Click here to switch to the map view.

The map label for this gene is tyrB [H]

Identifier: 218551367

GI number: 218551367

Start: 4246130

End: 4247323

Strand: Direct

Name: tyrB [H]

Synonym: EFER_4146

Alternate gene names: 218551367

Gene position: 4246130-4247323 (Clockwise)

Preceding gene: 218551366

Following gene: 218551368

Centisome position: 92.53

GC content: 50.92

Gene sequence:

>1194_bases
GTGTTTCAAAAAGTTGACGCCTACGCTGGCGACCCGATTCTGTCGCTTATGGAGCGTTTCCTGACCGACCCCCGTAGCGA
CAAAGTGAATCTCAGTATCGGTCTTTATTACAACGAAGACGGCATTATTCCGCAGCTTAATGCTGTCGCAGAGGCTGAAG
CACGGCTTAATGCGCAGCCGCATGGCGCTTCACTTTATTTGCCGATGGAAGGGCTGGGAAGTTATCGACAGGCCATTGCT
CCGCTGCTGTTTGGTGCGGAACATCCGGTTGTTGAGCAACAGCGTGTGGCAACCATTCAAACGTTGGGCGGTTCCGGCGC
GTTAAAAGTGGGTGCAGATTTTTTGAAACGTTACTTCCCTGATTCTGGCGTCTGGGTAAGTGATCCCACATGGGAAAACC
ATATTGATCTGTTTGCCGGTGCGGGTTTTGAAGTCAGTACTTACCCCTGGTATGACGAAGCCACTAACGGTGTACGCTTC
AATGACTTACTGGCAACACTAAAAACATTACCCGCGCGTAGCATTATTTTGCTGCATCCTTGCTGCCATAACCCGACAGG
GGCTGATCTCACCAACGACCAGTGGGATGCGGTAATTGAAATTCTCAAAGCACGTGAATTAATCCCGTTCCTTGATATTG
CTTATCAGGGATTTGGTGCAGGAATGGACGAAGACGCATATGCACTTCGCGCCATTGCCAGTGCAGGTTTACCGGCATTA
ATCAGCAATTCATTTTCGAAAATCTTCTCTCTGTACGGCGAACGCGTTGGCGGTCTTTCGGTCATTTGTGAAGACCATGA
AGCCGCAGAGCGTGTACTGGGGCAACTGAAAGCCACGGTACGGCGTATTTATTCCAGCCCGCCGAGTTTTGGCGCTCAGG
TTGTGGCGACCGTGCTGGGTGATGAAGCGCTGAAAGCCAGCTGGCTGGCGGAAGTTGAAGCAATGCGTACCCGTATTCTG
GCGATGCGTCAGGAAATGGTGAAAGTGCTACGCGCAGAAATCCCCAATGGGAATTTTGATTATCTGCTTAAGCAGCGGGG
CATGTTTAGTTACACCGGACTAAGCGCTGCTCAGGTTGATCGCCTGCGTGAAGAATTTGGCGTGTATTTGATCGCCAGCG
GTCGCATGTGTGTTGCCGGACTTAATGCGCAAAATGTACATCGTGTTGCGAAGGCATTTGCTGCGGTAATGTAA

Upstream 100 bases:

>100_bases
CGACCATCTACCCGATAGACTTTAAACATCCTCTCGATCTTCTCCCGCTTCCGGTTTATTGTGTTTTAACTACCTGCCTG
TAAACCTGGAGAACCATCGC

Downstream 100 bases:

>100_bases
TTGGATTCAGCAGGCGGGTATCTCTCCCGCCTGTTCCTGACACCAGCCATCTTCTCTTTCCCTGTTCCATTTTTCACTCA
CCTTTGCATGGATTCGCAGA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQKVDAYAGDPILSLMERFLTDPRSDKVNLSIGLYYNEDGIIPQLNAVAEAEARLNAQPHGASLYLPMEGLGSYRQAIA
PLLFGAEHPVVEQQRVATIQTLGGSGALKVGADFLKRYFPDSGVWVSDPTWENHIDLFAGAGFEVSTYPWYDEATNGVRF
NDLLATLKTLPARSIILLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMDEDAYALRAIASAGLPAL
ISNSFSKIFSLYGERVGGLSVICEDHEAAERVLGQLKATVRRIYSSPPSFGAQVVATVLGDEALKASWLAEVEAMRTRIL
AMRQEMVKVLRAEIPNGNFDYLLKQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNAQNVHRVAKAFAAVM

Sequences:

>Translated_397_residues
MFQKVDAYAGDPILSLMERFLTDPRSDKVNLSIGLYYNEDGIIPQLNAVAEAEARLNAQPHGASLYLPMEGLGSYRQAIA
PLLFGAEHPVVEQQRVATIQTLGGSGALKVGADFLKRYFPDSGVWVSDPTWENHIDLFAGAGFEVSTYPWYDEATNGVRF
NDLLATLKTLPARSIILLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMDEDAYALRAIASAGLPAL
ISNSFSKIFSLYGERVGGLSVICEDHEAAERVLGQLKATVRRIYSSPPSFGAQVVATVLGDEALKASWLAEVEAMRTRIL
AMRQEMVKVLRAEIPNGNFDYLLKQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNAQNVHRVAKAFAAVM
>Mature_397_residues
MFQKVDAYAGDPILSLMERFLTDPRSDKVNLSIGLYYNEDGIIPQLNAVAEAEARLNAQPHGASLYLPMEGLGSYRQAIA
PLLFGAEHPVVEQQRVATIQTLGGSGALKVGADFLKRYFPDSGVWVSDPTWENHIDLFAGAGFEVSTYPWYDEATNGVRF
NDLLATLKTLPARSIILLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMDEDAYALRAIASAGLPAL
ISNSFSKIFSLYGERVGGLSVICEDHEAAERVLGQLKATVRRIYSSPPSFGAQVVATVLGDEALKASWLAEVEAMRTRIL
AMRQEMVKVLRAEIPNGNFDYLLKQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNAQNVHRVAKAFAAVM

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=39.9484536082474, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=39.4871794871795, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=25.9842519685039, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=90.9319899244333, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=42.3173803526448, Blast_Score=337, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=37.8787878787879, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=38.974358974359, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17569539, Length=375, Percent_Identity=39.4666666666667, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=30.7692307692308, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.361216730038, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=206, Percent_Identity=36.8932038834951, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.0493827160494, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=33.7264150943396, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=37.984496124031, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=37.984496124031, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=36.272040302267, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=36.272040302267, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=36.5979381443299, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43426; Mature: 43426

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKVDAYAGDPILSLMERFLTDPRSDKVNLSIGLYYNEDGIIPQLNAVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
HGASLYLPMEGLGSYRQAIAPLLFGAEHPVVEQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DSGVWVSDPTWENHIDLFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLPARSIILLHP
CCCEEECCCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMDEDAYALRAIASAGLPAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
ISNSFSKIFSLYGERVGGLSVICEDHEAAERVLGQLKATVRRIYSSPPSFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
DEALKASWLAEVEAMRTRILAMRQEMVKVLRAEIPNGNFDYLLKQRGMFSYTGLSAAQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCVAGLNAQNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQKVDAYAGDPILSLMERFLTDPRSDKVNLSIGLYYNEDGIIPQLNAVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
HGASLYLPMEGLGSYRQAIAPLLFGAEHPVVEQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DSGVWVSDPTWENHIDLFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLPARSIILLHP
CCCEEECCCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMDEDAYALRAIASAGLPAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
ISNSFSKIFSLYGERVGGLSVICEDHEAAERVLGQLKATVRRIYSSPPSFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
DEALKASWLAEVEAMRTRILAMRQEMVKVLRAEIPNGNFDYLLKQRGMFSYTGLSAAQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLREEFGVYLIASGRMCVAGLNAQNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]