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The map label for this gene is hisD

Identifier: 21673381

GI number: 21673381

Start: 554334

End: 555620

Strand: Reverse

Name: hisD

Synonym: CT0546

Alternate gene names: 21673381

Gene position: 555620-554334 (Counterclockwise)

Preceding gene: 21673383

Following gene: 21673380

Centisome position: 25.78

GC content: 62.47

Gene sequence:

>1287_bases
GTGCTAACGATCTACCATTTCCCCCAGGACGAGGCAGCCCTCAGAGAACAGCTCAACCGGACGGTATCGTTTGATCCCGA
TGCCCAGCGGACGGTCGATGACATTCTGTATCGCGTCAGAACGGAGGGCGATGCCGCCGTGCTCGACTATACCGAGCGCT
TCCAGGGGATACGGCTCTATGACATGCGGGTGCCGGAAGCGGAGATCGAGGCGGCGTACGCGGCGGCTGATCCGGAGTTC
ATCGCCATTCTCGAAGAGGCGTTTGCAAACATCACGGCGTTCCATCGCAACGAGGCGGAGAAAAGCTTTTTCTACGAACA
GAAGGGTGGCGTCATCCTCGGCCAGCGCGTCACGCCGATGGAGAAGGCGCTGCTCTACGTGCCCGGCGGCAAAGCCGCCT
ACCCCTCGTCGGTGCTGATGAATGCCGCGCCTGCGCAGGTGGCCGGCGTCGATGAAATCTCCATGACCACCCCGTGCGAC
GCTGAGGGCAAGGTCAATCCGCACATCCTCGCTGCCGCGAAAGTCGCCGGCATCACCAGCGTCTATCGCCTCGGCGGGGC
ACAGGCCGTGGCGGCGTTCGCCTACGGCACGGCGACCATTCCGAAGGTTGACATCGTCACCGGCCCTGGCAATAAATATG
TCGCACTCGCCAAGAAGCAGGTGTTCGGCCACGTCGCCATCGACAGTATCGCCGGGCCGTCAGAAGTGGTGGTTATCGCC
GACGCAGGCGCGGAGCCGGAATTCATCGTGATGGACATGTTCGCGCAGGCCGAGCACGATCCCGACGCATCAGCGGTGCT
CATCACGCCATCCGCCGAGCTGGCCGACGCCGTGCGGGAGACTGCTGCTCGCCTTGCGGGCACGATGCTTCGTGGCGAGG
TGATCACTCGCGCGCTCACGGATAACGGCGCGATTGTTGTAACCGGTTCGATGCAGGAAGCGTGCAAGGTGTCTGACATG
ATCGCTCCCGAGCACCTCGAACTGCACGTTGACAATCCCTGGGAGATTCTGCCTGACCTGCGTCATGCCGGAGCGATTTT
CATGGGGCAGTGGTCGTGCGAAACGGTCGGCGATTATTTTGCCGGACCGAACCACACGCTGCCAACCAACGGCACGGCGC
GATTCTTCTCGCCGCTCTCGGTGCGCGACTTCGTCAAACACACCTCGATCATCGCCTGGTCGAAGAGCGAGCTTGCCCGC
ACCGGGGAGAAGATCGCCCGCTTCGCCGACCATGAAGGGCTTCAGGCTCACGCCGAGGCGGTTCGCGTCAGACTGAAACA
CCTGTAA

Upstream 100 bases:

>100_bases
GCGGAGTTTCGTTTCAAAGCGCCAATGCTTACATTACGTGACAAGTGTTCAAAACCCGGCATATCGAAGCCACACTATTA
TTATAAAACAGAGAAGCGCA

Downstream 100 bases:

>100_bases
CAATGAAGGTCAGCGATTTCGATTACGCCCTTCCCGAAGAGCGCATCGCCTGTTATCCTCCCGCAAAACGCGGTTCGACG
AGACTGATTGTGCTCAATCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLYDMRVPEAEIEAAYAAADPEF
IAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPMEKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCD
AEGKVNPHILAAAKVAGITSVYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIA
DAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALTDNGAIVVTGSMQEACKVSDM
IAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELAR
TGEKIARFADHEGLQAHAEAVRVRLKHL

Sequences:

>Translated_428_residues
MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLYDMRVPEAEIEAAYAAADPEF
IAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPMEKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCD
AEGKVNPHILAAAKVAGITSVYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIA
DAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALTDNGAIVVTGSMQEACKVSDM
IAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELAR
TGEKIARFADHEGLQAHAEAVRVRLKHL
>Mature_428_residues
MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLYDMRVPEAEIEAAYAAADPEF
IAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPMEKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCD
AEGKVNPHILAAAKVAGITSVYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIA
DAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALTDNGAIVVTGSMQEACKVSDM
IAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELAR
TGEKIARFADHEGLQAHAEAVRVRLKHL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=418, Percent_Identity=37.3205741626794, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6319819, Length=431, Percent_Identity=34.8027842227378, Blast_Score=246, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CHLTE (Q8KEY6)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661446.1
- ProteinModelPortal:   Q8KEY6
- SMR:   Q8KEY6
- GeneID:   1006212
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0546
- NMPDR:   fig|194439.1.peg.540
- TIGR:   CT0546
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   CTEP194439:CT_0546-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46264; Mature: 46264

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 324-324 ACT_SITE 325-325 BINDING 126-126 BINDING 188-188 BINDING 211-211 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 325-325 BINDING 358-358 BINDING 412-412 BINDING 417-417

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLY
CEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCEEEE
DMRVPEAEIEAAYAAADPEFIAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPM
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEECCCCCH
EKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCDAEGKVNPHILAAAKVAGITS
HHEEEECCCCCCCCCHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHH
VYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIA
HHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEHHHHHCEEEECCCCCCCEEEEEE
DAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALT
ECCCCCCEEEEEHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
DNGAIVVTGSMQEACKVSDMIAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYF
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEECCCHHHHHHHC
AGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELARTGEKIARFADHEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHH
VRVRLKHL
HHHHHHCC
>Mature Secondary Structure
MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLY
CEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCEEEE
DMRVPEAEIEAAYAAADPEFIAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPM
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEECCCCCH
EKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCDAEGKVNPHILAAAKVAGITS
HHEEEECCCCCCCCCHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHH
VYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIA
HHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEHHHHHCEEEECCCCCCCEEEEEE
DAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALT
ECCCCCCEEEEEHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
DNGAIVVTGSMQEACKVSDMIAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYF
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEECCCHHHHHHHC
AGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELARTGEKIARFADHEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHH
VRVRLKHL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901