Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 21674247

GI number: 21674247

Start: 1338547

End: 1339827

Strand: Direct

Name: hemA [H]

Synonym: CT1426

Alternate gene names: 21674247

Gene position: 1338547-1339827 (Clockwise)

Preceding gene: 21674246

Following gene: 21674248

Centisome position: 62.12

GC content: 54.57

Gene sequence:

>1281_bases
ATGAACATCATTTCAGTTGGTGTCAACCACAAGACAGCACCTATTGAAATCCGTGAAAGGATCGCTCTTTCGGAGGTTCA
GAACAAGGAGCTCGTCACCGACCTGGTATCGAGCGGACTGGCAAGTGAAGCCATGGTTGTATCGACCTGCAACCGTACGG
AACTCTATGTGGTTCCGGGAATGCCCGAGGTGAACTGCGATTATCTCAAAGATTACATCATCTCATACAAAAACGCCCGT
AACGCCGTCCGTCCCGAACACTTCTTCAGCCGCTTCTACTGCGGCACCGCCCGTCACCTCTTCGAGGTTTCCTGCGCCAT
CGACTCTCTGGTGCTCGGCGAGGGTCAGATTCTTGGTCAGGTCAAGAATGCCTACCGCATCGCCGCGGAGGTGGGAACTG
CTGGCATTCTGCTCACCAGACTTTGCCACACTGCTTTCAGCGTCGCAAAAAAAGTCAAGACTCGCACCAAACTCATGGAG
GGCGCCGTTTCGGTCAGCTATGCGGCTGTCGAACTTGCCCAAAAGATCTTCTCGAACCTCTCGATGAAGAAAGTGCTGCT
GATCGGCGCCGGTGAAACCGGAGAGCTGGCGGCCAAGCACATGTACGCCAAGAACGCCCGGAACATCGTCATCACCAACA
GGACGCAGTCCAAGGCCGAGGCGCTTGCCGAAGAGCTGGGCACCAACCGCGTCCTTCCCTACGAAAGCTACAAGGAGCAT
CTGCACGAGTTCGACATCATCATCACGGCAGTCAGCACCAAGGAATACATCCTCAACGCTGCCGAGATGCAGCAGAGCAT
GGCGAAACGCCGCCTGAAACCGGTCATCATTCTCGATCTCGGTCTGCCAAGAAACGTCGATCCCGAAGTGGGCGCACTGC
AGAATATGTTCCTCAAGGATATCGACGCCCTCAAGCATATCATCGACAAAAACCTCGAACGCCGTCGCGCCGAGCTTCCG
AAGGTCAAGGCGATCATCGACGAGGAGCTGGTCGCGTTCGGCCAGTGGCTCAACACCCTCAAGGTGCGTCCGACCATCGT
TGACCTTCAGTCCAAGTTCCTTGAAATCAAGGAAAAAGAGCTTGAGCGCTACCGCTACAAGGTGAGCGAAGAGGAACTTC
GCCGCATGGAACACCTGACCGACAGGATCCTGAAAAAAATCCTGCATCATCCCATCAAGATGCTCAAGGCTCCGGTCGAT
ACCGCCGACAATATCCCCAGCAAGGTCAACCTCGTCAGGAACATCTTCGATCTTGAAGAACCAAACCAGTCACTCCAATA
A

Upstream 100 bases:

>100_bases
TGAAAATTCGGCACATTGCGGTATATTAATACACTTTTGGAGATTCCTTTTCCAAGCTCTTTTGAACGGGTTACGAACGG
CTCATCAAAACCATTCTATT

Downstream 100 bases:

>100_bases
AATCAATCAGTCATCGAATTTTGAAAAAAGAGCTTATCATCGGCACTCGGTCCAGCCCTCTTGCCCTGTGGCAGGCTGAA
TTCACCAAAGCAGAACTGTC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNIISVGVNHKTAPIEIRERIALSEVQNKELVTDLVSSGLASEAMVVSTCNRTELYVVPGMPEVNCDYLKDYIISYKNAR
NAVRPEHFFSRFYCGTARHLFEVSCAIDSLVLGEGQILGQVKNAYRIAAEVGTAGILLTRLCHTAFSVAKKVKTRTKLME
GAVSVSYAAVELAQKIFSNLSMKKVLLIGAGETGELAAKHMYAKNARNIVITNRTQSKAEALAEELGTNRVLPYESYKEH
LHEFDIIITAVSTKEYILNAAEMQQSMAKRRLKPVIILDLGLPRNVDPEVGALQNMFLKDIDALKHIIDKNLERRRAELP
KVKAIIDEELVAFGQWLNTLKVRPTIVDLQSKFLEIKEKELERYRYKVSEEELRRMEHLTDRILKKILHHPIKMLKAPVD
TADNIPSKVNLVRNIFDLEEPNQSLQ

Sequences:

>Translated_426_residues
MNIISVGVNHKTAPIEIRERIALSEVQNKELVTDLVSSGLASEAMVVSTCNRTELYVVPGMPEVNCDYLKDYIISYKNAR
NAVRPEHFFSRFYCGTARHLFEVSCAIDSLVLGEGQILGQVKNAYRIAAEVGTAGILLTRLCHTAFSVAKKVKTRTKLME
GAVSVSYAAVELAQKIFSNLSMKKVLLIGAGETGELAAKHMYAKNARNIVITNRTQSKAEALAEELGTNRVLPYESYKEH
LHEFDIIITAVSTKEYILNAAEMQQSMAKRRLKPVIILDLGLPRNVDPEVGALQNMFLKDIDALKHIIDKNLERRRAELP
KVKAIIDEELVAFGQWLNTLKVRPTIVDLQSKFLEIKEKELERYRYKVSEEELRRMEHLTDRILKKILHHPIKMLKAPVD
TADNIPSKVNLVRNIFDLEEPNQSLQ
>Mature_426_residues
MNIISVGVNHKTAPIEIRERIALSEVQNKELVTDLVSSGLASEAMVVSTCNRTELYVVPGMPEVNCDYLKDYIISYKNAR
NAVRPEHFFSRFYCGTARHLFEVSCAIDSLVLGEGQILGQVKNAYRIAAEVGTAGILLTRLCHTAFSVAKKVKTRTKLME
GAVSVSYAAVELAQKIFSNLSMKKVLLIGAGETGELAAKHMYAKNARNIVITNRTQSKAEALAEELGTNRVLPYESYKEH
LHEFDIIITAVSTKEYILNAAEMQQSMAKRRLKPVIILDLGLPRNVDPEVGALQNMFLKDIDALKHIIDKNLERRRAELP
KVKAIIDEELVAFGQWLNTLKVRPTIVDLQSKFLEIKEKELERYRYKVSEEELRRMEHLTDRILKKILHHPIKMLKAPVD
TADNIPSKVNLVRNIFDLEEPNQSLQ

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=423, Percent_Identity=33.096926713948, Blast_Score=228, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 48134; Mature: 48134

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIISVGVNHKTAPIEIRERIALSEVQNKELVTDLVSSGLASEAMVVSTCNRTELYVVPG
CCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECC
MPEVNCDYLKDYIISYKNARNAVRPEHFFSRFYCGTARHLFEVSCAIDSLVLGEGQILGQ
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VKNAYRIAAEVGTAGILLTRLCHTAFSVAKKVKTRTKLMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SMKKVLLIGAGETGELAAKHMYAKNARNIVITNRTQSKAEALAEELGTNRVLPYESYKEH
CEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHH
LHEFDIIITAVSTKEYILNAAEMQQSMAKRRLKPVIILDLGLPRNVDPEVGALQNMFLKD
HHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
IDALKHIIDKNLERRRAELPKVKAIIDEELVAFGQWLNTLKVRPTIVDLQSKFLEIKEKE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEEELRRMEHLTDRILKKILHHPIKMLKAPVDTADNIPSKVNLVRNIFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
PNQSLQ
CCCCCC
>Mature Secondary Structure
MNIISVGVNHKTAPIEIRERIALSEVQNKELVTDLVSSGLASEAMVVSTCNRTELYVVPG
CCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECC
MPEVNCDYLKDYIISYKNARNAVRPEHFFSRFYCGTARHLFEVSCAIDSLVLGEGQILGQ
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VKNAYRIAAEVGTAGILLTRLCHTAFSVAKKVKTRTKLMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SMKKVLLIGAGETGELAAKHMYAKNARNIVITNRTQSKAEALAEELGTNRVLPYESYKEH
CEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHH
LHEFDIIITAVSTKEYILNAAEMQQSMAKRRLKPVIILDLGLPRNVDPEVGALQNMFLKD
HHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
IDALKHIIDKNLERRRAELPKVKAIIDEELVAFGQWLNTLKVRPTIVDLQSKFLEIKEKE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEEELRRMEHLTDRILKKILHHPIKMLKAPVDTADNIPSKVNLVRNIFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
PNQSLQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1793335 [H]