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The map label for this gene is cqsS [H]

Identifier: 21674180

GI number: 21674180

Start: 1276209

End: 1278254

Strand: Direct

Name: cqsS [H]

Synonym: CT1358

Alternate gene names: 21674180

Gene position: 1276209-1278254 (Clockwise)

Preceding gene: 21674179

Following gene: 21674181

Centisome position: 59.22

GC content: 48.44

Gene sequence:

>2046_bases
ATGGTGTCAGGCATACTGGGAGCACTCGCTAATATTTTTTTTTATGTGGTTTTCAAATACGGCTTCCATCTGCCCTATGA
AAACTTCTGGCTCCGAATGGTTGCCACCCTGTTGTGCATAAGCCTCATCTTCATGCACCGTCTACCCGAGTCTTTTTCCC
CCTATTTTCCTTACTTCTGGCATACCTTCCTGATTATCATCCTGCCGTTCACTTTCACGGTGAACCTTCTCATGAACAAT
TTTCATGAGCTCTGGCTCTACTGGGAAATATTCATGGTATTCGTACTGATGATGTTTGTGCCAAACTGGTTGCTGTTCAT
GTTCGATTTACTTACCGGCGTATTGGGCGCAATCCTCTTTCACAATCTGTCAGTTCCCTATGTACCACTCAATCCGACCT
TTAATATTCCGCTCTATTCGATTGTCATAAGCTTTTCCATCGTCGCCGGATCTATTTTCAGCTTCGCTAACCGGAACACC
CTTAAAGAACTCGAAAGAAAAAAAGCGGAAGAAAAGTATCGCGCTCTTGAAGCCCTCGCAGGCAGTATCGCCCATGAGAT
GCGCAATCCACTCTCACAGGTGCGCCAAAATCTTGACGAAATCCTGCTGGAGTTGCCACGAAGCAGCACCGAAAATGATT
ACGCATCGCTTCCTAAAAAGAATATTGAAACGATCCAAAAGCGGGCAATCCAGGCACAGACGGCAATAAACCGTGGCCTT
CAGGTTATTACCGTAACACTTGGCAATTTCAGAAACACCGATGTCTCGAAAAAGGAGCTGACTTGCCTGTCAGCAACGAC
AATAACCCGAAAAGCCATAGAAGAGTATGGCTATGCCTCAGAACACGAACGACAAAAGATTTATCTTAGTCCGGGAGAAG
ATTTTATATTCCTTGGCGAAGAGAACAATTACATCCTGCTGTTTCACAATCTGCTGGAAAACGCCCTGCAGATTCTTCAG
CAGGTGCCTGACGGGCGCCTCGCGATCACAATCCAGCGAGGGGAATCAGTCAACAGAATTCTCATCCGTGATAATGGCCC
GGGAATTCCACCGAACATCCTTCCAAGAATCTTCGAGCCGTTCTTCACTTCGGGCAAGAAAAACGGCACAGGGCTTGGTC
TGGCGTTCTGCCAAAGGGTGATGAAATCTTTCAATGGACAAATCTCCTGCAAATCAGAAGTGGGCATATTCACGGAGTTT
ACTCTGGAATTCCCGGTTCTCGACAAGGCGACAATCAACAAATTCGAACGGAACCTCTATGCGGAATACACACCTTTCTT
GGCAGGAAAAAACGTACTCATGGCCGCCATTCCCGAAGCATATGTGCCATCGATCCGTCAACAGCTCATGCCGCTGAAAA
TCGGTCTGGATAACGCCGAGGATAACAACAAGGCCCTTGAAATGCTCGCAGCAAACCACTACGACCTTGTTCTTTCTGGT
ATCAGTCCTCTACCGGCTGGAACAGCAAAACTTGGAAACATCGTCAAAAACAAAGACCGGAATATTCCCGTTGTCGGTTG
CAGCTTCTCGCCCCTTCCCCCGGTCGACACCATCAATGGCGTCGCGTCCGTCATTATCATGCCGCCAGCGCTACCTGAAC
TGCTGAACGCCATGAAAAGCTCGCTGGAGATGGCCAGGGAAACACTCAAGGAATCGCTATCGGGCAAGACCGTGCTGGTA
GCGGACGATCTCGATTTCAACCGCAGGGTCATCAAGTTGATGCTCAACAAGCTGGGCATCACAATTTTCGAAGCTTCCAA
CGGCCTCGAAGCGCTTAATATTTTGAAATCACAGCCCTGCGACCTGCTGGTCATCGACATGAGAATGCCGGTTCTCGACG
GTTTTGAGACTGCCCAACGCATTCGCGCAATGCCATCGCCCTATCGCGACATACCGATACTCGGGCTGAGTGGCAATCTG
GACAATGCAACACTGAAACTTGCCAAAGAAAGCGGCATCAACGATACCCTCTTGAAACCGGTCAAGCTCAAGCCTTTCTT
GCAAAAAGTTACCTCCATGCTCAAGGTAAATACGCCAGCAGCATAA

Upstream 100 bases:

>100_bases
AGTGTATTGAAAAAGTAGTTGGAGATGGTTCTTGAAAAAACTCATTGAGCAGTTAACTGAATACCTAAGGGAAGGAACGT
TAGTTTCCCGTTCAGACGCT

Downstream 100 bases:

>100_bases
ATAGACCTAAGTTGAGCGATTCGCCGTTGTAACGGCGAATCGCTCAACTTAGGAAAACATAAAGCATTTTGCGGTTATTG
GCGTAAATACAGTGTTGCAC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MVSGILGALANIFFYVVFKYGFHLPYENFWLRMVATLLCISLIFMHRLPESFSPYFPYFWHTFLIIILPFTFTVNLLMNN
FHELWLYWEIFMVFVLMMFVPNWLLFMFDLLTGVLGAILFHNLSVPYVPLNPTFNIPLYSIVISFSIVAGSIFSFANRNT
LKELERKKAEEKYRALEALAGSIAHEMRNPLSQVRQNLDEILLELPRSSTENDYASLPKKNIETIQKRAIQAQTAINRGL
QVITVTLGNFRNTDVSKKELTCLSATTITRKAIEEYGYASEHERQKIYLSPGEDFIFLGEENNYILLFHNLLENALQILQ
QVPDGRLAITIQRGESVNRILIRDNGPGIPPNILPRIFEPFFTSGKKNGTGLGLAFCQRVMKSFNGQISCKSEVGIFTEF
TLEFPVLDKATINKFERNLYAEYTPFLAGKNVLMAAIPEAYVPSIRQQLMPLKIGLDNAEDNNKALEMLAANHYDLVLSG
ISPLPAGTAKLGNIVKNKDRNIPVVGCSFSPLPPVDTINGVASVIIMPPALPELLNAMKSSLEMARETLKESLSGKTVLV
ADDLDFNRRVIKLMLNKLGITIFEASNGLEALNILKSQPCDLLVIDMRMPVLDGFETAQRIRAMPSPYRDIPILGLSGNL
DNATLKLAKESGINDTLLKPVKLKPFLQKVTSMLKVNTPAA

Sequences:

>Translated_681_residues
MVSGILGALANIFFYVVFKYGFHLPYENFWLRMVATLLCISLIFMHRLPESFSPYFPYFWHTFLIIILPFTFTVNLLMNN
FHELWLYWEIFMVFVLMMFVPNWLLFMFDLLTGVLGAILFHNLSVPYVPLNPTFNIPLYSIVISFSIVAGSIFSFANRNT
LKELERKKAEEKYRALEALAGSIAHEMRNPLSQVRQNLDEILLELPRSSTENDYASLPKKNIETIQKRAIQAQTAINRGL
QVITVTLGNFRNTDVSKKELTCLSATTITRKAIEEYGYASEHERQKIYLSPGEDFIFLGEENNYILLFHNLLENALQILQ
QVPDGRLAITIQRGESVNRILIRDNGPGIPPNILPRIFEPFFTSGKKNGTGLGLAFCQRVMKSFNGQISCKSEVGIFTEF
TLEFPVLDKATINKFERNLYAEYTPFLAGKNVLMAAIPEAYVPSIRQQLMPLKIGLDNAEDNNKALEMLAANHYDLVLSG
ISPLPAGTAKLGNIVKNKDRNIPVVGCSFSPLPPVDTINGVASVIIMPPALPELLNAMKSSLEMARETLKESLSGKTVLV
ADDLDFNRRVIKLMLNKLGITIFEASNGLEALNILKSQPCDLLVIDMRMPVLDGFETAQRIRAMPSPYRDIPILGLSGNL
DNATLKLAKESGINDTLLKPVKLKPFLQKVTSMLKVNTPAA
>Mature_681_residues
MVSGILGALANIFFYVVFKYGFHLPYENFWLRMVATLLCISLIFMHRLPESFSPYFPYFWHTFLIIILPFTFTVNLLMNN
FHELWLYWEIFMVFVLMMFVPNWLLFMFDLLTGVLGAILFHNLSVPYVPLNPTFNIPLYSIVISFSIVAGSIFSFANRNT
LKELERKKAEEKYRALEALAGSIAHEMRNPLSQVRQNLDEILLELPRSSTENDYASLPKKNIETIQKRAIQAQTAINRGL
QVITVTLGNFRNTDVSKKELTCLSATTITRKAIEEYGYASEHERQKIYLSPGEDFIFLGEENNYILLFHNLLENALQILQ
QVPDGRLAITIQRGESVNRILIRDNGPGIPPNILPRIFEPFFTSGKKNGTGLGLAFCQRVMKSFNGQISCKSEVGIFTEF
TLEFPVLDKATINKFERNLYAEYTPFLAGKNVLMAAIPEAYVPSIRQQLMPLKIGLDNAEDNNKALEMLAANHYDLVLSG
ISPLPAGTAKLGNIVKNKDRNIPVVGCSFSPLPPVDTINGVASVIIMPPALPELLNAMKSSLEMARETLKESLSGKTVLV
ADDLDFNRRVIKLMLNKLGITIFEASNGLEALNILKSQPCDLLVIDMRMPVLDGFETAQRIRAMPSPYRDIPILGLSGNL
DNATLKLAKESGINDTLLKPVKLKPFLQKVTSMLKVNTPAA

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=540, Percent_Identity=25.1851851851852, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788549, Length=264, Percent_Identity=31.4393939393939, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788713, Length=177, Percent_Identity=30.5084745762712, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790567, Length=101, Percent_Identity=33.6633663366337, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=187, Percent_Identity=31.5508021390374, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76544; Mature: 76544

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSGILGALANIFFYVVFKYGFHLPYENFWLRMVATLLCISLIFMHRLPESFSPYFPYFW
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
HTFLIIILPFTFTVNLLMNNFHELWLYWEIFMVFVLMMFVPNWLLFMFDLLTGVLGAILF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNLSVPYVPLNPTFNIPLYSIVISFSIVAGSIFSFANRNTLKELERKKAEEKYRALEALA
HCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GSIAHEMRNPLSQVRQNLDEILLELPRSSTENDYASLPKKNIETIQKRAIQAQTAINRGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCC
QVITVTLGNFRNTDVSKKELTCLSATTITRKAIEEYGYASEHERQKIYLSPGEDFIFLGE
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEC
ENNYILLFHNLLENALQILQQVPDGRLAITIQRGESVNRILIRDNGPGIPPNILPRIFEP
CCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHH
FFTSGKKNGTGLGLAFCQRVMKSFNGQISCKSEVGIFTEFTLEFPVLDKATINKFERNLY
HHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHH
AEYTPFLAGKNVLMAAIPEAYVPSIRQQLMPLKIGLDNAEDNNKALEMLAANHYDLVLSG
HHHCCHHCCCCHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCHHEEEEC
ISPLPAGTAKLGNIVKNKDRNIPVVGCSFSPLPPVDTINGVASVIIMPPALPELLNAMKS
CCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHH
SLEMARETLKESLSGKTVLVADDLDFNRRVIKLMLNKLGITIFEASNGLEALNILKSQPC
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHCCCC
DLLVIDMRMPVLDGFETAQRIRAMPSPYRDIPILGLSGNLDNATLKLAKESGINDTLLKP
CEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEEHHHCCCCHHHCCC
VKLKPFLQKVTSMLKVNTPAA
CCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSGILGALANIFFYVVFKYGFHLPYENFWLRMVATLLCISLIFMHRLPESFSPYFPYFW
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
HTFLIIILPFTFTVNLLMNNFHELWLYWEIFMVFVLMMFVPNWLLFMFDLLTGVLGAILF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNLSVPYVPLNPTFNIPLYSIVISFSIVAGSIFSFANRNTLKELERKKAEEKYRALEALA
HCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GSIAHEMRNPLSQVRQNLDEILLELPRSSTENDYASLPKKNIETIQKRAIQAQTAINRGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCC
QVITVTLGNFRNTDVSKKELTCLSATTITRKAIEEYGYASEHERQKIYLSPGEDFIFLGE
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEC
ENNYILLFHNLLENALQILQQVPDGRLAITIQRGESVNRILIRDNGPGIPPNILPRIFEP
CCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHH
FFTSGKKNGTGLGLAFCQRVMKSFNGQISCKSEVGIFTEFTLEFPVLDKATINKFERNLY
HHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHH
AEYTPFLAGKNVLMAAIPEAYVPSIRQQLMPLKIGLDNAEDNNKALEMLAANHYDLVLSG
HHHCCHHCCCCHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCHHEEEEC
ISPLPAGTAKLGNIVKNKDRNIPVVGCSFSPLPPVDTINGVASVIIMPPALPELLNAMKS
CCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHH
SLEMARETLKESLSGKTVLVADDLDFNRRVIKLMLNKLGITIFEASNGLEALNILKSQPC
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHCCCC
DLLVIDMRMPVLDGFETAQRIRAMPSPYRDIPILGLSGNLDNATLKLAKESGINDTLLKP
CEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEEHHHCCCCHHHCCC
VKLKPFLQKVTSMLKVNTPAA
CCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA