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The map label for this gene is modE [H]

Identifier: 218549672

GI number: 218549672

Start: 2403677

End: 2404465

Strand: Direct

Name: modE [H]

Synonym: EFER_2348

Alternate gene names: 218549672

Gene position: 2403677-2404465 (Clockwise)

Preceding gene: 218549667

Following gene: 218549673

Centisome position: 52.38

GC content: 48.92

Gene sequence:

>789_bases
ATGCAGGCCGAAATCCTTCTTACCCTGAAACTTCAGCAAAAATTGTTCGCCGATCCGCGCCGGATTTCGCTACTAAAACA
CATCGCACTTTCTGGTTCTATCAGCCAGGGAGCGAAAGATGCAGGAATCAGCTATAAAAGCGCCTGGGATGCCATCAACG
AAATGAACAAACTGAGCGAGCATTCGTTGGTTGACCGCGCTACTGGCGGAAAAGGCGGTGGTGGTGCGGTACTGACTCGT
TACGGTCAGCGACTGATTCAGCTTTATGATTTGTTGGCACAAATTCAACAAAAAGCATTCGATGTTTTAAGCGATGACGA
TGCTCTGCCACTCGATAGCCTGCTGGCGGCGATCTCCCGTTTTTCCCTGCAAACCAGCGCCCGTAATCAGTGGTTTGGCA
CCATAACTGCCCGCGATCACCATCAAGTACAGGAACATGTCGATGTATTACTGGCTGATGGAAAAACGCGATTAAAAGTC
GCTATCACCGCTCGTAGTAGTGAGCGCCTTGGTCTGGAAGAAGGTAAAGAAGTTCTGATTCTGCTTAAAGCACCGTGGGT
CGGTATTACTCAGGAGACGAGTGTTGCCATGGCTGCTGACAACCAGTTGCCGGGTATTATTAGTTATATAGAACGAGGCG
AGGAGCAGTGCGAAGTGTTGATGACGTTACCAGATGGACAAACACTTTGTGCCACCGTACCGACAGAAAAATCGGCAAAC
CTACAAGAAGGTAGTTCTGTGACTGCATATTTTAATGCCGACCGGGTGATTATCGCGACCTTGTGCTAA

Upstream 100 bases:

>100_bases
ATTCTAACCGTATAACGCAGAAAAGCACTCCCCTTTTGTGCGGTCGTCTTTGCGCGACAGTGGTTTTCCGTCACAATAGT
CTTTTTATCAGGACATTGTT

Downstream 100 bases:

>100_bases
GCACATTGACAATCTTTGCTGGAACACGTATCCCTGTCAGTAATCGCTGCAAAAAATGGGATATAAAATGTCATCGTTGC
AAATTTTGCAAGGCACGTTT

Product: DNA-binding transcriptional regulator ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNKLSEHSLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHHQVQEHVDVLLADGKTRLKV
AITARSSERLGLEEGKEVLILLKAPWVGITQETSVAMAADNQLPGIISYIERGEEQCEVLMTLPDGQTLCATVPTEKSAN
LQEGSSVTAYFNADRVIIATLC

Sequences:

>Translated_262_residues
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNKLSEHSLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHHQVQEHVDVLLADGKTRLKV
AITARSSERLGLEEGKEVLILLKAPWVGITQETSVAMAADNQLPGIISYIERGEEQCEVLMTLPDGQTLCATVPTEKSAN
LQEGSSVTAYFNADRVIIATLC
>Mature_262_residues
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNKLSEHSLVDRATGGKGGGGAVLTR
YGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHHQVQEHVDVLLADGKTRLKV
AITARSSERLGLEEGKEVLILLKAPWVGITQETSVAMAADNQLPGIISYIERGEEQCEVLMTLPDGQTLCATVPTEKSAN
LQEGSSVTAYFNADRVIIATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=262, Percent_Identity=88.9312977099237, Blast_Score=436, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 28516; Mature: 28516

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNKLSE
CCCEEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
HSLVDRATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FSLQTSARNQWFGTITARDHHQVQEHVDVLLADGKTRLKVAITARSSERLGLEEGKEVLI
HHHHHCCCCCEEEEEECCHHHHHHHHHHEEEECCCEEEEEEEEECCCCCCCCCCCCEEEE
LLKAPWVGITQETSVAMAADNQLPGIISYIERGEEQCEVLMTLPDGQTLCATVPTEKSAN
EEECCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCC
LQEGSSVTAYFNADRVIIATLC
CCCCCCEEEEEECCEEEEEEEC
>Mature Secondary Structure
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNKLSE
CCCEEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
HSLVDRATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLDSLLAAISR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FSLQTSARNQWFGTITARDHHQVQEHVDVLLADGKTRLKVAITARSSERLGLEEGKEVLI
HHHHHCCCCCEEEEEECCHHHHHHHHHHEEEECCCEEEEEEEEECCCCCCCCCCCCEEEE
LLKAPWVGITQETSVAMAADNQLPGIISYIERGEEQCEVLMTLPDGQTLCATVPTEKSAN
EEECCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCC
LQEGSSVTAYFNADRVIIATLC
CCCCCCEEEEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]