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The map label for this gene is phoR [H]

Identifier: 218708603

GI number: 218708603

Start: 601845

End: 603143

Strand: Direct

Name: phoR [H]

Synonym: VS_0580

Alternate gene names: 218708603

Gene position: 601845-603143 (Clockwise)

Preceding gene: 218708602

Following gene: 218708604

Centisome position: 18.24

GC content: 46.65

Gene sequence:

>1299_bases
ATGGTTGAGAAGTTAACCTGGAAGAAGCTGGCTTGGGAGCTGGCTTTTTTTTACGCACCTTGGATTATAGTCGGATGGAT
ATTCGGTTATTTACCTTGGTTATTGCTGGCTGCAACAGTATTACAGTTAGCATGGCATCTACACTATCAAATGCGTTTGT
CTGCTTGGTTGTGGGATGAAAAGCGGTTAACACCCCCTTCAGGTTCTGGAAACTGGGAGTCTCTGTTTAATGGTATCTAT
CGTATGCAGCAGAGACAGCGTCGTAAGCGCAAAGAATTGACCAACCTTATCCGCCGTTTCAGAAACGGTGCTGAATCCCT
TCCCGATGCCGTTGTGGTGTTTCGCGGTGAAGGCAATATTGTTTGGTGCAACAAGCTTGCTCAGTATTTACTGGGTTTTC
GCTGGCCAGACGATTCAGGTCAACCGATCTCTAACTTGATCCGCACGCCGGACTTCATCAAGTACCTTAATAAACAAGAT
TTCTCAGAGCCGTTAGAGATGCCTTCGCCACTTAATGTGGAGCGCATGCTTGAGCTTCGTATAGTACCGTATACCGAGGG
CGAACACCTCATGGTAGTACGTGATGTTACTCAGCTAAAACAGCTAGAAGGCATGCGTCGTAACTTTTTCGCTAACGTTT
CTCACGAGCTACGCACTCCAATGACCGTACTTCAGGGCTATCTTGAAATGACGGAAGATCCAGACATGGTCGTTGGACCT
ATGTGGCCTAAGGCTCATGGTGTGATGACTGAGCAGTTAAATCGTATGAACAGTTTGGTCAATCAGCTTCTTACTCTTTC
TAAGATAGAAGCGGCGCCAATGCATGAATTGGATGAAGTGGTGAATGTTCCGGCGATGTTGGAAGTTCTTGAAAAAGAAG
CCGCTAGTCTCAGTGGAGAGCGAGAACACAAGCTGAAATTTGATATCGATAAGAGTTTACGCGTATTAGCGGATGAAGAT
CAGCTGAGAAGTGCGATATCGAATCTGGTTTACAATGCAGTGAAATACACGCCGCCTGGTGCGACCGTAAAGGTTCGTTG
GTATCAAACCAGTCAAGGTGCGTGTTTGGATGTGTCAGACACCGGAGACGGTATCGAACCACAACACTTGCATCGACTTA
CAGAGCGTTTCTATCGTGTTGATAAAGCACGCTCACGCGATACTGGGGGCAGTGGCCTAGGGTTAGCGATTGTGAAACAT
GCGCTTAGTCACCATGATTCACATTTAGAAATTCAAAGTGAAGTGGGTGTTGGTAGCCGATTCCATTTCACGCTACCTAG
CCGATTGACAGTGTCATGA

Upstream 100 bases:

>100_bases
TGCTGGTCATGACAAATTAATTCAAACGGTTCGCGGCGCAGGCTACCGTTTTTCTACAAAGGCTTAACGTGGCTTCACTG
CCCAGTTTATGGAGTCCTGA

Downstream 100 bases:

>100_bases
GTTCTTTAATACGCCGGATGCGTTTCCCCATCAGTTCATTATTAGCATTAGCTTTGGTTACCCCTGTTCATGCCGAGCAA
AGTGTCGATTCTCTTCCTGA

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVEKLTWKKLAWELAFFYAPWIIVGWIFGYLPWLLLAATVLQLAWHLHYQMRLSAWLWDEKRLTPPSGSGNWESLFNGIY
RMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQD
FSEPLEMPSPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMVVGP
MWPKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGEREHKLKFDIDKSLRVLADED
QLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALSHHDSHLEIQSEVGVGSRFHFTLPSRLTVS

Sequences:

>Translated_432_residues
MVEKLTWKKLAWELAFFYAPWIIVGWIFGYLPWLLLAATVLQLAWHLHYQMRLSAWLWDEKRLTPPSGSGNWESLFNGIY
RMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQD
FSEPLEMPSPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMVVGP
MWPKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGEREHKLKFDIDKSLRVLADED
QLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALSHHDSHLEIQSEVGVGSRFHFTLPSRLTVS
>Mature_432_residues
MVEKLTWKKLAWELAFFYAPWIIVGWIFGYLPWLLLAATVLQLAWHLHYQMRLSAWLWDEKRLTPPSGSGNWESLFNGIY
RMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNIVWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQD
FSEPLEMPSPLNVERMLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMVVGP
MWPKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGEREHKLKFDIDKSLRVLADED
QLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSDTGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALSHHDSHLEIQSEVGVGSRFHFTLPSRLTVS

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=430, Percent_Identity=58.8372093023256, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=31.6239316239316, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=32.03125, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=26.7857142857143, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=365, Percent_Identity=23.5616438356164, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=29.646017699115, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788713, Length=405, Percent_Identity=22.4691358024691, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=29.5652173913043, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.0742358078603, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=27.7056277056277, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=27.3408239700375, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=252, Percent_Identity=29.7619047619048, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=28.6324786324786, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788279, Length=282, Percent_Identity=26.9503546099291, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=212, Percent_Identity=29.7169811320755, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=28.2926829268293, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=28.1512605042017, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787374, Length=244, Percent_Identity=23.3606557377049, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49731; Mature: 49731

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKLTWKKLAWELAFFYAPWIIVGWIFGYLPWLLLAATVLQLAWHLHYQMRLSAWLWDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
KRLTPPSGSGNWESLFNGIYRMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEEECCCCE
VWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDFSEPLEMPSPLNVERMLELR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHEEE
IVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMVVGP
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEECC
MWPKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
REHKLKFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSD
CCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCCEEEECC
TGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCE
FHFTLPSRLTVS
EEEECCCCEECC
>Mature Secondary Structure
MVEKLTWKKLAWELAFFYAPWIIVGWIFGYLPWLLLAATVLQLAWHLHYQMRLSAWLWDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
KRLTPPSGSGNWESLFNGIYRMQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRGEGNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEEECCCCE
VWCNKLAQYLLGFRWPDDSGQPISNLIRTPDFIKYLNKQDFSEPLEMPSPLNVERMLELR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHEEE
IVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMVVGP
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEECC
MWPKAHGVMTEQLNRMNSLVNQLLTLSKIEAAPMHELDEVVNVPAMLEVLEKEAASLSGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
REHKLKFDIDKSLRVLADEDQLRSAISNLVYNAVKYTPPGATVKVRWYQTSQGACLDVSD
CCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCCEEEECC
TGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLEIQSEVGVGSR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCE
FHFTLPSRLTVS
EEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]