTTIEA
EHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]