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The map label for this gene is dmsA [H]

Identifier: 218551400

GI number: 218551400

Start: 4289538

End: 4291964

Strand: Direct

Name: dmsA [H]

Synonym: EFER_4181

Alternate gene names: 218551400

Gene position: 4289538-4291964 (Clockwise)

Preceding gene: 218551389

Following gene: 218551401

Centisome position: 93.48

GC content: 49.48

Gene sequence:

>2427_bases
ATGAAAGAGTTGTTAAATACAACAATCTCCCGACGTGATGCGGTGACTACAACTGCAAAACTGGGAGCTGCCGTTGCACT
AAGCAACGCCATCACTTTGCCTTTTTCCACAACCGTCAGGGCCGAAACATCGGATACCGGTAAAACCAACGAAAATGCTG
AAACCGTCAGGCATAGTGCTTGCCTGGTGAATTGCGGAAGTCGTTGTCCATTAAAGGTTATCGTAAAAGACGGACGCATT
GTTCGTATTGAAGCCGAGGACGCTAAGGACGACTCTGTTTTTGGTGAACATCAGATTCGACCTTGCCTACGTGGTCGTTC
CAGCCGCTGGCGTGTTTATAGCCCCGACCGTATTAAATATCCCATGAAACGAGTAGGAAAACGTGGCGAGGGGAAATTCC
AAAAAATTTCCTGGGATGAAGCGACAGCATTAATCGCTGCTGAATTAAAACGTATCACTGAAAAATATGGCCGAGAGGCA
ATTTATTATAATTATCAATCTGGCGCTTACTATCAGACTCAGGGTAGCCCGGCATGGAAACGTCTGCTGAATATTACCGG
CGGTTATTTGCGTTACCATAATACTTACTCGACTGCGCAAATTGGTGCTGCAACACCTTATACACACGGTGTATATGTTG
GCAGCCATTTCACCGAAGTTGCTAATTCCGATTTAGTGGTACTTTTTGGTCTTAACCTGTCAGAAACGCGTATGTCCGGT
GGTGGACAGGTGGAAGAGCTGCGTCGTGCGCTCGATAAATCCAAAGCCCGTGTCATTATCATTGATCCTCGCTATACCGA
CTCTGTTATCACTGAACATGCTGAGTGGTTACCTATTCGTCCAACTACTGACGCCGCACTGGTGGCGGGTATTGCACACA
CACTGATCACCGAAAACCTGATCAACGAAGAGCAGGTAAATAAGTACTGTGTGGGTTATGACCGCTCTACACTGCCAGAA
TCGGCGGCACCGAACGCCAGCTATAAAGACTATGTGCTGGGAACCGGGGAAGATGGTGTGGAAAAAACACCTGAATGGGC
GGCAAGTATCACCGGATTACCCGCGACGCGTATTCGCCAGTTAGCAAGGGAAATGGTTGCGGCGAAAGCCTGTTATATCT
GCCAGGGCTGGGGGCCGCAGCGTCATGCCAACGGTGAACAAACTGTTCGTGCAATCCAGACTTTGCCAGTACTAACCGGT
CATTTCGGCTTACCTGGTACGAACAATGGCAACTGGCCTTACGGTACGCCGTATGGTGTTCCTTCACTGCCTGTGGGCGA
AAACCCGATTACCACCTCTATTCCGTGCTATCTCTGGACCGATGCGATCCAAAATCCTGAAAAGATGACGGCCAATACAA
TGGGCGTAAAAGGCGCGGAGAAACTCAAAACTGGGATCAAGCTAATTGTTAACCAGGCGGGTAACGCTCTGTTAAACCAG
CATGGAGAAACCAATCGTACCCGTAAGATTCTCGCCGACGATACATTGTGTGAAACCATCATCGTTATCGAAAACCATAT
GACCCCAAGTGCAAAATATGCAGATATTTTGCTGCCGGAAACCAGCTACCTTGAGGCCGAGGATCTGGTAGACAGTTCAT
ACTCTGCAGGATCGCACAACTATATGATTGCGCTGCAAAGAACCATCGAGCCGATGTGGGAAGTGCGGAGTACTTATGAT
ATTTGCGCCGATATTGCCGGGCATCTTGGTTTGCGCGAGCAATTCACTGAAGGAAAAACTCAGGCGCAATGGGCAGAGCT
GCACTATCAGCAAATCCGTGAAAAACGCCCGTACCTGCCGGAATGGCAGGTAGCAAAAGAGATGGGCGTTATCGACCAGC
GTATCGCGACAGAGAAAGAGAGCATTGCTTTTGCCGATTTCCGCGCTGATCCGCAGGCGAATCCGCTAAAAACGCCATCC
GGTAAAATCGAAGTGTATTCCCAGGCACTGGCTGATCTGGCGCAGAAATGGATCTTGCCAGAGGGCGATCGTATTCCTGC
TGTGCCTGAGTTCTGTGTGGTGAAAGAGTCACATCTGAATAAAGAACTGACTGCGAAGTACCCGTTACAACTCAGTGGAT
TCCATACCAAAGGCCATACTCACTCAACTTACACCAACGTGCTAATGCTGCACGAAGCGGTGCCAGATGAAGTATGGATC
AACCCGATCGATGCCAGTGCGCGGCAACTGTCGTCTGGTGATCTGGTACACGTGTTTAATGATCGTGGTGTGGTTGAGAT
CCCTTGCAAAGTGACCCAGCGTATTTTACCTGGCGTTGTTGCCATGCCTCAGGGAGCGTGGACGCGTCTGGACAGCAATG
GTGTTGATGTTGGTGGCTGTATTAACACGCTGACAACTCACCTGACCTCGCCGCTGGCGAAAGGGAACCCGCAACATACC
AACCTTGTTGAAATTAAACGCGCTTAA

Upstream 100 bases:

>100_bases
TCTCACTTGATCATAATCAATCATGATGAATTACTAATTCTTTATGATTACCTCATATGTCGTATTAATAATAATTATGA
AAACAATGTGAGAAAATAAA

Downstream 100 bases:

>100_bases
GGAGTGATCCACAATGAAACAGTATGGTTTTTACGTTGACTCCTCGCGTTGCTCTGGCTGCAAAACCTGCCAGGTAAGCT
GCAAGGATAATAAAGATTTG

Product: anaerobic dimethyl sulfoxide reductase chain A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 808; Mature: 808

Protein sequence:

>808_residues
MKELLNTTISRRDAVTTTAKLGAAVALSNAITLPFSTTVRAETSDTGKTNENAETVRHSACLVNCGSRCPLKVIVKDGRI
VRIEAEDAKDDSVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFQKISWDEATALIAAELKRITEKYGREA
IYYNYQSGAYYQTQGSPAWKRLLNITGGYLRYHNTYSTAQIGAATPYTHGVYVGSHFTEVANSDLVVLFGLNLSETRMSG
GGQVEELRRALDKSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITENLINEEQVNKYCVGYDRSTLPE
SAAPNASYKDYVLGTGEDGVEKTPEWAASITGLPATRIRQLAREMVAAKACYICQGWGPQRHANGEQTVRAIQTLPVLTG
HFGLPGTNNGNWPYGTPYGVPSLPVGENPITTSIPCYLWTDAIQNPEKMTANTMGVKGAEKLKTGIKLIVNQAGNALLNQ
HGETNRTRKILADDTLCETIIVIENHMTPSAKYADILLPETSYLEAEDLVDSSYSAGSHNYMIALQRTIEPMWEVRSTYD
ICADIAGHLGLREQFTEGKTQAQWAELHYQQIREKRPYLPEWQVAKEMGVIDQRIATEKESIAFADFRADPQANPLKTPS
GKIEVYSQALADLAQKWILPEGDRIPAVPEFCVVKESHLNKELTAKYPLQLSGFHTKGHTHSTYTNVLMLHEAVPDEVWI
NPIDASARQLSSGDLVHVFNDRGVVEIPCKVTQRILPGVVAMPQGAWTRLDSNGVDVGGCINTLTTHLTSPLAKGNPQHT
NLVEIKRA

Sequences:

>Translated_808_residues
MKELLNTTISRRDAVTTTAKLGAAVALSNAITLPFSTTVRAETSDTGKTNENAETVRHSACLVNCGSRCPLKVIVKDGRI
VRIEAEDAKDDSVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFQKISWDEATALIAAELKRITEKYGREA
IYYNYQSGAYYQTQGSPAWKRLLNITGGYLRYHNTYSTAQIGAATPYTHGVYVGSHFTEVANSDLVVLFGLNLSETRMSG
GGQVEELRRALDKSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITENLINEEQVNKYCVGYDRSTLPE
SAAPNASYKDYVLGTGEDGVEKTPEWAASITGLPATRIRQLAREMVAAKACYICQGWGPQRHANGEQTVRAIQTLPVLTG
HFGLPGTNNGNWPYGTPYGVPSLPVGENPITTSIPCYLWTDAIQNPEKMTANTMGVKGAEKLKTGIKLIVNQAGNALLNQ
HGETNRTRKILADDTLCETIIVIENHMTPSAKYADILLPETSYLEAEDLVDSSYSAGSHNYMIALQRTIEPMWEVRSTYD
ICADIAGHLGLREQFTEGKTQAQWAELHYQQIREKRPYLPEWQVAKEMGVIDQRIATEKESIAFADFRADPQANPLKTPS
GKIEVYSQALADLAQKWILPEGDRIPAVPEFCVVKESHLNKELTAKYPLQLSGFHTKGHTHSTYTNVLMLHEAVPDEVWI
NPIDASARQLSSGDLVHVFNDRGVVEIPCKVTQRILPGVVAMPQGAWTRLDSNGVDVGGCINTLTTHLTSPLAKGNPQHT
NLVEIKRA
>Mature_808_residues
MKELLNTTISRRDAVTTTAKLGAAVALSNAITLPFSTTVRAETSDTGKTNENAETVRHSACLVNCGSRCPLKVIVKDGRI
VRIEAEDAKDDSVFGEHQIRPCLRGRSSRWRVYSPDRIKYPMKRVGKRGEGKFQKISWDEATALIAAELKRITEKYGREA
IYYNYQSGAYYQTQGSPAWKRLLNITGGYLRYHNTYSTAQIGAATPYTHGVYVGSHFTEVANSDLVVLFGLNLSETRMSG
GGQVEELRRALDKSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITENLINEEQVNKYCVGYDRSTLPE
SAAPNASYKDYVLGTGEDGVEKTPEWAASITGLPATRIRQLAREMVAAKACYICQGWGPQRHANGEQTVRAIQTLPVLTG
HFGLPGTNNGNWPYGTPYGVPSLPVGENPITTSIPCYLWTDAIQNPEKMTANTMGVKGAEKLKTGIKLIVNQAGNALLNQ
HGETNRTRKILADDTLCETIIVIENHMTPSAKYADILLPETSYLEAEDLVDSSYSAGSHNYMIALQRTIEPMWEVRSTYD
ICADIAGHLGLREQFTEGKTQAQWAELHYQQIREKRPYLPEWQVAKEMGVIDQRIATEKESIAFADFRADPQANPLKTPS
GKIEVYSQALADLAQKWILPEGDRIPAVPEFCVVKESHLNKELTAKYPLQLSGFHTKGHTHSTYTNVLMLHEAVPDEVWI
NPIDASARQLSSGDLVHVFNDRGVVEIPCKVTQRILPGVVAMPQGAWTRLDSNGVDVGGCINTLTTHLTSPLAKGNPQHT
NLVEIKRA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=813, Percent_Identity=51.2915129151292, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=808, Percent_Identity=50.7425742574257, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=809, Percent_Identity=48.9493201483313, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=757, Percent_Identity=30.1188903566711, Blast_Score=268, Evalue=9e-73,
Organism=Escherichia coli, GI87081994, Length=857, Percent_Identity=29.75495915986, Blast_Score=260, Evalue=3e-70,
Organism=Escherichia coli, GI1787231, Length=762, Percent_Identity=30.8398950131234, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI3868721, Length=769, Percent_Identity=26.0078023407022, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89325; Mature: 89325

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELLNTTISRRDAVTTTAKLGAAVALSNAITLPFSTTVRAETSDTGKTNENAETVRHSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
CLVNCGSRCPLKVIVKDGRIVRIEAEDAKDDSVFGEHQIRPCLRGRSSRWRVYSPDRIKY
HEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCC
PMKRVGKRGEGKFQKISWDEATALIAAELKRITEKYGREAIYYNYQSGAYYQTQGSPAWK
CHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHH
RLLNITGGYLRYHNTYSTAQIGAATPYTHGVYVGSHFTEVANSDLVVLFGLNLSETRMSG
HHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHCCCCEEEEECCCCHHHHCCC
GGQVEELRRALDKSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITENL
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHH
INEEQVNKYCVGYDRSTLPESAAPNASYKDYVLGTGEDGVEKTPEWAASITGLPATRIRQ
CCHHHHHHEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCHHHHHH
LAREMVAAKACYICQGWGPQRHANGEQTVRAIQTLPVLTGHFGLPGTNNGNWPYGTPYGV
HHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PSLPVGENPITTSIPCYLWTDAIQNPEKMTANTMGVKGAEKLKTGIKLIVNQAGNALLNQ
CCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHC
HGETNRTRKILADDTLCETIIVIENHMTPSAKYADILLPETSYLEAEDLVDSSYSAGSHN
CCCCCHHHHHHCCCHHHEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCC
YMIALQRTIEPMWEVRSTYDICADIAGHLGLREQFTEGKTQAQWAELHYQQIREKRPYLP
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
EWQVAKEMGVIDQRIATEKESIAFADFRADPQANPLKTPSGKIEVYSQALADLAQKWILP
CHHHHHHHHHHHHHHHCCHHCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
EGDRIPAVPEFCVVKESHLNKELTAKYPLQLSGFHTKGHTHSTYTNVLMLHEAVPDEVWI
CCCCCCCCCHHEEEEHHHCCCCCEEECCEEEECEECCCCCCCHHHHEEEEECCCCCCCEE
NPIDASARQLSSGDLVHVFNDRGVVEIPCKVTQRILPGVVAMPQGAWTRLDSNGVDVGGC
CCCCHHHHHCCCCCEEEEECCCCEEEECHHHHHHHCCCCEECCCCCCEEECCCCCCHHHH
INTLTTHLTSPLAKGNPQHTNLVEIKRA
HHHHHHHHHCHHHCCCCCCCCEEEEECC
>Mature Secondary Structure
MKELLNTTISRRDAVTTTAKLGAAVALSNAITLPFSTTVRAETSDTGKTNENAETVRHSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
CLVNCGSRCPLKVIVKDGRIVRIEAEDAKDDSVFGEHQIRPCLRGRSSRWRVYSPDRIKY
HEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCC
PMKRVGKRGEGKFQKISWDEATALIAAELKRITEKYGREAIYYNYQSGAYYQTQGSPAWK
CHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHH
RLLNITGGYLRYHNTYSTAQIGAATPYTHGVYVGSHFTEVANSDLVVLFGLNLSETRMSG
HHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHCCCCEEEEECCCCHHHHCCC
GGQVEELRRALDKSKARVIIIDPRYTDSVITEHAEWLPIRPTTDAALVAGIAHTLITENL
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHH
INEEQVNKYCVGYDRSTLPESAAPNASYKDYVLGTGEDGVEKTPEWAASITGLPATRIRQ
CCHHHHHHEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCHHHHHH
LAREMVAAKACYICQGWGPQRHANGEQTVRAIQTLPVLTGHFGLPGTNNGNWPYGTPYGV
HHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PSLPVGENPITTSIPCYLWTDAIQNPEKMTANTMGVKGAEKLKTGIKLIVNQAGNALLNQ
CCCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHC
HGETNRTRKILADDTLCETIIVIENHMTPSAKYADILLPETSYLEAEDLVDSSYSAGSHN
CCCCCHHHHHHCCCHHHEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCC
YMIALQRTIEPMWEVRSTYDICADIAGHLGLREQFTEGKTQAQWAELHYQQIREKRPYLP
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
EWQVAKEMGVIDQRIATEKESIAFADFRADPQANPLKTPSGKIEVYSQALADLAQKWILP
CHHHHHHHHHHHHHHHCCHHCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
EGDRIPAVPEFCVVKESHLNKELTAKYPLQLSGFHTKGHTHSTYTNVLMLHEAVPDEVWI
CCCCCCCCCHHEEEEHHHCCCCCEEECCEEEECEECCCCCCCHHHHEEEEECCCCCCCEE
NPIDASARQLSSGDLVHVFNDRGVVEIPCKVTQRILPGVVAMPQGAWTRLDSNGVDVGGC
CCCCHHHHHCCCCCEEEEECCCCEEEECHHHHHHHCCCCEECCCCCCEEECCCCCCHHHH
INTLTTHLTSPLAKGNPQHTNLVEIKRA
HHHHHHHHHCHHHCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]