Click here to switch to the map view.

The map label for this gene is typA [H]

Identifier: 21674245

GI number: 21674245

Start: 1335553

End: 1337382

Strand: Reverse

Name: typA [H]

Synonym: CT1424

Alternate gene names: 21674245

Gene position: 1337382-1335553 (Counterclockwise)

Preceding gene: 21674250

Following gene: 21674239

Centisome position: 62.06

GC content: 59.02

Gene sequence:

>1830_bases
ATGAGCAGGAAACAGAATATTCGCAATATCGCCATTATCGCGCACGTCGATCATGGCAAGACCACCCTCGTGGACTCCAT
TTTCAAGCAGACGGGCGCGTTCAGGGAGAACCAGCATGTTGACGTCAGGGTGATGGACTCCAATCCGCAGGAGCGTGAGC
GGGGCATCACCATTTTTTCGAAAAATGCAGCCGTGCAGCACAAGGGGTGCAAAATCAATATCGTCGACACCCCCGGTCAC
GCCGATTTCGGCGGCGAGGTCGAGCGCATCCTGAAGATGGTCGATGGCGTGCTCCTGCTTGTCGATGCTTTCGAGGGGCC
GATGCCGCAGACCAAGTTCGTGCTTCGCAAGGCGCTCGAACTGCATCTGAAGCCGATCGTGGTCATCAACAAGATCGACC
GTCCGCAGGCCGATCCGGAGAAGGTGCATGATCAGGTGCTCGACCTTTTCATTGCGCTCGGCGCTGACGAAGATCAGCTC
GATTTCCCCTACATCTTCGCTTCGGCCAAGAACGGCATTGCCAAATGTAATATGTCGGATCCGGACGGCGACATGAGCCT
TCTGCTCGACATGATCGTCAAGGAGATTCCCGCCCCTGAAGCGGACGACGATGCTGGATTCCAGATGCTCGTCACCAGCC
TCGACTACAGTGACTATATCGGCAAGATCGCCATCGGCCGCATTCAGCGCGGCAAGGTTGCGCCCGGCAACCAGCTCACG
CTGGTGACGCAGGATGGTGTGGTTGGCAAAGGTACGGTCACCAAGCTTTTCCTTTTCGACCGCACGCAGCGCGTCGAGGC
GATGGAGGCGACGGCGGGCGACATCGTCGCGCTTGCCGGTATCGCGGCGGCCAACGTCGGTGAAACACTTACCACCCCCG
ACCAGCCCGAACCGATCGAATCGTTCGAGATCAGCAAGCCGACGCTTTCCATGCTCTTTTCAGTGAACGACTCGCCGTTC
GCCGGTCAGGAGGGCAAGGAGGTGACCAGCCGCAAAATCCGCGAGCGGCTCATGAAAGAGATCATGACCAACGTCGCGCT
CAACGTCGAGGAGACCGACAGCGCCGACACCTTCCGCGTGTCGGGACGCGGCGAGCTTCACCTCTCCGTACTGATCGAGA
CCATGCGCCGCGAGGGCTACGAACTGGCCATCTCCCGTCCCGAGGTGATTCTTCGCGAGGAGAACGGCGTGACGATGGAG
CCGGTCGAGCATGTTACCATCGACGTTCCGGAAGAGTACACCGGCGTGGTTATCGAAAAGATGGGCCGCAGGAAGGCCGA
GATGACCAACATGAGCACCCTGCGCGGCGGCATGAACCGCCTGGAGTTCGAAATTCCGACGCGCGGCCTGATCGGTTACA
ACCTCGAATTCACCACCGACACCAAGGGTGAGGGCATGATGTCGCACGTGTTCCACAACTACCAGCCCTACAAAGGCAAG
CTGCCGTCGCGCGAAACCGGCGCTCTGGTCTCTGCCGAAACCGGCGTGGCCGTGGCCTATGCGATTTCGAGTCTCGAAGA
TCGAGGCACCTTCTTCATTGGGCCGAACGCGAAGGTTTATGAAGGCATGGTGGTTGGCGAATCGACTCGTGACCTCGACA
TCACGGTGAACATCTGCAAGACCAAGAAGCTCACCAACATGCGTGCCTCCGGCTCGGACGACTCGATCCGCCTGACGCCG
CCGAAGAGGCTTTCGCTTGAACAGGCGCTGGAGTTTATCAATGACGACGAGCTGCTCGAAGTGACGCCCGAGAACATCAG
GATCCGCAAGAAGATTCTCAACGCCGACCTCAGAGCCAAGGCGACGAAGAAAGCCAAGGCGATGGCGTGA

Upstream 100 bases:

>100_bases
AATATCTTCACGCCTGCCAGATGATAATTTCAATGGAAAAAGTGTATATTCGGCCCGATTGAAAACCTGGGCAGTAAAAT
ATACTTATTTATCGCAAAAG

Downstream 100 bases:

>100_bases
GGGGAGAATTGATAATTAACAATGGATAGTGGATAATGAAAAAGGTTGCTCCGAGTGAGCAGCCTTTTTTGTTTGGTGCG
AGCGCAAGATGAGATCGGTC

Product: GTP-binding elongation factor family protein, TypA subfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSRKQNIRNIAIIAHVDHGKTTLVDSIFKQTGAFRENQHVDVRVMDSNPQERERGITIFSKNAAVQHKGCKINIVDTPGH
ADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELHLKPIVVINKIDRPQADPEKVHDQVLDLFIALGADEDQL
DFPYIFASAKNGIAKCNMSDPDGDMSLLLDMIVKEIPAPEADDDAGFQMLVTSLDYSDYIGKIAIGRIQRGKVAPGNQLT
LVTQDGVVGKGTVTKLFLFDRTQRVEAMEATAGDIVALAGIAAANVGETLTTPDQPEPIESFEISKPTLSMLFSVNDSPF
AGQEGKEVTSRKIRERLMKEIMTNVALNVEETDSADTFRVSGRGELHLSVLIETMRREGYELAISRPEVILREENGVTME
PVEHVTIDVPEEYTGVVIEKMGRRKAEMTNMSTLRGGMNRLEFEIPTRGLIGYNLEFTTDTKGEGMMSHVFHNYQPYKGK
LPSRETGALVSAETGVAVAYAISSLEDRGTFFIGPNAKVYEGMVVGESTRDLDITVNICKTKKLTNMRASGSDDSIRLTP
PKRLSLEQALEFINDDELLEVTPENIRIRKKILNADLRAKATKKAKAMA

Sequences:

>Translated_609_residues
MSRKQNIRNIAIIAHVDHGKTTLVDSIFKQTGAFRENQHVDVRVMDSNPQERERGITIFSKNAAVQHKGCKINIVDTPGH
ADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELHLKPIVVINKIDRPQADPEKVHDQVLDLFIALGADEDQL
DFPYIFASAKNGIAKCNMSDPDGDMSLLLDMIVKEIPAPEADDDAGFQMLVTSLDYSDYIGKIAIGRIQRGKVAPGNQLT
LVTQDGVVGKGTVTKLFLFDRTQRVEAMEATAGDIVALAGIAAANVGETLTTPDQPEPIESFEISKPTLSMLFSVNDSPF
AGQEGKEVTSRKIRERLMKEIMTNVALNVEETDSADTFRVSGRGELHLSVLIETMRREGYELAISRPEVILREENGVTME
PVEHVTIDVPEEYTGVVIEKMGRRKAEMTNMSTLRGGMNRLEFEIPTRGLIGYNLEFTTDTKGEGMMSHVFHNYQPYKGK
LPSRETGALVSAETGVAVAYAISSLEDRGTFFIGPNAKVYEGMVVGESTRDLDITVNICKTKKLTNMRASGSDDSIRLTP
PKRLSLEQALEFINDDELLEVTPENIRIRKKILNADLRAKATKKAKAMA
>Mature_608_residues
SRKQNIRNIAIIAHVDHGKTTLVDSIFKQTGAFRENQHVDVRVMDSNPQERERGITIFSKNAAVQHKGCKINIVDTPGHA
DFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELHLKPIVVINKIDRPQADPEKVHDQVLDLFIALGADEDQLD
FPYIFASAKNGIAKCNMSDPDGDMSLLLDMIVKEIPAPEADDDAGFQMLVTSLDYSDYIGKIAIGRIQRGKVAPGNQLTL
VTQDGVVGKGTVTKLFLFDRTQRVEAMEATAGDIVALAGIAAANVGETLTTPDQPEPIESFEISKPTLSMLFSVNDSPFA
GQEGKEVTSRKIRERLMKEIMTNVALNVEETDSADTFRVSGRGELHLSVLIETMRREGYELAISRPEVILREENGVTMEP
VEHVTIDVPEEYTGVVIEKMGRRKAEMTNMSTLRGGMNRLEFEIPTRGLIGYNLEFTTDTKGEGMMSHVFHNYQPYKGKL
PSRETGALVSAETGVAVAYAISSLEDRGTFFIGPNAKVYEGMVVGESTRDLDITVNICKTKKLTNMRASGSDDSIRLTPP
KRLSLEQALEFINDDELLEVTPENIRIRKKILNADLRAKATKKAKAMA

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=493, Percent_Identity=28.3975659229209, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=44.3609022556391, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=38.6666666666667, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=40.8163265306122, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI25306287, Length=133, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923640, Length=133, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI25306283, Length=133, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI34147630, Length=271, Percent_Identity=29.520295202952, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=38.5714285714286, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=38.5714285714286, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=35.5072463768116, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=35.5072463768116, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=53.3996683250415, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=508, Percent_Identity=29.1338582677165, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789738, Length=167, Percent_Identity=38.9221556886228, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790412, Length=326, Percent_Identity=27.3006134969325, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789737, Length=326, Percent_Identity=27.3006134969325, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790835, Length=149, Percent_Identity=33.5570469798658, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789559, Length=164, Percent_Identity=32.3170731707317, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=323, Percent_Identity=34.0557275541796, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17506493, Length=162, Percent_Identity=36.4197530864198, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=42.2535211267606, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=40.7692307692308, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=40.7692307692308, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=145, Percent_Identity=42.0689655172414, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=37.3134328358209, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=262, Percent_Identity=29.0076335877863, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25141371, Length=268, Percent_Identity=26.1194029850746, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994658, Length=309, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=486, Percent_Identity=29.4238683127572, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324707, Length=150, Percent_Identity=40.6666666666667, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=150, Percent_Identity=40.6666666666667, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324761, Length=270, Percent_Identity=33.7037037037037, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=37.7777777777778, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=155, Percent_Identity=37.4193548387097, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=37.5838926174497, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI78706572, Length=520, Percent_Identity=26.9230769230769, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI28574573, Length=191, Percent_Identity=38.2198952879581, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=38.3233532934132, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=38.3233532934132, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=38.3233532934132, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=42.1768707482993, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363316, Length=275, Percent_Identity=32, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864358, Length=275, Percent_Identity=32, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=39.5522388059701, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221458488, Length=164, Percent_Identity=40.8536585365854, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19921738, Length=227, Percent_Identity=28.6343612334802, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28572034, Length=167, Percent_Identity=32.9341317365269, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67291; Mature: 67160

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00216 SUGAR_TRANSPORT_1 ; PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKQNIRNIAIIAHVDHGKTTLVDSIFKQTGAFRENQHVDVRVMDSNPQERERGITIFS
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCEEEE
KNAAVQHKGCKINIVDTPGHADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALE
CCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
LHLKPIVVINKIDRPQADPEKVHDQVLDLFIALGADEDQLDFPYIFASAKNGIAKCNMSD
HHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEECCCCC
PDGDMSLLLDMIVKEIPAPEADDDAGFQMLVTSLDYSDYIGKIAIGRIQRGKVAPGNQLT
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCEEECEEECCCCCCCCEEE
LVTQDGVVGKGTVTKLFLFDRTQRVEAMEATAGDIVALAGIAAANVGETLTTPDQPEPIE
EEECCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
SFEISKPTLSMLFSVNDSPFAGQEGKEVTSRKIRERLMKEIMTNVALNVEETDSADTFRV
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECEECCCCCCEEEE
SGRGELHLSVLIETMRREGYELAISRPEVILREENGVTMEPVEHVTIDVPEEYTGVVIEK
CCCCCEEHHHHHHHHHCCCCEEEECCCEEEEECCCCCEECCCCEEEEECCCHHHHHHHHH
MGRRKAEMTNMSTLRGGMNRLEFEIPTRGLIGYNLEFTTDTKGEGMMSHVFHNYQPYKGK
HCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCC
LPSRETGALVSAETGVAVAYAISSLEDRGTFFIGPNAKVYEGMVVGESTRDLDITVNICK
CCCCCCCCEEECCCCEEEEHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCEEEEEEEEC
TKKLTNMRASGSDDSIRLTPPKRLSLEQALEFINDDELLEVTPENIRIRKKILNADLRAK
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCHHHH
ATKKAKAMA
HHHHHHCCC
>Mature Secondary Structure 
SRKQNIRNIAIIAHVDHGKTTLVDSIFKQTGAFRENQHVDVRVMDSNPQERERGITIFS
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCEEEE
KNAAVQHKGCKINIVDTPGHADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALE
CCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
LHLKPIVVINKIDRPQADPEKVHDQVLDLFIALGADEDQLDFPYIFASAKNGIAKCNMSD
HHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEECCCCC
PDGDMSLLLDMIVKEIPAPEADDDAGFQMLVTSLDYSDYIGKIAIGRIQRGKVAPGNQLT
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCEEECEEECCCCCCCCEEE
LVTQDGVVGKGTVTKLFLFDRTQRVEAMEATAGDIVALAGIAAANVGETLTTPDQPEPIE
EEECCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
SFEISKPTLSMLFSVNDSPFAGQEGKEVTSRKIRERLMKEIMTNVALNVEETDSADTFRV
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECEECCCCCCEEEE
SGRGELHLSVLIETMRREGYELAISRPEVILREENGVTMEPVEHVTIDVPEEYTGVVIEK
CCCCCEEHHHHHHHHHCCCCEEEECCCEEEEECCCCCEECCCCEEEEECCCHHHHHHHHH
MGRRKAEMTNMSTLRGGMNRLEFEIPTRGLIGYNLEFTTDTKGEGMMSHVFHNYQPYKGK
HCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCC
LPSRETGALVSAETGVAVAYAISSLEDRGTFFIGPNAKVYEGMVVGESTRDLDITVNICK
CCCCCCCCEEECCCCEEEEHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCEEEEEEEEC
TKKLTNMRASGSDDSIRLTPPKRLSLEQALEFINDDELLEVTPENIRIRKKILNADLRAK
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCHHHH
ATKKAKAMA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]