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The map label for this gene is prsA

Identifier: 21674183

GI number: 21674183

Start: 1280762

End: 1281733

Strand: Direct

Name: prsA

Synonym: CT1361

Alternate gene names: 21674183

Gene position: 1280762-1281733 (Clockwise)

Preceding gene: 21674181

Following gene: 21674184

Centisome position: 59.43

GC content: 54.84

Gene sequence:

>972_bases
ATGGAAACACCAATCAAAATTGTCGCTGGACGCAGCAATCCGGAACTGGCAAAAAAAATCGCCGCTTACCTTGGCACACC
GCTGTGTGATGCAAAGGCAGAGAACTTCTCGGACGGAGAGATTTCAGTCAACTATTTCGAGTCGATCAGAGGCTCGGATA
TGTTCATCATCCAGTCCACCAATCCCCCGGCTGACAATCTGATGGAACTGCTCATCATGATCGACGCCGCCAAGCGCTCT
TCGGCATACCGGATCACCGCCGTCCTGCCCTATTACGGCTATGCCCGTCAGGACAGAAAGGACAAGCCGCGCGTGGCGAT
TACCGCCAAGCTCGTTGCCAATCTGCTCACGCAGGCTGGAGCTGACAGGATTCTCACCATGGATCTGCACGCGCCGCAGA
TTCAGGGCTTTTTCGATATTCCGTTCGATCACCTCTATTCAAGCGTGGTGCTGATCGACCACGTCAAAAACATGGATATT
GCCGACAACCTCGTCGTGGCTTCGCCGGACGTAGGCGGCGTCAAGCTCGCCCGCAAGTTCGCCTCCGAACTCGGCACCGA
GCTGGTCATTGTCGACAAGCGCCGTCCGAAAGCGAACGTGGCTGAAGTGATGAACATCATCGGCGACGTGAAAGGCAAAA
ACGTGCTGCTGGTCGATGACATGATCGACACGGCAGGCACCATCGTCAACGCAGCCAAGGCCATCAAGGAGGCCGGCGGT
CTGAAAATCTACGCCGCGGCCACCCACCCGATTCTCTCCGGCCCGGCCATCGAGCGCATCAACACCTCGGTGTTCGAAAA
GGTTATCGTCACCGATTCGCTGGTTTCGGAACACGACTTTTGCTCGAAAATCGAGACGGTCACCATCAGCAACCTCTTCG
GCGAGGCAATCAAGAGAATCTATGACGGCGAGTCGGTCAGCTATCTGTTCGACAGCAAGAACATATCGCAAAAAATTACC
AATCACCATTAA

Upstream 100 bases:

>100_bases
GAATCCTTTTACCGTTCCGGTTGCGACAGCCGTGCTCCGTACCCGGTAAACGAAGATGGAACCATAATATAATTCGTTTC
ATCAGAAAAAGCAGTGAACG

Downstream 100 bases:

>100_bases
TACAAGCGTTAACTGTTAAAGGAACCAGAGGAAATAGCATGGAAACAAGAGCATTGTCTGTAAACCTTCGCGAGGTCAAG
AAAAACGGGGCCGCAAAACT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
METPIKIVAGRSNPELAKKIAAYLGTPLCDAKAENFSDGEISVNYFESIRGSDMFIIQSTNPPADNLMELLIMIDAAKRS
SAYRITAVLPYYGYARQDRKDKPRVAITAKLVANLLTQAGADRILTMDLHAPQIQGFFDIPFDHLYSSVVLIDHVKNMDI
ADNLVVASPDVGGVKLARKFASELGTELVIVDKRRPKANVAEVMNIIGDVKGKNVLLVDDMIDTAGTIVNAAKAIKEAGG
LKIYAAATHPILSGPAIERINTSVFEKVIVTDSLVSEHDFCSKIETVTISNLFGEAIKRIYDGESVSYLFDSKNISQKIT
NHH

Sequences:

>Translated_323_residues
METPIKIVAGRSNPELAKKIAAYLGTPLCDAKAENFSDGEISVNYFESIRGSDMFIIQSTNPPADNLMELLIMIDAAKRS
SAYRITAVLPYYGYARQDRKDKPRVAITAKLVANLLTQAGADRILTMDLHAPQIQGFFDIPFDHLYSSVVLIDHVKNMDI
ADNLVVASPDVGGVKLARKFASELGTELVIVDKRRPKANVAEVMNIIGDVKGKNVLLVDDMIDTAGTIVNAAKAIKEAGG
LKIYAAATHPILSGPAIERINTSVFEKVIVTDSLVSEHDFCSKIETVTISNLFGEAIKRIYDGESVSYLFDSKNISQKIT
NHH
>Mature_323_residues
METPIKIVAGRSNPELAKKIAAYLGTPLCDAKAENFSDGEISVNYFESIRGSDMFIIQSTNPPADNLMELLIMIDAAKRS
SAYRITAVLPYYGYARQDRKDKPRVAITAKLVANLLTQAGADRILTMDLHAPQIQGFFDIPFDHLYSSVVLIDHVKNMDI
ADNLVVASPDVGGVKLARKFASELGTELVIVDKRRPKANVAEVMNIIGDVKGKNVLLVDDMIDTAGTIVNAAKAIKEAGG
LKIYAAATHPILSGPAIERINTSVFEKVIVTDSLVSEHDFCSKIETVTISNLFGEAIKRIYDGESVSYLFDSKNISQKIT
NHH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=49.6774193548387, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=49.0322580645161, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=48.5623003194888, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=48.3870967741936, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4506133, Length=332, Percent_Identity=36.7469879518072, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI194018537, Length=340, Percent_Identity=38.2352941176471, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=36.4285714285714, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=36.4285714285714, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=36.4285714285714, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=36.4285714285714, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=51.9230769230769, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=47.741935483871, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=47.741935483871, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=47.741935483871, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=47.4025974025974, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=34.1246290801187, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=44.6601941747573, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=44.8387096774194, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=43.4083601286174, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=39.7959183673469, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=39.0909090909091, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=50.3225806451613, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=46.8468468468468, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=37.1287128712871, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=37.1287128712871, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45552010, Length=202, Percent_Identity=37.1287128712871, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_CHLTE (Q8KCQ2)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662248.1
- ProteinModelPortal:   Q8KCQ2
- SMR:   Q8KCQ2
- GeneID:   1006738
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1361
- NMPDR:   fig|194439.1.peg.1342
- TIGR:   CT1361
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK01259
- BioCyc:   CTEP194439:CT_1361-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 35266; Mature: 35266

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPIKIVAGRSNPELAKKIAAYLGTPLCDAKAENFSDGEISVNYFESIRGSDMFIIQST
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCEEEEECC
NPPADNLMELLIMIDAAKRSSAYRITAVLPYYGYARQDRKDKPRVAITAKLVANLLTQAG
CCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCC
ADRILTMDLHAPQIQGFFDIPFDHLYSSVVLIDHVKNMDIADNLVVASPDVGGVKLARKF
CCEEEEEECCCCCCCCEEECCHHHHHHHHHEEHHHCCCCCCCCEEEECCCCCHHHHHHHH
ASELGTELVIVDKRRPKANVAEVMNIIGDVKGKNVLLVDDMIDTAGTIVNAAKAIKEAGG
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
LKIYAAATHPILSGPAIERINTSVFEKVIVTDSLVSEHDFCSKIETVTISNLFGEAIKRI
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDGESVSYLFDSKNISQKITNHH
HCCCCEEEEECCCCHHHHHCCCC
>Mature Secondary Structure
METPIKIVAGRSNPELAKKIAAYLGTPLCDAKAENFSDGEISVNYFESIRGSDMFIIQST
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCEEEEECC
NPPADNLMELLIMIDAAKRSSAYRITAVLPYYGYARQDRKDKPRVAITAKLVANLLTQAG
CCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCC
ADRILTMDLHAPQIQGFFDIPFDHLYSSVVLIDHVKNMDIADNLVVASPDVGGVKLARKF
CCEEEEEECCCCCCCCEEECCHHHHHHHHHEEHHHCCCCCCCCEEEECCCCCHHHHHHHH
ASELGTELVIVDKRRPKANVAEVMNIIGDVKGKNVLLVDDMIDTAGTIVNAAKAIKEAGG
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
LKIYAAATHPILSGPAIERINTSVFEKVIVTDSLVSEHDFCSKIETVTISNLFGEAIKRI
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDGESVSYLFDSKNISQKITNHH
HCCCCEEEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901