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The map label for this gene is groEL [H]

Identifier: 213691590

GI number: 213691590

Start: 796166

End: 797791

Strand: Direct

Name: groEL [H]

Synonym: Blon_0694

Alternate gene names: 213691590

Gene position: 796166-797791 (Clockwise)

Preceding gene: 213691589

Following gene: 213691592

Centisome position: 28.11

GC content: 64.08

Gene sequence:

>1626_bases
ATGGCAAAGATCATCTCTTATGATGAGGAAGCCCGTCAGGGCATGCTGGAGGGCCTTGACAAGCTCGCCAACACCGTCAA
GGTCACCTTGGGCCCGAAGGGCCGCAACGTCGTGCTCGACAAGACCTACGGCGCTCCGACCATCACCAACGATGGTGTGT
CCATCGCCAAGGAAATCGACCTTGAAGACCCGTACGAGCGCATCGGCGCCGAGCTGGTCAAGGAAGTCGCCAAGAAGACC
GACGACGTCGCCGGTGACGGCACCACCACTGCGACCGTGCTTGCTCAGTCCCTGGTTCACGAGGGTCTGAAGAACGTGGT
CGCCGGCTCCAACCCGATCGCCCTGCGTCGCGGCATCGAGAAGGCCACCGAGGTCATCGTCAAGGAACTCGTCGCTGCCG
CCAAGGACGTCGAGACCAAGGACCAGATCGCCGCTACCGCCACCATCTCCGCCGCCGACCCTGAGGTCGGCGAGAAGATC
GCTGAGGCTCTGGACAAGGTCGGCCAGGACGGCGTTGTGACCGTTGAAGACAACAACCGCTTCGGCCTGGACCTCGACTT
CACCGAGGGCATGCGTTTCGACAAGGGCTACATCGCCCCGTACTTCGTCACCAACGCTGACGACCAGACCGCAGTGCTCG
AAGATCCGTACATTCTGCTGACCTCCGGCAAGGTCTCCTCCCAGCAGGACATCGTGCACGTGGCCGAGCTGGTCATGAAG
ACCGGCAAGCCGCTGCTGATCATCGCTGAGGACGTCGATGGCGAAGCACTGCCGACCCTGATCCTGAACAACATCCGTGG
CACCTTCAAGTCCTGCGCCGTCAAGGCCCCGGGCTTTGGCGACCGTCGCAAGGCCATGCTGCAGGATATGGCCATCCTGA
CCGGTGCTCAGGTTGTCTCCGACGAACTGGGCCTGAAGCTCGAGTCCGTCGACACCTCCGTGCTCGGCCATGCCAAGAAG
GTCATCGTCTCCAAGGACGAGACCACCATCGTTCAGGGCGCTGGCTCCAAGGAAGACATCGACGCTCGCGTGGCCCAGAT
CCGCGCTGAGATCGAGAACACCGACTCCGATTACGACCGTGAGAAGCTGCAGGAGCGTCTGGCCAAGCTGGCCGGCGGCG
TGGCTGTCATCAAGGTCGGCGCTGCCACCGAGGTTGAGGCCAAGGAGCGCAAGCACCGCATCGAAGATGCCGTGCGTAAC
GCCAAGGCCGCCATCGAGGAAGGCCTGCTGCCCGGCGGTGGCGTGGCCCTCGTTCAGGCTGCTGCCAAGGCCGAGAAGGC
TGAGGCCGTCACCTCCCTGACCGGCGAAGAGGCTACCGGTGCCGCCATCGTGTTCCGCGCCATCGAGGCCCCGATCAAGC
AGATCGCCGAGAACGCCGGCGTGTCCGGTGACGTGGTCATCAACACCGTCCGCTCCCTGCCTGATGGCGAAGGCTTCAAC
GCCGCCACCGACACCTACGAAGACCTGCTGGCCGCCGGTGTGACCGACCCGGTCAAGGTGACCCGCTCCGCTCTGCAGAA
CGCCGCCTCCATCGCTGGTCTGTTCCTGACCACCGAGGCCGTCGTTGCCAACAAGCCAGAGCCGAAGCCTGCTGCCCCGG
CCGCCGGTGCCGACATGGGCTACTGA

Upstream 100 bases:

>100_bases
GAGGTCGAGAGTGATAATCGACAGCTGACGGCTGGTCGTCACGACTCGACGCTTGCGAGTGATAACCGGTATACCTAGCC
ATTTGGAGGAATACGCAACC

Downstream 100 bases:

>100_bases
TCCGCAAACGATCGCTAGCTGATTGAGCTGAAAGGGGATTCCTTCGGGAGTCCCCTTTTTTGTATTCTGGTTCCCCTCTT
TGAGGGGAGCTGTCGAACGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKT
DDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKI
AEALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMK
TGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKK
VIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRN
AKAAIEEGLLPGGGVALVQAAAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFN
AATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKPAAPAAGADMGY

Sequences:

>Translated_541_residues
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKT
DDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKI
AEALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMK
TGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKK
VIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRN
AKAAIEEGLLPGGGVALVQAAAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFN
AATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKPAAPAAGADMGY
>Mature_540_residues
AKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKTD
DVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIA
EALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMKT
GKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKKV
IVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNA
KAAIEEGLLPGGGVALVQAAAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFNA
ATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKPAAPAAGADMGY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=44.3181818181818, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=44.3181818181818, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI24307939, Length=242, Percent_Identity=26.8595041322314, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=55.4716981132075, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=44.9905482041588, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=41.2322274881517, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144674, Length=158, Percent_Identity=31.0126582278481, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=46.8690702087287, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322524, Length=183, Percent_Identity=28.4153005464481, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322350, Length=551, Percent_Identity=21.4156079854809, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=45.4545454545455, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=45.4545454545455, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=42.8842504743833, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=42.8842504743833, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=42.8842504743833, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=37.8326996197719, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=32.9608938547486, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=32.9608938547486, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI28571140, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18858175, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17647245, Length=191, Percent_Identity=31.413612565445, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56818; Mature: 56687

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEID
CCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHCC
LEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNR
HHHHHHHHHHHHHHHCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCE
FGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMK
EEEEEEHHCCCCCCCCCCCEEEEECCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
TGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
DELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDR
HHHCCEEHHCCHHHHHHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHH
EKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
AATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKPAAPAAGADMG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
Y
C
>Mature Secondary Structure 
AKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEID
CCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHCC
LEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNR
HHHHHHHHHHHHHHHCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCE
FGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMK
EEEEEEHHCCCCCCCCCCCEEEEECCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHH
TGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
DELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDR
HHHCCEEHHCCHHHHHHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHH
EKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFN
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
AATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKPAAPAAGADMG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA