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The map label for this gene is arlS [H]

Identifier: 213691414

GI number: 213691414

Start: 577717

End: 579018

Strand: Reverse

Name: arlS [H]

Synonym: Blon_0509

Alternate gene names: 213691414

Gene position: 579018-577717 (Counterclockwise)

Preceding gene: 213691415

Following gene: 213691413

Centisome position: 20.44

GC content: 64.13

Gene sequence:

>1302_bases
ATGACCGACACCGACACGACCAACCGGCCGGCCGGGCACGCCGCGCGCCCGCGCAAACCCGCCAGCTTCCGCATCCGCCT
CGCCGTCACCGTCGGACTGCTCCTGCTCGGCATGCTCCTCGCCGTGATCCTCGTACAGAACATCTCGCTCGACTGGGCGT
TCCAGCATCAGGTGGACACCATCTCCACAGGCAGCAACCAGAACACCATCACGACGGAACCTGCCACGCCCCAGGACGGG
GTTCCCGGCACGGCCGACTCATGTAACGCGGATCCCTGCGACGTGACCGGTGCCATTCTCTCTCCGACCGCCGGGCAGAC
CGGCACGGAGGGCGTGGTGCTCACCGTCAGGGACGGCGTCGTGCAATGGATGCGCTACGGATCGCTCGCCGTGTTCGCCG
TATCCGCGCTCCTGGCCGTGCTCCTCGTCTGGAACCTGTCGGGCAAACTCACCGCACACCTCGACTCCATCAGCCGCCAG
ACCGGCCAACTCGACCCCGACCATCCCGCCGGGCGCATCAGCCTCGATCATCCCGACGCCGAGACCGCCGGCCTAGCCGA
CGCGCTCAACACGATGCTCGACCGCATCGAGCAATCCAACGAACTGCAACGATCGTTCATCCGCAACGCCAGCCACGAAC
TGAAAACACCGATCACGACCATCGGCACCAGCCTCGAAGCGCTCATGGCCCAGGACCGGTTCCCCGAGGACGTCAAACCA
GCCATCAGCCACGCCATCGAAGCGAACCGCAAAAGCAGTGAACTCATCAACAGTCTGCTCGAACTCTCCCGCATCCAGAC
CGTGCCCGACACCAGCACGGAAACCGTGGACCCCGCCCGCATCGTACGCGACACGCTCGAAACCCACCGCGAACAGGCAC
AGGCACGTCACCTGCGCATCGACGCCGACGGACTCGCCGCATACCACGGCCCCTTCATCGAGACGAACCCGCGCTACCTC
TCGCTCGCTGTGGACAACCTGATACGCAACGCCATCATCCACAACACCGACCACGGCGCCATCACCTGCACCATCCACGA
CGACAAGCAGCACGTCACCATCAGCATCACCAACACCACAAAACAGCCGGACCACCCCGAAGCCACGGCCGACCTCATCC
AACCATTCCACCGAGGAGACGCAACCCGCATGGCCAACCAACCTGGCCACGGCCTCGGACTATCCATCACCAAAGCCTGC
ACAGACGCCATCGGCGCCAGCCTCAACATCAGCCGTCCCACAGCCGATGTATTCCGCGCCGGAATCATGCTAAATCGACA
TATCGGCATGCCCATTAGATGA

Upstream 100 bases:

>100_bases
ACCAGCCCGACCTCGTCAAGACCGCCGTCTACTCGCTACGACGCAAACTGCCCGACCCCTCGCTCATCGCCTCGTCGCGC
GGAGAGGGATACCGCATACC

Downstream 100 bases:

>100_bases
TTTATTCACGATAAGATATCCTTACTCATACTGACTGATTAGTCAATGAATGCGAGGATATCGATGAATAGTGCGGAACG
GAGACGTAGAACGCGCGAAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDTDTTNRPAGHAARPRKPASFRIRLAVTVGLLLLGMLLAVILVQNISLDWAFQHQVDTISTGSNQNTITTEPATPQDG
VPGTADSCNADPCDVTGAILSPTAGQTGTEGVVLTVRDGVVQWMRYGSLAVFAVSALLAVLLVWNLSGKLTAHLDSISRQ
TGQLDPDHPAGRISLDHPDAETAGLADALNTMLDRIEQSNELQRSFIRNASHELKTPITTIGTSLEALMAQDRFPEDVKP
AISHAIEANRKSSELINSLLELSRIQTVPDTSTETVDPARIVRDTLETHREQAQARHLRIDADGLAAYHGPFIETNPRYL
SLAVDNLIRNAIIHNTDHGAITCTIHDDKQHVTISITNTTKQPDHPEATADLIQPFHRGDATRMANQPGHGLGLSITKAC
TDAIGASLNISRPTADVFRAGIMLNRHIGMPIR

Sequences:

>Translated_433_residues
MTDTDTTNRPAGHAARPRKPASFRIRLAVTVGLLLLGMLLAVILVQNISLDWAFQHQVDTISTGSNQNTITTEPATPQDG
VPGTADSCNADPCDVTGAILSPTAGQTGTEGVVLTVRDGVVQWMRYGSLAVFAVSALLAVLLVWNLSGKLTAHLDSISRQ
TGQLDPDHPAGRISLDHPDAETAGLADALNTMLDRIEQSNELQRSFIRNASHELKTPITTIGTSLEALMAQDRFPEDVKP
AISHAIEANRKSSELINSLLELSRIQTVPDTSTETVDPARIVRDTLETHREQAQARHLRIDADGLAAYHGPFIETNPRYL
SLAVDNLIRNAIIHNTDHGAITCTIHDDKQHVTISITNTTKQPDHPEATADLIQPFHRGDATRMANQPGHGLGLSITKAC
TDAIGASLNISRPTADVFRAGIMLNRHIGMPIR
>Mature_432_residues
TDTDTTNRPAGHAARPRKPASFRIRLAVTVGLLLLGMLLAVILVQNISLDWAFQHQVDTISTGSNQNTITTEPATPQDGV
PGTADSCNADPCDVTGAILSPTAGQTGTEGVVLTVRDGVVQWMRYGSLAVFAVSALLAVLLVWNLSGKLTAHLDSISRQT
GQLDPDHPAGRISLDHPDAETAGLADALNTMLDRIEQSNELQRSFIRNASHELKTPITTIGTSLEALMAQDRFPEDVKPA
ISHAIEANRKSSELINSLLELSRIQTVPDTSTETVDPARIVRDTLETHREQAQARHLRIDADGLAAYHGPFIETNPRYLS
LAVDNLIRNAIIHNTDHGAITCTIHDDKQHVTISITNTTKQPDHPEATADLIQPFHRGDATRMANQPGHGLGLSITKACT
DAIGASLNISRPTADVFRAGIMLNRHIGMPIR

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=26.027397260274, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790861, Length=310, Percent_Identity=22.258064516129, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=275, Percent_Identity=25.0909090909091, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=28.9719626168224, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46745; Mature: 46614

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTDTTNRPAGHAARPRKPASFRIRLAVTVGLLLLGMLLAVILVQNISLDWAFQHQVDT
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCE
ISTGSNQNTITTEPATPQDGVPGTADSCNADPCDVTGAILSPTAGQTGTEGVVLTVRDGV
ECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCEEEEEHHHH
VQWMRYGSLAVFAVSALLAVLLVWNLSGKLTAHLDSISRQTGQLDPDHPAGRISLDHPDA
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
ETAGLADALNTMLDRIEQSNELQRSFIRNASHELKTPITTIGTSLEALMAQDRFPEDVKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
AISHAIEANRKSSELINSLLELSRIQTVPDTSTETVDPARIVRDTLETHREQAQARHLRI
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
DADGLAAYHGPFIETNPRYLSLAVDNLIRNAIIHNTDHGAITCTIHDDKQHVTISITNTT
CCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECC
KQPDHPEATADLIQPFHRGDATRMANQPGHGLGLSITKACTDAIGASLNISRPTADVFRA
CCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHH
GIMLNRHIGMPIR
HHHEECCCCCCCC
>Mature Secondary Structure 
TDTDTTNRPAGHAARPRKPASFRIRLAVTVGLLLLGMLLAVILVQNISLDWAFQHQVDT
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCE
ISTGSNQNTITTEPATPQDGVPGTADSCNADPCDVTGAILSPTAGQTGTEGVVLTVRDGV
ECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCEEEEEHHHH
VQWMRYGSLAVFAVSALLAVLLVWNLSGKLTAHLDSISRQTGQLDPDHPAGRISLDHPDA
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
ETAGLADALNTMLDRIEQSNELQRSFIRNASHELKTPITTIGTSLEALMAQDRFPEDVKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
AISHAIEANRKSSELINSLLELSRIQTVPDTSTETVDPARIVRDTLETHREQAQARHLRI
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
DADGLAAYHGPFIETNPRYLSLAVDNLIRNAIIHNTDHGAITCTIHDDKQHVTISITNTT
CCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECC
KQPDHPEATADLIQPFHRGDATRMANQPGHGLGLSITKACTDAIGASLNISRPTADVFRA
CCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHH
GIMLNRHIGMPIR
HHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA