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The map label for this gene is glmS

Identifier: 21672320

GI number: 21672320

Start: 26225

End: 28051

Strand: Reverse

Name: glmS

Synonym: BUsg027

Alternate gene names: 21672320

Gene position: 28051-26225 (Counterclockwise)

Preceding gene: 21672321

Following gene: 21672317

Centisome position: 4.37

GC content: 27.37

Gene sequence:

>1827_bases
ATGTGTGGTATTGTTGCTGCAGTAACACAACGTAACATAATTGATTTTCTTCTCGAAGGTATTAAAAAATTAGAATATCG
TGGATATGACTCTTCAGGATTAGCTATAATAAATAAAAACCAAAATATTGTTCGGATCCGATGCGTAGGAAGAGTAAATA
AGCTTTTAAAAAAAGTTAAGAAAAAAAAATTATTCAGTAATATTGGTCTTGCTCACACTAGATGGGCTACTCATGGACAA
GTTTCAGAAAAAAATACACATCCTCACATATCTTCACATATTGCAGTAGTCCATAACGGAGTAATTGAAAACAACACAAA
ATTACGACATTTTTTAGAAAAAAAAGGCTATATATTTTATTCAGATACAGATACAGAGGTAATCGCACATTTATTGCATT
GGGAACAAACTAAAACAGGAGAATCACTAGTAGAAGTTATACAAAGGAGCAAAATGAAATTAAACGGAAATTATAGTATG
GTTGTTATGGATGCCTACAATTCATCAAGATTAATAGCCGTTCGCTCTGGAAGTCCTTTAGTTATTGGATTAGGTATCAA
AGAAAACTTTATAGCTTCAGATCAAATTGCATTATTAAATATCACTAAACGTTTTATATATTTAGAAGAAGGAGATACTG
CTATTGTTGAAACCAAAAAAATAAATATTTTTAATAAAAATAATCTTATAATTAAAAGAAAAGAAATTACATCTAATGTA
AAATATAAATCAATAAATAAAGGTAAGTATAAACATTATATGGAAAAAGAAATATATGAACAACCTATTTCAATTCAAAA
TACATTAAATAATCGTATAAAAAAAGACACAATTAATTTTTCCGAATTAGGAGATAGAGAAAAAAAATTTTTTTTAAATG
CAGAACATATTCAAATAGTAGCATGTGGTACATCTTATCATGCTGCAATGGTTTCTAGATATTGGTTTGAATCACTTGCT
AACATTCCATGTGATGTTGAAATAGCTTCTGAATTTTCTTCACGAAAATTAGCAGTTAGAAAAAAAAGTGTTTTTATTAC
CTTATCACAATCTGGTGAAACAGCAGACACATTAGCAGCGCTTAGAATTTCAAAAAAACTAGGTTATCTAGGAAGTTTAA
CTATATGCAATATGAAAGGTTCATCTTTAGTTCAAGAATCTGATTGTTATTTATTAACTAAAGCAGGAATAGAAATAGGA
GTAGCTTCAACAAAATCTTTTACTACACAGTTAACTGTTTTACTAATGTTAATAGCAAAAATAACAAAATTAAAAAAACA
AAAAAATAATATTGAAAAAAAAATTGCACAAATACTAAGTCTTCTACCGTCTAAAGTAGAAGCAATTTTAAAAAAAAACA
CTCTAATTAAAACTCTTGCAAATCAATTATGTAACAAAAAAAATATATTATTTCTCGGACGAGGAGATCAATATCCTATT
GCTATGGAAGGAGCTTTAAAATTAAAAGAAATTTCTTATATTCATGCTGAAGCTTATCCTTCTGGAGAATTGAAGCACGG
TCCTCTTGCATTAATTGATAAAAATATACCAGTTATTATTACAGCACCAAAAAATTCATTACTTGAAAAAACAAAAAAAA
ATATTAAAGAGATATGCGCGAGAGGTGGTATAATTTACGTTTTTTCAGATCAAGAAATTGATTTAGAAAAAAACATGACT
ATTATAAAAATTCCTTACGTAGAAGAAATAATAGCACCTATTTTATATATAATTCCATTGCAATTGCTTGCTTATTATAT
TGCATTGAGTAAAGGAAAAAATATTGATCAACCAAGACATCTTGCAAAATCAGTTACAGTAGAATAA

Upstream 100 bases:

>100_bases
ACGTCCTCAAAAAATCATAAAAAAAACTGATCAATAATATTAAACAATTGATATATTTCATTGTGAAACTATTCAATAAA
AATTAAAAAGGTATATTTCT

Downstream 100 bases:

>100_bases
AATTTTTTTTATTTTTATCTTTAACAAACATAACTTTTTTATCAAAAAAAAGAGTATGAGCGATCAATTTTAAAAACTTA
ATCTCATACTCTATGTAGAT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVAAVTQRNIIDFLLEGIKKLEYRGYDSSGLAIINKNQNIVRIRCVGRVNKLLKKVKKKKLFSNIGLAHTRWATHGQ
VSEKNTHPHISSHIAVVHNGVIENNTKLRHFLEKKGYIFYSDTDTEVIAHLLHWEQTKTGESLVEVIQRSKMKLNGNYSM
VVMDAYNSSRLIAVRSGSPLVIGLGIKENFIASDQIALLNITKRFIYLEEGDTAIVETKKINIFNKNNLIIKRKEITSNV
KYKSINKGKYKHYMEKEIYEQPISIQNTLNNRIKKDTINFSELGDREKKFFLNAEHIQIVACGTSYHAAMVSRYWFESLA
NIPCDVEIASEFSSRKLAVRKKSVFITLSQSGETADTLAALRISKKLGYLGSLTICNMKGSSLVQESDCYLLTKAGIEIG
VASTKSFTTQLTVLLMLIAKITKLKKQKNNIEKKIAQILSLLPSKVEAILKKNTLIKTLANQLCNKKNILFLGRGDQYPI
AMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIITAPKNSLLEKTKKNIKEICARGGIIYVFSDQEIDLEKNMT
IIKIPYVEEIIAPILYIIPLQLLAYYIALSKGKNIDQPRHLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVAAVTQRNIIDFLLEGIKKLEYRGYDSSGLAIINKNQNIVRIRCVGRVNKLLKKVKKKKLFSNIGLAHTRWATHGQ
VSEKNTHPHISSHIAVVHNGVIENNTKLRHFLEKKGYIFYSDTDTEVIAHLLHWEQTKTGESLVEVIQRSKMKLNGNYSM
VVMDAYNSSRLIAVRSGSPLVIGLGIKENFIASDQIALLNITKRFIYLEEGDTAIVETKKINIFNKNNLIIKRKEITSNV
KYKSINKGKYKHYMEKEIYEQPISIQNTLNNRIKKDTINFSELGDREKKFFLNAEHIQIVACGTSYHAAMVSRYWFESLA
NIPCDVEIASEFSSRKLAVRKKSVFITLSQSGETADTLAALRISKKLGYLGSLTICNMKGSSLVQESDCYLLTKAGIEIG
VASTKSFTTQLTVLLMLIAKITKLKKQKNNIEKKIAQILSLLPSKVEAILKKNTLIKTLANQLCNKKNILFLGRGDQYPI
AMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIITAPKNSLLEKTKKNIKEICARGGIIYVFSDQEIDLEKNMT
IIKIPYVEEIIAPILYIIPLQLLAYYIALSKGKNIDQPRHLAKSVTVE
>Mature_608_residues
MCGIVAAVTQRNIIDFLLEGIKKLEYRGYDSSGLAIINKNQNIVRIRCVGRVNKLLKKVKKKKLFSNIGLAHTRWATHGQ
VSEKNTHPHISSHIAVVHNGVIENNTKLRHFLEKKGYIFYSDTDTEVIAHLLHWEQTKTGESLVEVIQRSKMKLNGNYSM
VVMDAYNSSRLIAVRSGSPLVIGLGIKENFIASDQIALLNITKRFIYLEEGDTAIVETKKINIFNKNNLIIKRKEITSNV
KYKSINKGKYKHYMEKEIYEQPISIQNTLNNRIKKDTINFSELGDREKKFFLNAEHIQIVACGTSYHAAMVSRYWFESLA
NIPCDVEIASEFSSRKLAVRKKSVFITLSQSGETADTLAALRISKKLGYLGSLTICNMKGSSLVQESDCYLLTKAGIEIG
VASTKSFTTQLTVLLMLIAKITKLKKQKNNIEKKIAQILSLLPSKVEAILKKNTLIKTLANQLCNKKNILFLGRGDQYPI
AMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIITAPKNSLLEKTKKNIKEICARGGIIYVFSDQEIDLEKNMT
IIKIPYVEEIIAPILYIIPLQLLAYYIALSKGKNIDQPRHLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=36.2573099415205, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=35.5587808417997, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI29570798, Length=269, Percent_Identity=27.1375464684015, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=60.1639344262295, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI87082251, Length=320, Percent_Identity=21.25, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788651, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=37.2685185185185, Blast_Score=281, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=37.2685185185185, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=37.8752886836028, Blast_Score=278, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=455, Percent_Identity=38.4615384615385, Blast_Score=292, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323731, Length=439, Percent_Identity=32.5740318906606, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.5609756097561, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.9186046511628, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_BUCAP (Q8KA75)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660387.1
- ProteinModelPortal:   Q8KA75
- SMR:   Q8KA75
- EnsemblBacteria:   EBBUCT00000000306
- GeneID:   1005843
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg027
- GeneTree:   EBGT00050000007826
- HOGENOM:   HBG645312
- OMA:   TGIFAYM
- ProtClustDB:   PRK00331
- BioCyc:   BAPH198804:BUSG027-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 68478; Mature: 68478

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 603-603

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVAAVTQRNIIDFLLEGIKKLEYRGYDSSGLAIINKNQNIVRIRCVGRVNKLLKKVK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHH
KKKLFSNIGLAHTRWATHGQVSEKNTHPHISSHIAVVHNGVIENNTKLRHFLEKKGYIFY
HHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHCEEEEECCEECCCHHHHHHHHHCCEEEE
SDTDTEVIAHLLHWEQTKTGESLVEVIQRSKMKLNGNYSMVVMDAYNSSRLIAVRSGSPL
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCEEEEEEEECCCCEEEEEECCCCE
VIGLGIKENFIASDQIALLNITKRFIYLEEGDTAIVETKKINIFNKNNLIIKRKEITSNV
EEEECCCCCCCCCCCEEEEEEEEEEEEEECCCEEEEEEEEEEEEECCCEEEEEHHHCCCC
KYKSINKGKYKHYMEKEIYEQPISIQNTLNNRIKKDTINFSELGDREKKFFLNAEHIQIV
CEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCEEEEE
ACGTSYHAAMVSRYWFESLANIPCDVEIASEFSSRKLAVRKKSVFITLSQSGETADTLAA
EECCCHHHHHHHHHHHHHHCCCCCCEEHHHCCCCCEEEEEEEEEEEEEECCCCCHHHHHH
LRISKKLGYLGSLTICNMKGSSLVQESDCYLLTKAGIEIGVASTKSFTTQLTVLLMLIAK
HHHHHHCCCCCCEEEEECCCCCCEECCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHH
ITKLKKQKNNIEKKIAQILSLLPSKVEAILKKNTLIKTLANQLCNKKNILFLGRGDQYPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCE
AMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIITAPKNSLLEKTKKNIKEICA
EECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGIIYVFSDQEIDLEKNMTIIKIPYVEEIIAPILYIIPLQLLAYYIALSKGKNIDQPRH
CCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVAAVTQRNIIDFLLEGIKKLEYRGYDSSGLAIINKNQNIVRIRCVGRVNKLLKKVK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHH
KKKLFSNIGLAHTRWATHGQVSEKNTHPHISSHIAVVHNGVIENNTKLRHFLEKKGYIFY
HHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHCEEEEECCEECCCHHHHHHHHHCCEEEE
SDTDTEVIAHLLHWEQTKTGESLVEVIQRSKMKLNGNYSMVVMDAYNSSRLIAVRSGSPL
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCEEEEEEEECCCCEEEEEECCCCE
VIGLGIKENFIASDQIALLNITKRFIYLEEGDTAIVETKKINIFNKNNLIIKRKEITSNV
EEEECCCCCCCCCCCEEEEEEEEEEEEEECCCEEEEEEEEEEEEECCCEEEEEHHHCCCC
KYKSINKGKYKHYMEKEIYEQPISIQNTLNNRIKKDTINFSELGDREKKFFLNAEHIQIV
CEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCEEEEE
ACGTSYHAAMVSRYWFESLANIPCDVEIASEFSSRKLAVRKKSVFITLSQSGETADTLAA
EECCCHHHHHHHHHHHHHHCCCCCCEEHHHCCCCCEEEEEEEEEEEEEECCCCCHHHHHH
LRISKKLGYLGSLTICNMKGSSLVQESDCYLLTKAGIEIGVASTKSFTTQLTVLLMLIAK
HHHHHHCCCCCCEEEEECCCCCCEECCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHH
ITKLKKQKNNIEKKIAQILSLLPSKVEAILKKNTLIKTLANQLCNKKNILFLGRGDQYPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCE
AMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIITAPKNSLLEKTKKNIKEICA
EECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGIIYVFSDQEIDLEKNMTIIKIPYVEEIIAPILYIIPLQLLAYYIALSKGKNIDQPRH
CCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438