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The map label for this gene is malR [H]

Identifier: 218231939

GI number: 218231939

Start: 595742

End: 596449

Strand: Direct

Name: malR [H]

Synonym: BCB4264_A0615

Alternate gene names: 218231939

Gene position: 595742-596449 (Clockwise)

Preceding gene: 218232726

Following gene: 218231115

Centisome position: 10.99

GC content: 32.77

Gene sequence:

>708_bases
ATGATTAAAGTTTTAATTGTAGAAGATGACCCGATGGTAGCAATGTTAAATACGCATTATTTAGAGCAAGTAGGAGGGTT
TGAACTTGTTCAAGCAGTTAACTCAGTAAAGTCGGCGATAGAAGTATTAGAGAAATCACGAGTGGATTTAGTATTACTTG
ATATTTTTATGCCTGAAGAGACTGGGTTTGAGCTTTTAATGTATATTCGGAATCAAGAAAAAGAAATCGATATTATAATG
ATTTCAGCTGTACATGATATGGGGAGTATTAAAAAAGCATTACAATACGGAGTTGTAGATTATTTAATTAAACCATTTAC
ATTCGAACGATTTAAAGAGGCATTAACTATATATCGAGAAAAACTTACTTTCATGAAAGAACAACAAAAGCTTAGTCAAT
CGGAATTAGATTCGTTAATTTTACAAAAAGAAAAAAGAGAGCCTACTGTCACTAAAGAGCTTCCGAAAGGATTAACGAAG
CAAACGTTGCAATTAATTTGGCAGAAGATCGAGTCGTTGAATGGACGAGCGTTTACAACAGATGAAATGGCACAATTAGT
TGGAATTTCAAGAGTTTCTATTCGGAAATATGTAATGTTTCTGACTGACATTGGGGTGTTAGAAAACGAAATGATGTACC
AACATGTGGGAAGACCTGTAAGTAAATTAAGATGTGTTAATCAAAAGAAAATAGAGTTTTACGTATAA

Upstream 100 bases:

>100_bases
GTATACAGCGAATAAATGGGGAAATTGATATACATTCATTAGTAGGAAAGGGAACAACGATAACAATTGAAATACCTAAA
GGTAGGGATGAGAGGCAAAT

Downstream 100 bases:

>100_bases
GCGACTTAGTATAAGTCGCTTATACTTTTTTTAATTACAAAATCAATTACAAAACTTACAAAAACTATTTTTACTATTGA
AAGCGTTTTAATATTGTTAT

Product: response regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEKSRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIIM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKLSQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRAFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVNQKKIEFYV

Sequences:

>Translated_235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEKSRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIIM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKLSQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRAFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVNQKKIEFYV
>Mature_235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEKSRVDLVLLDIFMPEETGFELLMYIRNQEKEIDIIM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKLSQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRAFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVNQKKIEFYV

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=226, Percent_Identity=43.8053097345133, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1786838, Length=218, Percent_Identity=28.8990825688073, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=36.6071428571429, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788550, Length=137, Percent_Identity=32.1167883211679, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=170, Percent_Identity=30.5882352941176, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27290; Mature: 27290

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEKSRVDLVLLDIFMPEE
CEEEEEECCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
TGFELLMYIRNQEKEIDIIMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYRE
CCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLTFMKEQQKLSQSELDSLILQKEKREPTVTKELPKGLTKQTLQLIWQKIESLNGRAFTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEECH
DEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVNQKKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSVKSAIEVLEKSRVDLVLLDIFMPEE
CEEEEEECCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
TGFELLMYIRNQEKEIDIIMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYRE
CCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLTFMKEQQKLSQSELDSLILQKEKREPTVTKELPKGLTKQTLQLIWQKIESLNGRAFTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEECH
DEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVNQKKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]