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The map label for this gene is nox [H]

Identifier: 213693172

GI number: 213693172

Start: 2580936

End: 2582282

Strand: Direct

Name: nox [H]

Synonym: Blon_2322

Alternate gene names: 213693172

Gene position: 2580936-2582282 (Clockwise)

Preceding gene: 213693170

Following gene: 213693176

Centisome position: 91.11

GC content: 64.51

Gene sequence:

>1347_bases
ATGACCACAGTCGCCGTCATCGGCTGCACGCACGCCGGCACGTTCGCCACCACTTCGATTCTCGCCGAGCATCCCGATTG
GACCGTCCATGTTTTCGAGCGCAACGGTACGCTGTCCTTCCTCTCCTGCGGCATCGCCCTGTGGGTGGGCGACCACGTGT
CCGACCCGAAGAAAATGTTCTACTCCTCCCCTGCCGCTCTGGCCGAAGCCGGCGCGACCATGCACATGCGCACCGACGTG
ACGTCCGTGGACCTCGACGCCAGAACCCTCACCTACCGCGCGCTGGACGAGGCCGGAGACCCCGCCGAGCAGACCCTCGC
TTTCGACAAACTGGTCGTGACCACCGGATCGCGCCCGGTCATCCCGCCAATCCCCGGCATCGACAGCCCGCATGTGCTGC
TGTGCAAGAACTGGGATCACGCCATCGCCATCAAGGAGAAGGCGAAAACCGCCAAGTCCGCGGTGGTGATCGGTTCGGGC
TATATCGGCGCGGAAATCGCCGAGCAGTTCAGCGTCACCGGCGTCAAGACCACGCTGGTCGACGGCCTTGATCGTCCGCT
GGCCAATAATTTCGATAAGACCATCACCGATCAGGTGGCGGCCGCGTTCGAGGAGCACGGCGTCACGCTCGCGCTCGGCC
AGAAGGTGGTCGCGTTCCGCGACAATGACGACGACACCGTCACCGTGGTCACCGAAAAGGGCGAGTACACGGCCGAGATG
GCGATTCTGGCCGTCGGCTTCCTGCCGAACACCGACCTGCTCAAGGGCAAGGTGGACATGCTGCCGAACGGCGCGATCGT
GGTCGACGACTACATGCAGGCGTCCGTGCCGGGCGTGTACGCCGCCGGCGACTCCGCCACCGTGTTCTACAACCCCACCG
GCCAGCACGATTACATTCCGCTGGCCACCAACGCGGTGCGCCAGGGCCTGCTGGTGGGCCGCAACATCGAGACGCCGACC
GTGAAGTACATGGGCACGCAGGCCACGTCCGCCGTGCAGCTGTACGATCTCTCGCTCGCCGCCTCCGGCCTGACCTGCGC
CGGTGCCGAACGCCGCGGGCTCACGGTCCGCGAGACCTCGCTCACCGAGGATTATCGCCCGGACTTCATGCTCATCACCA
CCCCAGTCACGTCGATTCTGACCTGGGACCCGGAAACCCGCAAGGTCAAGGGCGGCCAGTTCTGTTCCAAAGCCGATATC
TCCGGCGCGGCAAATGTGATTTCCATGGCGATTCAGGCCGGCTTCACCATCGACCAGCTCGCCAACGTGGACTTCCTGTT
CCAGCCGAACTTCGACAAGCCCGTCTATTACGTGGGTGCCGTGGCCATGAAGGCGGCGGCCAAGTAA

Upstream 100 bases:

>100_bases
TGATCTTCCTCACATTTGCCGCCACGGCGTTCTCCATACTTCTACGCTACGATTCAGGGCAATGGCATCAGACGCCATGG
CCACAAGCAAAGGAGCATTT

Downstream 100 bases:

>100_bases
GACGGCCGTACTCACCGCAAAAAGAAACCCCGGCGTGATGGGCGCCGGGGAGAGAAAGGAGAGAAGAAAGAGGTTAAGTT
ATGCAGCTTGTTCGGCCGTG

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMFYSSPAALAEAGATMHMRTDV
TSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPVIPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSG
YIGAEIAEQFSVTGVKTTLVDGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVAFRDNDDDTVTVVTEKGEYTAEM
AILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASVPGVYAAGDSATVFYNPTGQHDYIPLATNAVRQGLLVGRNIETPT
VKYMGTQATSAVQLYDLSLAASGLTCAGAERRGLTVRETSLTEDYRPDFMLITTPVTSILTWDPETRKVKGGQFCSKADI
SGAANVISMAIQAGFTIDQLANVDFLFQPNFDKPVYYVGAVAMKAAAK

Sequences:

>Translated_448_residues
MTTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMFYSSPAALAEAGATMHMRTDV
TSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPVIPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSG
YIGAEIAEQFSVTGVKTTLVDGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVAFRDNDDDTVTVVTEKGEYTAEM
AILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASVPGVYAAGDSATVFYNPTGQHDYIPLATNAVRQGLLVGRNIETPT
VKYMGTQATSAVQLYDLSLAASGLTCAGAERRGLTVRETSLTEDYRPDFMLITTPVTSILTWDPETRKVKGGQFCSKADI
SGAANVISMAIQAGFTIDQLANVDFLFQPNFDKPVYYVGAVAMKAAAK
>Mature_447_residues
TTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMFYSSPAALAEAGATMHMRTDVT
SVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPVIPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSGY
IGAEIAEQFSVTGVKTTLVDGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVAFRDNDDDTVTVVTEKGEYTAEMA
ILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASVPGVYAAGDSATVFYNPTGQHDYIPLATNAVRQGLLVGRNIETPTV
KYMGTQATSAVQLYDLSLAASGLTCAGAERRGLTVRETSLTEDYRPDFMLITTPVTSILTWDPETRKVKGGQFCSKADIS
GAANVISMAIQAGFTIDQLANVDFLFQPNFDKPVYYVGAVAMKAAAK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=229, Percent_Identity=24.4541484716157, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI21389617, Length=229, Percent_Identity=24.4541484716157, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI65787454, Length=229, Percent_Identity=24.4541484716157, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789065, Length=218, Percent_Identity=25.6880733944954, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789915, Length=209, Percent_Identity=29.1866028708134, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789765, Length=194, Percent_Identity=28.3505154639175, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=226, Percent_Identity=26.9911504424779, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585130, Length=189, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281359715, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281359713, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639250, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18543267, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639252, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639257, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47796; Mature: 47665

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMF
CCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEECCEEEEECCCCCCHHHHH
YSSPAALAEAGATMHMRTDVTSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPV
HCCCHHHHHCCCEEEEECCCEEEECCCCEEEEEEHHCCCCCHHHHHEEEEEEEECCCCCC
IPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSGYIGAEIAEQFSVTGVKTTLV
CCCCCCCCCCCEEEECCCCCEEEEHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHH
DGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVAFRDNDDDTVTVVTEKGEYTAEM
HCCCCHHHCCCCHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCEEEEEEECCCCEEEE
AILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASVPGVYAAGDSATVFYNPTGQHDYIP
EEEEEECCCCCHHCCCCHHCCCCCCEEEECCHHCCCCEEEECCCCEEEEECCCCCCCEEE
LATNAVRQGLLVGRNIETPTVKYMGTQATSAVQLYDLSLAASGLTCAGAERRGLTVRETS
ECHHHHHCCCEECCCCCCCEEEEECCCCCCEEEEEEEEEECCCCEECCCCCCCCEEEECC
LTEDYRPDFMLITTPVTSILTWDPETRKVKGGQFCSKADISGAANVISMAIQAGFTIDQL
CCCCCCCCEEEEECCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHH
ANVDFLFQPNFDKPVYYVGAVAMKAAAK
CCEEEEECCCCCCCEEEEHHHHHHHCCC
>Mature Secondary Structure 
TTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMF
CEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEECCEEEEECCCCCCHHHHH
YSSPAALAEAGATMHMRTDVTSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPV
HCCCHHHHHCCCEEEEECCCEEEECCCCEEEEEEHHCCCCCHHHHHEEEEEEEECCCCCC
IPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSGYIGAEIAEQFSVTGVKTTLV
CCCCCCCCCCCEEEECCCCCEEEEHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHH
DGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVAFRDNDDDTVTVVTEKGEYTAEM
HCCCCHHHCCCCHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCEEEEEEECCCCEEEE
AILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASVPGVYAAGDSATVFYNPTGQHDYIP
EEEEEECCCCCHHCCCCHHCCCCCCEEEECCHHCCCCEEEECCCCEEEEECCCCCCCEEE
LATNAVRQGLLVGRNIETPTVKYMGTQATSAVQLYDLSLAASGLTCAGAERRGLTVRETS
ECHHHHHCCCEECCCCCCCEEEEECCCCCCEEEEEEEEEECCCCEECCCCCCCCEEEECC
LTEDYRPDFMLITTPVTSILTWDPETRKVKGGQFCSKADISGAANVISMAIQAGFTIDQL
CCCCCCCCEEEEECCCCEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHH
ANVDFLFQPNFDKPVYYVGAVAMKAAAK
CCEEEEECCCCCCCEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]