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The map label for this gene is hldE [H]

Identifier: 21673994

GI number: 21673994

Start: 1098737

End: 1099720

Strand: Direct

Name: hldE [H]

Synonym: CT1168

Alternate gene names: 21673994

Gene position: 1098737-1099720 (Clockwise)

Preceding gene: 21673987

Following gene: 21674000

Centisome position: 50.99

GC content: 56.91

Gene sequence:

>984_bases
ATGACCCCGGAAAAGATCGAGCAGATATTTCGATCGTTCAAAGAGAAGAAAATCGCCGTTATCGGTGATGTAATGATCGA
CAAATATATCTTCGGCCACGTTTCGCGAATTTCACCCGAATATCCGGTACCAGTGGTCGATGTCAACCGCGAGAGTAGCC
GACTTGGAGGCGCGGCCAACGTGGCGGTCAACATCCATGCGCTCGGCGCCGAAGCGCTCCTGATTGGCGTCACCGGCGAC
GACACGGAGCGCAGAAACCTCGAAGCCCTGATGACGGAACATGGCCTCAATCCGGCTATGCTGGCCGCCGACAGCACCCG
CCCGACAACCTGCAAAACCCGAATCCTGTCACAAAACCATCACATCACGAGGGTTGACTACGAAAGCCGCACTCCGGTGG
ATGCGGAGCTGGAAAAACGACTGCTCGGCATGTTCATGGAGATCGCTAACGCGGTCGATGCGGTGGTACTCGAAGATTAC
AACAAGGGAGTGCTCACCCCGTCGCTGATCGTGTCACTGATCGCCGCCTGTCGTGAACGCAACAAACCAGTACTGGTCGA
CCCAAAACTCAAGGGCTTCTTTTCCTACGGCGGATGTTCAGTGTTCAAACCCAACCTCTCCGAACTCGCCGCCTCGCTTG
GCATTCCGGTGGCCAACGACGACCGTGAAGTCGAACAAGCCTGCCTCCTGCTCGGCGAAAAACTCACTGTCGAAAGCCTC
GTAGTGACACGAAGCGAAAAAGGGATGACTGTCTACGACGGCTCGTTCACCCACATCCCGGCATTGTCGCTCGATGTCGC
GGACGTCTCTGGTGCGGGAGATACCGTGATCGGCACACTGGCTCTAGGGCTGGCTTCAGGCCTCGACCTGGTGACCAGCA
CCAGAATCGCCAATCTTGCGGCCAATACTGTCTGCCAGGAGGTCGGTGCCGTGCCGGTCAGACCGGACAAGCTCTTCAGT
GCTTGTCTGGCACATCTTCAATGA

Upstream 100 bases:

>100_bases
TTTAAATATAAAAATATTCTTGTAAAATAAAACCAAACGATGCGACCGTCACCAAACTATTTTCGATTATATTAGCTAAA
CCAATTTCAGAGCATAGCTT

Downstream 100 bases:

>100_bases
TGGTGACGTGGTTATCCACCACCGAAGGCCACGCCGGTTTGTAGGAAGGATTCTGTGCAAGATCCCTCATCTTGAGCAAT
GAGTAAAACGGCACCTCGAA

Product: carbohydrate kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTPEKIEQIFRSFKEKKIAVIGDVMIDKYIFGHVSRISPEYPVPVVDVNRESSRLGGAANVAVNIHALGAEALLIGVTGD
DTERRNLEALMTEHGLNPAMLAADSTRPTTCKTRILSQNHHITRVDYESRTPVDAELEKRLLGMFMEIANAVDAVVLEDY
NKGVLTPSLIVSLIAACRERNKPVLVDPKLKGFFSYGGCSVFKPNLSELAASLGIPVANDDREVEQACLLLGEKLTVESL
VVTRSEKGMTVYDGSFTHIPALSLDVADVSGAGDTVIGTLALGLASGLDLVTSTRIANLAANTVCQEVGAVPVRPDKLFS
ACLAHLQ

Sequences:

>Translated_327_residues
MTPEKIEQIFRSFKEKKIAVIGDVMIDKYIFGHVSRISPEYPVPVVDVNRESSRLGGAANVAVNIHALGAEALLIGVTGD
DTERRNLEALMTEHGLNPAMLAADSTRPTTCKTRILSQNHHITRVDYESRTPVDAELEKRLLGMFMEIANAVDAVVLEDY
NKGVLTPSLIVSLIAACRERNKPVLVDPKLKGFFSYGGCSVFKPNLSELAASLGIPVANDDREVEQACLLLGEKLTVESL
VVTRSEKGMTVYDGSFTHIPALSLDVADVSGAGDTVIGTLALGLASGLDLVTSTRIANLAANTVCQEVGAVPVRPDKLFS
ACLAHLQ
>Mature_326_residues
TPEKIEQIFRSFKEKKIAVIGDVMIDKYIFGHVSRISPEYPVPVVDVNRESSRLGGAANVAVNIHALGAEALLIGVTGDD
TERRNLEALMTEHGLNPAMLAADSTRPTTCKTRILSQNHHITRVDYESRTPVDAELEKRLLGMFMEIANAVDAVVLEDYN
KGVLTPSLIVSLIAACRERNKPVLVDPKLKGFFSYGGCSVFKPNLSELAASLGIPVANDDREVEQACLLLGEKLTVESLV
VTRSEKGMTVYDGSFTHIPALSLDVADVSGAGDTVIGTLALGLASGLDLVTSTRIANLAANTVCQEVGAVPVRPDKLFSA
CLAHLQ

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=313, Percent_Identity=39.6166134185303, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 35124; Mature: 34993

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEKIEQIFRSFKEKKIAVIGDVMIDKYIFGHVSRISPEYPVPVVDVNRESSRLGGAAN
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHCCCCEE
VAVNIHALGAEALLIGVTGDDTERRNLEALMTEHGLNPAMLAADSTRPTTCKTRILSQNH
EEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCC
HITRVDYESRTPVDAELEKRLLGMFMEIANAVDAVVLEDYNKGVLTPSLIVSLIAACRER
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
NKPVLVDPKLKGFFSYGGCSVFKPNLSELAASLGIPVANDDREVEQACLLLGEKLTVESL
CCCEEECCCHHCEEECCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHH
VVTRSEKGMTVYDGSFTHIPALSLDVADVSGAGDTVIGTLALGLASGLDLVTSTRIANLA
EEEECCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ANTVCQEVGAVPVRPDKLFSACLAHLQ
HHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEKIEQIFRSFKEKKIAVIGDVMIDKYIFGHVSRISPEYPVPVVDVNRESSRLGGAAN
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHCCCCEE
VAVNIHALGAEALLIGVTGDDTERRNLEALMTEHGLNPAMLAADSTRPTTCKTRILSQNH
EEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCC
HITRVDYESRTPVDAELEKRLLGMFMEIANAVDAVVLEDYNKGVLTPSLIVSLIAACRER
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
NKPVLVDPKLKGFFSYGGCSVFKPNLSELAASLGIPVANDDREVEQACLLLGEKLTVESL
CCCEEECCCHHCEEECCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHH
VVTRSEKGMTVYDGSFTHIPALSLDVADVSGAGDTVIGTLALGLASGLDLVTSTRIANLA
EEEECCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ANTVCQEVGAVPVRPDKLFSACLAHLQ
HHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA