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The map label for this gene is sgbH

Identifier: 218702347

GI number: 218702347

Start: 4263489

End: 4264151

Strand: Direct

Name: sgbH

Synonym: ECIAI39_4093

Alternate gene names: 218702347

Gene position: 4263489-4264151 (Clockwise)

Preceding gene: 218702346

Following gene: 218702348

Centisome position: 83.08

GC content: 58.52

Gene sequence:

>663_bases
ATGAGCCGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCGCAGCGCGACGTGATGCTGTTAAAAGA
CAGCGTCGATATCGTCGAAGCGGGCACCATTCTCTGTTTAAACGAAGGGCTTGGCGCGGTGAAAGCCTTGCGCGAACAGT
GCCCGGATAAAATCATCGTTGCTGACTGGAAGGTCGCCGACGCGGGTGAAACGCTCGCGCACCAGGCGTTTGGCGCAGGT
GCTAACTGGATGACCATCATCTGCGCCGCACCGCTCGCGACGGTAGAAAAAGGTCACGCCATGGCGCAACGCTGCAGTGG
TGAAATCCAGATCGAGCTGTTCGGTAACTGGACGCTGGACGACGCCCGCGACTGGCATCGTATTGGCGTGCGGCAGGCGA
TTTATCATCGTGGTCGTGATGCACAGGCCAGCGGGCAACAGTGGGGCGAAGCCGATCTGGCACGTATGAAGGCGCTTTCC
GATATCGGCCTTGAGCTTTCCATTACCGGCGGGATTACCCCTGCTGACCTGCCGCTGTTTAAAGATATTCGCGTGAAAGC
GTTTATTGCCGGGCGAGCACTGGCAGGCGCAGCAAATCCGGTGCAGGTGGCTGGCGATTTCCATGCACAAATTGATGCCA
TCTGGGGAGGTGCGCGTGCGTAA

Upstream 100 bases:

>100_bases
ATATGACCGCACATCAGCTTTACCAACAAAAATACCAACGCTATCAGCATCTCATTGCCGCACTTCAGGGCTTTCACGCC
CGCATCAAGGAGCACACATT

Downstream 100 bases:

>100_bases
TCATCCGTTAGGGATTTATGAAAAAGCGCTGGCGAAAGATCTCTCCTGGCCGGAGCGGCTGGTGCTGGCAAAAAGCTGTG
GCTTTGATTTTGTCGAAATG

Product: 3-keto-L-gulonate-6-phosphate decarboxylase

Products: NA

Alternate protein names: KGPDC; 3-dehydro-L-gulonate-6-phosphate decarboxylase [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSRPLLQLALDHSSLEAAQRDVMLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIVADWKVADAGETLAHQAFGAG
ANWMTIICAAPLATVEKGHAMAQRCSGEIQIELFGNWTLDDARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALS
DIGLELSITGGITPADLPLFKDIRVKAFIAGRALAGAANPVQVAGDFHAQIDAIWGGARA

Sequences:

>Translated_220_residues
MSRPLLQLALDHSSLEAAQRDVMLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIVADWKVADAGETLAHQAFGAG
ANWMTIICAAPLATVEKGHAMAQRCSGEIQIELFGNWTLDDARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALS
DIGLELSITGGITPADLPLFKDIRVKAFIAGRALAGAANPVQVAGDFHAQIDAIWGGARA
>Mature_219_residues
SRPLLQLALDHSSLEAAQRDVMLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIVADWKVADAGETLAHQAFGAGA
NWMTIICAAPLATVEKGHAMAQRCSGEIQIELFGNWTLDDARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALSD
IGLELSITGGITPADLPLFKDIRVKAFIAGRALAGAANPVQVAGDFHAQIDAIWGGARA

Specific function: Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. KGPDC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790006, Length=220, Percent_Identity=98.1818181818182, Blast_Score=432, Evalue=1e-123,
Organism=Escherichia coli, GI1790640, Length=216, Percent_Identity=46.2962962962963, Blast_Score=211, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.85 [H]

Molecular weight: Translated: 23542; Mature: 23411

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPLLQLALDHSSLEAAQRDVMLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIV
CCCCHHHHHHCCHHHHHHHHCEEEEECCCCEEECCEEEEECCCCHHHHHHHHHCCCCEEE
ADWKVADAGETLAHQAFGAGANWMTIICAAPLATVEKGHAMAQRCSGEIQIELFGNWTLD
EEEEECCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCC
DARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALSDIGLELSITGGITPADLPLF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHH
KDIRVKAFIAGRALAGAANPVQVAGDFHAQIDAIWGGARA
HHCEEEEEEECHHHCCCCCCEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SRPLLQLALDHSSLEAAQRDVMLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIV
CCCHHHHHHCCHHHHHHHHCEEEEECCCCEEECCEEEEECCCCHHHHHHHHHCCCCEEE
ADWKVADAGETLAHQAFGAGANWMTIICAAPLATVEKGHAMAQRCSGEIQIELFGNWTLD
EEEEECCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCC
DARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALSDIGLELSITGGITPADLPLF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHH
KDIRVKAFIAGRALAGAANPVQVAGDFHAQIDAIWGGARA
HHCEEEEEEECHHHCCCCCCEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 9274005; 11741871 [H]