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The map label for this gene is mraY

Identifier: 21672878

GI number: 21672878

Start: 34234

End: 35340

Strand: Reverse

Name: mraY

Synonym: CT0037

Alternate gene names: 21672878

Gene position: 35340-34234 (Counterclockwise)

Preceding gene: 21672879

Following gene: 21672877

Centisome position: 1.64

GC content: 54.83

Gene sequence:

>1107_bases
ATGCTCTATTACATTCTTCGATACATCAACGAACTCTACAGTCTTCCCGGCATGGGGGTCATCGAATATCTGACCTTCAG
GGCCAGCGCGGCGGCCATCACGGCCCTCTTGATCATCATCTTCGCCGGGCAGAGGTTCATCCGCTTTCTCAAGTCGAAAT
TCGTCGAACCAATCAAAGAGGAGGCGCCACCAGAACATCGCAAGAAAAAAGATGTCCCCACGATGGGCGGACTCATGATC
ATTTTCGCTATTGAAGTTTCGGCATTTCTCTGGGCCAAGATCGATGATCCGCATGTCTGGCTCATCATGCTGGCCGTCTT
CTGGATGGGCCTGATCGGCTTCATCGACGACTACCAGAAGGTTGTGCTGAAGGTCAAGGGCGGCCTTGCCGGCCACTACA
AGCTGATCGGGCAGGTAACGCTCGGCCTGGTCATCGGCTTCTACACCTGGAACGATCCCGTTTTTTCGGTACTGCTCTCC
GATACCACCGTACCCTTTTTCAAAAAGCTCTCGGTCGATTATGGCATCTTCTACATTCCGGTGGTAATATTCATCATCAC
GGCGGTCTCCAACGCAGTCAACCTCACCGACGGCCTCGACGGCCTGGCGGCGGGCAATGCGGCCATCGTCACCTTCGCCC
TCGGCGTCTTCGCCTACCTCTGTGGTAACGCGGTCTATTCCGGCTATCTCAGCATCCCCTTCATCTCAGGCGCGGGCGAG
GTTGCCGTGGTAAGTATGGCCATCGTCATGGCGTGTGTGGGATTTCTGTGGTTCAACTCCAGCCCTGCCGAGGTGTTCAT
GGGCGACACCGGTTCTCTCTCGCTCGGTAGCGCCATCGCGGTGATCGCGCTCATGATAAAGCAGGAACTCCTTTTACCGG
TGCTGGCGGGAGTCTTTTTCGTCGAGACCCTTTCGGTTTCGATGCAGGTCGCCTGGTTCAAGATTTCAAAAAAGCTGTAC
GGCGAAGGGCGTCGCATTTTCCTGATGGCGCCGCTGCATCACCATTTTCAGCTGAAGGGATGGGCGGAACAGAAGATCGT
GATCCGTTTCTGGATCATTTCAATCCTGCTCTTTCTGACAAGCCTCATGACCCTGAAACTGCGATAA

Upstream 100 bases:

>100_bases
GGTGACGCGTTGCTCTTCAAGGGGTCTCGCGGAATGAAGCTTGAACTGGCGGCGGACGATCTTATCAAACAGAATCAACA
GCACTCGATCTGAACCGGTA

Downstream 100 bases:

>100_bases
CGTGAAACCGGAAGAGCTGAAAGGGAAAGTGGCGTCGGTGATCGGCGCCGGCAAAAGCGGTGTATCAGCGGCTGGCCTGC
TCGCGCGGGCGGGGGCGCGG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLYYILRYINELYSLPGMGVIEYLTFRASAAAITALLIIIFAGQRFIRFLKSKFVEPIKEEAPPEHRKKKDVPTMGGLMI
IFAIEVSAFLWAKIDDPHVWLIMLAVFWMGLIGFIDDYQKVVLKVKGGLAGHYKLIGQVTLGLVIGFYTWNDPVFSVLLS
DTTVPFFKKLSVDYGIFYIPVVIFIITAVSNAVNLTDGLDGLAAGNAAIVTFALGVFAYLCGNAVYSGYLSIPFISGAGE
VAVVSMAIVMACVGFLWFNSSPAEVFMGDTGSLSLGSAIAVIALMIKQELLLPVLAGVFFVETLSVSMQVAWFKISKKLY
GEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIISILLFLTSLMTLKLR

Sequences:

>Translated_368_residues
MLYYILRYINELYSLPGMGVIEYLTFRASAAAITALLIIIFAGQRFIRFLKSKFVEPIKEEAPPEHRKKKDVPTMGGLMI
IFAIEVSAFLWAKIDDPHVWLIMLAVFWMGLIGFIDDYQKVVLKVKGGLAGHYKLIGQVTLGLVIGFYTWNDPVFSVLLS
DTTVPFFKKLSVDYGIFYIPVVIFIITAVSNAVNLTDGLDGLAAGNAAIVTFALGVFAYLCGNAVYSGYLSIPFISGAGE
VAVVSMAIVMACVGFLWFNSSPAEVFMGDTGSLSLGSAIAVIALMIKQELLLPVLAGVFFVETLSVSMQVAWFKISKKLY
GEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIISILLFLTSLMTLKLR
>Mature_368_residues
MLYYILRYINELYSLPGMGVIEYLTFRASAAAITALLIIIFAGQRFIRFLKSKFVEPIKEEAPPEHRKKKDVPTMGGLMI
IFAIEVSAFLWAKIDDPHVWLIMLAVFWMGLIGFIDDYQKVVLKVKGGLAGHYKLIGQVTLGLVIGFYTWNDPVFSVLLS
DTTVPFFKKLSVDYGIFYIPVVIFIITAVSNAVNLTDGLDGLAAGNAAIVTFALGVFAYLCGNAVYSGYLSIPFISGAGE
VAVVSMAIVMACVGFLWFNSSPAEVFMGDTGSLSLGSAIAVIALMIKQELLLPVLAGVFFVETLSVSMQVAWFKISKKLY
GEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIISILLFLTSLMTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=371, Percent_Identity=44.2048517520216, Blast_Score=298, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_CHLTE (Q8KGD1)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660943.1
- GeneID:   1006455
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0037
- NMPDR:   fig|194439.1.peg.37
- TIGR:   CT0037
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BioCyc:   CTEP194439:CT_0037-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 40770; Mature: 40770

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb648f40)-; HASH(0x403bd2c4)-; HASH(0x403bd564)-; HASH(0x403bd834)-; HASH(0x403bcf58)-; HASH(0x403bd300)-; HASH(0x403bc3a0)-; HASH(0x403be1dc)-; HASH(0x403bd5ac)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYYILRYINELYSLPGMGVIEYLTFRASAAAITALLIIIFAGQRFIRFLKSKFVEPIKE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAPPEHRKKKDVPTMGGLMIIFAIEVSAFLWAKIDDPHVWLIMLAVFWMGLIGFIDDYQK
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLKVKGGLAGHYKLIGQVTLGLVIGFYTWNDPVFSVLLSDTTVPFFKKLSVDYGIFYIP
HHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCHHHHHHCCCCCHHHHH
VVIFIITAVSNAVNLTDGLDGLAAGNAAIVTFALGVFAYLCGNAVYSGYLSIPFISGAGE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECEEECCCCH
VAVVSMAIVMACVGFLWFNSSPAEVFMGDTGSLSLGSAIAVIALMIKQELLLPVLAGVFF
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLSVSMQVAWFKISKKLYGEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIISILLFLT
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
SLMTLKLR
HHHHHCCH
>Mature Secondary Structure
MLYYILRYINELYSLPGMGVIEYLTFRASAAAITALLIIIFAGQRFIRFLKSKFVEPIKE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAPPEHRKKKDVPTMGGLMIIFAIEVSAFLWAKIDDPHVWLIMLAVFWMGLIGFIDDYQK
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLKVKGGLAGHYKLIGQVTLGLVIGFYTWNDPVFSVLLSDTTVPFFKKLSVDYGIFYIP
HHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCHHHHHHCCCCCHHHHH
VVIFIITAVSNAVNLTDGLDGLAAGNAAIVTFALGVFAYLCGNAVYSGYLSIPFISGAGE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECEEECCCCH
VAVVSMAIVMACVGFLWFNSSPAEVFMGDTGSLSLGSAIAVIALMIKQELLLPVLAGVFF
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLSVSMQVAWFKISKKLYGEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIISILLFLT
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
SLMTLKLR
HHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12093901