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The map label for this gene is gyrB [H]

Identifier: 213691852

GI number: 213691852

Start: 1135934

End: 1138252

Strand: Direct

Name: gyrB [H]

Synonym: Blon_0961

Alternate gene names: 213691852

Gene position: 1135934-1138252 (Clockwise)

Preceding gene: 213691851

Following gene: 213691853

Centisome position: 40.1

GC content: 60.72

Gene sequence:

>2319_bases
ATGCCCAAAGAAGAATACGGCGCCAAGGACCTAGCTGTTCTTGAGGGCTTGGATGCGGTACGCAAGCGTCCGGGCATGTA
CATCGGCACCACCGACTCGCAGGGGCTTATGCACTGCTTGTGGGAGATCATCGACAACTCCGTGGATGAGGCCTTGGCCG
GCTTCTGCAACGATATCGTAGTCACCTTGCACACCGACGGTTCCGTGGAAGTTGCGGACAATGGCCGAGGCATTCCGGTG
GATAAGGAACCGAAAACCGGCCTGTCCGGCGTGGAGGTCGTACTGACCAAACTGCACGCCGGTGCCAAGTTCGGCAATTC
GTCTTATAACGCCGTCGGTGGCCTGCACGGCGTGGGCTCCTCCGTGGTCAATGCCCTGAGCTCCCGACTGGACGTCGAAG
TGGATCGTGACGGCAAGACGCACCACATGACCTTCCACCAAGGTCACCCTGGCGTATACACGGATGCCGACCCGGCCAAT
CCGTCTCCCGATTCCCCGTTCAAGCGCACTCGCAAGAACCGACCCACCGAGCTGGAAATCATCGGCAAGGTATCTCCCAA
AACCACTGGTACCCGTATTCGCTACTGGTATGATCCGGAGATCTTCAACAAAACCGCCGAGTTCTCATACGAACAGCTCA
TCGACCGCGTGCGTCAGACCAGCTTCCTGGTGCCCGGCCTCAAAATCACCATCATCGACGAAAACGTACCCGAAACGGCG
GCGACTGACACCGTCGAGGCCGCTGATACCGCCACAGTCGAACCCGTGCAAGAGCAGGTGCCGGCTTTGGACGTCTCGTC
CAACGATGCCGAACTCTTCGGCGACTCCACCGAAACCCAAGTCGACAGTACCGGGAGCCTGACCGAGGAGAATTTCTCAC
TGACGGCCAGCGACCAGGTCGTCGACGGCGCGTTCGGCGAACAGCCCGCGCACCCGCGCGTCGTGGAATTCCTGCACACC
GGCGGCGTCAAGGACTTCGTCGACTTCCTGTCCAAAGGCGAGCCGATCTCCGACATCTGGCGCATCCAAGGCGAGGGCAC
CTATAAGGAGGAGACCCAGGCCGTGGGTGAGGGCGGCGAACTGCACGCCCAGGAAATCGAACGCACCTGCGGCTTGGACA
TCGCCCTGCGATGGGTCAACGGCTATGACACCACAATCATGAGCTTCGTGAACATCGTGGAGACGCCCGGCGGCGGTACT
CACGTGGACGGTTTCATGAACGCCATCACCAAGCAGATTCGCAAGGCGGTGGAAGACAACGCCCGCAAGCTCAAGGTGAA
CATGAAGGACTCCGCCATGAAGGTGGAGCGCGACGATATCCAAGCCGGACTCGTGGCCGTGGTCACCGCACGCGTGGCCG
AACCTCAGTTCCAAGGCCAGACCAAGGATGTACTCGGCACCGCGCAGGTCAAGCCGATCGTCACCCGGCTCACCGACAAG
CAATTCGGTGAGATGATCACCGGCTCCAAGCGCGGGTACAAGGAACAATCCGGCCGCGTGCTGGAGAAAATCGTCGGCGA
AATGCACGCACGCATCCAGTCGCGCAAGGCCAAGGAGGTCACGCGCCGCAAGAACGCGCTCGAATCCGCCTCGATGCCGG
CCAAACTCTCCGACTGCCAGCCGGGCAATGACGACGTGGCCGAACTGTTCATCGTCGAGGGTGATTCCGCACTCGGTACC
GCCAAAGCCGCACGCAACGCCGGTTTCCAGGCACTGCTGCCGATTCGAGGCAAGATCCTGAACGTGCAGAAGGCGTCGAT
CACGCAGATGCTCTCCAACAAGGAGTGCGCAGCCATCATCCAGGTGGTGGGCGCCGGCTCCGGCCAGAGCTTTGACATCG
AACAGTCGCGCTACCACAAGATCATCATGATGACCGATGCCGATGTGGATGGTGCTCATATCCGTATCCTGTTGCTGACG
CTGTTCTACCGATACATGCGTCCGCTCATCGAACACGGCTACGTGTATGCCGCAGTGCCGCCGCTGCACCGCATCGCGTT
GACCGGCTCGCACAAGGGCGAATACATCTACACGTATTCCGATGACGAGCTGGCCGGCAAACTGGCCGACCTCGACAAGA
AGCACATCGGATACAACGACGACATCCAGCGATACAAGGGTCTGGGCGAGATGGACGCCGACCAGCTGGCGGACACCACC
ATGGACCCGCGCACGCGCATGCTGCGCCGCATCCGTATGGAGGACGCCGCCCAGGCATCCGAGATTTTCAGCCTGCTGAT
GGGCGACGACGTGCCGCCGCGCAAGCAGTTCATCGTCGACAACGCCGACGATTTCGATCGCTCCAAGATCGATACCTGA

Upstream 100 bases:

>100_bases
CCCGTCCCGTTCACAGACCCTGCGCGACTTCCTGGATCAATGATCATCTGGCTCCCCTCTGTGAGGGGAGCCAAGCATTT
GAAGAGAAAAATAGGACTGT

Downstream 100 bases:

>100_bases
TCGAAGACGTCGCTGATAATGACATCGTGCTTACCGAGAATTTCCGTAATTGGCGTTTGAGGTGAGCACGTTGTCATATG
TTTTATTCGTGTTGCCCATG

Product: DNA topoisomerase (ATP-hydrolyzing)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MPKEEYGAKDLAVLEGLDAVRKRPGMYIGTTDSQGLMHCLWEIIDNSVDEALAGFCNDIVVTLHTDGSVEVADNGRGIPV
DKEPKTGLSGVEVVLTKLHAGAKFGNSSYNAVGGLHGVGSSVVNALSSRLDVEVDRDGKTHHMTFHQGHPGVYTDADPAN
PSPDSPFKRTRKNRPTELEIIGKVSPKTTGTRIRYWYDPEIFNKTAEFSYEQLIDRVRQTSFLVPGLKITIIDENVPETA
ATDTVEAADTATVEPVQEQVPALDVSSNDAELFGDSTETQVDSTGSLTEENFSLTASDQVVDGAFGEQPAHPRVVEFLHT
GGVKDFVDFLSKGEPISDIWRIQGEGTYKEETQAVGEGGELHAQEIERTCGLDIALRWVNGYDTTIMSFVNIVETPGGGT
HVDGFMNAITKQIRKAVEDNARKLKVNMKDSAMKVERDDIQAGLVAVVTARVAEPQFQGQTKDVLGTAQVKPIVTRLTDK
QFGEMITGSKRGYKEQSGRVLEKIVGEMHARIQSRKAKEVTRRKNALESASMPAKLSDCQPGNDDVAELFIVEGDSALGT
AKAARNAGFQALLPIRGKILNVQKASITQMLSNKECAAIIQVVGAGSGQSFDIEQSRYHKIIMMTDADVDGAHIRILLLT
LFYRYMRPLIEHGYVYAAVPPLHRIALTGSHKGEYIYTYSDDELAGKLADLDKKHIGYNDDIQRYKGLGEMDADQLADTT
MDPRTRMLRRIRMEDAAQASEIFSLLMGDDVPPRKQFIVDNADDFDRSKIDT

Sequences:

>Translated_772_residues
MPKEEYGAKDLAVLEGLDAVRKRPGMYIGTTDSQGLMHCLWEIIDNSVDEALAGFCNDIVVTLHTDGSVEVADNGRGIPV
DKEPKTGLSGVEVVLTKLHAGAKFGNSSYNAVGGLHGVGSSVVNALSSRLDVEVDRDGKTHHMTFHQGHPGVYTDADPAN
PSPDSPFKRTRKNRPTELEIIGKVSPKTTGTRIRYWYDPEIFNKTAEFSYEQLIDRVRQTSFLVPGLKITIIDENVPETA
ATDTVEAADTATVEPVQEQVPALDVSSNDAELFGDSTETQVDSTGSLTEENFSLTASDQVVDGAFGEQPAHPRVVEFLHT
GGVKDFVDFLSKGEPISDIWRIQGEGTYKEETQAVGEGGELHAQEIERTCGLDIALRWVNGYDTTIMSFVNIVETPGGGT
HVDGFMNAITKQIRKAVEDNARKLKVNMKDSAMKVERDDIQAGLVAVVTARVAEPQFQGQTKDVLGTAQVKPIVTRLTDK
QFGEMITGSKRGYKEQSGRVLEKIVGEMHARIQSRKAKEVTRRKNALESASMPAKLSDCQPGNDDVAELFIVEGDSALGT
AKAARNAGFQALLPIRGKILNVQKASITQMLSNKECAAIIQVVGAGSGQSFDIEQSRYHKIIMMTDADVDGAHIRILLLT
LFYRYMRPLIEHGYVYAAVPPLHRIALTGSHKGEYIYTYSDDELAGKLADLDKKHIGYNDDIQRYKGLGEMDADQLADTT
MDPRTRMLRRIRMEDAAQASEIFSLLMGDDVPPRKQFIVDNADDFDRSKIDT
>Mature_771_residues
PKEEYGAKDLAVLEGLDAVRKRPGMYIGTTDSQGLMHCLWEIIDNSVDEALAGFCNDIVVTLHTDGSVEVADNGRGIPVD
KEPKTGLSGVEVVLTKLHAGAKFGNSSYNAVGGLHGVGSSVVNALSSRLDVEVDRDGKTHHMTFHQGHPGVYTDADPANP
SPDSPFKRTRKNRPTELEIIGKVSPKTTGTRIRYWYDPEIFNKTAEFSYEQLIDRVRQTSFLVPGLKITIIDENVPETAA
TDTVEAADTATVEPVQEQVPALDVSSNDAELFGDSTETQVDSTGSLTEENFSLTASDQVVDGAFGEQPAHPRVVEFLHTG
GVKDFVDFLSKGEPISDIWRIQGEGTYKEETQAVGEGGELHAQEIERTCGLDIALRWVNGYDTTIMSFVNIVETPGGGTH
VDGFMNAITKQIRKAVEDNARKLKVNMKDSAMKVERDDIQAGLVAVVTARVAEPQFQGQTKDVLGTAQVKPIVTRLTDKQ
FGEMITGSKRGYKEQSGRVLEKIVGEMHARIQSRKAKEVTRRKNALESASMPAKLSDCQPGNDDVAELFIVEGDSALGTA
KAARNAGFQALLPIRGKILNVQKASITQMLSNKECAAIIQVVGAGSGQSFDIEQSRYHKIIMMTDADVDGAHIRILLLTL
FYRYMRPLIEHGYVYAAVPPLHRIALTGSHKGEYIYTYSDDELAGKLADLDKKHIGYNDDIQRYKGLGEMDADQLADTTM
DPRTRMLRRIRMEDAAQASEIFSLLMGDDVPPRKQFIVDNADDFDRSKIDT

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=393, Percent_Identity=28.2442748091603, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI19913406, Length=403, Percent_Identity=25.5583126550869, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI48994957, Length=370, Percent_Identity=38.1081081081081, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1789408, Length=371, Percent_Identity=35.5795148247978, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI212645845, Length=341, Percent_Identity=26.9794721407625, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17535065, Length=363, Percent_Identity=24.7933884297521, Blast_Score=93, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324241, Length=385, Percent_Identity=24.9350649350649, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=392, Percent_Identity=23.469387755102, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 84683; Mature: 84552

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKEEYGAKDLAVLEGLDAVRKRPGMYIGTTDSQGLMHCLWEIIDNSVDEALAGFCNDIV
CCCHHCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCEE
VTLHTDGSVEVADNGRGIPVDKEPKTGLSGVEVVLTKLHAGAKFGNSSYNAVGGLHGVGS
EEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SVVNALSSRLDVEVDRDGKTHHMTFHQGHPGVYTDADPANPSPDSPFKRTRKNRPTELEI
HHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEE
IGKVSPKTTGTRIRYWYDPEIFNKTAEFSYEQLIDRVRQTSFLVPGLKITIIDENVPETA
EEECCCCCCCCEEEEEECHHHHCHHHHCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCC
ATDTVEAADTATVEPVQEQVPALDVSSNDAELFGDSTETQVDSTGSLTEENFSLTASDQV
CCCCHHHCCCCCCCHHHHHCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
VDGAFGEQPAHPRVVEFLHTGGVKDFVDFLSKGEPISDIWRIQGEGTYKEETQAVGEGGE
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHEECCCCCCHHHHHHHCCCCC
LHAQEIERTCGLDIALRWVNGYDTTIMSFVNIVETPGGGTHVDGFMNAITKQIRKAVEDN
CCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
ARKLKVNMKDSAMKVERDDIQAGLVAVVTARVAEPQFQGQTKDVLGTAQVKPIVTRLTDK
CEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHH
QFGEMITGSKRGYKEQSGRVLEKIVGEMHARIQSRKAKEVTRRKNALESASMPAKLSDCQ
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PGNDDVAELFIVEGDSALGTAKAARNAGFQALLPIRGKILNVQKASITQMLSNKECAAII
CCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHCCCHHHHHH
QVVGAGSGQSFDIEQSRYHKIIMMTDADVDGAHIRILLLTLFYRYMRPLIEHGYVYAAVP
HHHCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECC
PLHRIALTGSHKGEYIYTYSDDELAGKLADLDKKHIGYNDDIQRYKGLGEMDADQLADTT
CCEEEEEECCCCCCEEEEECCHHHHHHHHHCHHHHCCCCCHHHHHCCCCCCCHHHHHCCC
MDPRTRMLRRIRMEDAAQASEIFSLLMGDDVPPRKQFIVDNADDFDRSKIDT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHCCCC
>Mature Secondary Structure 
PKEEYGAKDLAVLEGLDAVRKRPGMYIGTTDSQGLMHCLWEIIDNSVDEALAGFCNDIV
CCHHCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCEE
VTLHTDGSVEVADNGRGIPVDKEPKTGLSGVEVVLTKLHAGAKFGNSSYNAVGGLHGVGS
EEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SVVNALSSRLDVEVDRDGKTHHMTFHQGHPGVYTDADPANPSPDSPFKRTRKNRPTELEI
HHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEE
IGKVSPKTTGTRIRYWYDPEIFNKTAEFSYEQLIDRVRQTSFLVPGLKITIIDENVPETA
EEECCCCCCCCEEEEEECHHHHCHHHHCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCC
ATDTVEAADTATVEPVQEQVPALDVSSNDAELFGDSTETQVDSTGSLTEENFSLTASDQV
CCCCHHHCCCCCCCHHHHHCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
VDGAFGEQPAHPRVVEFLHTGGVKDFVDFLSKGEPISDIWRIQGEGTYKEETQAVGEGGE
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHEECCCCCCHHHHHHHCCCCC
LHAQEIERTCGLDIALRWVNGYDTTIMSFVNIVETPGGGTHVDGFMNAITKQIRKAVEDN
CCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
ARKLKVNMKDSAMKVERDDIQAGLVAVVTARVAEPQFQGQTKDVLGTAQVKPIVTRLTDK
CEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHH
QFGEMITGSKRGYKEQSGRVLEKIVGEMHARIQSRKAKEVTRRKNALESASMPAKLSDCQ
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PGNDDVAELFIVEGDSALGTAKAARNAGFQALLPIRGKILNVQKASITQMLSNKECAAII
CCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHCCCHHHHHH
QVVGAGSGQSFDIEQSRYHKIIMMTDADVDGAHIRILLLTLFYRYMRPLIEHGYVYAAVP
HHHCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECC
PLHRIALTGSHKGEYIYTYSDDELAGKLADLDKKHIGYNDDIQRYKGLGEMDADQLADTT
CCEEEEEECCCCCCEEEEECCHHHHHHHHHCHHHHCCCCCHHHHHCCCCCCCHHHHHCCC
MDPRTRMLRRIRMEDAAQASEIFSLLMGDDVPPRKQFIVDNADDFDRSKIDT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7981652 [H]