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The map label for this gene is relA [H]

Identifier: 213691862

GI number: 213691862

Start: 1152786

End: 1155110

Strand: Direct

Name: relA [H]

Synonym: Blon_0971

Alternate gene names: 213691862

Gene position: 1152786-1155110 (Clockwise)

Preceding gene: 213691861

Following gene: 213691865

Centisome position: 40.69

GC content: 60.34

Gene sequence:

>2325_bases
ATGGCAGAGATTGATGGCGAGCAGTACGCCGCCCGTAAACTGGGTTGCGAGATCAGCGCTGATCCGCTCAATCCGCTGGA
ACCAATCAAGAAAGTGTGCAAGTCCCACCATCCCGGTGAGGATTTGTCCATCCTCGACCGCGCGTACCGGCGCGCCGTCA
TCCAGCATTGCACGCAACGGCGCAAGTCGGGCGAACCATACATCGTCCATCCGTTGGCCGTTTCCCAGATTCTCGCGGAT
CTGGGCATGGGGCCGATTGTGGTGGCGGCCGGTCTGCTGCATGACACGGTGGAGGACACCGACTACACGTTGGATCAATG
CCGTGCCGAGTTCGGCGACACCGTGGCCGGTCTGGTCGATGGCGTCACCAAGCTCAGCCAGCTTGAAGTGGGCGACTCCG
CCCAGGCCGAAACGATTCGCAAGCTGGTGGTGGCCATGAGCCGTGATGTGCGCACCCTGGTGGTCAAGCTGGCCGACCGT
GTGCACAACGCCCGCACCTGGCGCTATGTGAAGACCACGTCGGCGCAGAGGAAGGCGCGCGAAACCCTCGACGTATACGC
CCCTTTGGCCAATCGTCTCGGTATGAACGCCATCAAGACGGAGCTTGAGGAACTGAGCTTCAAAGTGCTCTATCCGAAGA
TCTATAACGAGATCGTTGTGCTGGTGGCCCGCCGGGCCGGTCAGCGCGACGTGTATCTGGCGCAGATTCTGGCGGAGATC
AACGAGGATCTCGATGAGCAGAGCATCAAGGCATACGTCACCGGCCGCCCGAAGGACTACTTCTCGATTTATCAGAAGAT
GATCGTGCGCGGGCATGATTTCGCGAACATCTACGATCTGGTCGGCGTGCGCATCATCGTCGACACGATTCAGGATTGCT
ATGCGGCGCTCGGTGCCGTGCATGCGCGGTGGAACCCGGTTCCCGGCCGGTTCAAGGACTACATCGCCATGCCGAAGCTC
AACATGTACCAGTCGCTGCATACCACGGTGGTGGGTCCGGGCGGCAAACCGGTGGAAATCCAGATTCGCACCTGGGACAT
GCACCGCCGCGCCGAGTTCGGCATCGCCGCGCATTGGAAATACAAGGAAAACGGTCAGGCCGGGCGTGCCTTGAGCTCGC
CGGACAAGTCCGACCGCAGGCGTGACGAGAAGAACCAGGAGCTTTCCGAAGCCGACAATCTCAAATGGATTCAGCAGCTT
GCCGATTGGACCAGCGAAACCCCCGACTCCAATGAGTTTCTGGGGTCGCTCAAGGAGGATCTCGGCTCGTCCGAAGTCTA
CGTGTTCACGCCGAAAGGCAAGATCGTATCCCTGCCCGCTCATGCCACGCCCGTCGACTTCGCGTATGCCGTGCACACCG
AAGTGGGTCATCGCACGATGGGCGCACGTGTCAACGGACGTCTGGTGCCGCTTGACACCACGCTCGACAATGGGGACACC
GTCGAGATTCTGACGTCCAAGTCCGATACGGCCGGGCCTTCGCGCGACTGGCTGAGTTTCGTCAAGAGTCCGAAGGCGCG
CAATAAGATTCGTCAATGGTTCTCCAAGGAACGCCGCACTGAGGCCATCGAGGAGGGTCGCGACGAGCTGACTCGGGCGA
TGCGCAAACGCAACCTGCCGGTCAACACGCTGTTGACCCCGGAAGCGTTGGTGGGTGTGGCCGACGATCTCAACTTCCCG
AACGCGGACGCCGTGTTCGCGGCCATCGGGGACGGTCAGGTCTCCACGCAGAACGTCATTTCGCATTTGGTCAAGGACGC
GGGTGCCGACGAGGTCGATGAAGAGGTCGAGCAGGAGGTTCTGCCGCTCAAGCCCGTGGAGCGCAAGACTTCCAGCAGCT
CCACCGGGGTATCCGTCAAGGGCGTGGGCGATGTGTGGATCAAACTCGCCCGTTGTTGCATGCCGGTGCCCGGTGATGAC
ATCATCGGATTCATCACCCGCAACCAGGGTGTGTCCGTGCATCGCACCGATTGTCAGAATATGATCGACTTGAAGAGCAA
GCAGCCCGAGCGTGTGGTCGAGGTCGAATGGACCAGCACCAAGGGTCTGTTCATGGTCAAGATTCAAGTCGAGGCATTGG
ATCGCCGCAACCTGCTGTCGGATGTGACGCGCGTGCTTTCCGATCATGGCGTGAATATCATCTCGGGTACGATCGCCACG
GGTTCCGATCGAGTGGCCACCAGCCAGTTCAGCTTCGAGATGGCGGATCCGCAGCATCTCAACTCGCTGTTGGCTGCCGT
GCGCAAGATTGACGGTGTGTTCGACGTATACCGCATCACCGGTGCCAAGGAATCCGCCGAACCCCGTCTGCGCAAGATGA
AGTAG

Upstream 100 bases:

>100_bases
ACGGCAACAACGGTTGCGGAACCAATGATGGCGGACGGGTGCGTGCGCATGGCACTGGTTCGCGGTTACAATGAACTTCA
TGACGAGGGAGGTGACTGGC

Downstream 100 bases:

>100_bases
GGATGTGGGTGGCATACGGCGGGGCCCCGGTCCGAATCGTCGGATCGGGGCCCCGCCTTGTGGCACTTATGGCATGAAGG
TATGGGCGGTTTTTACCGCT

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MAEIDGEQYAARKLGCEISADPLNPLEPIKKVCKSHHPGEDLSILDRAYRRAVIQHCTQRRKSGEPYIVHPLAVSQILAD
LGMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVDGVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADR
VHNARTWRYVKTTSAQRKARETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLAQILAEI
NEDLDEQSIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAVHARWNPVPGRFKDYIAMPKL
NMYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWKYKENGQAGRALSSPDKSDRRRDEKNQELSEADNLKWIQQL
ADWTSETPDSNEFLGSLKEDLGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDT
VEILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLPVNTLLTPEALVGVADDLNFP
NADAVFAAIGDGQVSTQNVISHLVKDAGADEVDEEVEQEVLPLKPVERKTSSSSTGVSVKGVGDVWIKLARCCMPVPGDD
IIGFITRNQGVSVHRTDCQNMIDLKSKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIAT
GSDRVATSQFSFEMADPQHLNSLLAAVRKIDGVFDVYRITGAKESAEPRLRKMK

Sequences:

>Translated_774_residues
MAEIDGEQYAARKLGCEISADPLNPLEPIKKVCKSHHPGEDLSILDRAYRRAVIQHCTQRRKSGEPYIVHPLAVSQILAD
LGMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVDGVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADR
VHNARTWRYVKTTSAQRKARETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLAQILAEI
NEDLDEQSIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAVHARWNPVPGRFKDYIAMPKL
NMYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWKYKENGQAGRALSSPDKSDRRRDEKNQELSEADNLKWIQQL
ADWTSETPDSNEFLGSLKEDLGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDT
VEILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLPVNTLLTPEALVGVADDLNFP
NADAVFAAIGDGQVSTQNVISHLVKDAGADEVDEEVEQEVLPLKPVERKTSSSSTGVSVKGVGDVWIKLARCCMPVPGDD
IIGFITRNQGVSVHRTDCQNMIDLKSKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIAT
GSDRVATSQFSFEMADPQHLNSLLAAVRKIDGVFDVYRITGAKESAEPRLRKMK
>Mature_773_residues
AEIDGEQYAARKLGCEISADPLNPLEPIKKVCKSHHPGEDLSILDRAYRRAVIQHCTQRRKSGEPYIVHPLAVSQILADL
GMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVDGVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADRV
HNARTWRYVKTTSAQRKARETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLAQILAEIN
EDLDEQSIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAVHARWNPVPGRFKDYIAMPKLN
MYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWKYKENGQAGRALSSPDKSDRRRDEKNQELSEADNLKWIQQLA
DWTSETPDSNEFLGSLKEDLGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDTV
EILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLPVNTLLTPEALVGVADDLNFPN
ADAVFAAIGDGQVSTQNVISHLVKDAGADEVDEEVEQEVLPLKPVERKTSSSSTGVSVKGVGDVWIKLARCCMPVPGDDI
IGFITRNQGVSVHRTDCQNMIDLKSKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIATG
SDRVATSQFSFEMADPQHLNSLLAAVRKIDGVFDVYRITGAKESAEPRLRKMK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=739, Percent_Identity=38.5656292286874, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789147, Length=709, Percent_Identity=36.3892806770099, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 86160; Mature: 86029

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIDGEQYAARKLGCEISADPLNPLEPIKKVCKSHHPGEDLSILDRAYRRAVIQHCTQR
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RKSGEPYIVHPLAVSQILADLGMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVD
HHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHH
GVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADRVHNARTWRYVKTTSAQRKAR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHH
ETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLAQILAEI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NEDLDEQSIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAV
HHCCCHHCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HARWNPVPGRFKDYIAMPKLNMYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWK
HHCCCCCCCHHHHHHCCCCHHHHHHHHHEEECCCCCEEEEEEEEECCHHHHCCCEEEEEE
YKENGQAGRALSSPDKSDRRRDEKNQELSEADNLKWIQQLADWTSETPDSNEFLGSLKED
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDT
CCCCCEEEECCCCCEEECCCCCCCCCHHEEEHHHHCCHHCCCEECCEEEEEECCCCCCCE
VEILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLP
EEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNTLLTPEALVGVADDLNFPNADAVFAAIGDGQVSTQNVISHLVKDAGADEVDEEVEQEV
CCEEECHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
LPLKPVERKTSSSSTGVSVKGVGDVWIKLARCCMPVPGDDIIGFITRNQGVSVHRTDCQN
CCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHH
MIDLKSKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIAT
HHHHCCCCCCEEEEEEEECCCCEEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GSDRVATSQFSFEMADPQHLNSLLAAVRKIDGVFDVYRITGAKESAEPRLRKMK
CCCCEEECCCEEECCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
AEIDGEQYAARKLGCEISADPLNPLEPIKKVCKSHHPGEDLSILDRAYRRAVIQHCTQR
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RKSGEPYIVHPLAVSQILADLGMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVD
HHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHH
GVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADRVHNARTWRYVKTTSAQRKAR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHH
ETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLAQILAEI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NEDLDEQSIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAV
HHCCCHHCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HARWNPVPGRFKDYIAMPKLNMYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWK
HHCCCCCCCHHHHHHCCCCHHHHHHHHHEEECCCCCEEEEEEEEECCHHHHCCCEEEEEE
YKENGQAGRALSSPDKSDRRRDEKNQELSEADNLKWIQQLADWTSETPDSNEFLGSLKED
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDT
CCCCCEEEECCCCCEEECCCCCCCCCHHEEEHHHHCCHHCCCEECCEEEEEECCCCCCCE
VEILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLP
EEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNTLLTPEALVGVADDLNFPNADAVFAAIGDGQVSTQNVISHLVKDAGADEVDEEVEQEV
CCEEECHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
LPLKPVERKTSSSSTGVSVKGVGDVWIKLARCCMPVPGDDIIGFITRNQGVSVHRTDCQN
CCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHH
MIDLKSKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIAT
HHHHCCCCCCEEEEEEEECCCCEEEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
GSDRVATSQFSFEMADPQHLNSLLAAVRKIDGVFDVYRITGAKESAEPRLRKMK
CCCCEEECCCEEECCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]