Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 213691804

GI number: 213691804

Start: 1076751

End: 1077644

Strand: Direct

Name: nadC [H]

Synonym: Blon_0912

Alternate gene names: 213691804

Gene position: 1076751-1077644 (Clockwise)

Preceding gene: 213691803

Following gene: 213691805

Centisome position: 38.01

GC content: 66.67

Gene sequence:

>894_bases
ATGCTCACATCACACATCATCCGCGTCGCCGTCGAAGCGGCGCTCGCCGAAGACGCGCCCTACGGCGACATCACCTGCGA
GACCACCATCCCCGCGGACGAAACCGGCTCGGCCCACCTCACCGCACGCGAAAACGGCGTGATGAGCGGCATCGACGTGT
TCGCCGCAGCCTTCGCCGCGCAGAACCCGGCCGTCACCGTCACCGCCGCCATCAAGGACGGCAAACGATTCCAGCGTGGC
CAGGTACTCGCCACCGTGGAAGGTCCGGTACGCGACCTGCTCACCGCCGAGCGCATCGCCCTCAACTTCACCCAGCGCAT
GAGCGGCATCGCCACCATGACCGCCGCCTTCGTGGACGCGGTGAACGCCATCTACGGCGATGACTATGACGGACCCGTCA
CCCGGCCACGCCGCTACGAGCGCACCCGCATCGTCGATACGCGCAAAACCACGCCCGGCCTGCGCCCGTTCGAGAAATAC
GCCGTGGTCTGTGGCGGTGGCCACAACCATCGCTACGGACTGTCCGACGCGGTCATGATGAAGGACAACCATCTGGCGGC
GCTCGCCGCGCGCGGCATCGACCTGGCCGGCGCGATCCGCCACGTGCGCGAACAGGTGGGCCACACCACGCATATCGAAG
TGGAAGTCGACCGCCTTGACCAGATTCCCGCCGTGCTCGCCGGCGGAGCGGACACCATCATGCTGGACAATTTCTCGCTC
GACGACACCCGTCGCGGCGTGGAGCTCATCGACGGCAAGGCCATCGTGGAAGCCAGCGGCAACATGAGCCTGGAGCGAGT
GCCAGCCGTGGCCGCCACCGGCGTGGACGTGATCTCCGTGGGTGCGCTCACCCACTCCGTGCGTAGCATCGACCTCGGAT
TGGATTGGAACTAG

Upstream 100 bases:

>100_bases
GCTCGCCCGCACCGAGTCGAGAGGCGCCCACGCCCGCACCGACTACAGCGAGCCAGTCGACAACTGGGCCCACTCCGTCG
CCTACATCAAGGACTAACCC

Downstream 100 bases:

>100_bases
TCATGGCCGATACCCCCAACACGTCCAGCGAAGCCGGCGAACTGTACCTGGACGCCGCCGCCACCGAACCAGTGAGCCCG
GCAGTCATCGAGGCCATGAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLTSHIIRVAVEAALAEDAPYGDITCETTIPADETGSAHLTARENGVMSGIDVFAAAFAAQNPAVTVTAAIKDGKRFQRG
QVLATVEGPVRDLLTAERIALNFTQRMSGIATMTAAFVDAVNAIYGDDYDGPVTRPRRYERTRIVDTRKTTPGLRPFEKY
AVVCGGGHNHRYGLSDAVMMKDNHLAALAARGIDLAGAIRHVREQVGHTTHIEVEVDRLDQIPAVLAGGADTIMLDNFSL
DDTRRGVELIDGKAIVEASGNMSLERVPAVAATGVDVISVGALTHSVRSIDLGLDWN

Sequences:

>Translated_297_residues
MLTSHIIRVAVEAALAEDAPYGDITCETTIPADETGSAHLTARENGVMSGIDVFAAAFAAQNPAVTVTAAIKDGKRFQRG
QVLATVEGPVRDLLTAERIALNFTQRMSGIATMTAAFVDAVNAIYGDDYDGPVTRPRRYERTRIVDTRKTTPGLRPFEKY
AVVCGGGHNHRYGLSDAVMMKDNHLAALAARGIDLAGAIRHVREQVGHTTHIEVEVDRLDQIPAVLAGGADTIMLDNFSL
DDTRRGVELIDGKAIVEASGNMSLERVPAVAATGVDVISVGALTHSVRSIDLGLDWN
>Mature_297_residues
MLTSHIIRVAVEAALAEDAPYGDITCETTIPADETGSAHLTARENGVMSGIDVFAAAFAAQNPAVTVTAAIKDGKRFQRG
QVLATVEGPVRDLLTAERIALNFTQRMSGIATMTAAFVDAVNAIYGDDYDGPVTRPRRYERTRIVDTRKTTPGLRPFEKY
AVVCGGGHNHRYGLSDAVMMKDNHLAALAARGIDLAGAIRHVREQVGHTTHIEVEVDRLDQIPAVLAGGADTIMLDNFSL
DDTRRGVELIDGKAIVEASGNMSLERVPAVAATGVDVISVGALTHSVRSIDLGLDWN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=288, Percent_Identity=32.6388888888889, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1786299, Length=294, Percent_Identity=38.7755102040816, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=299, Percent_Identity=30.1003344481605, Blast_Score=132, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31714; Mature: 31714

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSHIIRVAVEAALAEDAPYGDITCETTIPADETGSAHLTARENGVMSGIDVFAAAFAA
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
QNPAVTVTAAIKDGKRFQRGQVLATVEGPVRDLLTAERIALNFTQRMSGIATMTAAFVDA
CCCCEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNAIYGDDYDGPVTRPRRYERTRIVDTRKTTPGLRPFEKYAVVCGGGHNHRYGLSDAVMM
HHHHCCCCCCCCCCCCCCCCHHEEEECCCCCCCCCCCHHEEEEECCCCCCCCCCCCEEEE
KDNHLAALAARGIDLAGAIRHVREQVGHTTHIEVEVDRLDQIPAVLAGGADTIMLDNFSL
CCCCEEEHHHCCCCHHHHHHHHHHHHCCEEEEEEECCCHHCCCHHHCCCCCEEEEECCCC
DDTRRGVELIDGKAIVEASGNMSLERVPAVAATGVDVISVGALTHSVRSIDLGLDWN
CCHHCCEEEECCEEEEEECCCCCHHHCCCHHHCCCCCEEHHHHHHHHEEEEECCCCC
>Mature Secondary Structure
MLTSHIIRVAVEAALAEDAPYGDITCETTIPADETGSAHLTARENGVMSGIDVFAAAFAA
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
QNPAVTVTAAIKDGKRFQRGQVLATVEGPVRDLLTAERIALNFTQRMSGIATMTAAFVDA
CCCCEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNAIYGDDYDGPVTRPRRYERTRIVDTRKTTPGLRPFEKYAVVCGGGHNHRYGLSDAVMM
HHHHCCCCCCCCCCCCCCCCHHEEEECCCCCCCCCCCHHEEEEECCCCCCCCCCCCEEEE
KDNHLAALAARGIDLAGAIRHVREQVGHTTHIEVEVDRLDQIPAVLAGGADTIMLDNFSL
CCCCEEEHHHCCCCHHHHHHHHHHHHCCEEEEEEECCCHHCCCHHHCCCCCEEEEECCCC
DDTRRGVELIDGKAIVEASGNMSLERVPAVAATGVDVISVGALTHSVRSIDLGLDWN
CCHHCCEEEECCEEEEEECCCCCHHHCCCHHHCCCCCEEHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]