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The map label for this gene is glyA [H]

Identifier: 21674408

GI number: 21674408

Start: 1497331

End: 1498653

Strand: Reverse

Name: glyA [H]

Synonym: CT1590

Alternate gene names: 21674408

Gene position: 1498653-1497331 (Counterclockwise)

Preceding gene: 21674409

Following gene: 21674407

Centisome position: 69.54

GC content: 60.02

Gene sequence:

>1323_bases
ATGGACAACGATATTCTGAAACGGCTCGACCCCGAGGTCTTCGAGGCGATTGCCAATGAAACAAAACGCCAAACCGAAAC
GCTCGAACTGATCGCTTCGGAGAACTTCACCAGCAAGGCGGTCATGGAAGCTTGCGGCTCGGTGATGACCAACAAGTACG
CCGAGGGCTACCCCGGCAAGCGCTACTACGGCGGCTGCGAATTTGTTGATGTGGCCGAGAACCTCGCCCGCGACCGCGCC
AAGAAGCTTTTCGGCTGTGAGTACGTCAACGTGCAGCCGCACTCCGGTTCCAGCGCCAACATGGCGGTGCTTTTCGCCGT
GCTCAAGCCGGGCGACGCCATCATGGGCCTCGACCTCTCCCACGGCGGCCACCTGACTCACGGCAGCAAGGTGAACTTCT
CCGGCCAGTTCTTTGATGCCCACTCTTACGGCGTTGACAAAGAGACTGGCATCATCGACATGAACAAGGTCGAAGAGATG
GCCAGGCGAGTCAAGCCGAAGCTCATCATCACCGGCGCGAGTGCCTACTCGCAGGGCTTTGACTTCAAGGCGTTCCGCGA
AGTCGCCGACAAAGTCGGTGCGCTGCTCATGGCCGACATCGCCCACCCGGCGGGCCTCGTTGCTGCGGGCCTTTCTGCCA
ACCCGATGCCGCATTGCCACTTCGTGACCACCACCACGCACAAGACCCTGCGCGGCCCACGCGGCGGCATGATCATGATG
GGCAAGGATTTCGAGAATCCGCTCGGCCTGACTATCAACACCAAGAACGGCTCGCGCGTCAAGATGATGTCCGAGGTGAT
CGACGCCGAGGTGATGCCCGGCATCCAGGGCGGCCCGCTCATGCACATCATCGCCGGCAAGGCGGTTGCCTTCGGCGAAG
CGCTCCAGCCCGAGTTTAAAGCCTATGCGCAGCAGATCAAGGACAACGCCGCTGCAATGGCCGCGAAGTTCCTCGCGGCG
GGCTACCACATCGTCAGCGGTGGTACGAAAAACCACCTCATGCTGCTCGACCTGCGCAACAAGAACGTCAACGGCAAGGT
AGCCGAAAACCTCCTGCACGAAGCCGGAATCACGGTTAACAAAAACATGGTGCCTTTCGACGACAAATCGCCGTTCGTCA
CCAGCGGCATCCGCATCGGCACCCCGGCGATGACCACTCGTGGGATGAAGGTTGCCGAAGCTGAAAAGATCGTTGAATTC
ATCGATCGCGTCATCAGCGCTGCCAACGACGCCAACGTCGCCGATGTCTGCAAGGCCGTCAGGGCTGAAGTTCGCGAGCT
GTGCCTTGGCTTCCCGCTCAACAACTACGGTTCTCTCGTCTAA

Upstream 100 bases:

>100_bases
AATGGCTTCGGGCAATGAACGGATTCTCTTCGAGCGCCTTGCCGATGAGCAGTTGAAACAGCACAAAAAAGATTAACCTC
CAGCGGGAGAAGGAAACACG

Downstream 100 bases:

>100_bases
GTGATATGCGATAAAGTATTACAAAGGCCGGTCATCTCTGTGGACGCCGGCCTTTTTTGTCTTTTTTATAATAAATTTAC
TATCACCATTGGTTAAGTCC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDNDILKRLDPEVFEAIANETKRQTETLELIASENFTSKAVMEACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFGCEYVNVQPHSGSSANMAVLFAVLKPGDAIMGLDLSHGGHLTHGSKVNFSGQFFDAHSYGVDKETGIIDMNKVEEM
ARRVKPKLIITGASAYSQGFDFKAFREVADKVGALLMADIAHPAGLVAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMM
GKDFENPLGLTINTKNGSRVKMMSEVIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFKAYAQQIKDNAAAMAAKFLAA
GYHIVSGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKVAEAEKIVEF
IDRVISAANDANVADVCKAVRAEVRELCLGFPLNNYGSLV

Sequences:

>Translated_440_residues
MDNDILKRLDPEVFEAIANETKRQTETLELIASENFTSKAVMEACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFGCEYVNVQPHSGSSANMAVLFAVLKPGDAIMGLDLSHGGHLTHGSKVNFSGQFFDAHSYGVDKETGIIDMNKVEEM
ARRVKPKLIITGASAYSQGFDFKAFREVADKVGALLMADIAHPAGLVAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMM
GKDFENPLGLTINTKNGSRVKMMSEVIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFKAYAQQIKDNAAAMAAKFLAA
GYHIVSGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKVAEAEKIVEF
IDRVISAANDANVADVCKAVRAEVRELCLGFPLNNYGSLV
>Mature_440_residues
MDNDILKRLDPEVFEAIANETKRQTETLELIASENFTSKAVMEACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFGCEYVNVQPHSGSSANMAVLFAVLKPGDAIMGLDLSHGGHLTHGSKVNFSGQFFDAHSYGVDKETGIIDMNKVEEM
ARRVKPKLIITGASAYSQGFDFKAFREVADKVGALLMADIAHPAGLVAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMM
GKDFENPLGLTINTKNGSRVKMMSEVIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFKAYAQQIKDNAAAMAAKFLAA
GYHIVSGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKVAEAEKIVEF
IDRVISAANDANVADVCKAVRAEVRELCLGFPLNNYGSLV

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=47.1464019851117, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=47.1464019851117, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=47.1464019851117, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=47.1464019851117, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI22547186, Length=410, Percent_Identity=47.8048780487805, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=45.9057071960298, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI22547189, Length=409, Percent_Identity=44.7432762836186, Blast_Score=311, Evalue=7e-85,
Organism=Escherichia coli, GI1788902, Length=424, Percent_Identity=55.188679245283, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25144732, Length=418, Percent_Identity=47.8468899521531, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=418, Percent_Identity=47.8468899521531, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=435, Percent_Identity=43.448275862069, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=432, Percent_Identity=44.212962962963, Blast_Score=347, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24640005, Length=403, Percent_Identity=50.1240694789082, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221329721, Length=407, Percent_Identity=49.8771498771499, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 47448; Mature: 47448

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNDILKRLDPEVFEAIANETKRQTETLELIASENFTSKAVMEACGSVMTNKYAEGYPGK
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
RYYGGCEFVDVAENLARDRAKKLFGCEYVNVQPHSGSSANMAVLFAVLKPGDAIMGLDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEEEECCCCEEEEEEEC
HGGHLTHGSKVNFSGQFFDAHSYGVDKETGIIDMNKVEEMARRVKPKLIITGASAYSQGF
CCCCCCCCCEECCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEECHHHHCCC
DFKAFREVADKVGALLMADIAHPAGLVAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMM
CHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCEEEEEECCHHHHCCCCCCEEEE
GKDFENPLGLTINTKNGSRVKMMSEVIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFK
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHCCHHHH
AYAQQIKDNAAAMAAKFLAAGYHIVSGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVN
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEC
KNMVPFDDKSPFVTSGIRIGTPAMTTRGMKVAEAEKIVEFIDRVISAANDANVADVCKAV
CCCCCCCCCCCCEECCEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAEVRELCLGFPLNNYGSLV
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDNDILKRLDPEVFEAIANETKRQTETLELIASENFTSKAVMEACGSVMTNKYAEGYPGK
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
RYYGGCEFVDVAENLARDRAKKLFGCEYVNVQPHSGSSANMAVLFAVLKPGDAIMGLDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEEEECCCCEEEEEEEC
HGGHLTHGSKVNFSGQFFDAHSYGVDKETGIIDMNKVEEMARRVKPKLIITGASAYSQGF
CCCCCCCCCEECCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEECHHHHCCC
DFKAFREVADKVGALLMADIAHPAGLVAAGLSANPMPHCHFVTTTTHKTLRGPRGGMIMM
CHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCEEEEEECCHHHHCCCCCCEEEE
GKDFENPLGLTINTKNGSRVKMMSEVIDAEVMPGIQGGPLMHIIAGKAVAFGEALQPEFK
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHCCHHHH
AYAQQIKDNAAAMAAKFLAAGYHIVSGGTKNHLMLLDLRNKNVNGKVAENLLHEAGITVN
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEC
KNMVPFDDKSPFVTSGIRIGTPAMTTRGMKVAEAEKIVEFIDRVISAANDANVADVCKAV
CCCCCCCCCCCCEECCEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAEVRELCLGFPLNNYGSLV
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA