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The map label for this gene is malY [C]

Identifier: 213693170

GI number: 213693170

Start: 2578060

End: 2579313

Strand: Direct

Name: malY [C]

Synonym: Blon_2320

Alternate gene names: 213693170

Gene position: 2578060-2579313 (Clockwise)

Preceding gene: 213693169

Following gene: 213693172

Centisome position: 91.01

GC content: 61.0

Gene sequence:

>1254_bases
ATGAGCATGAACAACATTCCCCAGTCAACGACTGTGAGCAACGCAACCGCCGGCGTCTCTTGCTTTGATGCCAATCACAT
CGACGTGACGACCATCGAGGATCTGGAGCAGGTCGGTTCGGATAAATGGACCCGTTACCCCGGCTGCATCGGCGCATTCA
TCGCCGAGATGGATTACGGTCTGGCACCGTGCGTGGCCGAAGCCATCGAAGAGGCCACTGAACGTGGCGCGCTCGGCTAC
ATTCCCGACCCATGGAAGAAGGAGGTCGCCCGCTCGTGCGCCGCATGGCAGCGCCGCTACGGCTGGGAGGTGGATCCAAC
GTGCATCCGCCCGGTGCCGGACGTGCTGGAGGCGTTCGAAGTGTTCCTGCGCGAGATCGTGCGCGCCGGTAACTCCATCG
TGGTACCGACTCCGGCCTATATGCCGTTCCTAAGTGTGCCGCGTCTGTATGGCGTGGAGGTCCTTGAGATTCCGATGCTG
TGCGCGGGCGCCGGCGAGAGCAGCGGGCGCAATGATGAATGGCTGTTCGATTTCGACGCCATTGAGCAGGCGTTCGCGAA
CGGCTGCCATGCCTTCGTGCTGTGCAACCCGCACAACCCGATCGGCAAGGTATTGACGCGCGAGGAAATGCTGCGATTGT
CCGATCTGGCCGCCAAGTACGACGTGCGTATATTCTCCGATGAGATTCACGCGCCGTTCGTCTACCAAGGCCACACGCAT
GTGCCATTCGCCTCAATCAACCGGCAGACGGCCATGCAGGCTTTCACCTCCACTTCAGCCTCGAAGTCGTTCAACATTCC
CGGCACCAAGTGCGCGCAGGTGATTCTCACCAATCCGGATGATCTGGAACTATGGATGAGGAACGCGGAATGGTCCGAGC
ACCAGACGGCCACCATCGGTGCCATAGCCACCACTGCGGCCTATGACGGCGGCGCGGCATGGTTCGAGGGCGTGATGGCA
TATATCGAGCGCAATATCGCGCTGGTCAACGAGCAGATGCGCACGAGATTCGCCAAGGTGCGCTATGTGGAGCCGCAGGG
CACGTATATCGCGTGGCTGGATTTCTCGTCACTGGGCATCGATGACCCGGCCGACTATTTCTTCAAGAAGGCCAACGTGG
CGTTGACAGACGGCCGTGAATGCGGCGAGGTCGGGCGCGGTTGCGTGCGTATGAACTTCGCCATGCCCTACCCGCTACTG
GAGGAATGCTTCGACCGCATGGCCGCCGCGCTCGAGGCGGACGGGCTGTTGTAG

Upstream 100 bases:

>100_bases
CAAGTAGTCGCACAGCGATAAGCAAGCTTGCGAGCGCCATCACGATTTCGGGGAGCCAGACCGTTGAGCGGCCCTTCTGC
ACCGGGAACAATGGCATGTT

Downstream 100 bases:

>100_bases
AACAAAATCGCGGCTCCCCTCAAAGAGGGGAGCCGAGGAACGGCCGAATTAGTCGAAGTCGGCGCCGAGGGCTTCGAGTT
TGCCTCGGAAGTCGGCGTAG

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSMNNIPQSTTVSNATAGVSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYGLAPCVAEAIEEATERGALGY
IPDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFEVFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPML
CAGAGESSGRNDEWLFDFDAIEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTH
VPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIGAIATTAAYDGGAAWFEGVMA
YIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSSLGIDDPADYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLL
EECFDRMAAALEADGLL

Sequences:

>Translated_417_residues
MSMNNIPQSTTVSNATAGVSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYGLAPCVAEAIEEATERGALGY
IPDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFEVFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPML
CAGAGESSGRNDEWLFDFDAIEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTH
VPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIGAIATTAAYDGGAAWFEGVMA
YIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSSLGIDDPADYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLL
EECFDRMAAALEADGLL
>Mature_416_residues
SMNNIPQSTTVSNATAGVSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYGLAPCVAEAIEEATERGALGYI
PDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFEVFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPMLC
AGAGESSGRNDEWLFDFDAIEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTHV
PFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIGAIATTAAYDGGAAWFEGVMAY
IERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSSLGIDDPADYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLLE
ECFDRMAAALEADGLL

Specific function: Acts As A Beta-Cystathionase And As A Repressor Of The Maltose Regulon. [C]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=156, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI56713254, Length=156, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI95147551, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169881279, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169881281, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787909, Length=367, Percent_Identity=29.700272479564, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322401, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573069, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24646114, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573067, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573065, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 46188; Mature: 46056

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNNIPQSTTVSNATAGVSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYG
CCCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
LAPCVAEAIEEATERGALGYIPDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
VFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPMLCAGAGESSGRNDEWLFDFDA
HHHHHHHHCCCEEEECCCCCCHHHCCCHHHCCHHEECCHHEECCCCCCCCCCCEEEEHHH
IEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTH
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEECCCCC
VPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIG
CCHHHCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCHHHHCCCCCCCCCCCEEHH
AIATTAAYDGGAAWFEGVMAYIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSSLGI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCC
DDPADYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLLEECFDRMAAALEADGLL
CCCHHHHHHHCCEEEECCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SMNNIPQSTTVSNATAGVSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYG
CCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
LAPCVAEAIEEATERGALGYIPDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
VFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPMLCAGAGESSGRNDEWLFDFDA
HHHHHHHHCCCEEEECCCCCCHHHCCCHHHCCHHEECCHHEECCCCCCCCCCCEEEEHHH
IEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTH
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEECCCCC
VPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIG
CCHHHCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCHHHHCCCCCCCCCCCEEHH
AIATTAAYDGGAAWFEGVMAYIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSSLGI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCC
DDPADYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLLEECFDRMAAALEADGLL
CCCHHHHHHHCCEEEECCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]