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The map label for this gene is ligA [H]

Identifier: 218709509

GI number: 218709509

Start: 1652386

End: 1653264

Strand: Reverse

Name: ligA [H]

Synonym: VS_1518

Alternate gene names: 218709509

Gene position: 1653264-1652386 (Counterclockwise)

Preceding gene: 218709527

Following gene: 218709507

Centisome position: 50.11

GC content: 44.14

Gene sequence:

>879_bases
TTGTTGACCACTACAGATATTAATACGGAGCAGATGATGAGATTAACCAAATTGGCGATAGCCACTCTATGGGCGTGTTC
GCTTTCTTCTCATTCATCCTATTTACCGCCTGATCATCTGGTGCTCGCAAACACATACCAACAAGGCATTGATGTTTCTG
AATACTGGAAGAGTGAAAAGCTTGATGGGATTCGTGCTCTTTGGGACGGACAACACCTTTATACTCGAAATGGGAATCGC
ATTTACTCACCGAAGTGGTTTACAAAAAACTTACCGAAGGTACACCTTGAAGGGGAGCTCTGGGCAGGAAGAGGAAAGTT
CCACTTAGTCCAATCTACCGTCCTCGATCACACACCTAGTGATGTTGCGTGGCGCCAAATAGACTTGATGCTGTTTGATA
TGCCAGGGGCTACTGGCGATTATCAAAAGCGCTATTACAACATATTGCATTGGGTAAGTATGATTGGAGAACCTCATGTC
AGCTACATCGAACATGTACCTATTCAAAATGAAGAAGCTCTGTTTTATCAATTAGACAATGTCGATGAACGTAATGGCGA
AGGTTTGATGCTCAGAAAGATCACCAGTCGTTATCAAGCAGGTCGAAGCAATGACCTGTTAAAACTAAAAAGGCATCACG
ATGCCGAAGCCACAGTTATTGGCTACAAAGGCGGGACAGGGAAGTATAAAGGGATGATGGGTTCGATTTTGGTTCACACG
GAAGAAGGGGTTGAGTTTTATATCGGAAGCGGGTTCAGTGATCAAATGAGACTTGCGCCGCCTGAGATCGGCAGCCGTAT
TACCTTTCGCTACAATGGCTTTACTCAAAATGGAAAACCCAAGTTTGCGCGCTTCGTTAGAGAAAAGAGTGAGTATTAA

Upstream 100 bases:

>100_bases
TAATGAATGAAAGTAAAGGTTAGATAAGGTTGATGAGTTGATCGCATCTTCTAGCAAAGATTGTCTAACTGTGTGTTAGA
GCGCTTAGGATTAAAGGCAT

Downstream 100 bases:

>100_bases
TACCAATCAGATTGTTCAGTACAATATAGTCATACACACACAGTAAACGAAAAAGAGCTCTGAATATCAGAGCTCTTTTT
CGTATTCAATATCAGGGATA

Product: DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLTTTDINTEQMMRLTKLAIATLWACSLSSHSSYLPPDHLVLANTYQQGIDVSEYWKSEKLDGIRALWDGQHLYTRNGNR
IYSPKWFTKNLPKVHLEGELWAGRGKFHLVQSTVLDHTPSDVAWRQIDLMLFDMPGATGDYQKRYYNILHWVSMIGEPHV
SYIEHVPIQNEEALFYQLDNVDERNGEGLMLRKITSRYQAGRSNDLLKLKRHHDAEATVIGYKGGTGKYKGMMGSILVHT
EEGVEFYIGSGFSDQMRLAPPEIGSRITFRYNGFTQNGKPKFARFVREKSEY

Sequences:

>Translated_292_residues
MLTTTDINTEQMMRLTKLAIATLWACSLSSHSSYLPPDHLVLANTYQQGIDVSEYWKSEKLDGIRALWDGQHLYTRNGNR
IYSPKWFTKNLPKVHLEGELWAGRGKFHLVQSTVLDHTPSDVAWRQIDLMLFDMPGATGDYQKRYYNILHWVSMIGEPHV
SYIEHVPIQNEEALFYQLDNVDERNGEGLMLRKITSRYQAGRSNDLLKLKRHHDAEATVIGYKGGTGKYKGMMGSILVHT
EEGVEFYIGSGFSDQMRLAPPEIGSRITFRYNGFTQNGKPKFARFVREKSEY
>Mature_292_residues
MLTTTDINTEQMMRLTKLAIATLWACSLSSHSSYLPPDHLVLANTYQQGIDVSEYWKSEKLDGIRALWDGQHLYTRNGNR
IYSPKWFTKNLPKVHLEGELWAGRGKFHLVQSTVLDHTPSDVAWRQIDLMLFDMPGATGDYQKRYYNILHWVSMIGEPHV
SYIEHVPIQNEEALFYQLDNVDERNGEGLMLRKITSRYQAGRSNDLLKLKRHHDAEATVIGYKGGTGKYKGMMGSILVHT
EEGVEFYIGSGFSDQMRLAPPEIGSRITFRYNGFTQNGKPKFARFVREKSEY

Specific function: Catalyzes efficient strand joining on a single nicked DNA [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF01068 DNA_ligase_A_M [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 33588; Mature: 33588

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00333 DNA_LIGASE_A2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTTDINTEQMMRLTKLAIATLWACSLSSHSSYLPPDHLVLANTYQQGIDVSEYWKSEK
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCHHHHHHHHC
LDGIRALWDGQHLYTRNGNRIYSPKWFTKNLPKVHLEGELWAGRGKFHLVQSTVLDHTPS
CCCHHHHCCCCEEEECCCCEEECCCHHCCCCCEEEECCEEEECCCCEEEEEHHHHCCCCC
DVAWRQIDLMLFDMPGATGDYQKRYYNILHWVSMIGEPHVSYIEHVPIQNEEALFYQLDN
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECC
VDERNGEGLMLRKITSRYQAGRSNDLLKLKRHHDAEATVIGYKGGTGKYKGMMGSILVHT
CCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCEEEEEEEE
EEGVEFYIGSGFSDQMRLAPPEIGSRITFRYNGFTQNGKPKFARFVREKSEY
CCCEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLTTTDINTEQMMRLTKLAIATLWACSLSSHSSYLPPDHLVLANTYQQGIDVSEYWKSEK
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHCCCHHHHHHHHC
LDGIRALWDGQHLYTRNGNRIYSPKWFTKNLPKVHLEGELWAGRGKFHLVQSTVLDHTPS
CCCHHHHCCCCEEEECCCCEEECCCHHCCCCCEEEECCEEEECCCCEEEEEHHHHCCCCC
DVAWRQIDLMLFDMPGATGDYQKRYYNILHWVSMIGEPHVSYIEHVPIQNEEALFYQLDN
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECC
VDERNGEGLMLRKITSRYQAGRSNDLLKLKRHHDAEATVIGYKGGTGKYKGMMGSILVHT
CCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCEEEEEEEE
EEGVEFYIGSGFSDQMRLAPPEIGSRITFRYNGFTQNGKPKFARFVREKSEY
CCCEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550458; 7542800; 9060431 [H]