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The map label for this gene is hisA [H]

Identifier: 213691723

GI number: 213691723

Start: 974340

End: 975065

Strand: Direct

Name: hisA [H]

Synonym: Blon_0828

Alternate gene names: 213691723

Gene position: 974340-975065 (Clockwise)

Preceding gene: 213691722

Following gene: 213691724

Centisome position: 34.4

GC content: 61.43

Gene sequence:

>726_bases
ATGTCGTTGACTCTGCTGCCCGCCGTCGATGTACGCGATGGCAAGGCCGTGCGCCTACGCCAGGGTGAATCCGGTTCCGA
AACCGATTACGGTTCGCCGTTCGAGGCCGCCCGTACTTGGGTTGAGGCCGGTGCCGAATGGATTCACCTGGTCGACCTTG
ATGCCGCTTTTGGTACGGGCAACAATCGCGATCAGCTGCGAGAAATCGTTCACGAGCTTGGTGACCGCGTGAACATCGAA
CTGTCCGGCGGCGTGCGCGATGACGCTTCGTTGGACGCGGCCCTTGAGGCCGGTGCCGCCCGAGTGAACATCGGCACCGC
CGCTTTGGAGAATCCGGATTGGACCGCTTCGGTCATCAAGAAGTACGGCGACCGCGTGGCTGTTGGTCTGGATGTGCGCG
GTCACACACTGGCGGCGCGCGGCTGGACACGCGAAGGCGGTGACCTGTTTGAGACCATGAAGTTCCTTGACTCCGTGGGC
TGCTCGCGTTATGTGGTCACCGACGTGGCCAAGGACGGCATGATGTCCGGCCCGAACATCCAACTGCTGCGTGAAGTCGC
CGAACGCACCGACGCCAAGGTCACGGCTTCCGGTGGTATCTCCAAGCTGGACGATTTGCGCGCCATCAAGGAACTGGCTG
AAATTGGTGTTGATTCTGCCATCCTCGGCAAGTCCCTCTATGCACGTGCGTTCACGCTCCAGGAAGCGCTCGCAGTCGCG
AAGTAG

Upstream 100 bases:

>100_bases
AGCTCCTCAAGAACTGGATCGCCACACTGTAAAAAGCATGAAGCTCCCTCTGACGAGAGAGCTCAAATCGTGTATATGTA
ACTGAAGAAAGGCTCTTCTT

Downstream 100 bases:

>100_bases
GCAAAGGACTCGCCTTGGCGAGACTGTTAATCTGCCTTCGCTCAGCTATCGCTTCACTCAGGTCTCGCCTACGGACAGCC
CACTGGGCTGTCCGCTTAAC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTGNNRDQLREIVHELGDRVNIE
LSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIKKYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVG
CSRYVVTDVAKDGMMSGPNIQLLREVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALAVA
K

Sequences:

>Translated_241_residues
MSLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTGNNRDQLREIVHELGDRVNIE
LSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIKKYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVG
CSRYVVTDVAKDGMMSGPNIQLLREVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALAVA
K
>Mature_240_residues
SLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTGNNRDQLREIVHELGDRVNIEL
SGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIKKYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVGC
SRYVVTDVAKDGMMSGPNIQLLREVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALAVAK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=33.7448559670782, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25758; Mature: 25627

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTG
CCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHCCCC
NNRDQLREIVHELGDRVNIELSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIK
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCEEEEECHHHCCCCCHHHHHHH
KYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVGCSRYVVTDVAKDGMMSGPNI
HCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
QLLREVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALAVA
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure 
SLTLLPAVDVRDGKAVRLRQGESGSETDYGSPFEAARTWVEAGAEWIHLVDLDAAFGTG
CEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHCCCC
NNRDQLREIVHELGDRVNIELSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIK
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCEEEEECHHHCCCCCHHHHHHH
KYGDRVAVGLDVRGHTLAARGWTREGGDLFETMKFLDSVGCSRYVVTDVAKDGMMSGPNI
HCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
QLLREVAERTDAKVTASGGISKLDDLRAIKELAEIGVDSAILGKSLYARAFTLQEALAVA
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA