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The map label for this gene is ribBA [H]

Identifier: 21674409

GI number: 21674409

Start: 1498678

End: 1499961

Strand: Reverse

Name: ribBA [H]

Synonym: CT1591

Alternate gene names: 21674409

Gene position: 1499961-1498678 (Counterclockwise)

Preceding gene: 21674413

Following gene: 21674408

Centisome position: 69.61

GC content: 57.55

Gene sequence:

>1284_bases
GTGATGAGCAACAATCAGTTCGATTCCATAGAATCAGCCATCGAAGACATTAAAAACGGCAAGCTGATCATCGTCGTCGA
TGACGAAGATCGGGAGGATGAAGGCGATTTTATTGCCGCTGCCGAGCATGTGACCCCCGAGATGGTGAACTTCATCACCA
AAGAGGCGCGCGGCCTGCTCTGCGTGGCTATTCCCATGGAGCGCGCCCGCGAGTTGCAGCTTGAACCGATGGTGCAGCGC
AACACCTCCCAGCACGAAACAAACTTCACCGTTTCAATCGACGCGATCGCCGAAGGGGTGACCACCGGCATTTCGGCCTA
CGACCGATACATGACGCTCAAGATGCTTGCCGATCCGTCCTCCACGGCGGACGACTTCTCACGCCCCGGCCACATCTTCC
CGCTCCGGGCGATGGATGGCGGTGTGCTACGCAGGGTTGGTCACACCGAGGCCGCGGTCGATCTCTGTCGTCTTGCCGGA
TGCCAGCCAGCCGGTTTGCTCTGCGAAATCCTGCACGACGACGGCAGCATGGCGCGTGTGCCCGAACTGCTGAAGCTCAA
AGAGAAGCTCGGCATGAAGCTCATCACGATCAAAGATCTCGTGGCTTACCGGATGCAGCGGTCGAAGCTCGTGCACCGCG
CCGTCGAGTCGAAGCTACCGACCGCGTATGGCGAGTTCAAGCTCATTGCCTACGAAACCATCGTCGATCAGCAGAATCAC
ATGGCCTTCGTCAAGGGCGATGTTGGCAACGGCGAGCCGGTGCTTGCCCGGGTGCACTCGCAGTGCGCCACGGGCGATAC
CTTCGGTTCGTTGCGTTGCGACTGCGGTCACCAGCTCGAAACCGCTCTGCGCATGATTGAAAAGGAGGGGCGTGGCGTCC
TGATTTACCTCATGCAGGAGGGGCGAGGCATCGGCCTCATCAACAAGCTCAAGGCCTACAACCTTCAGGACGAAGGGTTC
GACACGGTCGAGGCCAACGAGAAGCTCGGTTTCAAACCCGACCTTCGCGACTACGGCATCGGTGCGCAGATTCTTCAGGA
CCTTGGTGTCAGGAAGATGCGGTTGATGACCAACAACCCGAAAAAGATTGTCGGTCTGGAAGGCTATGGTCTTGAAATCG
TCGAACGCGTACCGCTCGAAATCGAGCCGAACGAGGTGAACCGCCACTACCTGCAGACCAAGCGCGACAAGCTTGGTCAC
ATGATTCAAATGGCTTCGGGCAATGAACGGATTCTCTTCGAGCGCCTTGCCGATGAGCAGTTGAAACAGCACAAAAAAGA
TTAA

Upstream 100 bases:

>100_bases
TCAGGAATTTTAGGGGTGCCCGTAATTTTACTATTATATTCTTTTCATGTAATTTCCGACTAGCAATCCGAGCTAGGTAA
CCACAGTATTGATCAGGAGT

Downstream 100 bases:

>100_bases
CCTCCAGCGGGAGAAGGAAACACGATGGACAACGATATTCTGAAACGGCTCGACCCCGAGGTCTTCGAGGCGATTGCCAA
TGAAACAAAACGCCAAACCG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MMSNNQFDSIESAIEDIKNGKLIIVVDDEDREDEGDFIAAAEHVTPEMVNFITKEARGLLCVAIPMERARELQLEPMVQR
NTSQHETNFTVSIDAIAEGVTTGISAYDRYMTLKMLADPSSTADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLCRLAG
CQPAGLLCEILHDDGSMARVPELLKLKEKLGMKLITIKDLVAYRMQRSKLVHRAVESKLPTAYGEFKLIAYETIVDQQNH
MAFVKGDVGNGEPVLARVHSQCATGDTFGSLRCDCGHQLETALRMIEKEGRGVLIYLMQEGRGIGLINKLKAYNLQDEGF
DTVEANEKLGFKPDLRDYGIGAQILQDLGVRKMRLMTNNPKKIVGLEGYGLEIVERVPLEIEPNEVNRHYLQTKRDKLGH
MIQMASGNERILFERLADEQLKQHKKD

Sequences:

>Translated_427_residues
MMSNNQFDSIESAIEDIKNGKLIIVVDDEDREDEGDFIAAAEHVTPEMVNFITKEARGLLCVAIPMERARELQLEPMVQR
NTSQHETNFTVSIDAIAEGVTTGISAYDRYMTLKMLADPSSTADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLCRLAG
CQPAGLLCEILHDDGSMARVPELLKLKEKLGMKLITIKDLVAYRMQRSKLVHRAVESKLPTAYGEFKLIAYETIVDQQNH
MAFVKGDVGNGEPVLARVHSQCATGDTFGSLRCDCGHQLETALRMIEKEGRGVLIYLMQEGRGIGLINKLKAYNLQDEGF
DTVEANEKLGFKPDLRDYGIGAQILQDLGVRKMRLMTNNPKKIVGLEGYGLEIVERVPLEIEPNEVNRHYLQTKRDKLGH
MIQMASGNERILFERLADEQLKQHKKD
>Mature_427_residues
MMSNNQFDSIESAIEDIKNGKLIIVVDDEDREDEGDFIAAAEHVTPEMVNFITKEARGLLCVAIPMERARELQLEPMVQR
NTSQHETNFTVSIDAIAEGVTTGISAYDRYMTLKMLADPSSTADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLCRLAG
CQPAGLLCEILHDDGSMARVPELLKLKEKLGMKLITIKDLVAYRMQRSKLVHRAVESKLPTAYGEFKLIAYETIVDQQNH
MAFVKGDVGNGEPVLARVHSQCATGDTFGSLRCDCGHQLETALRMIEKEGRGVLIYLMQEGRGIGLINKLKAYNLQDEGF
DTVEANEKLGFKPDLRDYGIGAQILQDLGVRKMRLMTNNPKKIVGLEGYGLEIVERVPLEIEPNEVNRHYLQTKRDKLGH
MIQMASGNERILFERLADEQLKQHKKD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=191, Percent_Identity=53.9267015706806, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=49.4949494949495, Blast_Score=201, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=44.1747572815534, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.0292397660819, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 47823; Mature: 47823

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSNNQFDSIESAIEDIKNGKLIIVVDDEDREDEGDFIAAAEHVTPEMVNFITKEARGLL
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEHHHCCHHHHHHHHHHCCCEE
CVAIPMERARELQLEPMVQRNTSQHETNFTVSIDAIAEGVTTGISAYDRYMTLKMLADPS
EEEECHHHHHCCCCCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCC
STADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLCRLAGCQPAGLLCEILHDDGSMARV
CCHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHH
PELLKLKEKLGMKLITIKDLVAYRMQRSKLVHRAVESKLPTAYGEFKLIAYETIVDQQNH
HHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCC
MAFVKGDVGNGEPVLARVHSQCATGDTFGSLRCDCGHQLETALRMIEKEGRGVLIYLMQE
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEEEEEC
GRGIGLINKLKAYNLQDEGFDTVEANEKLGFKPDLRDYGIGAQILQDLGVRKMRLMTNNP
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEHCCCCC
KKIVGLEGYGLEIVERVPLEIEPNEVNRHYLQTKRDKLGHMIQMASGNERILFERLADEQ
CEEEEECCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LKQHKKD
HHHHCCC
>Mature Secondary Structure
MMSNNQFDSIESAIEDIKNGKLIIVVDDEDREDEGDFIAAAEHVTPEMVNFITKEARGLL
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEHHHCCHHHHHHHHHHCCCEE
CVAIPMERARELQLEPMVQRNTSQHETNFTVSIDAIAEGVTTGISAYDRYMTLKMLADPS
EEEECHHHHHCCCCCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCC
STADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLCRLAGCQPAGLLCEILHDDGSMARV
CCHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHH
PELLKLKEKLGMKLITIKDLVAYRMQRSKLVHRAVESKLPTAYGEFKLIAYETIVDQQNH
HHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCC
MAFVKGDVGNGEPVLARVHSQCATGDTFGSLRCDCGHQLETALRMIEKEGRGVLIYLMQE
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEEEEEC
GRGIGLINKLKAYNLQDEGFDTVEANEKLGFKPDLRDYGIGAQILQDLGVRKMRLMTNNP
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEHCCCCC
KKIVGLEGYGLEIVERVPLEIEPNEVNRHYLQTKRDKLGHMIQMASGNERILFERLADEQ
CEEEEECCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LKQHKKD
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA