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The map label for this gene is pyrH [H]

Identifier: 218233853

GI number: 218233853

Start: 3845014

End: 3845736

Strand: Reverse

Name: pyrH [H]

Synonym: BCB4264_A3923

Alternate gene names: 218233853

Gene position: 3845736-3845014 (Counterclockwise)

Preceding gene: 218236064

Following gene: 218234587

Centisome position: 70.97

GC content: 38.31

Gene sequence:

>723_bases
ATGAGTAAACCGAAATATAATCGTGTCGTTTTAAAGCTAAGTGGAGAAGCTTTAGCTGGAGAGCAAGGATTTGGAATTAA
CCCAACTGTTATTAAGTCAGTTGCGGAACAAGTAAAAGAAATTGCAGAACTTGATGTAGAGGTTGCTGTTGTTGTTGGTG
GCGGTAACATTTGGCGTGGAAAAATTGGAAGTGAAATGGGCATGGATCGTGCAGGGGCAGATTACATGGGCATGTTAGCG
ACAGTTATGAATTCATTAGCTCTTCAAGATAGCTTGGAGAATATCGGAATTCAAACTCGTGTACAAACTTCAATTGAGAT
GCGTCAAGTTGCAGAACCTTACATTCGTCGTAAAGCAGTTCGTCACTTAGAGAAAAAACGTGTTGTTATCTTTGCAGCAG
GTACAGGTAACCCATACTTCTCTACAGATACAACAGCAGCATTACGTGCGGCAGAAATTGAAGCAGATGTAATTTTAATG
GCGAAAAACAATGTAGATGGTGTATATAATGCGGATCCATCTATTGATCCAACAGCTACAAAATACGAAACGCTTACTTA
CTTAGATGTATTAAAAGAAGGTTTAGGTGTAATGGATTCTACAGCTTCTTCTCTATGTATGGATAATGATATTCCATTAA
TTGTATTCTCAGTTATGGAAAAAGGTAATATTAAACGTGCCGTTTTAGGCGAAAATATCGGAACAGTGGTAAGGGGGAAA
TAA

Upstream 100 bases:

>100_bases
AGAAGTAATGAACCAAGTAAAAGGTAGTAACTAATACAGATTAGGGAACACATTGTGTTCCCTTTTTTAAAATAAAGATG
TAAGCAATTGGAGGTTCATT

Downstream 100 bases:

>100_bases
ATATGGGACAACAAGTATTGAAGTCTTCAAATGAAAAAATGGAAAAAGCAGTTGCTGCTTATTCTCGTGAATTAGCAACA
GTTCGTGCTGGCCGTGCAAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSKPKYNRVVLKLSGEALAGEQGFGINPTVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLA
TVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK

Sequences:

>Translated_240_residues
MSKPKYNRVVLKLSGEALAGEQGFGINPTVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLA
TVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
>Mature_239_residues
SKPKYNRVVLKLSGEALAGEQGFGINPTVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLAT
VMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMA
KNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=48.3050847457627, Blast_Score=235, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25900; Mature: 25769

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPKYNRVVLKLSGEALAGEQGFGINPTVIKSVAEQVKEIAELDVEVAVVVGGGNIWRG
CCCCCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEC
KIGSEMGMDRAGADYMGMLATVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPSIDPTAT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEEEECCCCCEECCCCCCCCCCC
KYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
HHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCEEECCC
>Mature Secondary Structure 
SKPKYNRVVLKLSGEALAGEQGFGINPTVIKSVAEQVKEIAELDVEVAVVVGGGNIWRG
CCCCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEC
KIGSEMGMDRAGADYMGMLATVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPSIDPTAT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHEECCEEEEEEEECCCCCEECCCCCCCCCCC
KYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFSVMEKGNIKRAVLGENIGTVVRGK
HHHHHHHHHHHHHHCCCHHCCHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]