BacMap

Definition	Vibrio splendidus LGP32 chromosome 1, complete genome.
Accession	NC_011753
Length	3,299,303

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The map label for this gene is ccmA [H]

Identifier: 218708849

GI number: 218708849

Start: 871380

End: 871997

Strand: Direct

Name: ccmA [H]

Synonym: VS_0849

Alternate gene names: 218708849

Gene position: 871380-871997 (Clockwise)

Preceding gene: 218708848

Following gene: 218708850

Centisome position: 26.41

GC content: 44.82

Gene sequence:

>618_bases
ATGCTAGAAGTCTCAAATTTAACTGCTATTCGTGACGACAGGGTTCTGTTTGAATCGTTGTCTTTTCAATTGAAACCCGG
TGAGCTGGTTCAAGTTGAAGGTCGTAACGGTACTGGGAAAACGACACTCCTTAGGATTATCACCGGCTTAGGTGATCGTG
ATGAAGGCACTATCTCTTGGGATGGTGAGTCCATTGAAACGAGTCGAGATGTGTATCACCAAAATTTGCTTTTTCTTGGT
CACCAAACTGGCGTAAAACGCGAGCTCAGTGCCTATGAAAACCTGAGCTTCTATCAATCGATTCACAGCAGTGGAACGAG
TAAGGAAGAACTTTACAATGCATTGGCTCAAGTCGGCCTTGCTGGACGAGAAGATGTGCCTGCAGGTCAACTTTCGGCGG
GTCAACAGCGCCGTGTAGCATTGGCTCGTCTGTGGTTAAGTAAGCAAATGTTATGGATTCTAGACGAACCGCTGACTGCA
ATAGACAAGCAGGGTGTTAAGGTTTTGGAGTCTCTTTTTTCTCAGCATGCAGATAACGGTGGCATTGTGTTATTAACCAC
ACACCAAGATATGTTTGCTGATAGCCCGAAACTAAGAAAAATAAAGTTGGGTGAGTAA

Upstream 100 bases:

>100_bases
AGTTTCTTACGGAGTTTGTCCTTTCGAAAACGCCTAGTCCTGTTTTGTCACCTTATTGGTGTGCTACTATAGCCCTCTCA
TTACTCGACTAAATTTACCT

Downstream 100 bases:

>100_bases
TATGATCTCTTCAATGACAACGATCATCCGACGTGAGCTATTGATCGCATTTCGTCGCCAAGCCGATATCTTTAACCCTC
TGTGGTTTTTTATTATTGTC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLEVSNLTAIRDDRVLFESLSFQLKPGELVQVEGRNGTGKTTLLRIITGLGDRDEGTISWDGESIETSRDVYHQNLLFLG
HQTGVKRELSAYENLSFYQSIHSSGTSKEELYNALAQVGLAGREDVPAGQLSAGQQRRVALARLWLSKQMLWILDEPLTA
IDKQGVKVLESLFSQHADNGGIVLLTTHQDMFADSPKLRKIKLGE

Sequences:

>Translated_205_residues
MLEVSNLTAIRDDRVLFESLSFQLKPGELVQVEGRNGTGKTTLLRIITGLGDRDEGTISWDGESIETSRDVYHQNLLFLG
HQTGVKRELSAYENLSFYQSIHSSGTSKEELYNALAQVGLAGREDVPAGQLSAGQQRRVALARLWLSKQMLWILDEPLTA
IDKQGVKVLESLFSQHADNGGIVLLTTHQDMFADSPKLRKIKLGE
>Mature_205_residues
MLEVSNLTAIRDDRVLFESLSFQLKPGELVQVEGRNGTGKTTLLRIITGLGDRDEGTISWDGESIETSRDVYHQNLLFLG
HQTGVKRELSAYENLSFYQSIHSSGTSKEELYNALAQVGLAGREDVPAGQLSAGQQRRVALARLWLSKQMLWILDEPLTA
IDKQGVKVLESLFSQHADNGGIVLLTTHQDMFADSPKLRKIKLGE

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI105990541, Length=193, Percent_Identity=29.5336787564767, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI27881501, Length=188, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI30795238, Length=188, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=27.1794871794872, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21536376, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI148612844, Length=204, Percent_Identity=28.4313725490196, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI150417984, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI255708477, Length=204, Percent_Identity=28.4313725490196, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI171184400, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI89111135, Length=190, Percent_Identity=28.4210526315789, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082064, Length=203, Percent_Identity=56.1576354679803, Blast_Score=203, Evalue=6e-54,
Organism=Escherichia coli, GI1788225, Length=204, Percent_Identity=32.3529411764706, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=32.5301204819277, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789991, Length=199, Percent_Identity=29.1457286432161, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1788165, Length=191, Percent_Identity=31.413612565445, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1787029, Length=205, Percent_Identity=30.2439024390244, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=33.1632653061224, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1786703, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788761, Length=196, Percent_Identity=29.0816326530612, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1789672, Length=191, Percent_Identity=29.8429319371728, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790544, Length=215, Percent_Identity=27.4418604651163, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787041, Length=204, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787370, Length=165, Percent_Identity=29.6969696969697, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789873, Length=186, Percent_Identity=28.494623655914, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1786872, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367384, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787105, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789593, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=184, Percent_Identity=28.804347826087, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788506, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87081791, Length=168, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787712, Length=169, Percent_Identity=30.1775147928994, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789586, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081782, Length=180, Percent_Identity=25.5555555555556, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=24.8704663212435, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790467, Length=165, Percent_Identity=29.0909090909091, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786319, Length=178, Percent_Identity=27.5280898876405, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=168, Percent_Identity=26.7857142857143, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI87081834, Length=186, Percent_Identity=25.2688172043011, Blast_Score=60, Evalue=8e-11,
Organism=Escherichia coli, GI1790190, Length=178, Percent_Identity=25.2808988764045, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17565586, Length=170, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920532, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580930, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666092, Length=174, Percent_Identity=28.1609195402299, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574744, Length=187, Percent_Identity=29.9465240641711, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648314, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221512771, Length=174, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22751; Mature: 22751

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEVSNLTAIRDDRVLFESLSFQLKPGELVQVEGRNGTGKTTLLRIITGLGDRDEGTISW
CCCCCCCEEECCCHHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
DGESIETSRDVYHQNLLFLGHQTGVKRELSAYENLSFYQSIHSSGTSKEELYNALAQVGL
CCCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
AGREDVPAGQLSAGQQRRVALARLWLSKQMLWILDEPLTAIDKQGVKVLESLFSQHADNG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
GIVLLTTHQDMFADSPKLRKIKLGE
CEEEEEECHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MLEVSNLTAIRDDRVLFESLSFQLKPGELVQVEGRNGTGKTTLLRIITGLGDRDEGTISW
CCCCCCCEEECCCHHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
DGESIETSRDVYHQNLLFLGHQTGVKRELSAYENLSFYQSIHSSGTSKEELYNALAQVGL
CCCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
AGREDVPAGQLSAGQQRRVALARLWLSKQMLWILDEPLTAIDKQGVKVLESLFSQHADNG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
GIVLLTTHQDMFADSPKLRKIKLGE
CEEEEEECHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]