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The map label for this gene is 218531168

Identifier: 218531168

GI number: 218531168

Start: 3401700

End: 3402629

Strand: Reverse

Name: 218531168

Synonym: Mchl_3218

Alternate gene names: NA

Gene position: 3402629-3401700 (Counterclockwise)

Preceding gene: 218531176

Following gene: 218531163

Centisome position: 58.89

GC content: 69.89

Gene sequence:

>930_bases
CTGAGCACCCTCTACGTCACCCATCCGAGCGCGGTCGAACACGTGGTACCGACCGGCCATCCAGAACGGCCGGCCCGCAT
GCAGGCGGTCGAGCGCGCCCTCGAGGACGAGCGCTTCGCCGCCCTGGTACGCTGCCACGCCCCGAGGGCGGAGGCTTCGG
TCGCCGAACTCGTCCACCCGGCGTCCTACGTCGAGACCATCGTCGCGGCCTCGCCCGACGAGGGCTTCTTTCAGATCGAC
GGCGACACGCTGATGTCGCCGGGCTCGCTCAACACCTGCCTGCACGCCATCGGCGGGTCGAACCACGCCGTCGATGCGGT
GATGAAGGGCGAGTGCGCCAACGCCTTCGTCGCCATGCGCCCGCCCGGCCACCACGCCGAACGCGACCGCGCCATGGGCT
TCTGCCTGTTCAACCACGCGGCGATCGCCGTGCGGCACGCCCAGAAGGCGTTCGGCGCCACCCGCGTCGCCCTGGTGGAT
TTCGACGTCCACCACGGCAACGGCTCGCAGGATATCTTCTGGGCCGACAAGACCGTGATGTACGCCTCGACCCACCAGAT
GCCGCTGTTTCCGGGCTCCGGCGCCACGGGCGAGCGGGGCGACCATGACACCATCGTCAACGCCCCGCTCAAGGCGTTCG
ACGGCAGCGAGTTGTTTCGCGAAGCCTTCGACGCGCGCATCCTGCCGCGGCTCGACGCCTTCGCGCCCGACCTGATCGTG
ATCTCGGCGGGGTTCGACGCGCACAAGCTCGATCCGCTGGCCAACATCCAGCTCGACGAGGCGGATTTCGGCTGGGCGAC
GCGGCGGCTGATGGAGGTGGCCGACCGCCATGCCGGCGGTCGCGTCGTGTCGGTCCTGGAGGGCGGCTACAGCCTCGACG
GCCTTGCCCGCTCGGTTGCCGCGCACATGGATGCGCTGATGGGGCGGTGA

Upstream 100 bases:

>100_bases
GCATCGGCAACAACACGCTCGCCCCGCTTTCGCAGGGCGGCACGTGACGAGGCGGGGCGCCCAAAAGGCATCACCGTCTT
GTGCACCGGGAGAAACGGCC

Downstream 100 bases:

>100_bases
CGGGCACCGCCCCGGCCGGATAGCCTACCCCGTGCACCGGGATCAGGGTGATGAGCACGGCGTTGGCGGACAGAGAGTTC
CGGCGACGCGGCTCAGCGCC

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSTLYVTHPSAVEHVVPTGHPERPARMQAVERALEDERFAALVRCHAPRAEASVAELVHPASYVETIVAASPDEGFFQID
GDTLMSPGSLNTCLHAIGGSNHAVDAVMKGECANAFVAMRPPGHHAERDRAMGFCLFNHAAIAVRHAQKAFGATRVALVD
FDVHHGNGSQDIFWADKTVMYASTHQMPLFPGSGATGERGDHDTIVNAPLKAFDGSELFREAFDARILPRLDAFAPDLIV
ISAGFDAHKLDPLANIQLDEADFGWATRRLMEVADRHAGGRVVSVLEGGYSLDGLARSVAAHMDALMGR

Sequences:

>Translated_309_residues
MSTLYVTHPSAVEHVVPTGHPERPARMQAVERALEDERFAALVRCHAPRAEASVAELVHPASYVETIVAASPDEGFFQID
GDTLMSPGSLNTCLHAIGGSNHAVDAVMKGECANAFVAMRPPGHHAERDRAMGFCLFNHAAIAVRHAQKAFGATRVALVD
FDVHHGNGSQDIFWADKTVMYASTHQMPLFPGSGATGERGDHDTIVNAPLKAFDGSELFREAFDARILPRLDAFAPDLIV
ISAGFDAHKLDPLANIQLDEADFGWATRRLMEVADRHAGGRVVSVLEGGYSLDGLARSVAAHMDALMGR
>Mature_308_residues
STLYVTHPSAVEHVVPTGHPERPARMQAVERALEDERFAALVRCHAPRAEASVAELVHPASYVETIVAASPDEGFFQIDG
DTLMSPGSLNTCLHAIGGSNHAVDAVMKGECANAFVAMRPPGHHAERDRAMGFCLFNHAAIAVRHAQKAFGATRVALVDF
DVHHGNGSQDIFWADKTVMYASTHQMPLFPGSGATGERGDHDTIVNAPLKAFDGSELFREAFDARILPRLDAFAPDLIVI
SAGFDAHKLDPLANIQLDEADFGWATRRLMEVADRHAGGRVVSVLEGGYSLDGLARSVAAHMDALMGR

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=306, Percent_Identity=35.6209150326797, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI153085395, Length=329, Percent_Identity=31.6109422492401, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI17158039, Length=334, Percent_Identity=32.3353293413174, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI30795204, Length=334, Percent_Identity=32.3353293413174, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI30795202, Length=334, Percent_Identity=32.3353293413174, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI169234807, Length=327, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI148539870, Length=327, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI20070354, Length=311, Percent_Identity=35.048231511254, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI62750347, Length=330, Percent_Identity=31.5151515151515, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI62750349, Length=330, Percent_Identity=31.5151515151515, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI226529806, Length=311, Percent_Identity=32.475884244373, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI8923769, Length=304, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI13128862, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI13128860, Length=255, Percent_Identity=25.8823529411765, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI262073088, Length=193, Percent_Identity=26.9430051813472, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI293336691, Length=256, Percent_Identity=25.390625, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073092, Length=191, Percent_Identity=29.3193717277487, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=316, Percent_Identity=33.5443037974684, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206283, Length=316, Percent_Identity=33.5443037974684, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17540332, Length=316, Percent_Identity=33.5443037974684, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193209491, Length=325, Percent_Identity=32.9230769230769, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537347, Length=308, Percent_Identity=32.1428571428571, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25154020, Length=296, Percent_Identity=31.0810810810811, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25154022, Length=288, Percent_Identity=30.2083333333333, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17534739, Length=306, Percent_Identity=27.1241830065359, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=293, Percent_Identity=24.2320819112628, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561978, Length=253, Percent_Identity=27.6679841897233, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=329, Percent_Identity=30.3951367781155, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325141, Length=291, Percent_Identity=28.5223367697594, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323999, Length=297, Percent_Identity=24.5791245791246, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=139, Percent_Identity=31.6546762589928, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321244, Length=297, Percent_Identity=23.9057239057239, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281360899, Length=314, Percent_Identity=33.7579617834395, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24642142, Length=314, Percent_Identity=33.7579617834395, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642144, Length=314, Percent_Identity=33.7579617834395, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642146, Length=314, Percent_Identity=33.7579617834395, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24641720, Length=217, Percent_Identity=37.3271889400922, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI281360799, Length=217, Percent_Identity=37.3271889400922, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI281360801, Length=217, Percent_Identity=37.3271889400922, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24644244, Length=299, Percent_Identity=25.4180602006689, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657891, Length=256, Percent_Identity=26.171875, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33264; Mature: 33133

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLYVTHPSAVEHVVPTGHPERPARMQAVERALEDERFAALVRCHAPRAEASVAELVHP
CCEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH
ASYVETIVAASPDEGFFQIDGDTLMSPGSLNTCLHAIGGSNHAVDAVMKGECANAFVAMR
HHHHHHHHHCCCCCCEEEECCCCEECCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEC
PPGHHAERDRAMGFCLFNHAAIAVRHAQKAFGATRVALVDFDVHHGNGSQDIFWADKTVM
CCCCCCCHHHHHEEEEHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCEEEECCCEEE
YASTHQMPLFPGSGATGERGDHDTIVNAPLKAFDGSELFREAFDARILPRLDAFAPDLIV
EECCCCCCCCCCCCCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCHHCCHHHCCCCCEEE
ISAGFDAHKLDPLANIQLDEADFGWATRRLMEVADRHAGGRVVSVLEGGYSLDGLARSVA
EECCCCCHHCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
AHMDALMGR
HHHHHHHCC
>Mature Secondary Structure 
STLYVTHPSAVEHVVPTGHPERPARMQAVERALEDERFAALVRCHAPRAEASVAELVHP
CEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH
ASYVETIVAASPDEGFFQIDGDTLMSPGSLNTCLHAIGGSNHAVDAVMKGECANAFVAMR
HHHHHHHHHCCCCCCEEEECCCCEECCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEC
PPGHHAERDRAMGFCLFNHAAIAVRHAQKAFGATRVALVDFDVHHGNGSQDIFWADKTVM
CCCCCCCHHHHHEEEEHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCEEEECCCEEE
YASTHQMPLFPGSGATGERGDHDTIVNAPLKAFDGSELFREAFDARILPRLDAFAPDLIV
EECCCCCCCCCCCCCCCCCCCCCCEECCCHHHCCHHHHHHHHHCCHHCCHHHCCCCCEEE
ISAGFDAHKLDPLANIQLDEADFGWATRRLMEVADRHAGGRVVSVLEGGYSLDGLARSVA
EECCCCCHHCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
AHMDALMGR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]