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The map label for this gene is uvrB [H]

Identifier: 218708975

GI number: 218708975

Start: 1012930

End: 1014960

Strand: Direct

Name: uvrB [H]

Synonym: VS_0980

Alternate gene names: 218708975

Gene position: 1012930-1014960 (Clockwise)

Preceding gene: 218708964

Following gene: 218708976

Centisome position: 30.7

GC content: 45.94

Gene sequence:

>2031_bases
ATGAGTAAACTCTTTGACTTGGTATCGGACTACAGCCCGTCCGGTGACCAGCCGACAGCGATAACCAAATTACTAGATGG
ATTGGATTCTGGTTTGGCACATCAAACTCTATTAGGGGTAACGGGCTCTGGTAAAACATTTACCCTTGCCAACGTCATTT
CCCAATCTCAAAGACCTGCGATCTTGTTAGCGCCCAATAAGACATTGGCCGCGCAATTATATGGCGAGATGAAATCTTTC
TTTCCTAACAATGCCGTTGAGTATTTCGTTTCATACTACGATTACTACCAGCCAGAAGCTTACGTTCCGACAACAGACAC
ATTCATCGAGAAAGATGCGTCTGTGAACGCCCATATCGAACAAATGAGGCTGTCGGCAACCAAGGCCTTGCTAGAACGAA
AAGACGCCATCATCGTCGCGTCTGTATCGGCTATCTATGGTCTGGGTGATCCTAAATCTTACCTGAAGATGATGCTTCAC
TTGAGTCGTGGTGAGGTCATGGACCAACGCGATATCTTGCGCCGCTTGGCTGAGCTGCAATATTCAAGAAACGACGTTGC
GTTCGAGCGTGGCCAGTTCCGCGTCCGTGGTGAAGTGATTGATATCTTCCCGGCTGAATCAGATCAGGATGCAGTGCGCA
TCGAAATGTTCGATGATGAGGTGGATTGCATCAGTATCTTTGATCCACTGACAGGTGCGGTCAAGCAAAGAGACTTACCG
CGCTTTACCGTGTATCCGAAAACTCACTATGTAACGCCAAGGGAGAAAATCCTTGAGGCGATTGAGAACATCAAGGACGA
ACTGCGCGATCGTGCTCAATACCTAAAAGACAACAACAAGCTTTTAGAAGAACAGCGTATTTCTCAGAGAACTCAGTTTG
ATATCGAGATGATGACAGAACTTGGTTTCTGTTCTGGTATCGAAAACTATTCACGGTATTTGAGTGGCCGTGCCGAAGGA
GAAGCGCCGCCAACGTTATTTGATTACTTACCTGATGATGGTCTGTTGATTATCGATGAGTCACACGTGACCGTGCCGCA
AATTGGCGCCATGTATAAAGGTGACCGTTCGCGTAAGGAAACTCTAGTTGAGTTTGGTTTCCGTCTGCCTTCGGCATTGG
ATAACCGTCCAATGAAGTTTGAAGAATTTGAGTCTATAGCCCCGCAAACGATTTTTGTGTCGGCCACGCCAGGCAATTAC
GAAATCGAGAAATCAGATGGTGAGATTGCTGATCAAGTGGTGCGTCCTACTGGTTTGTTAGACCCAATTATCGAAGTAAG
GCCTGTCGCGACTCAGGTTGATGACCTATTGTCTGAAATCAGAATACGTTCAGTGAAAGAAGAGCGTGTACTTGTCACGA
CGCTAACTAAGCGAATGGCAGAGGACTTAACTGAATACCTGAGTGAGCATGGCGTTAAAGTTCGTTACTTGCACTCTGAT
ATCGATACCGTTGAACGCGTAGAAATTATCAGAGACCTACGTTTGGGCGAGTTTGACGTGTTAGTGGGCATTAACTTACT
TCGAGAAGGTTTGGATATGCCGGAAGTATCGCTGGTGGCGATTCTTGATGCTGATAAAGAGGGCTTTTTACGCTCTGAGC
GTTCTTTGATCCAGACCATTGGCCGTGCAGCTCGTAATTTGGAAGGTCGAGCAATTCTATATGGTGACTCGATTACTAAG
TCGATGAGAAAGGCGATTGATGAAACCGACCGTCGTAGAGAGAAACAGCAGGCTTACAATGAAGAGCAAGGTATCACGCC
GCAAGCGCTTAAACGTAATATCAAAGATATTATGGAGTTGGGTGACCTGACCAAGTCGAAACAGCAGCGACAATCTAAGC
AAGTTCCACTATCTAAGGTGGCAGAACCTTCTGAAAACTATGCAGTGCTTACGCCACAACAGCTCGATAAAGAGATCAGT
AAACTGGAAGCGGCGATGTATCAGCATGCTCAGAATTTGGAATTTGAATTGGCGGCACAGAAGCGTGATGAAATTGAACA
ATTGAGAAAGCAGTTTATTTCTAATAGCTAA

Upstream 100 bases:

>100_bases
CTCGAATCTTAAGAAGCATTTCTCTAGATAATAGTTGCAACGACACTCCTCCTAGAGTGACAATGACCTGATTAAAAAAA
CAGTATGGAAATGGCGACCT

Downstream 100 bases:

>100_bases
CCTTACTTCTTACTTCTTACTTAAGGCGTTTATACCCATAAAATAAGAATTGAGAGTGCTTCAGACAAAAAAACAGCCAG
TAGGAAACGTTCTACTGGCT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSKLFDLVSDYSPSGDQPTAITKLLDGLDSGLAHQTLLGVTGSGKTFTLANVISQSQRPAILLAPNKTLAAQLYGEMKSF
FPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPKSYLKMMLH
LSRGEVMDQRDILRRLAELQYSRNDVAFERGQFRVRGEVIDIFPAESDQDAVRIEMFDDEVDCISIFDPLTGAVKQRDLP
RFTVYPKTHYVTPREKILEAIENIKDELRDRAQYLKDNNKLLEEQRISQRTQFDIEMMTELGFCSGIENYSRYLSGRAEG
EAPPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPMKFEEFESIAPQTIFVSATPGNY
EIEKSDGEIADQVVRPTGLLDPIIEVRPVATQVDDLLSEIRIRSVKEERVLVTTLTKRMAEDLTEYLSEHGVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGRAILYGDSITK
SMRKAIDETDRRREKQQAYNEEQGITPQALKRNIKDIMELGDLTKSKQQRQSKQVPLSKVAEPSENYAVLTPQQLDKEIS
KLEAAMYQHAQNLEFELAAQKRDEIEQLRKQFISNS

Sequences:

>Translated_676_residues
MSKLFDLVSDYSPSGDQPTAITKLLDGLDSGLAHQTLLGVTGSGKTFTLANVISQSQRPAILLAPNKTLAAQLYGEMKSF
FPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPKSYLKMMLH
LSRGEVMDQRDILRRLAELQYSRNDVAFERGQFRVRGEVIDIFPAESDQDAVRIEMFDDEVDCISIFDPLTGAVKQRDLP
RFTVYPKTHYVTPREKILEAIENIKDELRDRAQYLKDNNKLLEEQRISQRTQFDIEMMTELGFCSGIENYSRYLSGRAEG
EAPPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPMKFEEFESIAPQTIFVSATPGNY
EIEKSDGEIADQVVRPTGLLDPIIEVRPVATQVDDLLSEIRIRSVKEERVLVTTLTKRMAEDLTEYLSEHGVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGRAILYGDSITK
SMRKAIDETDRRREKQQAYNEEQGITPQALKRNIKDIMELGDLTKSKQQRQSKQVPLSKVAEPSENYAVLTPQQLDKEIS
KLEAAMYQHAQNLEFELAAQKRDEIEQLRKQFISNS
>Mature_675_residues
SKLFDLVSDYSPSGDQPTAITKLLDGLDSGLAHQTLLGVTGSGKTFTLANVISQSQRPAILLAPNKTLAAQLYGEMKSFF
PNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIEQMRLSATKALLERKDAIIVASVSAIYGLGDPKSYLKMMLHL
SRGEVMDQRDILRRLAELQYSRNDVAFERGQFRVRGEVIDIFPAESDQDAVRIEMFDDEVDCISIFDPLTGAVKQRDLPR
FTVYPKTHYVTPREKILEAIENIKDELRDRAQYLKDNNKLLEEQRISQRTQFDIEMMTELGFCSGIENYSRYLSGRAEGE
APPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPMKFEEFESIAPQTIFVSATPGNYE
IEKSDGEIADQVVRPTGLLDPIIEVRPVATQVDDLLSEIRIRSVKEERVLVTTLTKRMAEDLTEYLSEHGVKVRYLHSDI
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGRAILYGDSITKS
MRKAIDETDRRREKQQAYNEEQGITPQALKRNIKDIMELGDLTKSKQQRQSKQVPLSKVAEPSENYAVLTPQQLDKEISK
LEAAMYQHAQNLEFELAAQKRDEIEQLRKQFISNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=74.8892171344165, Blast_Score=1030, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=312, Percent_Identity=24.6794871794872, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76813; Mature: 76682

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLFDLVSDYSPSGDQPTAITKLLDGLDSGLAHQTLLGVTGSGKTFTLANVISQSQRPA
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHCCCCCCE
ILLAPNKTLAAQLYGEMKSFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHH
QMRLSATKALLERKDAIIVASVSAIYGLGDPKSYLKMMLHLSRGEVMDQRDILRRLAELQ
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSRNDVAFERGQFRVRGEVIDIFPAESDQDAVRIEMFDDEVDCISIFDPLTGAVKQRDLP
HCCCCHHECCCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RFTVYPKTHYVTPREKILEAIENIKDELRDRAQYLKDNNKLLEEQRISQRTQFDIEMMTE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRAEGEAPPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
TLVEFGFRLPSALDNRPMKFEEFESIAPQTIFVSATPGNYEIEKSDGEIADQVVRPTGLL
HHHHHHHHCCHHHCCCCCCHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCCCC
DPIIEVRPVATQVDDLLSEIRIRSVKEERVLVTTLTKRMAEDLTEYLSEHGVKVRYLHSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGRAILYGDSITKSMRKAIDETDRRREKQQAYNEEQGITPQALKRNIKDIMEL
HHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHHHH
GDLTKSKQQRQSKQVPLSKVAEPSENYAVLTPQQLDKEISKLEAAMYQHAQNLEFELAAQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEHHH
KRDEIEQLRKQFISNS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKLFDLVSDYSPSGDQPTAITKLLDGLDSGLAHQTLLGVTGSGKTFTLANVISQSQRPA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEECCCCCEEHHHHHHCCCCCCE
ILLAPNKTLAAQLYGEMKSFFPNNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHH
QMRLSATKALLERKDAIIVASVSAIYGLGDPKSYLKMMLHLSRGEVMDQRDILRRLAELQ
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YSRNDVAFERGQFRVRGEVIDIFPAESDQDAVRIEMFDDEVDCISIFDPLTGAVKQRDLP
HCCCCHHECCCCEEEECEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RFTVYPKTHYVTPREKILEAIENIKDELRDRAQYLKDNNKLLEEQRISQRTQFDIEMMTE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRAEGEAPPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
TLVEFGFRLPSALDNRPMKFEEFESIAPQTIFVSATPGNYEIEKSDGEIADQVVRPTGLL
HHHHHHHHCCHHHCCCCCCHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCCCC
DPIIEVRPVATQVDDLLSEIRIRSVKEERVLVTTLTKRMAEDLTEYLSEHGVKVRYLHSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGRAILYGDSITKSMRKAIDETDRRREKQQAYNEEQGITPQALKRNIKDIMEL
HHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHHHH
GDLTKSKQQRQSKQVPLSKVAEPSENYAVLTPQQLDKEISKLEAAMYQHAQNLEFELAAQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEHHH
KRDEIEQLRKQFISNS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]