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The map label for this gene is folK [H]

Identifier: 218235679

GI number: 218235679

Start: 78614

End: 79129

Strand: Direct

Name: folK [H]

Synonym: BCB4264_A0081

Alternate gene names: 218235679

Gene position: 78614-79129 (Clockwise)

Preceding gene: 218233912

Following gene: 218235456

Centisome position: 1.45

GC content: 34.88

Gene sequence:

>516_bases
ATGAACAATATAGCTTACATTGCATTAGGGTCAAATATTGGAGAGCGTTATACGTATCTTACTGAAGCGATTCAGTTTTT
AAATAAAAATCCTTATATTCAGGTTGATGATATTTCATCTGTATATGAAACTGAGCCAGTTGGCTATACTGACCAAAGTT
GCTTTTTAAATTTAGTTATAAAAATTTCTACCAATTTATCACCACAAGAGTTATTGAAAGTAACACAAAAAGTAGAAAAT
GACCTAGGAAGAAAAAGGGAAATTAGGTGGGGGCCGAGGACTATCGACCTTGACATTTTACTTTATAATCAAGAGAATAT
TGAAGCAGAGAATCTTATTGTTCCGCATCCGCGGATGTTTGAAAGAGCTTTTGTTATCGTTCCGTTGTTAGAGATTAATC
AAGACATAAAACAAAACATTTCACGTTCACAAGTAGAAGAAATGAAAAGGCGAGAGGGAGTAACGGTATGGAAGCAGAAA
AATGGGGAAGACGCATTCGTGCTTTTCGAAAGCTAA

Upstream 100 bases:

>100_bases
ATGAAAGTATTTCACGCTGTACAATTAAGGTAATTAAGCCGGATCCACCGATACCGGGTCATTATCGTGCTGTAGCAGTA
GAAATTACGAGAGAACGTCC

Downstream 100 bases:

>100_bases
AAGGCTATACACAAGAAGGTTTTGCTAAAGAACTAGGGGTATCTGTATCTGTTTTAGGTGAGGTTGAGAGAGGGAATAGA
TCGCCTTCTCAAGATTTTGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIQVDDISSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFES

Sequences:

>Translated_171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIQVDDISSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFES
>Mature_171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIQVDDISSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFES

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=42.2222222222222, Blast_Score=113, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=41.9117647058824, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19881; Mature: 19881

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIQVDDISSVYETEPVGYTDQSCFLNLVI
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHCCCCCCCCHHHEEEEEE
KISTNLSPQELLKVTQKVENDLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFES
HHHEEEEEHHHCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIQVDDISSVYETEPVGYTDQSCFLNLVI
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHCCCCCCCCHHHEEEEEE
KISTNLSPQELLKVTQKVENDLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFES
HHHEEEEEHHHCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]