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The map label for this gene is lyxK

Identifier: 218702346

GI number: 218702346

Start: 4261996

End: 4263492

Strand: Direct

Name: lyxK

Synonym: ECIAI39_4092

Alternate gene names: 218702346

Gene position: 4261996-4263492 (Clockwise)

Preceding gene: 218702345

Following gene: 218702347

Centisome position: 83.05

GC content: 57.18

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGGCTGTATGACCGCGAAGGCCGGGAGGC
AGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGCCCGCAGCCAGGCTGGGCAGAGCGCGATATGGCAGAACTGTGGCAAT
GCTGCATGGCTGTCATTCGCACCCTGCTTACTCATTCTGGTGTCAGCGGGGAGCAAATAGTGGGTATCGGTATCTCCGCA
CAGGGAAAGGGCTTGTTTTTGCTGGATAAAAACGACAAGCCGCTCGGGAATGCTATTTTGTCCTCGGACCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGGAAGATGGCATCCCGGAAAAACTCTACCCGCTGACCCGACAAACCTTGTGGACCGGGC
ATCCGGTGTCGCTGTTACGCTGGCTGAAAGAGCACGAACCGGAACGCTACGCGCAAATTGGCTGCGTAATGATGACGCAC
GACTATCTGCGCTGGTGTTTAACCGACGTCAAAGGCTGTGAAGAGAGCAATATTTCCGAGTCCAATCTCTACAACATGAG
TCGCGGGGAATATGACCCGTGTCTCACCGACTGGCTGGGGATCGCTGAAATCAACCACGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATTTGCGGGGAAATCACCGCTCAGACAGCCGCACTGACCGGTCTGAAAGCGGGCACGCCCGTTGTCGGCGGC
CTGTTTGATGTGGTTTCCACCGCACTCTGCGCCGGGATCGAAGACGAATTTACCCTTAATGCGGTGATGGGCACCTGGGC
GGTGACCAGCGGCATAACCCGTGGTTTACGTGACGGTGAAGCGCATCCATATGTCTATGGTCGCTACGTTAACGATGGTC
AATTTATCGTTCACGAAGCTAGCCCCACCTCTTCCGGCAACCTCGAATGGTTTACCGCACAGTGGGGAGAAATCTCGTTT
GATGAGATTAACCAGGCCGTTGCCAGCTTGCCGAAGGCCGGGGGCGATCTCTTTTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTCGAGATGACCAGCGGTTTCTACGGGATGCAGGCCATTCATACCCGCGCACACCTGTTGCAGGCCATTTATG
AAGGCGTGGTGTTCAGCCATATGACCCATCTCAACCGGATGCGCGAACGTTTTACTGATGTGCACACCCTGCGCGTCACT
GGCGGCCCGGCGCATTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGGCTGCGTATCGAACTGCCGCAGGTGGA
AGAAACCGGCTGCTTTGGTGCGGCACTTGCCGCCCGCGTCGGCACCGGAGTTTATCGCGATTTCAGCGAAGCCCAACGTG
ATTTACAGCACCCAGTACGCACCCTGCTGCCGGATATGACCGCACATCAGCTTTACCAACAAAAATACCAACGCTATCAG
CATCTCATTGCCGCACTTCAGGGCTTTCACGCCCGCATCAAGGAGCACACATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGACGCACTGGGGAATCAGGTTCGCGACATGTTTGTTAAAGATGTGCCGCAGGGAGCTGATCTGCTGAAAGCCG
TGGATGAGGTGCAATAAACC

Downstream 100 bases:

>100_bases
GCCGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCGCAGCGCGACGTGATGCTGTTAAAAGACAGC
GTCGATATCGTCGAAGCGGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRTLLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTDVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARIKEHTL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRTLLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTDVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARIKEHTL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRTLLTHSGVSGEQIVGIGISAQ
GKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHD
YLRWCLTDVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGL
FDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISFD
EINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQH
LIAALQGFHARIKEHTL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=489, Percent_Identity=24.7443762781186, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI164663828, Length=542, Percent_Identity=23.2472324723247, Blast_Score=93, Evalue=7e-19,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=98.3935742971888, Blast_Score=1018, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.1485148514851, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=23.5772357723577, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1790361, Length=476, Percent_Identity=23.3193277310924, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24655555, Length=460, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655560, Length=460, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655570, Length=460, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655574, Length=460, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655565, Length=460, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656367, Length=520, Percent_Identity=23.2692307692308, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21357867, Length=532, Percent_Identity=22.3684210526316, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656372, Length=167, Percent_Identity=28.1437125748503, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55278; Mature: 55146

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
TLLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTDVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHTL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
TLLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTDVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHTL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]