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The map label for this gene is glmS

Identifier: 21672971

GI number: 21672971

Start: 124386

End: 126230

Strand: Direct

Name: glmS

Synonym: CT0130

Alternate gene names: 21672971

Gene position: 124386-126230 (Clockwise)

Preceding gene: 21672970

Following gene: 21672972

Centisome position: 5.77

GC content: 58.1

Gene sequence:

>1845_bases
ATGTGCGGAATCATTGGTTATATCGGCAGGCGCGAAGCTGCGCCTCTCTTGCTGAACGGTTTGAAACGGCTGGAGTATCG
CGGTTATGACTCGGCAGGCATGGCCGTCCTGAACGGCTCGATGAAGATGCTCAAAAAGAAGGGGAGCGTCAGCAATCTTG
AAGAGCTTCTGAATGTGTCGGGCACCGTCATGCTCGGCGCGACGGTCGGCATCGCCCACACCCGCTGGGCGACCCATGGC
GATCCGAGCGACCGGAATGCTCATCCTCACATGAATGTTTCCGGCGATATCGCCCTGATCCACAACGGCATCATCGAAAA
CTATTCTGCCCTCAAGCAGGAGTTGATGGGCGAGGGCTATGTCTTTGAAAGTGATACCGATTCAGAGGTGCTCGTTCACC
TGATTGACCGCATCTGGAAAAACGATTCGGCGCTCGGTCTTGAAGGTGCGGTGCGTCAGGCGCTCCGGCATGTCGAGGGC
GCATATGGTATCTGCGTCGTCTCCTCGCGCGAGCCGGACAAGATCGTGGTGGCTCGCAAGGGCAGCCCTTTGGTGATCGG
TCTCGGTGATGGCGAGTTCTTCATCGCTTCCGATGCGGCACCCATCGTCGAGCACACCAACAAGGTGGTTTATCTGTCGG
ACGGAGAGATGGCGGTTGTGACGCGCGACAGCTACACGGTCAAGACGATTGAAAATGTCGAGCAGCAAAAAAGGGTGACG
GAGCTCGACTTCAGCCTTGAAAAGATCGAGAAGGGCGGGTTCGAGCACTTCATGCTCAAGGAGATTTTCGAGCAGCCCGA
GGTGATGCGCGATGTCATGCGTGGCCGGGTGCGTGTCGAGGAGGGACGGGTGCATCTTGGTGGCATCCACGACTATCTCG
ACCGGCTGAAGCAGGCCAAGCGGATCATGATCTGCGCCTGTGGCACGAGCTGGCACGCCGGTCTGATCGGTGAGTATCTG
ATCGAGGAGTTTGCCCGGATTCCGGTAGAGGTCGATTACGCCTCGGAGTTCAGGTACCGCAACCCGATTGTCTCTTCCGA
CGATGTGGTGATCGTGATCTCCCAGTCGGGCGAAACCGCCGACACGCTGGCCGCACTCAGGCTGGCCAAGGAGAAGGGGG
CCATGGTGATGGGAATCTGCAATGTGGTCGGTTCGACGATTCCGCGCGAGACGCTGTGCGGCATGTACACCCACGCTGGG
CCTGAGGTGGGCGTGGCCTCGACCAAGGCGTTTACGGCGCAGGTGATAGTGCTCTTCATGCTCGCTATGGCGTTGAGCAA
AGGGCGCACCATTTCGCAGGAGGAGATCAAGCTCAATCTGAGGGAGCTGGCTGAAGTGCCGGACAAGGTTGCATGGATTC
TGGAGCAGAACGACGCGATCAAGGAGATTGCCGTCAAGCTCAAGGATGCACGCAACGCGCTTTATCTTGGCCGGGGATAT
AACTTCCCCGTTGCGCTCGAAGGCGCGCTGAAACTCAAGGAGATTTCCTACATCCATGCCGAGGGCTATCCAGCCGCCGA
GATGAAGCACGGTCCGATCGCCCTGATTGACGAGGATATGCCGGTAATCGTTATTGCCACCCGTGACAATACCTATGCCA
AGATTCTGAGCAACATCGAGGAGGTTCGTAGCCGCAAAGGAAGGGTGATCGCCATCGCCAGTGAAGGTGACCGGGAGATC
GAGCGGCTGACGGAAGATGTGATCTACATCCCGCAGGCTTCCGCCGCAGTACTGCCGCTGCTGACGGTTATTCCGCTGCA
ACTGCTCTCTTATCACGTAGCAACGCTGCGCGGCTGTAACGTCGATCGTCCTCGCAACCTCGCCAAGTCGGTGACGGTGG
AGTAG

Upstream 100 bases:

>100_bases
TGGGAGCAGAATTCTTTTCATAATACGGTTTTTTTTGCCTCAAAAGGGTGCGGCTACCGGCAGGAAGCAGCGGTAACGTT
TTACAAAAGATTGTTTATCT

Downstream 100 bases:

>100_bases
CGATTTTTTTCTCGATTCAGCTCCTTCCCTTTTGCTGCGTCAGACAGGCGAAAGGGGGGCTTTTTACCTTGATAGACCCT
CCAAAAAAAGATAAAGAGCA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MCGIIGYIGRREAAPLLLNGLKRLEYRGYDSAGMAVLNGSMKMLKKKGSVSNLEELLNVSGTVMLGATVGIAHTRWATHG
DPSDRNAHPHMNVSGDIALIHNGIIENYSALKQELMGEGYVFESDTDSEVLVHLIDRIWKNDSALGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEFFIASDAAPIVEHTNKVVYLSDGEMAVVTRDSYTVKTIENVEQQKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRVRVEEGRVHLGGIHDYLDRLKQAKRIMICACGTSWHAGLIGEYL
IEEFARIPVEVDYASEFRYRNPIVSSDDVVIVISQSGETADTLAALRLAKEKGAMVMGICNVVGSTIPRETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRELAEVPDKVAWILEQNDAIKEIAVKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
ERLTEDVIYIPQASAAVLPLLTVIPLQLLSYHVATLRGCNVDRPRNLAKSVTVE

Sequences:

>Translated_614_residues
MCGIIGYIGRREAAPLLLNGLKRLEYRGYDSAGMAVLNGSMKMLKKKGSVSNLEELLNVSGTVMLGATVGIAHTRWATHG
DPSDRNAHPHMNVSGDIALIHNGIIENYSALKQELMGEGYVFESDTDSEVLVHLIDRIWKNDSALGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEFFIASDAAPIVEHTNKVVYLSDGEMAVVTRDSYTVKTIENVEQQKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRVRVEEGRVHLGGIHDYLDRLKQAKRIMICACGTSWHAGLIGEYL
IEEFARIPVEVDYASEFRYRNPIVSSDDVVIVISQSGETADTLAALRLAKEKGAMVMGICNVVGSTIPRETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRELAEVPDKVAWILEQNDAIKEIAVKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
ERLTEDVIYIPQASAAVLPLLTVIPLQLLSYHVATLRGCNVDRPRNLAKSVTVE
>Mature_614_residues
MCGIIGYIGRREAAPLLLNGLKRLEYRGYDSAGMAVLNGSMKMLKKKGSVSNLEELLNVSGTVMLGATVGIAHTRWATHG
DPSDRNAHPHMNVSGDIALIHNGIIENYSALKQELMGEGYVFESDTDSEVLVHLIDRIWKNDSALGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEFFIASDAAPIVEHTNKVVYLSDGEMAVVTRDSYTVKTIENVEQQKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRVRVEEGRVHLGGIHDYLDRLKQAKRIMICACGTSWHAGLIGEYL
IEEFARIPVEVDYASEFRYRNPIVSSDDVVIVISQSGETADTLAALRLAKEKGAMVMGICNVVGSTIPRETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRELAEVPDKVAWILEQNDAIKEIAVKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
ERLTEDVIYIPQASAAVLPLLTVIPLQLLSYHVATLRGCNVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=681, Percent_Identity=40.5286343612335, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=40.7624633431085, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=45.9546925566343, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1788651, Length=221, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=716, Percent_Identity=38.268156424581, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17539970, Length=711, Percent_Identity=34.8804500703235, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=44.7795823665893, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322745, Length=450, Percent_Identity=43.1111111111111, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=38.4074941451991, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40.4878048780488, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323958, Length=252, Percent_Identity=27.3809523809524, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=41.812865497076, Blast_Score=544, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CHLTE (Q8KG38)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661036.1
- ProteinModelPortal:   Q8KG38
- GeneID:   1006837
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0130
- NMPDR:   fig|194439.1.peg.130
- TIGR:   CT0130
- HOGENOM:   HBG645312
- OMA:   ITIVIAE
- ProtClustDB:   PRK00331
- BioCyc:   CTEP194439:CT_0130-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67578; Mature: 67578

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 609-609

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYIGRREAAPLLLNGLKRLEYRGYDSAGMAVLNGSMKMLKKKGSVSNLEELLNVS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHCCC
GTVMLGATVGIAHTRWATHGDPSDRNAHPHMNVSGDIALIHNGIIENYSALKQELMGEGY
CEEEEEEEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCE
VFESDTDSEVLVHLIDRIWKNDSALGLEGAVRQALRHVEGAYGICVVSSREPDKIVVARK
EECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEC
GSPLVIGLGDGEFFIASDAAPIVEHTNKVVYLSDGEMAVVTRDSYTVKTIENVEQQKRVT
CCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEECCCEEEHHHHHHHHHHHHH
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRVRVEEGRVHLGGIHDYLDRLKQAK
HHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCEEEECCCEEECCHHHHHHHHHHCC
RIMICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRNPIVSSDDVVIVISQSGETA
EEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCCCCEEEEEECCCCCH
DTLAALRLAKEKGAMVMGICNVVGSTIPRETLCGMYTHAGPEVGVASTKAFTAQVIVLFM
HHHHHHHHHHHCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAMALSKGRTISQEEIKLNLRELAEVPDKVAWILEQNDAIKEIAVKLKDARNALYLGRGY
HHHHHHCCCCCCHHHHHCCHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCCEEEEECCC
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIE
CCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
EVRSRKGRVIAIASEGDREIERLTEDVIYIPQASAAVLPLLTVIPLQLLSYHVATLRGCN
HHHHCCCCEEEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
VDRPRNLAKSVTVE
CCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIIGYIGRREAAPLLLNGLKRLEYRGYDSAGMAVLNGSMKMLKKKGSVSNLEELLNVS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCHHHHHHHHCCC
GTVMLGATVGIAHTRWATHGDPSDRNAHPHMNVSGDIALIHNGIIENYSALKQELMGEGY
CEEEEEEEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCE
VFESDTDSEVLVHLIDRIWKNDSALGLEGAVRQALRHVEGAYGICVVSSREPDKIVVARK
EECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEC
GSPLVIGLGDGEFFIASDAAPIVEHTNKVVYLSDGEMAVVTRDSYTVKTIENVEQQKRVT
CCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEECCCEEEHHHHHHHHHHHHH
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRVRVEEGRVHLGGIHDYLDRLKQAK
HHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCEEEECCCEEECCHHHHHHHHHHCC
RIMICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRNPIVSSDDVVIVISQSGETA
EEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCCCCEEEEEECCCCCH
DTLAALRLAKEKGAMVMGICNVVGSTIPRETLCGMYTHAGPEVGVASTKAFTAQVIVLFM
HHHHHHHHHHHCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAMALSKGRTISQEEIKLNLRELAEVPDKVAWILEQNDAIKEIAVKLKDARNALYLGRGY
HHHHHHCCCCCCHHHHHCCHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCCEEEEECCC
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIE
CCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
EVRSRKGRVIAIASEGDREIERLTEDVIYIPQASAAVLPLLTVIPLQLLSYHVATLRGCN
HHHHCCCCEEEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
VDRPRNLAKSVTVE
CCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901