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The map label for this gene is pyrC [H]

Identifier: 213692324

GI number: 213692324

Start: 1607532

End: 1609028

Strand: Reverse

Name: pyrC [H]

Synonym: Blon_1449

Alternate gene names: 213692324

Gene position: 1609028-1607532 (Counterclockwise)

Preceding gene: 213692325

Following gene: 213692323

Centisome position: 56.8

GC content: 63.46

Gene sequence:

>1497_bases
GTGAGCATCACCCTACGCAACATCAAGGTCTGGAACACCGGCGAAGTCATCGACCTCGTGGTGCCCGGGACCGCTGCCGC
CTACTTCGCCGACACCTCCGCCGTGGCTGACGGTGCCGATATCGACGCCACCGGACTGACCGTGGCCCCCGGTTTCGAAG
ACCCGCACGTCCACTTCCGCGATCCCGGCCAGACCTACAAGGAATCTATGGTCTCCGGCTGCCGCGCGTCCGCATCCGGC
GGATACACGAACGTGCTCATCATGCCGAACACGTTGCCGGCACTGGATGGGCAGACCGTGTCTGACCTGGAAGCGGCCGG
TGCGAAAGAGGTTCTGGATGCCGGCTTCGACAACGTCATCGACTTCCTGCAGCAGTACGATACTGCGCACGATGTTCAAT
TGCCGGTTCGTTACGATCTGTGCGTGTGCGCGTCCAAGGATCGCGCCGGTCATGAGGCAAGCGACGTTGCCGACTGGCTC
AGGTACGTGCCCGGATTCGAGGACGACGCCAAGACGCCGGCCATGCTCACGCACCCCATCACCGCAATTAGCGACGACGG
TTCCGCTGTGACGCCGGAGATCCTGGACCAGGTGCTGGAGAACGTCAAGGCCTCCGACCTGTACCTAATCGAGCATTGCG
AGCATCACGATACAGGTGCCGTGAACGAAGGCCCGGTCTCGCGCGAACTTGGCGTGCCTGGCATTCCGGAAGACACCGAG
CTCAAGATCGTGGCCCGCGATATAGAAGCGGCCCGCCGCACTGGTGTCCACGTACACTTCCAACATGTGAGCACTGCCAT
CTCGTTCGAGGCGATTCGCAAGGCCAAGGCCGAAGGATTGCCAATCACCTGCGAGACCGCGCCGCACTATCTGGCGTTGA
GCGACGAGGCGCTGCTCAAGTACGGCACGCTCGCCAAGATGAATCCGCCGCTGCGCTCCGAAGCGGACCGCAAAGCCACC
ATCGCGGCCATCGCCGACGGCACCGTGGATCTGCTGGCCACCGACCATGCGCCGCACACGTTGGCAGAGAAGGAACTCGG
CTTCCTTGAGGCACCCAACGGCATCATCGGACTGGAATGCGCGTACGGCGTGTGCCACAAGGTGCTCGTCGACGGCGGCT
TCATTTCCGATGAGCGTCTGATCGAGCTCATGTCCGTGGGACCCGCCGAACTCATGGGGCATGTGCCAACCGACGTGGCC
GCGCTGGTCGAGGACTACGCCGAACCCGCGCCCACTGGGGATGATCCGGATGGCGTGATTGCGGGGGAGAGCGACGCTCA
GCCGCAGCGTGAAGGCGTCAACCGACTGCTCGACCTGAGCCGCGTGGATGACGCCGACAATGTCGACCTCGTGGTGCTCA
ACACCGCTGAGGAATGGACCGTGGACCCTGAACAGTTCCACTCCAGGGCTCGTAACACCCCGTTTGGCGGCTGGCAGGTC
ACCGGACGCCCCCTCGCCACGATCATCGGCTCCCAGCTGATGTTCAGCCGTCTGTAG

Upstream 100 bases:

>100_bases
GCGTGACCACCACCGAGCCCGGCATCAAGCAGATGTTCCACCTCGTGCACTCCGAACGGCTCGAATACCGCTGCGACTAC
TGCGACGAGGAAGCCAAACT

Downstream 100 bases:

>100_bases
ATAACATAAGGAGCAGCATGGATCGCCTGATCGAAGCGATTGACAACACTCAGAACCCCAGCGTCGTGGGCCTCGACCCC
ACCGAGGCGTTGGTACCGCC

Product: amidohydrolase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSITLRNIKVWNTGEVIDLVVPGTAAAYFADTSAVADGADIDATGLTVAPGFEDPHVHFRDPGQTYKESMVSGCRASASG
GYTNVLIMPNTLPALDGQTVSDLEAAGAKEVLDAGFDNVIDFLQQYDTAHDVQLPVRYDLCVCASKDRAGHEASDVADWL
RYVPGFEDDAKTPAMLTHPITAISDDGSAVTPEILDQVLENVKASDLYLIEHCEHHDTGAVNEGPVSRELGVPGIPEDTE
LKIVARDIEAARRTGVHVHFQHVSTAISFEAIRKAKAEGLPITCETAPHYLALSDEALLKYGTLAKMNPPLRSEADRKAT
IAAIADGTVDLLATDHAPHTLAEKELGFLEAPNGIIGLECAYGVCHKVLVDGGFISDERLIELMSVGPAELMGHVPTDVA
ALVEDYAEPAPTGDDPDGVIAGESDAQPQREGVNRLLDLSRVDDADNVDLVVLNTAEEWTVDPEQFHSRARNTPFGGWQV
TGRPLATIIGSQLMFSRL

Sequences:

>Translated_498_residues
MSITLRNIKVWNTGEVIDLVVPGTAAAYFADTSAVADGADIDATGLTVAPGFEDPHVHFRDPGQTYKESMVSGCRASASG
GYTNVLIMPNTLPALDGQTVSDLEAAGAKEVLDAGFDNVIDFLQQYDTAHDVQLPVRYDLCVCASKDRAGHEASDVADWL
RYVPGFEDDAKTPAMLTHPITAISDDGSAVTPEILDQVLENVKASDLYLIEHCEHHDTGAVNEGPVSRELGVPGIPEDTE
LKIVARDIEAARRTGVHVHFQHVSTAISFEAIRKAKAEGLPITCETAPHYLALSDEALLKYGTLAKMNPPLRSEADRKAT
IAAIADGTVDLLATDHAPHTLAEKELGFLEAPNGIIGLECAYGVCHKVLVDGGFISDERLIELMSVGPAELMGHVPTDVA
ALVEDYAEPAPTGDDPDGVIAGESDAQPQREGVNRLLDLSRVDDADNVDLVVLNTAEEWTVDPEQFHSRARNTPFGGWQV
TGRPLATIIGSQLMFSRL
>Mature_497_residues
SITLRNIKVWNTGEVIDLVVPGTAAAYFADTSAVADGADIDATGLTVAPGFEDPHVHFRDPGQTYKESMVSGCRASASGG
YTNVLIMPNTLPALDGQTVSDLEAAGAKEVLDAGFDNVIDFLQQYDTAHDVQLPVRYDLCVCASKDRAGHEASDVADWLR
YVPGFEDDAKTPAMLTHPITAISDDGSAVTPEILDQVLENVKASDLYLIEHCEHHDTGAVNEGPVSRELGVPGIPEDTEL
KIVARDIEAARRTGVHVHFQHVSTAISFEAIRKAKAEGLPITCETAPHYLALSDEALLKYGTLAKMNPPLRSEADRKATI
AAIADGTVDLLATDHAPHTLAEKELGFLEAPNGIIGLECAYGVCHKVLVDGGFISDERLIELMSVGPAELMGHVPTDVAA
LVEDYAEPAPTGDDPDGVIAGESDAQPQREGVNRLLDLSRVDDADNVDLVVLNTAEEWTVDPEQFHSRARNTPFGGWQVT
GRPLATIIGSQLMFSRL

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=166, Percent_Identity=34.3373493975904, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786722, Length=392, Percent_Identity=28.8265306122449, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87082175, Length=371, Percent_Identity=26.6846361185984, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=232, Percent_Identity=28.8793103448276, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=322, Percent_Identity=27.0186335403727, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24642586, Length=89, Percent_Identity=41.5730337078652, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 53328; Mature: 53197

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITLRNIKVWNTGEVIDLVVPGTAAAYFADTSAVADGADIDATGLTVAPGFEDPHVHFR
CEEEEEEEEEECCCCEEEEEECCCCHHHCCCCHHCCCCCCCCCCCEEECCCCCCCCEEEC
DPGQTYKESMVSGCRASASGGYTNVLIMPNTLPALDGQTVSDLEAAGAKEVLDAGFDNVI
CCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCHHHHHHCCHHHHH
DFLQQYDTAHDVQLPVRYDLCVCASKDRAGHEASDVADWLRYVPGFEDDAKTPAMLTHPI
HHHHHHCCCCCEECCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCC
TAISDDGSAVTPEILDQVLENVKASDLYLIEHCEHHDTGAVNEGPVSRELGVPGIPEDTE
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LKIVARDIEAARRTGVHVHFQHVSTAISFEAIRKAKAEGLPITCETAPHYLALSDEALLK
EEEEEHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHH
YGTLAKMNPPLRSEADRKATIAAIADGTVDLLATDHAPHTLAEKELGFLEAPNGIIGLEC
HCCHHHCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHCCCEECCCCEEEHHH
AYGVCHKVLVDGGFISDERLIELMSVGPAELMGHVPTDVAALVEDYAEPAPTGDDPDGVI
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEE
AGESDAQPQREGVNRLLDLSRVDDADNVDLVVLNTAEEWTVDPEQFHSRARNTPFGGWQV
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHCCCCHHHHHHHHCCCCCCCEEE
TGRPLATIIGSQLMFSRL
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SITLRNIKVWNTGEVIDLVVPGTAAAYFADTSAVADGADIDATGLTVAPGFEDPHVHFR
EEEEEEEEEECCCCEEEEEECCCCHHHCCCCHHCCCCCCCCCCCEEECCCCCCCCEEEC
DPGQTYKESMVSGCRASASGGYTNVLIMPNTLPALDGQTVSDLEAAGAKEVLDAGFDNVI
CCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCHHHHHHCCHHHHH
DFLQQYDTAHDVQLPVRYDLCVCASKDRAGHEASDVADWLRYVPGFEDDAKTPAMLTHPI
HHHHHHCCCCCEECCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCC
TAISDDGSAVTPEILDQVLENVKASDLYLIEHCEHHDTGAVNEGPVSRELGVPGIPEDTE
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LKIVARDIEAARRTGVHVHFQHVSTAISFEAIRKAKAEGLPITCETAPHYLALSDEALLK
EEEEEHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCHHHHH
YGTLAKMNPPLRSEADRKATIAAIADGTVDLLATDHAPHTLAEKELGFLEAPNGIIGLEC
HCCHHHCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHCCCEECCCCEEEHHH
AYGVCHKVLVDGGFISDERLIELMSVGPAELMGHVPTDVAALVEDYAEPAPTGDDPDGVI
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEE
AGESDAQPQREGVNRLLDLSRVDDADNVDLVVLNTAEEWTVDPEQFHSRARNTPFGGWQV
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHCCCCHHHHHHHHCCCCCCCEEE
TGRPLATIIGSQLMFSRL
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA