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The map label for this gene is alsE [H]

Identifier: 218551502

GI number: 218551502

Start: 4388233

End: 4388919

Strand: Direct

Name: alsE [H]

Synonym: EFER_4285

Alternate gene names: 218551502

Gene position: 4388233-4388919 (Clockwise)

Preceding gene: 218551501

Following gene: 218551503

Centisome position: 95.63

GC content: 46.87

Gene sequence:

>687_bases
ATGAAAATCGCTCCCTCATTAATGTGTATGGATCTGCTGAAATTTAAAGAACAGATCGAGTTTATAGACAGTCACGCAGA
TTATTTTCACATCGACATAATGGATGGTCATTTTGTACCAAACCTGACTTTGTCACCGTTTTTTGTCAGCCAGGTGAAAA
AACTGGCGAGTAAACCGCTGGATTGCCACCTGATGGTGACTCGACCGCAGGATTACATCAGCCAGCTGGCGCAGGCTGGG
GCTAATTTCATCACGCTGCACCCGGAAACCATTAATGGTCAGGCGTTTCGCTTAATTGATGAAATCCGTCGCCTGGGAAT
GAAGGTCGGGCTGATCCTTAACCCTGAAACGCCGGTTGAGGCCATGAAATACTACATCCATAAGGCCGATAAAATTACGG
TGATGACTGTTGATCCGGGCTTCGCCGGGCAGCCATTTATTCCTGAGATGCTGAATAAAATTGCTGAACTAAAAGCATGG
CGCGAGCGTGAAGGTTTGCATTATGAAATCGAAGTGGATGGCTCTTGTAATCAGGCTACTTATGACCGACTGATAGCGGC
AGGTGCGGACGTGTTTATCGTTGGCACATCCGGGCTGTTTAATCATGCAGATAATATTACTGATGCCTGGCAGGTAATGA
CCACGCAGATCCTCAATGCCCGTAAAGGAGTGCAGAGTTATGGCTAA

Upstream 100 bases:

>100_bases
ATTCTGCAAGTACAAACCTACTACCAGCTGGTGGTGATGGGTGGATTAATTATCGCGGCTGTCGCCCTCGACCGTCTTAT
CAGTAAGTAAGGAATAGAAC

Downstream 100 bases:

>100_bases
ACAGCGTAGCGTGGTGGCGGGCGTGGATATGGGGGCGACTCATATCCGCTTTTGCCTGCAAACGGCTGCGGGGGAGATTG
TGCATTGCGAAAAGCGCCGT

Product: allulose-6-phosphate 3-epimerase

Products: fructose-6-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKIAPSLMCMDLLKFKEQIEFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLASKPLDCHLMVTRPQDYISQLAQAG
ANFITLHPETINGQAFRLIDEIRRLGMKVGLILNPETPVEAMKYYIHKADKITVMTVDPGFAGQPFIPEMLNKIAELKAW
REREGLHYEIEVDGSCNQATYDRLIAAGADVFIVGTSGLFNHADNITDAWQVMTTQILNARKGVQSYG

Sequences:

>Translated_228_residues
MKIAPSLMCMDLLKFKEQIEFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLASKPLDCHLMVTRPQDYISQLAQAG
ANFITLHPETINGQAFRLIDEIRRLGMKVGLILNPETPVEAMKYYIHKADKITVMTVDPGFAGQPFIPEMLNKIAELKAW
REREGLHYEIEVDGSCNQATYDRLIAAGADVFIVGTSGLFNHADNITDAWQVMTTQILNARKGVQSYG
>Mature_228_residues
MKIAPSLMCMDLLKFKEQIEFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLASKPLDCHLMVTRPQDYISQLAQAG
ANFITLHPETINGQAFRLIDEIRRLGMKVGLILNPETPVEAMKYYIHKADKITVMTVDPGFAGQPFIPEMLNKIAELKAW
REREGLHYEIEVDGSCNQATYDRLIAAGADVFIVGTSGLFNHADNITDAWQVMTTQILNARKGVQSYG

Specific function: D-ALLOSE METABOLISM. ESSENTIAL FOR THIS PATHWAY. [C]

COG id: COG0036

COG function: function code G; Pentose-5-phosphate-3-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribulose-phosphate 3-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI40385883, Length=199, Percent_Identity=39.6984924623116, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI219879828, Length=199, Percent_Identity=37.6884422110553, Blast_Score=130, Evalue=6e-31,
Organism=Homo sapiens, GI24307923, Length=153, Percent_Identity=32.6797385620915, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1790523, Length=228, Percent_Identity=88.5964912280702, Blast_Score=432, Evalue=1e-123,
Organism=Escherichia coli, GI1789788, Length=204, Percent_Identity=37.2549019607843, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790754, Length=160, Percent_Identity=33.75, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17552948, Length=223, Percent_Identity=35.8744394618834, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322341, Length=216, Percent_Identity=34.2592592592593, Blast_Score=125, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24586301, Length=198, Percent_Identity=37.3737373737374, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000056
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00834 Ribul_P_3_epim [H]

EC number: 5.1.3.- [C]

Molecular weight: Translated: 25675; Mature: 25675

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS01085 RIBUL_P_3_EPIMER_1 ; PS01086 RIBUL_P_3_EPIMER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAPSLMCMDLLKFKEQIEFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLASKPL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
DCHLMVTRPQDYISQLAQAGANFITLHPETINGQAFRLIDEIRRLGMKVGLILNPETPVE
CEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHH
AMKYYIHKADKITVMTVDPGFAGQPFIPEMLNKIAELKAWREREGLHYEIEVDGSCNQAT
HHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
YDRLIAAGADVFIVGTSGLFNHADNITDAWQVMTTQILNARKGVQSYG
HHHHHHCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIAPSLMCMDLLKFKEQIEFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLASKPL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
DCHLMVTRPQDYISQLAQAGANFITLHPETINGQAFRLIDEIRRLGMKVGLILNPETPVE
CEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHH
AMKYYIHKADKITVMTVDPGFAGQPFIPEMLNKIAELKAWREREGLHYEIEVDGSCNQAT
HHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
YDRLIAAGADVFIVGTSGLFNHADNITDAWQVMTTQILNARKGVQSYG
HHHHHHCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-allulose-6-phosphate [C]

Specific reaction: D-allulose-6-phosphate = fructose-6-phosphate [C]

General reaction: Isomerases; Racemases and Epimerases; Acting on Carbohydrates and Derivatives [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 9401019 [H]