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The map label for this gene is yvaE [H]

Identifier: 21674277

GI number: 21674277

Start: 1366634

End: 1366960

Strand: Direct

Name: yvaE [H]

Synonym: CT1456

Alternate gene names: 21674277

Gene position: 1366634-1366960 (Clockwise)

Preceding gene: 21674276

Following gene: 21674278

Centisome position: 63.42

GC content: 55.35

Gene sequence:

>327_bases
ATGCCCTGGCTCTATCTGATCCTCGCCATCATCGCCGAAGTCTCCGGCACCACCAGCATGAAGCTCTCGGCAGGCTTCAC
CAAGCCGGTGCCATCGGTTTTCATTTTCGTTTTTTACGCCACGAGTCTTACTTTCCTCACACTGGCGCTCAGAACTTTGC
CTGTCGGCATGTCCTACGCCATCTGGTCGGCGCTCGGCACGGCGCTCATCACGGCAATCGGCGTGCTCTGGTTCGGAGAA
GGATTGAACGCGCTCAAGATAATCTCCCTGATCCTGATCATCGCGGGCATTGCCGGATTGCATTTCAGTCAGGAACACAT
GAAGTAA

Upstream 100 bases:

>100_bases
CAGTTTCAGCCTGCAACTCTTTGGCGAGTGCGCAGACAAGGAGGCCTGCGCCCGGCGCATCAGCAACAAGCACAAAGAGA
AAACCTGAAATCCGGACACC

Downstream 100 bases:

>100_bases
GGCGAACAGGCATGAGTCACCAACATCCGGTTTACAGGCGAATTGTCGTCAAGGTTGGAACCAACGTCATTACGGGGCGC
AACGGCAAGCTCGATCCAGC

Product: SMR drug efflux transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MPWLYLILAIIAEVSGTTSMKLSAGFTKPVPSVFIFVFYATSLTFLTLALRTLPVGMSYAIWSALGTALITAIGVLWFGE
GLNALKIISLILIIAGIAGLHFSQEHMK

Sequences:

>Translated_108_residues
MPWLYLILAIIAEVSGTTSMKLSAGFTKPVPSVFIFVFYATSLTFLTLALRTLPVGMSYAIWSALGTALITAIGVLWFGE
GLNALKIISLILIIAGIAGLHFSQEHMK
>Mature_107_residues
PWLYLILAIIAEVSGTTSMKLSAGFTKPVPSVFIFVFYATSLTFLTLALRTLPVGMSYAIWSALGTALITAIGVLWFGEG
LNALKIISLILIIAGIAGLHFSQEHMK

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=96, Percent_Identity=44.7916666666667, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11632; Mature: 11501

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWLYLILAIIAEVSGTTSMKLSAGFTKPVPSVFIFVFYATSLTFLTLALRTLPVGMSYA
CHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IWSALGTALITAIGVLWFGEGLNALKIISLILIIAGIAGLHFSQEHMK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure 
PWLYLILAIIAEVSGTTSMKLSAGFTKPVPSVFIFVFYATSLTFLTLALRTLPVGMSYA
HHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IWSALGTALITAIGVLWFGEGLNALKIISLILIIAGIAGLHFSQEHMK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]