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The map label for this gene is pepB [H]

Identifier: 218709687

GI number: 218709687

Start: 1823600

End: 1825396

Strand: Reverse

Name: pepB [H]

Synonym: VS_1698

Alternate gene names: 218709687

Gene position: 1825396-1823600 (Counterclockwise)

Preceding gene: 218709688

Following gene: 218709686

Centisome position: 55.33

GC content: 47.08

Gene sequence:

>1797_bases
ATGACAACACCGAGTTGGGATCTAAGCATTGCTTATCGCGATCTTAATGATGCAAAAATCGAACAGGACATTGAACTCAT
TCAACAATGTATTGAGCTGTTGTACCTACACGTTGAAAAGCGTCATATTATCCTAGCGATGCAAAACGCCATTCAAACTT
CTGAAGCGGCAGGCACGTTACTGAGCACAATCAACACCTTCGCTAATTGCCACGCATCGGTAGACGCGACACACACAGAA
GCCAAAGCACTGCTTGGTCGAGTTGCGAAACTGAATTCTGAAATGTCTCAAGCGTTCAGCCCTTATGAAGACACGCTAAT
TCACGCAGAACCAGAGTTTATTGATGCAGTCTTAGAGCATGACAGCACAGATGTAGCAGGACAACGCTTTGCGATTGAAA
GCTCGCGTAAGTTATCAAGTAGCCGCCTTAGTGTTGCTGAAGAGCAGTTATTGGCAGCGATGAAGGTTGATGGCCGTGAT
GGGTGGGGTCGTTTATACGATAACCTGACCGGTTCTTTAAAACTGTCGCTAAAGCTGAACGGTGAAGACGAAGCGCTAGG
TTTTTCACAAGCTGCGAGCTTGTTGTACGGCAGCGAATTCGACAAACAAGAACAGGCATGGCGCGCAGTCCAAGGCGCAA
TGAAGACGCACCAAGAGTCTTTTACTTCAATTCTAAATGCGCTTGCGGGTTGGCGACTGACAGAGAACAAAAAACGCTCG
AAAATAAGCGAAGTGCATTTCCTTGATCCAAGCCTACACGCCAGCCGCATCGTACCTGAAACGCTAGACACCATGATGTC
GGTAGCAAAGGCAAATCGCGAAGTAGGCCAGAAAGCAGGTCTGTTAATGGCAAGAGTTCACGGGCTCGATGAAATGAAGC
CTTGGAACCATTTAGCCGCGATGCCTCCGCTGGGTGACAGCGAATCTAAGGTTTATTCATTTGATGAAGCGATTGAAGTG
ATCAAAACCGCTTTTGCTGAAGTCAATCCAGAGATGGCTGATTTTGTCGCATTAATGGTTGAGAACGGTTGGATTGATGC
CGCTCCGGCTGCGAACAAACGTTTAGGCGCGTACTGCACCAAGTTTGCTGCGACACGTACACCTCTTGTGTTCATGACAT
GGAGCGGTAGCCGCTCAGACTTAATGACATTGGCACACGAACTAGGCCATGCGTTCCATAACTGGGTGATGAAAGACATG
CCTTTGTGTCAGACGCGCTACCCAATGACGCTAGCAGAAACCGCTTCAATCTTTGCTGAAAACATCGTCCGTGACCACTT
GTTAAAACAAGCACAAACACGCAATGAGAAACTTGAAATGTTGTGGGAAGAGCTTTCTTCTTCACTCGCTTTGATGGTAA
ACATTCCAGTACGTTTCGAGTTTGAGAAAGCCTTCTATGAGCAGCGTGAAAAAGGTGAGCTAACGGCTCAGCAGCTGTGT
GACTTGATGGAAACCACTTGGAAGGAGTGGTATGGCGATGCAATGACAGAATCCGACCCTTACTTCTGGGCAAGCAAACT
GCACTTCAGCATCTCTCAAGTGAGCTTCTACAACTACCCATACCTGTTCGGTTACCTGTTCAGTAAAGGTGTTTACGCTC
AGCGCGATGCTAAGGGCGAACAATTCTACGGTGATTACGTTTCCTTGCTTCGTGATACGGGCAGCATGATGGCGGAAGAA
GTCGTTCAAAAACACTTGGGAATGGACCTGACTCAAGCTGACTTTTGGCAACAAAGCATCGACATGGTCAAAGTTCAAAT
CGATGAATTTGAAAGATTGCTCGATCAGGAAGATTAA

Upstream 100 bases:

>100_bases
GAAATAGAACCAGAAACAGAAATAAAAATCGAAATATAAAGCGGCGTTTACAGCCGCTATACCAGATTGGTATTACTACC
TACGTGAAAGGAATTTAGTC

Downstream 100 bases:

>100_bases
TTGATCTCAATCTGTTCATGGTAGGTAAGAGCTGTGTTAGCTTACGTGGCTCTTATCTTGCTGATATAAACAGAGATAAC
CAAAAGTTGTTCTAAATAGG

Product: putative oligopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTTPSWDLSIAYRDLNDAKIEQDIELIQQCIELLYLHVEKRHIILAMQNAIQTSEAAGTLLSTINTFANCHASVDATHTE
AKALLGRVAKLNSEMSQAFSPYEDTLIHAEPEFIDAVLEHDSTDVAGQRFAIESSRKLSSSRLSVAEEQLLAAMKVDGRD
GWGRLYDNLTGSLKLSLKLNGEDEALGFSQAASLLYGSEFDKQEQAWRAVQGAMKTHQESFTSILNALAGWRLTENKKRS
KISEVHFLDPSLHASRIVPETLDTMMSVAKANREVGQKAGLLMARVHGLDEMKPWNHLAAMPPLGDSESKVYSFDEAIEV
IKTAFAEVNPEMADFVALMVENGWIDAAPAANKRLGAYCTKFAATRTPLVFMTWSGSRSDLMTLAHELGHAFHNWVMKDM
PLCQTRYPMTLAETASIFAENIVRDHLLKQAQTRNEKLEMLWEELSSSLALMVNIPVRFEFEKAFYEQREKGELTAQQLC
DLMETTWKEWYGDAMTESDPYFWASKLHFSISQVSFYNYPYLFGYLFSKGVYAQRDAKGEQFYGDYVSLLRDTGSMMAEE
VVQKHLGMDLTQADFWQQSIDMVKVQIDEFERLLDQED

Sequences:

>Translated_598_residues
MTTPSWDLSIAYRDLNDAKIEQDIELIQQCIELLYLHVEKRHIILAMQNAIQTSEAAGTLLSTINTFANCHASVDATHTE
AKALLGRVAKLNSEMSQAFSPYEDTLIHAEPEFIDAVLEHDSTDVAGQRFAIESSRKLSSSRLSVAEEQLLAAMKVDGRD
GWGRLYDNLTGSLKLSLKLNGEDEALGFSQAASLLYGSEFDKQEQAWRAVQGAMKTHQESFTSILNALAGWRLTENKKRS
KISEVHFLDPSLHASRIVPETLDTMMSVAKANREVGQKAGLLMARVHGLDEMKPWNHLAAMPPLGDSESKVYSFDEAIEV
IKTAFAEVNPEMADFVALMVENGWIDAAPAANKRLGAYCTKFAATRTPLVFMTWSGSRSDLMTLAHELGHAFHNWVMKDM
PLCQTRYPMTLAETASIFAENIVRDHLLKQAQTRNEKLEMLWEELSSSLALMVNIPVRFEFEKAFYEQREKGELTAQQLC
DLMETTWKEWYGDAMTESDPYFWASKLHFSISQVSFYNYPYLFGYLFSKGVYAQRDAKGEQFYGDYVSLLRDTGSMMAEE
VVQKHLGMDLTQADFWQQSIDMVKVQIDEFERLLDQED
>Mature_597_residues
TTPSWDLSIAYRDLNDAKIEQDIELIQQCIELLYLHVEKRHIILAMQNAIQTSEAAGTLLSTINTFANCHASVDATHTEA
KALLGRVAKLNSEMSQAFSPYEDTLIHAEPEFIDAVLEHDSTDVAGQRFAIESSRKLSSSRLSVAEEQLLAAMKVDGRDG
WGRLYDNLTGSLKLSLKLNGEDEALGFSQAASLLYGSEFDKQEQAWRAVQGAMKTHQESFTSILNALAGWRLTENKKRSK
ISEVHFLDPSLHASRIVPETLDTMMSVAKANREVGQKAGLLMARVHGLDEMKPWNHLAAMPPLGDSESKVYSFDEAIEVI
KTAFAEVNPEMADFVALMVENGWIDAAPAANKRLGAYCTKFAATRTPLVFMTWSGSRSDLMTLAHELGHAFHNWVMKDMP
LCQTRYPMTLAETASIFAENIVRDHLLKQAQTRNEKLEMLWEELSSSLALMVNIPVRFEFEKAFYEQREKGELTAQQLCD
LMETTWKEWYGDAMTESDPYFWASKLHFSISQVSFYNYPYLFGYLFSKGVYAQRDAKGEQFYGDYVSLLRDTGSMMAEEV
VQKHLGMDLTQADFWQQSIDMVKVQIDEFERLLDQED

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 67664; Mature: 67533

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSWDLSIAYRDLNDAKIEQDIELIQQCIELLYLHVEKRHIILAMQNAIQTSEAAGTL
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
LSTINTFANCHASVDATHTEAKALLGRVAKLNSEMSQAFSPYEDTLIHAEPEFIDAVLEH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEECCCHHHHHHHHHC
DSTDVAGQRFAIESSRKLSSSRLSVAEEQLLAAMKVDGRDGWGRLYDNLTGSLKLSLKLN
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEEC
GEDEALGFSQAASLLYGSEFDKQEQAWRAVQGAMKTHQESFTSILNALAGWRLTENKKRS
CCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KISEVHFLDPSLHASRIVPETLDTMMSVAKANREVGQKAGLLMARVHGLDEMKPWNHLAA
HHHHHEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
MPPLGDSESKVYSFDEAIEVIKTAFAEVNPEMADFVALMVENGWIDAAPAANKRLGAYCT
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KFAATRTPLVFMTWSGSRSDLMTLAHELGHAFHNWVMKDMPLCQTRYPMTLAETASIFAE
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NIVRDHLLKQAQTRNEKLEMLWEELSSSLALMVNIPVRFEFEKAFYEQREKGELTAQQLC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHHCCCCHHHHHH
DLMETTWKEWYGDAMTESDPYFWASKLHFSISQVSFYNYPYLFGYLFSKGVYAQRDAKGE
HHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCH
QFYGDYVSLLRDTGSMMAEEVVQKHLGMDLTQADFWQQSIDMVKVQIDEFERLLDQED
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTPSWDLSIAYRDLNDAKIEQDIELIQQCIELLYLHVEKRHIILAMQNAIQTSEAAGTL
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
LSTINTFANCHASVDATHTEAKALLGRVAKLNSEMSQAFSPYEDTLIHAEPEFIDAVLEH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEECCCHHHHHHHHHC
DSTDVAGQRFAIESSRKLSSSRLSVAEEQLLAAMKVDGRDGWGRLYDNLTGSLKLSLKLN
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEEC
GEDEALGFSQAASLLYGSEFDKQEQAWRAVQGAMKTHQESFTSILNALAGWRLTENKKRS
CCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KISEVHFLDPSLHASRIVPETLDTMMSVAKANREVGQKAGLLMARVHGLDEMKPWNHLAA
HHHHHEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
MPPLGDSESKVYSFDEAIEVIKTAFAEVNPEMADFVALMVENGWIDAAPAANKRLGAYCT
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KFAATRTPLVFMTWSGSRSDLMTLAHELGHAFHNWVMKDMPLCQTRYPMTLAETASIFAE
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NIVRDHLLKQAQTRNEKLEMLWEELSSSLALMVNIPVRFEFEKAFYEQREKGELTAQQLC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHHCCCCHHHHHH
DLMETTWKEWYGDAMTESDPYFWASKLHFSISQVSFYNYPYLFGYLFSKGVYAQRDAKGE
HHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCH
QFYGDYVSLLRDTGSMMAEEVVQKHLGMDLTQADFWQQSIDMVKVQIDEFERLLDQED
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]