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The map label for this gene is ybiC [H]

Identifier: 218549632

GI number: 218549632

Start: 2364772

End: 2365857

Strand: Reverse

Name: ybiC [H]

Synonym: EFER_2307

Alternate gene names: 218549632

Gene position: 2365857-2364772 (Counterclockwise)

Preceding gene: 218549633

Following gene: 218549626

Centisome position: 51.56

GC content: 55.89

Gene sequence:

>1086_bases
ATGGAAAGTGGTCATCGCTTTGATGCTCAGACGCTGCACAGTTTTATTCAGGCTGTATTTCGTCAGATGGGTAGCGAGGA
ACAGGAAGCGAAATTAGTCGCCGATCATTTAATCGCGGCAAACCTGGCAGGGCATGATTCACATGGTATTGGCATGATCC
CAAGCTATGTGCGCTCCTGGAGTCAGGGGCATCTGCAAATTAACCACCATGCCAAAATCGTTAAAGAGGCGGGGGCGGCG
GTCACGCTCGATGGCGATCGCGCATTTGGTCAGGTAGCGGCACACGAAGCGATGGCGCTGGGGATTGAGAAAGCGCATCA
GCATGGCATAGCCGCCGTGGCGCTACATAACTCGCATCACATCGGTCGTATTGGTTACTGGGCAGAACAGTGCGCGGCGG
CGGGGTTTGTCTCTATCCACTTTGTTAGCGTGGTGGGTATTCCAATGGTCGCGCCGTTCCACGGCCGCGACAGCCGCTTT
GGCACCAACCCGTTCTGTGTGGTTTTCCCACGTAAAGATAATTTCCCGCTGTTGCTCGATTACGCCACCAGCGCCATCGC
ATTTGGTAAAACTCGCGTCGCCTGGCATAAAGGCGTACCCGTGCCGCCAGGCTGTCTGATTGACGTTAACGGCGTACCGA
CGACAAATCCGGCGGTAATGCAGGAGTCGCCGTTGGGTTCGTTGTTGACCTTTGCCGAACATAAAGGCTACGCCCTCGCG
GCGATGTGTGAAATTCTTGGCGGGGCGCTTTCCGGCGGTAAAACGACGCATCAGGAAACGTTACAAACCAGTCCCGATGC
CATTATTAACTGCATGACCACTATCATCATCAACCCGGAACTGTTCGGCGCGCCGGATTGTAGTGCGCAGACCGAAGCCT
TTGCCGAGTGGGTGAAAGCCTCGCCGCATGATGACGATAAGCCGATTTTGCTACCGGGCGAGTGGGAAGTGAACACGCGT
TGCGAACGGCAGGAGTTGGGGATTCCACTGGACGCGGGAAGCTGGCAGGCCATTTGCGATGCGGCGCGGCAGATTGGTAT
GCCGGAAGAGACGTTGCAGGCTTTCTGTCAGCAGTTAGCCAGCTAA

Upstream 100 bases:

>100_bases
CCCCACCGCAATATGAAATTCCTGCATCTTTATTGACCTTCCCGCGCCCGGCGTGCAGCATAAAAAAACAACAAACACAT
AACATAAACAGGAGTTAATC

Downstream 100 bases:

>100_bases
AAAAAAAAGCCCGTCCAGTGACGGACGGGCAAACAAGGGTAACATAGGATCAATGAGGGTTAGAGCATATGCGTCTGTCG
GCAAACAGACAGGGAAATAC

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAIINCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
CERQELGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS

Sequences:

>Translated_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAIINCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
CERQELGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS
>Mature_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAIINCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTR
CERQELGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLAS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=361, Percent_Identity=98.3379501385042, Blast_Score=734, Evalue=0.0,
Organism=Escherichia coli, GI1786727, Length=313, Percent_Identity=30.6709265175719, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790000, Length=331, Percent_Identity=24.4712990936556, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=316, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17536633, Length=345, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45553211, Length=313, Percent_Identity=30.6709265175719, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667912, Length=313, Percent_Identity=30.6709265175719, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667908, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667904, Length=311, Percent_Identity=30.8681672025724, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24658010, Length=306, Percent_Identity=28.4313725490196, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648360, Length=321, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38815; Mature: 38815

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAIINCMTTIIINPELFGAPDCSAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTRCERQELGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C
>Mature Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAIINCMTTIIINPELFGAPDCSAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTRCERQELGIPLDAGSWQAICDAARQIGMPEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]