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The map label for this gene is mutL [H]

Identifier: 218708321

GI number: 218708321

Start: 259676

End: 261847

Strand: Direct

Name: mutL [H]

Synonym: VS_0268

Alternate gene names: 218708321

Gene position: 259676-261847 (Clockwise)

Preceding gene: 218708320

Following gene: 218708322

Centisome position: 7.87

GC content: 47.1

Gene sequence:

>2172_bases
ATGACGATCAAAATACTGCCAGCTCGGCTAGCTAACCAAATCGCAGCGGGTGAAGTGGTAGAAAGACCTGCTTCTGTTGT
GAAAGAGTTGGTTGAGAACAGTTTGGATTCTGGTGCGACACGTATCGATATCGATATCGAGAAAGGTGGCGCTAAGATGA
TCCGCGTTCGTGACAACGGCAAGGGCATTGTTAAAGATGAGCTTGCCTTGGCATTAAGCCGTCATGCTACCTCTAAAATT
CATACTCTTGATGACCTTGAAGCGATCGTCAGCCTAGGTTTCCGAGGTGAAGCACTGGCGAGTATTAGCTCTGTTGCCCG
CCTAACTATGACTTCACGTCCTACGACTCAGGATCAAGCTTGGGCTGCACATAGTGAAGGTCGTGATATGCAGGTGAAAC
TGCAGCCAGCAGCGCATCCCATTGGCACCTCGGTTGAGGTATTGGATCTGTTCTTCAATACTCCGGCACGACGTAAATTC
TTACGCACCGAGAAAACTGAATTCACGCATATCGATGAGCTGCTTAAACGCATTGCATTGAGCCGTTTTGATGTGACGAT
TAACCTTCGTCATAACGGTAAAATGATTCGTCAGTACCGCGCTGCAAAAACACAAGTTCAAGCCGAAAAGCGCATCGCAG
CAGTATGTGGCAATCCTTTTGTTCGCCATATGCTTAAGATCGAACTTGAGCATCAAGGCTTAAAACTTCATGGTTGGATC
ACCACGCCTGAAGGAGCAAGACAACAAAGCGATCTGCAATACTGTTATGTGAATGGTCGTATGATGCGCGATAAGCTGAT
CAATCATGCGATTCGTCAAAGCTACGAAACTAGCTTGCGCCCCGACCAATTCGCGACGTATGTGTTGTTCATTGAGCTAG
ACCCACATCAGGTGGACGTGAATGTTCATCCTGCAAAACATGAAGTGCGTTTTCATCAAGCCCGCCTTGTACACGACTTT
ATCTACCAAGCCTTGAGTGATGGCTTAGCACAGAGTAAGCAAATCGATGCGGCGCCTGTGAATCAATCTGCTTTCCATCA
ATCAGAAGCGCCAAGTTATCAGCAAGATGATTCGGTGCCTGAAGTTGATGGTGTTGCAAGTTTCGCTGAACCTGAAAACA
CGCTACCTAGTAGCGCGGATCAAAGCCAAGTTTCGGAAAGGGTGCGACATGCTATTGAGCAAACGCCAGCCTACCCAAGA
AAAGCCGAATCTGAACAGGTTTATGATCAACCTCAGCACAGCGTTAATGATGGTGGGCAGCGTTATAGCTCGCCAGCTAA
TCGAGGTTCATCGCCTAACATAGGTCCGTCGGCTCATGAAACCAGTTTTACCGGCTCGCCTCGCCAAGAGTGGATAGAGT
CTCGACCTGAACCTAAAAAAGAAAAAGAGCCGCACCAACATCATGGTGAACCTGCTCCATCTAAGCGAGAAGTGAAGGCC
TATAAAGAGCTTCTGAAAACGCCAGATTTTGATGACCAAGTTGTACAGCCATCCTCACCTCACGAGCATGTGGCTCAAGT
GAACCCAATAGAAACTAAACCAGCTCAACAGAATCCAGCCCATTCAAAGCCAAGAGTACCTGTGACGGACTTGGGCAAAG
CGGTCTCGATTGTGGAACGTCAGTACTTGGTGATGGGTAATAAGAACGGCAGTGTGTTGGTTTCTTTGGCTAAGGCTGAG
TTATTGCGTGTTGTTGGCCAGCTTGATACGCGTGATGGCGCGTTAAAGAGCCAACCATTATTAGTGCCTTTATCCATCAA
ATTAGGCGCTGATTTAGTCGGTGTCGCTAAGGCGCTAAGTCCAATGCTGTCTGTGCTTGGTATCGAGCTTAAAGCTAGGA
ATAACGAAGCGATAATGGTGATGGGAGTGCCTTCTCCTTTGAGGCAGCAAAACTTACAAATTTTGATCCCAGATCTGTTA
TCGTACGCGGCTTCAATAAACGCTCAGGCCTCGGAAACTCAAGGTCATAGCTTTTCTAGCGATACGTTACCATTACTGGT
TAACTGGATCGGGATTCAGACAGCACAAGTAAAAAACGACTACACTTTATCTGAAGCGGTTCAACTAGTTGGGGAACTTG
AGCAACTTTGGCATGGTCTACTTCCATTAGATGATCCCGAATTTGTTAATCCTATCGACTTTTCTGCAACCATCGCTGCT
TTTATGGCTTAG

Upstream 100 bases:

>100_bases
CGCACAAATAGTTGGCTAATGTTGAAGTAATGTTTAGAACATAGAAGCAATCTCAAACGCGAGAAGTGCTTCTATAAATG
GCAGTAAGGTAGCTATACAT

Downstream 100 bases:

>100_bases
TTTGTAGGTGAATTTTCACTGCTGAGTTTTAGATAAATTAAGCTTATTTACGGCTTCGGCTGTTTACGATTTAACTGTTG
CGATGAGGCTTTTCTTAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MTIKILPARLANQIAAGEVVERPASVVKELVENSLDSGATRIDIDIEKGGAKMIRVRDNGKGIVKDELALALSRHATSKI
HTLDDLEAIVSLGFRGEALASISSVARLTMTSRPTTQDQAWAAHSEGRDMQVKLQPAAHPIGTSVEVLDLFFNTPARRKF
LRTEKTEFTHIDELLKRIALSRFDVTINLRHNGKMIRQYRAAKTQVQAEKRIAAVCGNPFVRHMLKIELEHQGLKLHGWI
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRPDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQALSDGLAQSKQIDAAPVNQSAFHQSEAPSYQQDDSVPEVDGVASFAEPENTLPSSADQSQVSERVRHAIEQTPAYPR
KAESEQVYDQPQHSVNDGGQRYSSPANRGSSPNIGPSAHETSFTGSPRQEWIESRPEPKKEKEPHQHHGEPAPSKREVKA
YKELLKTPDFDDQVVQPSSPHEHVAQVNPIETKPAQQNPAHSKPRVPVTDLGKAVSIVERQYLVMGNKNGSVLVSLAKAE
LLRVVGQLDTRDGALKSQPLLVPLSIKLGADLVGVAKALSPMLSVLGIELKARNNEAIMVMGVPSPLRQQNLQILIPDLL
SYAASINAQASETQGHSFSSDTLPLLVNWIGIQTAQVKNDYTLSEAVQLVGELEQLWHGLLPLDDPEFVNPIDFSATIAA
FMA

Sequences:

>Translated_723_residues
MTIKILPARLANQIAAGEVVERPASVVKELVENSLDSGATRIDIDIEKGGAKMIRVRDNGKGIVKDELALALSRHATSKI
HTLDDLEAIVSLGFRGEALASISSVARLTMTSRPTTQDQAWAAHSEGRDMQVKLQPAAHPIGTSVEVLDLFFNTPARRKF
LRTEKTEFTHIDELLKRIALSRFDVTINLRHNGKMIRQYRAAKTQVQAEKRIAAVCGNPFVRHMLKIELEHQGLKLHGWI
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRPDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQALSDGLAQSKQIDAAPVNQSAFHQSEAPSYQQDDSVPEVDGVASFAEPENTLPSSADQSQVSERVRHAIEQTPAYPR
KAESEQVYDQPQHSVNDGGQRYSSPANRGSSPNIGPSAHETSFTGSPRQEWIESRPEPKKEKEPHQHHGEPAPSKREVKA
YKELLKTPDFDDQVVQPSSPHEHVAQVNPIETKPAQQNPAHSKPRVPVTDLGKAVSIVERQYLVMGNKNGSVLVSLAKAE
LLRVVGQLDTRDGALKSQPLLVPLSIKLGADLVGVAKALSPMLSVLGIELKARNNEAIMVMGVPSPLRQQNLQILIPDLL
SYAASINAQASETQGHSFSSDTLPLLVNWIGIQTAQVKNDYTLSEAVQLVGELEQLWHGLLPLDDPEFVNPIDFSATIAA
FMA
>Mature_722_residues
TIKILPARLANQIAAGEVVERPASVVKELVENSLDSGATRIDIDIEKGGAKMIRVRDNGKGIVKDELALALSRHATSKIH
TLDDLEAIVSLGFRGEALASISSVARLTMTSRPTTQDQAWAAHSEGRDMQVKLQPAAHPIGTSVEVLDLFFNTPARRKFL
RTEKTEFTHIDELLKRIALSRFDVTINLRHNGKMIRQYRAAKTQVQAEKRIAAVCGNPFVRHMLKIELEHQGLKLHGWIT
TPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRPDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDFI
YQALSDGLAQSKQIDAAPVNQSAFHQSEAPSYQQDDSVPEVDGVASFAEPENTLPSSADQSQVSERVRHAIEQTPAYPRK
AESEQVYDQPQHSVNDGGQRYSSPANRGSSPNIGPSAHETSFTGSPRQEWIESRPEPKKEKEPHQHHGEPAPSKREVKAY
KELLKTPDFDDQVVQPSSPHEHVAQVNPIETKPAQQNPAHSKPRVPVTDLGKAVSIVERQYLVMGNKNGSVLVSLAKAEL
LRVVGQLDTRDGALKSQPLLVPLSIKLGADLVGVAKALSPMLSVLGIELKARNNEAIMVMGVPSPLRQQNLQILIPDLLS
YAASINAQASETQGHSFSSDTLPLLVNWIGIQTAQVKNDYTLSEAVQLVGELEQLWHGLLPLDDPEFVNPIDFSATIAAF
MA

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=34.2948717948718, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI189458898, Length=321, Percent_Identity=31.1526479750779, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=321, Percent_Identity=31.1526479750779, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.0319488817891, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI4505913, Length=338, Percent_Identity=27.5147928994083, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI310128478, Length=338, Percent_Identity=27.5147928994083, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=29.8165137614679, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=24.5810055865922, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=24.5810055865922, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1790612, Length=723, Percent_Identity=44.1217150760719, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.7826086956522, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=346, Percent_Identity=27.1676300578035, Blast_Score=122, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=375, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=354, Percent_Identity=29.0960451977401, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=27.5862068965517, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=187, Percent_Identity=32.0855614973262, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17136968, Length=322, Percent_Identity=32.6086956521739, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17136970, Length=375, Percent_Identity=26.9333333333333, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 79950; Mature: 79819

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKILPARLANQIAAGEVVERPASVVKELVENSLDSGATRIDIDIEKGGAKMIRVRDNG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCC
KGIVKDELALALSRHATSKIHTLDDLEAIVSLGFRGEALASISSVARLTMTSRPTTQDQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
WAAHSEGRDMQVKLQPAAHPIGTSVEVLDLFFNTPARRKFLRTEKTEFTHIDELLKRIAL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SRFDVTINLRHNGKMIRQYRAAKTQVQAEKRIAAVCGNPFVRHMLKIELEHQGLKLHGWI
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCEEEEEEE
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRPDQFATYVLFIELDPHQVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQALSDGLAQSKQIDAAPVNQSAFHQSEAPSYQQDDSVP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
EVDGVASFAEPENTLPSSADQSQVSERVRHAIEQTPAYPRKAESEQVYDQPQHSVNDGGQ
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHCCCHH
RYSSPANRGSSPNIGPSAHETSFTGSPRQEWIESRPEPKKEKEPHQHHGEPAPSKREVKA
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHH
YKELLKTPDFDDQVVQPSSPHEHVAQVNPIETKPAQQNPAHSKPRVPVTDLGKAVSIVER
HHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QYLVMGNKNGSVLVSLAKAELLRVVGQLDTRDGALKSQPLLVPLSIKLGADLVGVAKALS
EEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
PMLSVLGIELKARNNEAIMVMGVPSPLRQQNLQILIPDLLSYAASINAQASETQGHSFSS
HHHHHHCCEEEECCCCEEEEEECCCHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCC
DTLPLLVNWIGIQTAQVKNDYTLSEAVQLVGELEQLWHGLLPLDDPEFVNPIDFSATIAA
CCHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
FMA
HCC
>Mature Secondary Structure 
TIKILPARLANQIAAGEVVERPASVVKELVENSLDSGATRIDIDIEKGGAKMIRVRDNG
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCC
KGIVKDELALALSRHATSKIHTLDDLEAIVSLGFRGEALASISSVARLTMTSRPTTQDQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
WAAHSEGRDMQVKLQPAAHPIGTSVEVLDLFFNTPARRKFLRTEKTEFTHIDELLKRIAL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SRFDVTINLRHNGKMIRQYRAAKTQVQAEKRIAAVCGNPFVRHMLKIELEHQGLKLHGWI
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCEEEEEEE
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRPDQFATYVLFIELDPHQVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQALSDGLAQSKQIDAAPVNQSAFHQSEAPSYQQDDSVP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
EVDGVASFAEPENTLPSSADQSQVSERVRHAIEQTPAYPRKAESEQVYDQPQHSVNDGGQ
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHCCCHH
RYSSPANRGSSPNIGPSAHETSFTGSPRQEWIESRPEPKKEKEPHQHHGEPAPSKREVKA
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHH
YKELLKTPDFDDQVVQPSSPHEHVAQVNPIETKPAQQNPAHSKPRVPVTDLGKAVSIVER
HHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QYLVMGNKNGSVLVSLAKAELLRVVGQLDTRDGALKSQPLLVPLSIKLGADLVGVAKALS
EEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
PMLSVLGIELKARNNEAIMVMGVPSPLRQQNLQILIPDLLSYAASINAQASETQGHSFSS
HHHHHHCCEEEECCCCEEEEEECCCHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCC
DTLPLLVNWIGIQTAQVKNDYTLSEAVQLVGELEQLWHGLLPLDDPEFVNPIDFSATIAA
CCHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
FMA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]