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The map label for this gene is coaBC [H]

Identifier: 218708244

GI number: 218708244

Start: 177887

End: 179128

Strand: Reverse

Name: coaBC [H]

Synonym: VS_0181

Alternate gene names: 218708244

Gene position: 179128-177887 (Counterclockwise)

Preceding gene: 218708255

Following gene: 218708243

Centisome position: 5.43

GC content: 47.99

Gene sequence:

>1242_bases
ATGCAAACATTGGTTAATCAACTGGATAACGCTGACCAACAAGGCCTAGCTGGAAAAAAAATCCTACTTGGCATTAGTGG
TGGTATCGCAGCTTATAAATGTGCCGAACTGACTCGACGCTTAATCGAACGTGGTGCGCAGGTACAAGTCGTCATGACTA
ATGCGGCTAAGGAGTTCATTACTCCTCTCACCATGCAAGCTGTCTCTGGAAGGCCAGTGTCTGATAGTTTACTTGATCCT
GCTGCTGAAGCTTCCATGGGACACATCGAACTGGCGAAATGGGCTGACCTAGTCTTATTAGCACCCGCAACCGCAGACCT
TATTGCGCGCATGACCGCAGGCATGGGTAACGACCTACTGACCACTTTGGTTTTAGCAACCGATGCGCCAGTTGCGGTAT
CCCCAGCAATGAACCAACAAATGTACAGCCACCCTGCAACTCAAGAGAACATCGCAACGCTAAAACGTCGTGGATGTGAA
ATCTGGGGCCCGGCAGCTGGTGAACAGGCCTGTGGCGATGTTGGTATGGGGCGTATGTTAGAGCCAATGCAACTGGTCCA
TCGTTGTGAAGACTTCTTCCAACCTAAACCTCTTACTGGTCGTTCGGTGTTAATTACTGCGGGTCCAACTCGCGAAGCGA
TCGACCCAGTTCGTTACATTACCAATCATAGCTCGGGCAAGATGGGCTATGCACTGGCTGAAGCGGCCGCGAAACAAGGT
GCTACGGTAACTCTAATTAGTGGCCCTGTATCACTCGCGACACCAAATCAGGTTAATCGCATTGATGTAGACAGCGCACA
ACAGATGTTTGATGCCGTGAATGCCAATGCTGCTCAGCATGATATTTTCATCAGCTGCGCTGCGGTTGCCGATTACCGCC
CAGAGACCATTGCAGACCAGAAGCTTAAAAAAGTCGATGGTAAAGATGACATGACAATTCAAATGGTTAAGAACCCAGAC
ATTGTGGCTTCCGTTGCCTCAATGACTGAAGATCGTCCATTTACTGTCGGCTTCGCAGCAGAAACTCAAGATGTCGAGAA
GTATGCGCGCGGAAAATTGGAAAGAAAGAACCTCGATATGATTTGTGCTAACGATGTCTCTGTCGAAGGCCAAGGCTTTA
ATAGTAGTAGTAATGAGTTGCACCTTTATTGGAAAGGTGGCGATAAATCTCTACCTCTAGATAGCAAAGACTCTCTTGGT
TTCCAGATCCTTAATCAGATCCAACAGCTTATTGACGTATAA

Upstream 100 bases:

>100_bases
ACATCAACTTGATGAGTGTCAAACCTGTTCCAATTCTGCTTCTAGGCACTAATCCTTTGTTCTGATATCGTTAGTCCCAG
AGAAATTAAGGAACAGAATC

Downstream 100 bases:

>100_bases
ACGCACAATTTTACCCTGACAATATGCTGACACCTCTCGATTCTGTTGACCTAGGTCTTACAAAACTAGGAACAGAATTG
AATGGTGTTTATAATCCTGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQTLVNQLDNADQQGLAGKKILLGISGGIAAYKCAELTRRLIERGAQVQVVMTNAAKEFITPLTMQAVSGRPVSDSLLDP
AAEASMGHIELAKWADLVLLAPATADLIARMTAGMGNDLLTTLVLATDAPVAVSPAMNQQMYSHPATQENIATLKRRGCE
IWGPAAGEQACGDVGMGRMLEPMQLVHRCEDFFQPKPLTGRSVLITAGPTREAIDPVRYITNHSSGKMGYALAEAAAKQG
ATVTLISGPVSLATPNQVNRIDVDSAQQMFDAVNANAAQHDIFISCAAVADYRPETIADQKLKKVDGKDDMTIQMVKNPD
IVASVASMTEDRPFTVGFAAETQDVEKYARGKLERKNLDMICANDVSVEGQGFNSSSNELHLYWKGGDKSLPLDSKDSLG
FQILNQIQQLIDV

Sequences:

>Translated_413_residues
MQTLVNQLDNADQQGLAGKKILLGISGGIAAYKCAELTRRLIERGAQVQVVMTNAAKEFITPLTMQAVSGRPVSDSLLDP
AAEASMGHIELAKWADLVLLAPATADLIARMTAGMGNDLLTTLVLATDAPVAVSPAMNQQMYSHPATQENIATLKRRGCE
IWGPAAGEQACGDVGMGRMLEPMQLVHRCEDFFQPKPLTGRSVLITAGPTREAIDPVRYITNHSSGKMGYALAEAAAKQG
ATVTLISGPVSLATPNQVNRIDVDSAQQMFDAVNANAAQHDIFISCAAVADYRPETIADQKLKKVDGKDDMTIQMVKNPD
IVASVASMTEDRPFTVGFAAETQDVEKYARGKLERKNLDMICANDVSVEGQGFNSSSNELHLYWKGGDKSLPLDSKDSLG
FQILNQIQQLIDV
>Mature_413_residues
MQTLVNQLDNADQQGLAGKKILLGISGGIAAYKCAELTRRLIERGAQVQVVMTNAAKEFITPLTMQAVSGRPVSDSLLDP
AAEASMGHIELAKWADLVLLAPATADLIARMTAGMGNDLLTTLVLATDAPVAVSPAMNQQMYSHPATQENIATLKRRGCE
IWGPAAGEQACGDVGMGRMLEPMQLVHRCEDFFQPKPLTGRSVLITAGPTREAIDPVRYITNHSSGKMGYALAEAAAKQG
ATVTLISGPVSLATPNQVNRIDVDSAQQMFDAVNANAAQHDIFISCAAVADYRPETIADQKLKKVDGKDDMTIQMVKNPD
IVASVASMTEDRPFTVGFAAETQDVEKYARGKLERKNLDMICANDVSVEGQGFNSSSNELHLYWKGGDKSLPLDSKDSLG
FQILNQIQQLIDV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=178, Percent_Identity=32.0224719101124, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=64.9746192893401, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=30.9941520467836, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=183, Percent_Identity=29.5081967213115, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=30.4812834224599, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44343; Mature: 44343

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLVNQLDNADQQGLAGKKILLGISGGIAAYKCAELTRRLIERGAQVQVVMTNAAKEFI
CCHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
TPLTMQAVSGRPVSDSLLDPAAEASMGHIELAKWADLVLLAPATADLIARMTAGMGNDLL
CHHHHHHHCCCCCCHHHCCCHHHCCCCCEEHHHHCCEEEECCCHHHHHHHHHHCCCHHHH
TTLVLATDAPVAVSPAMNQQMYSHPATQENIATLKRRGCEIWGPAAGEQACGDVGMGRML
HHHHHHCCCCEEECCHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCCCHHHCCCCCHHHH
EPMQLVHRCEDFFQPKPLTGRSVLITAGPTREAIDPVRYITNHSSGKMGYALAEAAAKQG
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ATVTLISGPVSLATPNQVNRIDVDSAQQMFDAVNANAAQHDIFISCAAVADYRPETIADQ
CEEEEEECCEEECCCCCCCEECHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCCCHHHHH
KLKKVDGKDDMTIQMVKNPDIVASVASMTEDRPFTVGFAAETQDVEKYARGKLERKNLDM
HHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCE
ICANDVSVEGQGFNSSSNELHLYWKGGDKSLPLDSKDSLGFQILNQIQQLIDV
EEECCCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTLVNQLDNADQQGLAGKKILLGISGGIAAYKCAELTRRLIERGAQVQVVMTNAAKEFI
CCHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
TPLTMQAVSGRPVSDSLLDPAAEASMGHIELAKWADLVLLAPATADLIARMTAGMGNDLL
CHHHHHHHCCCCCCHHHCCCHHHCCCCCEEHHHHCCEEEECCCHHHHHHHHHHCCCHHHH
TTLVLATDAPVAVSPAMNQQMYSHPATQENIATLKRRGCEIWGPAAGEQACGDVGMGRML
HHHHHHCCCCEEECCHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCCCHHHCCCCCHHHH
EPMQLVHRCEDFFQPKPLTGRSVLITAGPTREAIDPVRYITNHSSGKMGYALAEAAAKQG
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ATVTLISGPVSLATPNQVNRIDVDSAQQMFDAVNANAAQHDIFISCAAVADYRPETIADQ
CEEEEEECCEEECCCCCCCEECHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCCCHHHHH
KLKKVDGKDDMTIQMVKNPDIVASVASMTEDRPFTVGFAAETQDVEKYARGKLERKNLDM
HHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCE
ICANDVSVEGQGFNSSSNELHLYWKGGDKSLPLDSKDSLGFQILNQIQQLIDV
EEECCCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]