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The map label for this gene is nadR [H]

Identifier: 218551366

GI number: 218551366

Start: 4245020

End: 4246054

Strand: Direct

Name: nadR [H]

Synonym: EFER_4145

Alternate gene names: 218551366

Gene position: 4245020-4246054 (Clockwise)

Preceding gene: 218551365

Following gene: 218551367

Centisome position: 92.51

GC content: 48.02

Gene sequence:

>1035_bases
GTGGCGCAAGGAGCTACAGGCATAATGAAACCTTTCTCAACGGGTCTGGTGGTCGGCAAGTTCGCTCCCTTACACTGTGG
TCATGAACGGTTGATTAATACCGCACTGGCGCAGTGTGAAGAGTTATACATCATCAGTTATTCCGTACCAGAAATGCCAG
GCTGTGAACCGGAGAAACGGTTGAGTTGGTTACAATTACGCTTCCCGCGAGCGAATATCCTGGTCCTTACTCCTGAACTT
GTTGCGAGCTATAACCTGACTGCAATACCGCCTAATGATGCAGATGAGGATATTCATCGCCATTATGTCGCGACGATATG
CCTGCAAGTATTACATTGTCGTCCACAAGCCGTCTTTACTGCGGAAGATTATGGAGATGGCTTCGTTAAGGTGCTGGCAC
AGCGATTTGCACAGCCTGTTAAGCATATTCGATTGCAGCGTCCTGTTGGCGATGAAGCGCCTTCGGGAACACTGATTCGT
TCCGATGTTCACCGTTACCGCTACATGTTGGCCTACGACGTATATCGTAGTTTTGTTCACCGGATCTGCCTGCTTGGTGG
GGAATCGACAGGTAAAAGCACGCTTTCAAAAGCGCTGGCGGAGGTGCTTGGTACGACGTATGTCGCTGAATTTGGGCGTG
AGTATTGGGAAGAGAAAAACGGTATCCTCACTGGAAATGATTTGCTGCATATTGCTCGTGAGCAGGTACGCCGGGAACAA
CATTCTTCAGCAAATCATTATCTTATTTGTGATACGTCGCCCCTTACAACGTTGTTTTATATGCTTGATCAATATGGTCA
TGCGCCACAAGAGTTACATCGTTTGGCAGAACGGGAATATTCACTGGTCGTGCTTTGCGGTGCTGAATTTCCGTTTATGC
AAGATGGCACCCGGCAAGGAGAAGCATTTCGTGCGCGTCAGCAGGCGTGGTATGAAATGGAATTAACGCGGAGGAATATT
CCTTATCTTTCCGTTGCAGGTTCGTTGGCTGAACGATTAAGACAAATTCTCGACCATCTACCCGATAGACTTTAA

Upstream 100 bases:

>100_bases
TGAATACCCTGGCAGTACCGCTGTATATGACACGTGGGTTGAATTTGACCGCGGGTTTATATTTCTTGTTCTGGATTAAC
GCCTGGCATGGTTTGTATCA

Downstream 100 bases:

>100_bases
ACATCCTCTCGATCTTCTCCCGCTTCCGGTTTATTGTGTTTTAACTACCTGCCTGTAAACCTGGAGAACCATCGCGTGTT
TCAAAAAGTTGACGCCTACG

Product: transcriptional regulator

Products: NA

Alternate protein names: Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAQGATGIMKPFSTGLVVGKFAPLHCGHERLINTALAQCEELYIISYSVPEMPGCEPEKRLSWLQLRFPRANILVLTPEL
VASYNLTAIPPNDADEDIHRHYVATICLQVLHCRPQAVFTAEDYGDGFVKVLAQRFAQPVKHIRLQRPVGDEAPSGTLIR
SDVHRYRYMLAYDVYRSFVHRICLLGGESTGKSTLSKALAEVLGTTYVAEFGREYWEEKNGILTGNDLLHIAREQVRREQ
HSSANHYLICDTSPLTTLFYMLDQYGHAPQELHRLAEREYSLVVLCGAEFPFMQDGTRQGEAFRARQQAWYEMELTRRNI
PYLSVAGSLAERLRQILDHLPDRL

Sequences:

>Translated_344_residues
MAQGATGIMKPFSTGLVVGKFAPLHCGHERLINTALAQCEELYIISYSVPEMPGCEPEKRLSWLQLRFPRANILVLTPEL
VASYNLTAIPPNDADEDIHRHYVATICLQVLHCRPQAVFTAEDYGDGFVKVLAQRFAQPVKHIRLQRPVGDEAPSGTLIR
SDVHRYRYMLAYDVYRSFVHRICLLGGESTGKSTLSKALAEVLGTTYVAEFGREYWEEKNGILTGNDLLHIAREQVRREQ
HSSANHYLICDTSPLTTLFYMLDQYGHAPQELHRLAEREYSLVVLCGAEFPFMQDGTRQGEAFRARQQAWYEMELTRRNI
PYLSVAGSLAERLRQILDHLPDRL
>Mature_343_residues
AQGATGIMKPFSTGLVVGKFAPLHCGHERLINTALAQCEELYIISYSVPEMPGCEPEKRLSWLQLRFPRANILVLTPELV
ASYNLTAIPPNDADEDIHRHYVATICLQVLHCRPQAVFTAEDYGDGFVKVLAQRFAQPVKHIRLQRPVGDEAPSGTLIRS
DVHRYRYMLAYDVYRSFVHRICLLGGESTGKSTLSKALAEVLGTTYVAEFGREYWEEKNGILTGNDLLHIAREQVRREQH
SSANHYLICDTSPLTTLFYMLDQYGHAPQELHRLAEREYSLVVLCGAEFPFMQDGTRQGEAFRARQQAWYEMELTRRNIP
YLSVAGSLAERLRQILDHLPDRL

Specific function: This enzyme has two activities:nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Found as a soluble cytoplasmic protein as well as a membrane-associated protein. In combination with corepressor (NAD), the cytoplasmic form of NadR would be capable of acting as a transcriptiona

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the bacterial RNK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: NA

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 39135; Mature: 39004

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGATGIMKPFSTGLVVGKFAPLHCGHERLINTALAQCEELYIISYSVPEMPGCEPEKR
CCCCCCCHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHH
LSWLQLRFPRANILVLTPELVASYNLTAIPPNDADEDIHRHYVATICLQVLHCRPQAVFT
HHHHEEECCCCCEEEECHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AEDYGDGFVKVLAQRFAQPVKHIRLQRPVGDEAPSGTLIRSDVHRYRYMLAYDVYRSFVH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RICLLGGESTGKSTLSKALAEVLGTTYVAEFGREYWEEKNGILTGNDLLHIAREQVRREQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHH
HSSANHYLICDTSPLTTLFYMLDQYGHAPQELHRLAEREYSLVVLCGAEFPFMQDGTRQG
HCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
EAFRARQQAWYEMELTRRNIPYLSVAGSLAERLRQILDHLPDRL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQGATGIMKPFSTGLVVGKFAPLHCGHERLINTALAQCEELYIISYSVPEMPGCEPEKR
CCCCCCHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHH
LSWLQLRFPRANILVLTPELVASYNLTAIPPNDADEDIHRHYVATICLQVLHCRPQAVFT
HHHHEEECCCCCEEEECHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AEDYGDGFVKVLAQRFAQPVKHIRLQRPVGDEAPSGTLIRSDVHRYRYMLAYDVYRSFVH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RICLLGGESTGKSTLSKALAEVLGTTYVAEFGREYWEEKNGILTGNDLLHIAREQVRREQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHH
HSSANHYLICDTSPLTTLFYMLDQYGHAPQELHRLAEREYSLVVLCGAEFPFMQDGTRQG
HCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
EAFRARQQAWYEMELTRRNIPYLSVAGSLAERLRQILDHLPDRL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 12446641 [H]