Click here to switch to the map view.

The map label for this gene is tyrR [H]

Identifier: 218709781

GI number: 218709781

Start: 1919688

End: 1921232

Strand: Reverse

Name: tyrR [H]

Synonym: VS_1793

Alternate gene names: 218709781

Gene position: 1921232-1919688 (Counterclockwise)

Preceding gene: 218709782

Following gene: 218709780

Centisome position: 58.23

GC content: 44.34

Gene sequence:

>1545_bases
GTGCGTCTTGAAGTATTGTGTGAAGACAGACTCGGCTTAACGCGTGAGTTGCTCGATATCTTGGCCTCAAAAAGCATTGA
TTTACGAGGAATCGAAATTGATGTTAAAGGTATTATTTACCTAAATTGCCCGGATATTAATTTTGATGCTTTTAGTGAAC
TTATGGCTGAAATTCGCCGAATTTCAGGTGTGAAGGATGTACGTAAAATCCAGTTTATGCCAAGCGAAAGGCATAACACA
GAACTGATTGCCCTGCTGGCAAACCTACCTGATCCTGTTATTGCGATTGACCTTAAAGGCTCAGTCGACATGGCAAACCA
CGCTGCATTGAATCTTTTCAACAAACAAGAAGAAGAAGTGATCGGTGAGCCACTAGCGACGTTCGTTCCTAGCTTCAACT
TCGCTCGTTGGATTGAAGGCGATGTAACGCGTCATCGTGAAGTCGTGGTGCTAGATGGTCTAGATTTCTCTATTGAAATT
CTGCCTATTTATCTAGGTGGTGATGTCAACGAGGCGGTACTGGCGAGTGCAGTAATGACGATTCGTTCTTGTAACCAAGA
AATGAACGCGCCAGACGCCATCCCTGAACAGAATAACCTAGGTTTTGAACACTTTGTTGGTGTCTCTAATCGCCATAAAG
CCTTGATCAGTCAAGCTAAGAAACTGGCTATGCTAGATCAACCTCTGCTTATTGAAGGGGATACAGGTACGGGGAAAGAG
ATGCTGGCGAAATCGTGTCATAACCGTTCAAATCGATCTTCTTTTCCATTTTTGATTCTAAGCTGTGCATCAATGCCTGA
TGACGTAGCAGAAACGGAATTGTTTGGACATGCACCGGGCTCATTCAACCATGAGCAAGGTCATAAAGGCATCTTTGAAC
AAGCGAATGGCGGTACGGTATTTTTAGATGAAATCGGCGAAATGAGCCCGCATCTACAAATCAAACTGCTGCGTTTCCTA
CAAGATGGTTCATTCCGTCGTGTTGGTGAAGAAGAAGAGATGCACGCGGATGTTCGTATTATCGCATCAACGCGCCATCG
CCTTTCTGAATTAGCCGACTCGGGCTCGTTTCGTGAAGATCTGTTCTACCGCTTGAACGTACTGACTTTGTCGATTCCTG
CTTTGCGTGAACGTTCAAACGATGTTGCGCCATTACTGGAGCTATTCGTTGCAAAGTACGCACAGCAGTTAGGTATGTTG
AAACCAAAGTTGACTCAAGAACTAATCGATCAATTAGGCAACTACCAATGGCCGGGCAATATTCGTCAGTTAGACAACAT
GGTTCTACGTGCACTAACAGAGTTGGATTCAGATACGTTAACGGTTGAGCAATTCCACCTGCCACAGCTTGACACTATGA
CTGCTGGAATGGCGAGCTTAAGCTTAGACGGCTCGCTTGACGAGATCATGAAAGACTATGAATCTCAGATTTTAGAGAAG
CTTTATCAGTCTTTCCCATCAAGCCGTAAGCTTGCTAAACGTCTGAATGTTTCTCACACCTCAATAGCGAATAAGCTTCG
TGATTACGGTATCAGAAAGAGTTGA

Upstream 100 bases:

>100_bases
GAGCGAAGAGTAAACATATGTTTACTCTTCTTCTTGACTGAACTTAGAGCTTAATTCACACTACTGTCAACTTATCCTGA
CACCTATAATAGGACTATTT

Downstream 100 bases:

>100_bases
TGATATTAGACTGCTAAATTCGGTAAGAGTGAGGCGGTAACGTAAAAAGAGACAAAAATAAGAACAAGACTATGGAAGAT
TCGAGTACGCAGCAACGTAT

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVKGIIYLNCPDINFDAFSELMAEIRRISGVKDVRKIQFMPSERHNT
ELIALLANLPDPVIAIDLKGSVDMANHAALNLFNKQEEEVIGEPLATFVPSFNFARWIEGDVTRHREVVVLDGLDFSIEI
LPIYLGGDVNEAVLASAVMTIRSCNQEMNAPDAIPEQNNLGFEHFVGVSNRHKALISQAKKLAMLDQPLLIEGDTGTGKE
MLAKSCHNRSNRSSFPFLILSCASMPDDVAETELFGHAPGSFNHEQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGSFRRVGEEEEMHADVRIIASTRHRLSELADSGSFREDLFYRLNVLTLSIPALRERSNDVAPLLELFVAKYAQQLGML
KPKLTQELIDQLGNYQWPGNIRQLDNMVLRALTELDSDTLTVEQFHLPQLDTMTAGMASLSLDGSLDEIMKDYESQILEK
LYQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKS

Sequences:

>Translated_514_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVKGIIYLNCPDINFDAFSELMAEIRRISGVKDVRKIQFMPSERHNT
ELIALLANLPDPVIAIDLKGSVDMANHAALNLFNKQEEEVIGEPLATFVPSFNFARWIEGDVTRHREVVVLDGLDFSIEI
LPIYLGGDVNEAVLASAVMTIRSCNQEMNAPDAIPEQNNLGFEHFVGVSNRHKALISQAKKLAMLDQPLLIEGDTGTGKE
MLAKSCHNRSNRSSFPFLILSCASMPDDVAETELFGHAPGSFNHEQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGSFRRVGEEEEMHADVRIIASTRHRLSELADSGSFREDLFYRLNVLTLSIPALRERSNDVAPLLELFVAKYAQQLGML
KPKLTQELIDQLGNYQWPGNIRQLDNMVLRALTELDSDTLTVEQFHLPQLDTMTAGMASLSLDGSLDEIMKDYESQILEK
LYQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKS
>Mature_514_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVKGIIYLNCPDINFDAFSELMAEIRRISGVKDVRKIQFMPSERHNT
ELIALLANLPDPVIAIDLKGSVDMANHAALNLFNKQEEEVIGEPLATFVPSFNFARWIEGDVTRHREVVVLDGLDFSIEI
LPIYLGGDVNEAVLASAVMTIRSCNQEMNAPDAIPEQNNLGFEHFVGVSNRHKALISQAKKLAMLDQPLLIEGDTGTGKE
MLAKSCHNRSNRSSFPFLILSCASMPDDVAETELFGHAPGSFNHEQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGSFRRVGEEEEMHADVRIIASTRHRLSELADSGSFREDLFYRLNVLTLSIPALRERSNDVAPLLELFVAKYAQQLGML
KPKLTQELIDQLGNYQWPGNIRQLDNMVLRALTELDSDTLTVEQFHLPQLDTMTAGMASLSLDGSLDEIMKDYESQILEK
LYQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKS

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=514, Percent_Identity=52.3346303501946, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1788550, Length=297, Percent_Identity=38.3838383838384, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1789233, Length=438, Percent_Identity=28.5388127853881, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1789087, Length=330, Percent_Identity=35.1515151515151, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790437, Length=303, Percent_Identity=34.3234323432343, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=34.4615384615385, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI87082152, Length=329, Percent_Identity=36.1702127659575, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1788905, Length=215, Percent_Identity=42.3255813953488, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1790299, Length=206, Percent_Identity=46.6019417475728, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=33.2298136645963, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786524, Length=216, Percent_Identity=43.0555555555556, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=32.8, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI87081858, Length=490, Percent_Identity=23.265306122449, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57631; Mature: 57631

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVKGIIYLNCPDINFDAFSELMAEIRR
CCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHH
ISGVKDVRKIQFMPSERHNTELIALLANLPDPVIAIDLKGSVDMANHAALNLFNKQEEEV
HCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
IGEPLATFVPSFNFARWIEGDVTRHREVVVLDGLDFSIEILPIYLGGDVNEAVLASAVMT
HCCCHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHH
IRSCNQEMNAPDAIPEQNNLGFEHFVGVSNRHKALISQAKKLAMLDQPLLIEGDTGTGKE
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
MLAKSCHNRSNRSSFPFLILSCASMPDDVAETELFGHAPGSFNHEQGHKGIFEQANGGTV
HHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCEE
FLDEIGEMSPHLQIKLLRFLQDGSFRRVGEEEEMHADVRIIASTRHRLSELADSGSFRED
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LFYRLNVLTLSIPALRERSNDVAPLLELFVAKYAQQLGMLKPKLTQELIDQLGNYQWPGN
HHHHHHHHEEECHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
IRQLDNMVLRALTELDSDTLTVEQFHLPQLDTMTAGMASLSLDGSLDEIMKDYESQILEK
HHHHHHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHCHHHEECCCCHHHHHHHHHHHHHHH
LYQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKS
HHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVKGIIYLNCPDINFDAFSELMAEIRR
CCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHH
ISGVKDVRKIQFMPSERHNTELIALLANLPDPVIAIDLKGSVDMANHAALNLFNKQEEEV
HCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
IGEPLATFVPSFNFARWIEGDVTRHREVVVLDGLDFSIEILPIYLGGDVNEAVLASAVMT
HCCCHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHH
IRSCNQEMNAPDAIPEQNNLGFEHFVGVSNRHKALISQAKKLAMLDQPLLIEGDTGTGKE
HHHHHHHCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
MLAKSCHNRSNRSSFPFLILSCASMPDDVAETELFGHAPGSFNHEQGHKGIFEQANGGTV
HHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCEE
FLDEIGEMSPHLQIKLLRFLQDGSFRRVGEEEEMHADVRIIASTRHRLSELADSGSFRED
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LFYRLNVLTLSIPALRERSNDVAPLLELFVAKYAQQLGMLKPKLTQELIDQLGNYQWPGN
HHHHHHHHEEECHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
IRQLDNMVLRALTELDSDTLTVEQFHLPQLDTMTAGMASLSLDGSLDEIMKDYESQILEK
HHHHHHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHCHHHEECCCCHHHHHHHHHHHHHHH
LYQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKS
HHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]