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The map label for this gene is ahpC [C]

Identifier: 218532053

GI number: 218532053

Start: 4373264

End: 4373929

Strand: Reverse

Name: ahpC [C]

Synonym: Mchl_4147

Alternate gene names: 218532053

Gene position: 4373929-4373264 (Counterclockwise)

Preceding gene: 218532056

Following gene: 218532052

Centisome position: 75.7

GC content: 68.92

Gene sequence:

>666_bases
ATGATTTCAAATATTGAAAGGCCCGATCTGGCGACCGAGCGGCCGGCCTGCCCCCCGGTGATGGGCGATCCCGCTCCGGG
CTTCCGCGCGCGCACGACGATGGGCGAGCGGACGCTTGAGGATTACCGCGGTCGCTGGCTGGTCCTGTTCTCCCATCCGG
CGGACTTCACGCCGGTCTGCACGAGCGAATTCCTCGCCTTCTCGCGCGCCCATCCCCGGTTCCAGATGCTGGATTGCGAT
CTGCTCGGCCTCTCAGTCGACAGCCTGTCGTCGCACCTCGCCTGGGCGCACAACATCGAGGAGCGCTTCGGCGTCTGCGT
TCCGTTCCCGATGCTGGAGGATCCCTCCATGGCCATCGCCCGCGCCTACGGCATGCTGCCGCCGGGCGCCGTGTCGAGCG
CGACCGTGAGGACCACCTTCGTCATCGATCCGGACGGGATCATCCGGGCCTCCACCACCTACCCGATGACGGTCGGACGC
AGCGTCGAGGAGATCCTGCGCCTCGTCGCCGCGCTTCAGGTCACCGACGAGGCGGACGTCGTCACACCGGAGGCCTGGCG
GCCGGGCGACCCGATCCTCGTCGCGCCGCCGCTGACGTTCCACGGAGCCGCCGCCCGGCCGGAGGGCGAGGCCGGCGACT
GGTACTTCCGAACGGGAACCTTGTGA

Upstream 100 bases:

>100_bases
ACATATTGACCTGATCGTTCAAAGCATATCAAATATTGACAGCGGTGCAATACGGGTACTATCTACCTCTGTACCGGCGA
AAAGCCTGGAGCATCGATAT

Downstream 100 bases:

>100_bases
CCATGACGGAGACGGACGGCCCGCACCCCCTCGTCCGGGGTTTCTACGAGCGGCGAACGGGCAGCATCCAGTACGTGGTC
TCGTGTCCGCGGACGAAGCG

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MISNIERPDLATERPACPPVMGDPAPGFRARTTMGERTLEDYRGRWLVLFSHPADFTPVCTSEFLAFSRAHPRFQMLDCD
LLGLSVDSLSSHLAWAHNIEERFGVCVPFPMLEDPSMAIARAYGMLPPGAVSSATVRTTFVIDPDGIIRASTTYPMTVGR
SVEEILRLVAALQVTDEADVVTPEAWRPGDPILVAPPLTFHGAAARPEGEAGDWYFRTGTL

Sequences:

>Translated_221_residues
MISNIERPDLATERPACPPVMGDPAPGFRARTTMGERTLEDYRGRWLVLFSHPADFTPVCTSEFLAFSRAHPRFQMLDCD
LLGLSVDSLSSHLAWAHNIEERFGVCVPFPMLEDPSMAIARAYGMLPPGAVSSATVRTTFVIDPDGIIRASTTYPMTVGR
SVEEILRLVAALQVTDEADVVTPEAWRPGDPILVAPPLTFHGAAARPEGEAGDWYFRTGTL
>Mature_221_residues
MISNIERPDLATERPACPPVMGDPAPGFRARTTMGERTLEDYRGRWLVLFSHPADFTPVCTSEFLAFSRAHPRFQMLDCD
LLGLSVDSLSSHLAWAHNIEERFGVCVPFPMLEDPSMAIARAYGMLPPGAVSSATVRTTFVIDPDGIIRASTTYPMTVGR
SVEEILRLVAALQVTDEADVVTPEAWRPGDPILVAPPLTFHGAAARPEGEAGDWYFRTGTL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=205, Percent_Identity=39.0243902439024, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=41.1428571428571, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=41.1428571428571, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=41.1428571428571, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI32189392, Length=174, Percent_Identity=40.8045977011494, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI5802974, Length=203, Percent_Identity=34.9753694581281, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI32483377, Length=178, Percent_Identity=37.6404494382022, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI5453549, Length=163, Percent_Identity=39.2638036809816, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI33188454, Length=86, Percent_Identity=44.1860465116279, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786822, Length=168, Percent_Identity=33.9285714285714, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25153706, Length=190, Percent_Identity=35.2631578947368, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=181, Percent_Identity=36.4640883977901, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565831, Length=174, Percent_Identity=37.3563218390805, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=155, Percent_Identity=36.7741935483871, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319407, Length=194, Percent_Identity=42.7835051546392, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323613, Length=171, Percent_Identity=38.5964912280702, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320661, Length=186, Percent_Identity=34.9462365591398, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17975518, Length=191, Percent_Identity=39.2670157068063, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24652436, Length=191, Percent_Identity=39.2670157068063, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24652434, Length=191, Percent_Identity=39.2670157068063, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17157991, Length=184, Percent_Identity=39.6739130434783, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24641739, Length=184, Percent_Identity=39.6739130434783, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17738015, Length=198, Percent_Identity=36.8686868686869, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581278, Length=183, Percent_Identity=36.6120218579235, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357347, Length=176, Percent_Identity=41.4772727272727, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=36.6120218579235, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=36.6120218579235, Blast_Score=120, Evalue=9e-28,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24201; Mature: 24201

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNIERPDLATERPACPPVMGDPAPGFRARTTMGERTLEDYRGRWLVLFSHPADFTPVC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCHH
TSEFLAFSRAHPRFQMLDCDLLGLSVDSLSSHLAWAHNIEERFGVCVPFPMLEDPSMAIA
HHHHHHHHCCCCCEEEECCEEEECCHHHHHHHHHHHHCHHHHCCEEECCCCCCCCCHHHH
RAYGMLPPGAVSSATVRTTFVIDPDGIIRASTTYPMTVGRSVEEILRLVAALQVTDEADV
HHHCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
VTPEAWRPGDPILVAPPLTFHGAAARPEGEAGDWYFRTGTL
CCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MISNIERPDLATERPACPPVMGDPAPGFRARTTMGERTLEDYRGRWLVLFSHPADFTPVC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCHH
TSEFLAFSRAHPRFQMLDCDLLGLSVDSLSSHLAWAHNIEERFGVCVPFPMLEDPSMAIA
HHHHHHHHCCCCCEEEECCEEEECCHHHHHHHHHHHHCHHHHCCEEECCCCCCCCCHHHH
RAYGMLPPGAVSSATVRTTFVIDPDGIIRASTTYPMTVGRSVEEILRLVAALQVTDEADV
HHHCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
VTPEAWRPGDPILVAPPLTFHGAAARPEGEAGDWYFRTGTL
CCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]