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The map label for this gene is czcR [H]

Identifier: 218709130

GI number: 218709130

Start: 1204216

End: 1204905

Strand: Reverse

Name: czcR [H]

Synonym: VS_1137

Alternate gene names: 218709130

Gene position: 1204905-1204216 (Counterclockwise)

Preceding gene: 218709134

Following gene: 218709129

Centisome position: 36.52

GC content: 43.19

Gene sequence:

>690_bases
ATGAGAATCAAAATGAAACGAGTTCTATTAGTCGAAGATAACCGTGAAATCGCAGGTGTCTTGTTTGATTATTTTGAGTG
TATTGGTATGGAACTCGATTATGCGGACAACGGCGAACTCGGCCTGCAACTCGCGTTGGAAAACTCATTTGATATCATCA
TATTGGATCTGATGTTGCCAAGAATGGACGGCCTCACGGTTTGTAATAAATTGCGAGACCAAGGCAACGCGACACCTATT
TTGATGCTGACCGCGCTAGATAGCCGCGATGATATGTTGAAAGGGTTTGAGCATGGTGCCGATGACTATCTAACCAAGCC
TTTTGATTTGGATATTTTAGAAGCAAGAATGAACGCACTAGTTCGTCGTTACCGCGGAAAAGTAGCCTCTTCAAAACTTC
AGTTCGGTGAACTCACCATCGACCAAAAAACCCGTAAAGCTTACCGCCAAGATAAGCTTCTTGCGCTAAACCCAACCACT
TACACCATACTTGAGATGCTCTGCCAAAACGCACCGGAAGTGGTGACTCGTGAAGATATCTCCTACAAATTATGGGAAGA
AGATGAACCCAATAATGATGTGCTGCGCAGTCACATCTATCAATTACGAAATCAACTCGACAAGCCTTTTGACAGTCAAA
TGTTGATTACGGTTCCTAAAATAGGATTCCGCTTGGAGTCATCTAATTGA

Upstream 100 bases:

>100_bases
ATTTTTTAATCTGAATCCAATCTACCCTCCCATAAGTGAAAGTTATGTTATTGACATATTTTTCACGCTCACTCAGGATA
ATGTTACCGTCTATTTCTGT

Downstream 100 bases:

>100_bases
TTTCCAACTTTCTGACAAGCACTAAAACCCTCACCGGCCGCTTAGCTGTTTTCTTTGGGCTAATGGCCGTGATTGTGTCT
GCGTTCGTCTATGTCGTTTT

Product: putative two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRIKMKRVLLVEDNREIAGVLFDYFECIGMELDYADNGELGLQLALENSFDIIILDLMLPRMDGLTVCNKLRDQGNATPI
LMLTALDSRDDMLKGFEHGADDYLTKPFDLDILEARMNALVRRYRGKVASSKLQFGELTIDQKTRKAYRQDKLLALNPTT
YTILEMLCQNAPEVVTREDISYKLWEEDEPNNDVLRSHIYQLRNQLDKPFDSQMLITVPKIGFRLESSN

Sequences:

>Translated_229_residues
MRIKMKRVLLVEDNREIAGVLFDYFECIGMELDYADNGELGLQLALENSFDIIILDLMLPRMDGLTVCNKLRDQGNATPI
LMLTALDSRDDMLKGFEHGADDYLTKPFDLDILEARMNALVRRYRGKVASSKLQFGELTIDQKTRKAYRQDKLLALNPTT
YTILEMLCQNAPEVVTREDISYKLWEEDEPNNDVLRSHIYQLRNQLDKPFDSQMLITVPKIGFRLESSN
>Mature_229_residues
MRIKMKRVLLVEDNREIAGVLFDYFECIGMELDYADNGELGLQLALENSFDIIILDLMLPRMDGLTVCNKLRDQGNATPI
LMLTALDSRDDMLKGFEHGADDYLTKPFDLDILEARMNALVRRYRGKVASSKLQFGELTIDQKTRKAYRQDKLLALNPTT
YTILEMLCQNAPEVVTREDISYKLWEEDEPNNDVLRSHIYQLRNQLDKPFDSQMLITVPKIGFRLESSN

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=33.9366515837104, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=36.1990950226244, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=31.651376146789, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.0357142857143, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789809, Length=180, Percent_Identity=32.7777777777778, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790552, Length=203, Percent_Identity=33.0049261083744, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.6964285714286, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=28, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI2367329, Length=210, Percent_Identity=32.8571428571429, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790860, Length=201, Percent_Identity=30.8457711442786, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=26.0683760683761, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=31.0924369747899, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=185, Percent_Identity=28.6486486486486, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=213, Percent_Identity=21.1267605633803, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=26.8722466960352, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=29.0909090909091, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26445; Mature: 26445

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKMKRVLLVEDNREIAGVLFDYFECIGMELDYADNGELGLQLALENSFDIIILDLMLP
CCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHC
RMDGLTVCNKLRDQGNATPILMLTALDSRDDMLKGFEHGADDYLTKPFDLDILEARMNAL
CCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHH
VRRYRGKVASSKLQFGELTIDQKTRKAYRQDKLLALNPTTYTILEMLCQNAPEVVTREDI
HHHHHCHHHHCCEEECEEEECHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCEECCCC
SYKLWEEDEPNNDVLRSHIYQLRNQLDKPFDSQMLITVPKIGFRLESSN
CEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC
>Mature Secondary Structure
MRIKMKRVLLVEDNREIAGVLFDYFECIGMELDYADNGELGLQLALENSFDIIILDLMLP
CCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHC
RMDGLTVCNKLRDQGNATPILMLTALDSRDDMLKGFEHGADDYLTKPFDLDILEARMNAL
CCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHH
VRRYRGKVASSKLQFGELTIDQKTRKAYRQDKLLALNPTTYTILEMLCQNAPEVVTREDI
HHHHHCHHHHCCEEECEEEECHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCEECCCC
SYKLWEEDEPNNDVLRSHIYQLRNQLDKPFDSQMLITVPKIGFRLESSN
CEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]