| Definition | Methylobacterium chloromethanicum CM4, complete genome. |
|---|---|
| Accession | NC_011757 |
| Length | 5,777,908 |
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The map label for this gene is algA [H]
Identifier: 218533134
GI number: 218533134
Start: 5631501
End: 5632934
Strand: Reverse
Name: algA [H]
Synonym: Mchl_5260
Alternate gene names: 218533134
Gene position: 5632934-5631501 (Counterclockwise)
Preceding gene: 218533135
Following gene: 218533129
Centisome position: 97.49
GC content: 69.67
Gene sequence:
>1434_bases ATGGCCGAGGCAGACCACGAAAAGATCCTGCCCGTGATCCTGTGCGGCGGCTCGGGCACGCGGCTGTGGCCGGCCTCGCG CGAGAGCATGCCGAAGCAGTTCACGCCGCTGGTCGATCCCGCGACCTCGACCTTCCAAGCCACCGTCCGCCGCGTCGCCG ACGAGACCGTGTTCGCGAGGCCGACGGTCATCGCCTCGGCCGAGTCCCGCTTCATCGTCGCCGAGCAGCTCGCGCAAGCG GGCATCGCTGCCGACATCCTGCTCGAACCCGAGCGGCGTGACTCCGCCGCCGCCGTCGCGGTAGCCGCACTTCACGGCGC GCGGCGCGGGCCGGAGACGGTGGTGCTGGTGATGGCCGCCGACCACGTGATCGAGGACGCCGCCGCCTTCGCACGCGCCG CGCAGGAGGCGGCCTTGGGCGCCCGGCTCGGCCAGATCATGACGCTGGGCATCACCCCGACCCGGCCGGCGACCGAGTAC GGCTACATCCGCACCGGCGGCGCCCTTCCCGACGCGCCGGGCCTGCACCGGGTCGAGCGCTTCGTCGAGAAGCCGGACGC GGCTGGCGCCGAGCGCCTGATCGGGGAGGGTGCCCTGTGGAACTCGGGCTACTTCCTGTTCCGCGCCGACGTGATGATCG CCGAGCTGGAAGCGCACGCACCCGACGTGCTGGAAGCCGCACGCGGCGCGCTCGCGAACGCCGCCATCGATCTCGACTTC GTCCGGCTCCAGGCCGAGTCCTTCGCGCGGGCGCCGAAAACCTCGATCGATTACGCGGTGATGGAGCGGACGACGCGGGC CGGTGTGCTCGCCGTCTCCTTTGCGTGGTCGGATGTCGGCACCTGGGACGCGGTGTGGCAGGTGCTGGAACGCGACGCAC AGGGCAATGCGGTGCGCGGCCGCGTCGAGTTAGTCGAGACCACAGGCAGCCTCGTCCATAGCGAGGGCGATGGGCTCACC ACGGTGGTCGGACTCGACAACGTGGTGGTGGTTGCGACGCCCGACGCGGTGCTGGTCGCCTCCAAGGCGAAGTCGGGCAA GGTCAAGGATCTCGTGGCCGTGCTGCGCGAGAAGGCGCATCCGGAGGCGGATGCCCACCGCCGGATGTACCGCCCCTGGG GCTGGTATCAGCGCATCGATATCGGCGAGCGCTTCCAGGTGAAGCGGATCATGGTGACGCCGGGCGGGCGGCTCTCGCTG CAGAAGCACTTCCACCGGGCCGAACACTGGGTGGTGGTGAAGGGCACGGCCGAGGTGACGCTGAACGATTCGATCGTGCT CGTGCACGAGAACGAGGCGGTCTACCTGCCGATCGGCTCGATGCACCGGCTGACCAATCCCGGGAAGATCCCGCTCGAAC TGATCGAGGTGCAGGTCGGCTCCTATACGGGCGAAGACGACATCATCCGAGTCGAGGACGTCTACGGGCGCTGA
Upstream 100 bases:
>100_bases TCATGGGATCGGCTAAGACGGCAGGGTCATTTTTCGCGCCCGCCGCTCCCGCATCCGTGCCCAACCGGCTGGCGCCTCCC GATACGCGACGGACTGGGCC
Downstream 100 bases:
>100_bases GCGCGGGGATCGGCCGACGGGTTGGCGAGGGCGCGCCCGAGCCGCGCGACATCCGCCCGGCCGCTCCTGAGCCCGAGCTT CGAGCGCCGCCACAGGATGT
Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
Products: NA
Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]
Number of amino acids: Translated: 477; Mature: 476
Protein sequence:
>477_residues MAEADHEKILPVILCGGSGTRLWPASRESMPKQFTPLVDPATSTFQATVRRVADETVFARPTVIASAESRFIVAEQLAQA GIAADILLEPERRDSAAAVAVAALHGARRGPETVVLVMAADHVIEDAAAFARAAQEAALGARLGQIMTLGITPTRPATEY GYIRTGGALPDAPGLHRVERFVEKPDAAGAERLIGEGALWNSGYFLFRADVMIAELEAHAPDVLEAARGALANAAIDLDF VRLQAESFARAPKTSIDYAVMERTTRAGVLAVSFAWSDVGTWDAVWQVLERDAQGNAVRGRVELVETTGSLVHSEGDGLT TVVGLDNVVVVATPDAVLVASKAKSGKVKDLVAVLREKAHPEADAHRRMYRPWGWYQRIDIGERFQVKRIMVTPGGRLSL QKHFHRAEHWVVVKGTAEVTLNDSIVLVHENEAVYLPIGSMHRLTNPGKIPLELIEVQVGSYTGEDDIIRVEDVYGR
Sequences:
>Translated_477_residues MAEADHEKILPVILCGGSGTRLWPASRESMPKQFTPLVDPATSTFQATVRRVADETVFARPTVIASAESRFIVAEQLAQA GIAADILLEPERRDSAAAVAVAALHGARRGPETVVLVMAADHVIEDAAAFARAAQEAALGARLGQIMTLGITPTRPATEY GYIRTGGALPDAPGLHRVERFVEKPDAAGAERLIGEGALWNSGYFLFRADVMIAELEAHAPDVLEAARGALANAAIDLDF VRLQAESFARAPKTSIDYAVMERTTRAGVLAVSFAWSDVGTWDAVWQVLERDAQGNAVRGRVELVETTGSLVHSEGDGLT TVVGLDNVVVVATPDAVLVASKAKSGKVKDLVAVLREKAHPEADAHRRMYRPWGWYQRIDIGERFQVKRIMVTPGGRLSL QKHFHRAEHWVVVKGTAEVTLNDSIVLVHENEAVYLPIGSMHRLTNPGKIPLELIEVQVGSYTGEDDIIRVEDVYGR >Mature_476_residues AEADHEKILPVILCGGSGTRLWPASRESMPKQFTPLVDPATSTFQATVRRVADETVFARPTVIASAESRFIVAEQLAQAG IAADILLEPERRDSAAAVAVAALHGARRGPETVVLVMAADHVIEDAAAFARAAQEAALGARLGQIMTLGITPTRPATEYG YIRTGGALPDAPGLHRVERFVEKPDAAGAERLIGEGALWNSGYFLFRADVMIAELEAHAPDVLEAARGALANAAIDLDFV RLQAESFARAPKTSIDYAVMERTTRAGVLAVSFAWSDVGTWDAVWQVLERDAQGNAVRGRVELVETTGSLVHSEGDGLTT VVGLDNVVVVATPDAVLVASKAKSGKVKDLVAVLREKAHPEADAHRRMYRPWGWYQRIDIGERFQVKRIMVTPGGRLSLQ KHFHRAEHWVVVKGTAEVTLNDSIVLVHENEAVYLPIGSMHRLTNPGKIPLELIEVQVGSYTGEDDIIRVEDVYGR
Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]
COG id: COG0836
COG function: function code M; Mannose-1-phosphate guanylyltransferase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]
Homologues:
Organism=Escherichia coli, GI1788362, Length=476, Percent_Identity=46.4285714285714, Blast_Score=397, Evalue=1e-112,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011051 - InterPro: IPR006375 - InterPro: IPR001538 - InterPro: IPR005835 - InterPro: IPR014710 [H]
Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]
EC number: =5.3.1.8; =2.7.7.13 [H]
Molecular weight: Translated: 51643; Mature: 51512
Theoretical pI: Translated: 5.78; Mature: 5.78
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEADHEKILPVILCGGSGTRLWPASRESMPKQFTPLVDPATSTFQATVRRVADETVFAR CCCCCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEC PTVIASAESRFIVAEQLAQAGIAADILLEPERRDSAAAVAVAALHGARRGPETVVLVMAA CEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEC DHVIEDAAAFARAAQEAALGARLGQIMTLGITPTRPATEYGYIRTGGALPDAPGLHRVER CHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHH FVEKPDAAGAERLIGEGALWNSGYFLFRADVMIAELEAHAPDVLEAARGALANAAIDLDF HHHCCCCCCHHHHHCCCCEECCCEEEEEECEEEEEHHCCCCHHHHHHHHHHHHHEEEEEH VRLQAESFARAPKTSIDYAVMERTTRAGVLAVSFAWSDVGTWDAVWQVLERDAQGNAVRG EEEEHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEC RVELVETTGSLVHSEGDGLTTVVGLDNVVVVATPDAVLVASKAKSGKVKDLVAVLREKAH EEEEEECCCCEEECCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCC PEADAHRRMYRPWGWYQRIDIGERFQVKRIMVTPGGRLSLQKHFHRAEHWVVVKGTAEVT CCCHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEEEEE LNDSIVLVHENEAVYLPIGSMHRLTNPGKIPLELIEVQVGSYTGEDDIIRVEDVYGR ECCCEEEEECCCEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCC >Mature Secondary Structure AEADHEKILPVILCGGSGTRLWPASRESMPKQFTPLVDPATSTFQATVRRVADETVFAR CCCCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEC PTVIASAESRFIVAEQLAQAGIAADILLEPERRDSAAAVAVAALHGARRGPETVVLVMAA CEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEC DHVIEDAAAFARAAQEAALGARLGQIMTLGITPTRPATEYGYIRTGGALPDAPGLHRVER CHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHH FVEKPDAAGAERLIGEGALWNSGYFLFRADVMIAELEAHAPDVLEAARGALANAAIDLDF HHHCCCCCCHHHHHCCCCEECCCEEEEEECEEEEEHHCCCCHHHHHHHHHHHHHEEEEEH VRLQAESFARAPKTSIDYAVMERTTRAGVLAVSFAWSDVGTWDAVWQVLERDAQGNAVRG EEEEHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEC RVELVETTGSLVHSEGDGLTTVVGLDNVVVVATPDAVLVASKAKSGKVKDLVAVLREKAH EEEEEECCCCEEECCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCC PEADAHRRMYRPWGWYQRIDIGERFQVKRIMVTPGGRLSLQKHFHRAEHWVVVKGTAEVT CCCHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEEEEE LNDSIVLVHENEAVYLPIGSMHRLTNPGKIPLELIEVQVGSYTGEDDIIRVEDVYGR ECCCEEEEECCCEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12928499 [H]